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Aliases for ZYX Gene

Aliases for ZYX Gene

  • Zyxin 2 3
  • Zyxin-2 3 4
  • ESP-2 3
  • HED-2 3

External Ids for ZYX Gene

Previous GeneCards Identifiers for ZYX Gene

  • GC07P141404
  • GC07P142472
  • GC07P142549
  • GC07P142595
  • GC07P142791
  • GC07P143078
  • GC07P137415

Summaries for ZYX Gene

Entrez Gene Summary for ZYX Gene

  • Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZYX Gene

ZYX (Zyxin) is a Protein Coding gene. Diseases associated with ZYX include tetraploidy. Among its related pathways are PAK Pathway and Focal adhesion. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for ZYX Gene

  • Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Gene Wiki entry for ZYX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYX Gene

Genomics for ZYX Gene

Regulatory Elements for ZYX Gene

Genomic Location for ZYX Gene

Start:
143,381,080 bp from pter
End:
143,391,111 bp from pter
Size:
10,032 bases
Orientation:
Plus strand

Genomic View for ZYX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZYX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYX Gene

Proteins for ZYX Gene

  • Protein details for ZYX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15942-ZYX_HUMAN
    Recommended name:
    Zyxin
    Protein Accession:
    Q15942
    Secondary Accessions:
    • A4D2G6
    • B4DQX7
    • Q6I9S4

    Protein attributes for ZYX Gene

    Size:
    572 amino acids
    Molecular mass:
    61277 Da
    Quaternary structure:
    • Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2).

    Alternative splice isoforms for ZYX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZYX Gene

Proteomics data for ZYX Gene at MOPED

Post-translational modifications for ZYX Gene

  • Ubiquitination at Lys265
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZYX Gene

Domains for ZYX Gene

Protein Domains for ZYX Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15942

UniProtKB/Swiss-Prot:

ZYX_HUMAN :
  • Q15942
Domain:
  • Contains 3 LIM zinc-binding domains.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with ZYX: view

No data available for Gene Families for ZYX Gene

Function for ZYX Gene

Molecular function for ZYX Gene

GENATLAS Biochemistry: zyxin component of cell junction matrix,concentrated at adhesion plaques and along actin-filament bundles,ubiquitous but most prominent in blood cells and tissues rich in smooth muscle and endothelial cells,involved in the spatial control of actin assembly and in communication between the adhesive membrane and the cell nucleus
UniProtKB/Swiss-Prot Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Gene Ontology (GO) - Molecular Function for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10831611
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZYX: view

Phenotypes for ZYX Gene

genes like me logo Genes that share phenotypes with ZYX: view

Animal Models for ZYX Gene

MGI Knock Outs for ZYX:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZYX Gene

Localization for ZYX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZYX Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZYX Gene COMPARTMENTS Subcellular localization image for ZYX gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 18297730
GO:0005634 nucleus IDA 24036928
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS 8940160
GO:0005887 integral component of plasma membrane TAS 8940160
genes like me logo Genes that share ontologies with ZYX: view

Pathways for ZYX Gene

genes like me logo Genes that share pathways with ZYX: view

Pathways by source for ZYX Gene

Gene Ontology (GO) - Biological Process for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8940160
GO:0007160 cell-matrix adhesion IC 24036928
GO:0007165 signal transduction TAS 8940160
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928
GO:0007229 integrin-mediated signaling pathway IMP 24036928
genes like me logo Genes that share ontologies with ZYX: view

Compounds for ZYX Gene

(6) Novoseek inferred chemical compound relationships for ZYX Gene

Compound -log(P) Hits PubMed IDs
leptomycin b 70.9 2
proline 34.1 1
phosphotyrosine 30 1
zinc 28.5 2
tyrosine 21.8 1
genes like me logo Genes that share compounds with ZYX: view

Transcripts for ZYX Gene

Unigene Clusters for ZYX Gene

Zyxin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZYX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ZYX Gene

GeneLoc Exon Structure for
ZYX
ECgene alternative splicing isoforms for
ZYX

Expression for ZYX Gene

mRNA expression in normal human tissues for ZYX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYX Gene

This gene is overexpressed in Whole Blood (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZYX Gene

SOURCE GeneReport for Unigene cluster for ZYX Gene Hs.490415

genes like me logo Genes that share expressions with ZYX: view

No data available for mRNA Expression by UniProt/SwissProt for ZYX Gene

Orthologs for ZYX Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZYX 35
  • 99.3 (n)
  • 99.48 (a)
ZYX 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZYX 35
  • 87.22 (n)
  • 88.89 (a)
ZYX 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZYX 35
  • 86.83 (n)
  • 88.17 (a)
ZYX 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zyx 35
  • 84.82 (n)
  • 88.26 (a)
Zyx 16
Zyx 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZYX 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zyx 35
  • 84.64 (n)
  • 87.72 (a)
chicken
(Gallus gallus)
Aves ZYX 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZYX 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3057 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7234 35
zebrafish
(Danio rerio)
Actinopterygii zyx 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Zyx102EF 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea zyx-1 36
  • 22 (a)
OneToMany
zyx-1 37
  • 47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8432 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ZYX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZYX Gene

ENSEMBL:
Gene Tree for ZYX (if available)
TreeFam:
Gene Tree for ZYX (if available)

Paralogs for ZYX Gene

Paralogs for ZYX Gene

Pseudogenes.org Pseudogenes for ZYX Gene

genes like me logo Genes that share paralogs with ZYX: view

Variants for ZYX Gene

Sequence variations from dbSNP and Humsavar for ZYX Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4495332 -- 143,384,763(+) CCAGC(A/G)CGATT intron-variant
rs4556013 -- 143,386,781(+) GCAGA(A/T)AATGG intron-variant
rs4725616 -- 143,386,318(+) GCAGC(A/G)TGGAT intron-variant
rs4726616 -- 143,386,404(+) AGCAA(A/G)GGGAC intron-variant
rs4726617 -- 143,387,377(+) GCCAC(A/G)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZYX Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV Loss 19592680
nsv482115 CNV Gain 20164927

Relevant External Links for ZYX Gene

HapMap Linkage Disequilibrium report
ZYX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYX Gene

Disorders for ZYX Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZYX Gene including...

Search for ZYX Gene in MalaCards »

(5) Novoseek inferred disease relationships for ZYX Gene

Disease -log(P) Hits PubMed IDs
lipoma 48.4 4
warts 26.7 1
ewings sarcoma 19.5 3
leukemia 0 2
tumors 0 10

Relevant External Links for ZYX

Genetic Association Database (GAD)
ZYX
Human Genome Epidemiology (HuGE) Navigator
ZYX
genes like me logo Genes that share disorders with ZYX: view

No data available for UniProtKB/Swiss-Prot for ZYX Gene

Publications for ZYX Gene

  1. Molecular characterization of human zyxin. (PMID: 8940160) Macalma T. … Beckerle M.C. (J. Biol. Chem. 1996) 2 3 4 23
  2. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. (PMID: 10801818) Drees B. … Golsteyn R.M. (J. Biol. Chem. 2000) 3 4 23
  3. Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation. (PMID: 11689660) Degenhardt Y.Y. … Silverstein S. (J. Virol. 2001) 3 4 23
  4. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PMID: 12695497) Garvalov B.K. … Way M. (J. Cell Biol. 2003) 3 4 23
  5. A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. (PMID: 8917469) Zumbrunn J. … Trueb B. (Eur. J. Biochem. 1996) 2 3 4

Products for ZYX Gene

Sources for ZYX Gene

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