External Ids for ZYX Gene
Previous GeneCards Identifiers for ZYX Gene
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZYX Gene
ZYX (Zyxin) is a Protein Coding gene. Diseases associated with ZYX include Hypotonia-Cystinuria Syndrome and Ewing Sarcoma. Among its related pathways are PAK Pathway and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. An important paralog of this gene is LPP.
UniProtKB/Swiss-Prot for ZYX Gene
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).