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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZYX Gene

protein-coding   GIFtS: 66
GCID: GC07P143078

Zyxin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
zyxin1 2
ESP-22
HED-22
zyxin-22
Zyxin-23

External Ids:    HGNC: 132001   Entrez Gene: 77912   Ensembl: ENSG000001598407   OMIM: 6020025   UniProtKB: Q159423   

Export aliases for ZYX gene to outside databases

Previous GC identifers: GC07P141404 GC07P142472 GC07P142549 GC07P142595 GC07P142791 GC07P137415


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZYX Gene:
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which
protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that
concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and
three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins
involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding.
Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in
gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in
multiple transcript variants that encode the same isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZYX Gene: 
ZYX (zyxin) is a protein-coding gene. Diseases associated with ZYX include tetraploidy, and lipoma, and among its related super-pathways are Focal Adhesion and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include protein binding and zinc ion binding. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942
Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and
ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of
a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

Gene Wiki entry for ZYX (Zyxin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZYX gene promoter:
         SRF   CP2   Ik-2   p53   SRF (504 AA)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ZYX promoter sequence
   Search SABiosciences Chromatin IP Primers for ZYX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZYX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q32

ZYX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZYX gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143078:  view genomic region     (about GC identifiers)

Start:
143,078,173 bp from pter      End:
143,088,204 bp from pter
Size:
10,032 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,480,492-142,490,336     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942 (See protein sequence)
Recommended Name: Zyxin  
Size: 572 amino acids; 61277 Da
Subunit: Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11,
16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the
first LIM domain of TES. Interacts with NEBL (isoform 2)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates
with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1
Secondary accessions: A4D2G6 Q6I9S4

Explore the universe of human proteins at neXtProt for ZYX: NX_Q15942

Explore proteomics data for ZYX at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15942

  • ZYX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZYX Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001010972.1  NP_003452.1  

    ENSEMBL proteins: 
     ENSP00000324422   ENSP00000413467   ENSP00000400537   ENSP00000346417   ENSP00000376642  
     ENSP00000411230   ENSP00000403714   ENSP00000394158  

    Human Recombinant Protein Products for ZYX: 
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    Novus Biologicals ZYX Protein
    Novus Biologicals ZYX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZYX 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA18297730
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS8940160
    GO:0005887integral to plasma membrane TAS8940160

    ZYX for ontologies           About GeneDecksing



    ZYX Antibody Products: 
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    ThermoFisher Antibodies for ZYX
    LSBio Antibodies in human, mouse, rat for ZYX 

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    Cloud-Clone Corp. CLIAs for ZYX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q15942

    ProtoNet protein and cluster: Q15942

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    ZYX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZYX_HUMAN, Q15942
    Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and
    ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of
    a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

         Genatlas biochemistry entry for ZYX:
    zyxin component of cell junction matrix,concentrated at adhesion plaques and along actin-filament
    bundles,ubiquitous but most prominent in blood cells and tissues rich in smooth muscle and endothelial
    cells,involved in the spatial control of actin assembly and in communication between the adhesive membrane and
    the cell nucleus

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10831611
    GO:0008270zinc ion binding IEA--
         
    ZYX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZYX:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zyx):
     cellular  normal 

    ZYX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zyxtm1Mbk for ZYX

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZYX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZYX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZYX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZYX 

    miRNA
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    hsa-miR-875-3p hsa-miR-15a hsa-miR-1205 hsa-miR-570 hsa-miR-103a hsa-miR-424 hsa-miR-323-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZYX 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZYX About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    2Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    3Sertoli-Sertoli Cell Junction Dynamics
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    4PAK Pathway
    Epithelial Adherens Junctions0.36
    5Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ZYX
        Cell adhesion Integrin-mediated cell adhesion and migration

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ZYX
        Remodeling of Adherens Junctions
    Germ Cell-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for ZYX
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ZYX
        Cell adhesion Integrin-mediated cell adhesion and migration

    4 BioSystems Pathways for ZYX
        Focal Adhesion
    Integrin-mediated cell adhesion
    E-cadherin signaling in keratinocytes
    Stabilization and expansion of the E-cadherin adherens junction


