External Ids for ZYX Gene
Previous GeneCards Identifiers for ZYX Gene
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZYX Gene
ZYX (Zyxin) is a Protein Coding gene. Diseases associated with ZYX include Ewing Sarcoma and Hypotonia-Cystinuria Syndrome. Among its related pathways are E-cadherin signaling in keratinocytes and Focal Adhesion. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is LPP.
UniProtKB/Swiss-Prot for ZYX Gene
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).