    1         Kegg Pathway  (Kegg details for ZYX):
        Focal adhesion


    ZYX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZYX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for ZYX (Q159421, 2, 3 ENSP000003244224) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2864284 I2D: score=3 STRING: ENSP00000244769
    HIPK3Q9H4222, 3MINT-61743 I2D: score=3 
    RGS2P412202, 3MINT-8269032 I2D: score=2 
    LASP1Q148471, 3, ENSP000003252404EBI-444225,EBI-742828 I2D: score=3 STRING: ENSP00000325240
    LATS1O958351, 3, ENSP000002533394EBI-444225,EBI-444209 I2D: score=3 STRING: ENSP00000253339
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8940160
    GO:0007267cell-cell signaling TAS8940160
    GO:0019048modulation by virus of host morphology or physiology IEA--

    ZYX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZYX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZYX

    6 Novoseek inferred chemical compound relationships for ZYX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 70.9 4 11395501 (1), 19173742 (1)
    proline 34.1 1 9296389 (1)
    phosphotyrosine 30 1 8748369 (1)
    zinc 28.5 3 9394617 (1), 1469049 (1)
    tyrosine 21.8 1 14576354 (1)
    fibrinogen 0 1 15120620 (1)

    Search CenterWatch for drugs/clinical trials and news about ZYX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZYX gene (2 alternative transcripts): 
    NM_001010972.1  NM_003461.4  

    Unigene Cluster for ZYX:

    Zyxin
    Hs.490415  [show with all ESTs]
    Unigene Representative Sequence: BC073825
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322764(uc011ktd.2 uc003wcw.3 uc003wcx.3 uc011kte.2)
    ENST00000449630 ENST00000468083 ENST00000457235 ENST00000354434 ENST00000392910(uc011ktf.2)
    ENST00000477373 ENST00000436448 ENST00000446634 ENST00000497119 ENST00000449423

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ZYX (see all 18):
    hsa-miR-875-3p hsa-miR-15a hsa-miR-1205 hsa-miR-570 hsa-miR-103a hsa-miR-424 hsa-miR-323-5p hsa-miR-3148
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZYX

    Additional mRNA sequence: 

    AK130138.1 AK298925.1 AK299005.1 AK302309.1 AK316227.1 BC002323.2 BC008743.2 BC009360.2 
    BC010031.2 BC017183.2 BC073825.1 CR457431.1 U15158.1 X94991.1 X95735.1 

    24/25 DOTS entries (see all 25):

    DT.449659  DT.100045554  DT.86838554  DT.97864738  DT.100674451  DT.97864739  DT.75130220  DT.40201031 
    DT.100674454  DT.100674443  DT.121071327  DT.121071344  DT.454463  DT.92035875  DT.100674444  DT.87016730 
    DT.92458526  DT.95261771  DT.97864737  DT.100638373  DT.100642216  DT.121071355  DT.100711751  DT.100840804 

    24/640 AceView cDNA sequences (see all 640):

    AA040172 BU630186 Z40137 AA310084 AI752696 BM796370 CA440569 CB216251 
    AA358885 AI741881 BU734011 BP376020 BQ928274 AA434229 BE868042 CD367134 
    BX394405 BQ953043 CB528766 BC017183 AA418981 BU507272 BM782681 CA441717 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZYX (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -                 -     -                                   -     -                                                         
    SP2:                          -     -                 -     -                                   -     -                                                         
    SP3:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP4:                                                                                                                                -                           
    SP5:                          -     -                                                                                                                           


    ECgene alternative splicing isoforms for ZYX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZYX expression in normal human tissues (normalized intensities)      ZYX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCAAGTT
    ZYX Expression
    About this image


    ZYX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose

    See ZYX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZYX

    SOURCE GeneReport for Unigene cluster: Hs.490415
        SABiosciences Expression via Pathway-Focused PCR Arrays including ZYX: 
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZYX gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zyx1 , 5 zyxin1, 5 85.29(n)1
    88.79(a)1
      6 (20.64 cM)5
    227931  NM_011777.21  NP_035907.11 
     423498285 
    chicken
    (Gallus gallus)
    Aves ZYX1 zyxin 62.96(n)
    60.16(a)
      418300  NM_001004386.1  NP_001004386.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZYX6
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343391.1(635643-673054)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30572 Xenopus laevis transcribed sequence with weak similarity more 76.49(n)    BJ068010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zyx1 zyxin 53.18(n)
    46.21(a)
      564246  NM_001109824.1  NP_001103294.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zyx-13 LIM domain containing proteins 47(a)   II(13057045-13070542)   --


    ENSEMBL Gene Tree for ZYX (if available)
    TreeFam Gene Tree for ZYX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZYX gene
    LPP2  TRIP62  FBLIM12  WTIP2  AJUBA2  LIMD12  
    9 SIMAP similar genes for ZYX using alignment to 10 protein entries:     ZYX_HUMAN (see all proteins):
    LIMS1    LHX8    LIMD1    LHX6    FBLIM1    PDLIM5
    LPP    CRIP1    LHX4

    ZYX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZYX
    PGOHUM00000249513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/280 SNPs in ZYX are shown (see all 280)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410610561,2
    --143079601(+) GGGCCC/TTTTCT 2 -- int10--------
    rs1931267731,2
    C--143079636(+) TTGGGA/GGTGGG 2 -- int10--------
    rs1431341661,2
    C--143079640(+) GGGTGA/GGGGGA 2 -- int10--------
    rs1482363391,2
    C--143079643(+) TGGGGA/GGATAG 2 -- int10--------
    rs2002126861,2
    --143079692(+) CCAGGA/GAGAAG 4 K E mis10--------
    rs1113477041,2
    C--143079781(+) CGGGTA/GAGGGA 2 -- int10--------
    rs64645461,2
    C,F,A,H--143079806(+) AAGCAG/AGGCTC 2 -- int123Minor allele frequency- A:0.31NS EA NA WA CSA 2352
    rs1856190511,2
    C--143079808(+) GCAGGG/TCTCAG 2 -- int10--------
    rs1507913281,2
    C--143079825(+) AGAGAC/TTGGGC 2 -- int10--------
    rs1886309081,2
    C--143079854(+) GTGTCC/TTCCTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZYX (143078173 - 143088204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZYX:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv517520CNV Loss19592680
    nsv482115CNV Gain20164927

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602002    OMIM disorders: --

    18 diseases for ZYX:    About MalaCards
    tetraploidy    lipoma    laryngeal carcinoma    vaccinia
    epididymitis    wilms tumor    laryngitis    acute leukemia
    infertility    sarcoma    endotheliitis    hepatocellular carcinoma
    ovarian cancer    melanoma    leukemia    breast cancer
    lung cancer    neuronitis


    ZYX for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for ZYX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoma 48.4 5 11433529 (1), 9598321 (1), 15465019 (1), 19701494 (1)
    warts 26.7 1 15122335 (1)
    ewings sarcoma 19.5 3 15748890 (2), 15184883 (1)
    leukemia 0 2 12659632 (1), 16959042 (1)
    tumors 0 10 16680155 (3), 15748890 (3), 17889706 (1), 10831611 (1) (see all 6)

    Genetic Association Database (GAD): ZYX
    Human Genome Epidemiology (HuGE) Navigator: ZYX (3 documents)

    Export disorders for ZYX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZYX gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with ZYX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human zyxin. (PubMed id 8940160)1, 2, 3, 9 Macalma T....Beckerle M.C. (1996)
    2. A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. (PubMed id 8917469)1, 2, 3 Zumbrunn J. and Trueb B. (1996)
    3. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. (PubMed id 10801818)1, 2, 9 Drees B....Golsteyn R.M. (2000)
    4. Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation. (PubMed id 11689660)1, 2, 9 Degenhardt Y.Y. and Silverstein S. (2001)
    5. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PubMed id 12695497)1, 2, 9 Garvalov B.K.... Way M. (2003)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. The LIM-domain protein zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo. (PubMed id 18297730)1, 2 Martynova N.Y.... Zaraisky A.G. (2008)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7791 HGNC: 13200 AceView: ZYX Ensembl:ENSG00000159840 euGenes: HUgn7791
    ECgene: ZYX Kegg: 7791 H-InvDB: ZYX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZYX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZYX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZYX gene:
    Search GeneIP for patents involving ZYX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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