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ZYX Gene

protein-coding   GIFtS: 67
GCID: GC07P143078

Zyxin

  See ZYX-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
zyxin1 2
ESP-22
HED-22
zyxin-22
Zyxin-23

External Ids:    HGNC: 132001   Entrez Gene: 77912   Ensembl: ENSG000001598407   OMIM: 6020025   UniProtKB: Q159423   

Export aliases for ZYX gene to outside databases

Previous GC identifers: GC07P141404 GC07P142472 GC07P142549 GC07P142595 GC07P142791 GC07P137415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZYX Gene:
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which
protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that
concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and
three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins
involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding.
Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in
gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in
multiple transcript variants that encode the same isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZYX Gene:
ZYX (zyxin) is a protein-coding gene. Diseases associated with ZYX include tetraploidy. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942
Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and
ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of
a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

Gene Wiki entry for ZYX (Zyxin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZYX gene promoter:
         SRF   CP2   Ik-2   p53   SRF (504 AA)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ZYX promoter sequence
   Search Chromatin IP Primers for ZYX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZYX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q32

ZYX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZYX gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143078:  view genomic region     (about GC identifiers)

Start:
143,078,173 bp from pter      End:
143,088,204 bp from pter
Size:
10,032 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,480,492-142,490,336     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942 (See protein sequence)
Recommended Name: Zyxin  
Size: 572 amino acids; 61277 Da
Subunit: Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11,
16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the
first LIM domain of TES. Interacts with NEBL (isoform 2)
Secondary accessions: A4D2G6 Q6I9S4

Explore the universe of human proteins at neXtProt for ZYX: NX_Q15942

Explore proteomics data for ZYX at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys265
  • Modification sites at PhosphoSitePlus

  • See ZYX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010972.1  NP_003452.1  

    ENSEMBL proteins: 
     ENSP00000324422   ENSP00000413467   ENSP00000400537   ENSP00000346417   ENSP00000376642  
     ENSP00000411230   ENSP00000403714   ENSP00000394158  

    ZYX Human Recombinant Protein Products:

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    Novus Biologicals ZYX Protein
    Novus Biologicals ZYX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZYX

     
    Search eBioscience for Proteins for ZYX 

    ZYX Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ZYX
    R&D Systems Antibodies for ZYX (Zyxin)
    Cell Signaling Technology (CST) Antibodies for ZYX  (zyxin)
    OriGene Antibodies for ZYX
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    Abcam antibodies for ZYX
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    ThermoFisher Antibodies for ZYX
    LSBio Antibodies in human, mouse, rat for ZYX

    ZYX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZYX
    Cloud-Clone Corp. CLIAs for ZYX
    Search eBioscience for ELISAs for ZYX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q15942

    ProtoNet protein and cluster: Q15942

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    Find genes that share domains with ZYX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZYX_HUMAN, Q15942
    Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and
    ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of
    a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

         Genatlas biochemistry entry for ZYX:
    zyxin component of cell junction matrix,concentrated at adhesion plaques and along actin-filament
    bundles,ubiquitous but most prominent in blood cells and tissues rich in smooth muscle and endothelial
    cells,involved in the spatial control of actin assembly and in communication between the adhesive membrane and
    the cell nucleus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10831611
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ZYX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZYX:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zyx):
     cellular  normal 

    Find genes that share phenotypes with ZYX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zyxtm1Mbk for ZYX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZYX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZYX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZYX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZYX

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZYX:
    hsa-mir-423-5p (MIRT038134), hsa-mir-16-1-3p (MIRT007089), hsa-mir-7-5p (MIRT025817), hsa-mir-221-3p (MIRT046890), hsa-mir-96-5p (MIRT027881), hsa-mir-193b-3p (MIRT041336), hsa-mir-16-5p (MIRT006534), hsa-mir-103a-3p (MIRT027220), hsa-mir-330-5p (MIRT038247)

    Block miRNA regulation of human, mouse, rat ZYX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZYX (see all 18):
    hsa-miR-875-3p hsa-miR-15a hsa-miR-1205 hsa-miR-570 hsa-miR-103a hsa-miR-424 hsa-miR-323-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZYX 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZYX

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZYX (NM_003461)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZYX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZYX

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZYX_HUMAN, Q15942: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates
    with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane4
    cytosol3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA18297730
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS8940160
    GO:0005887integral component of plasma membrane TAS8940160

    Find genes that share ontologies with ZYX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZYX About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    3Sertoli-Sertoli Cell Junction Dynamics
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    4PAK Pathway
    Epithelial Adherens Junctions0.36
    5Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction


    Find genes that share SuperPaths with ZYX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZYX
        Remodeling of Adherens Junctions
    Germ Cell-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for ZYX
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ZYX
        Cell adhesion Integrin-mediated cell adhesion and migration

    4 BioSystems Pathways for ZYX
        Focal Adhesion
    Integrin-mediated cell adhesion
    E-cadherin signaling in keratinocytes
    Stabilization and expansion of the E-cadherin adherens junction


    1 Kegg Pathway  (Kegg details for ZYX):
        Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZYX: 
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZYX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZYX (Q159421, 2, 3 ENSP000003244224) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2864284 I2D: score=3 STRING: ENSP00000244769
    HIPK3Q9H4222, 3MINT-61743 I2D: score=3 
    RGS2P412202, 3MINT-8269032 I2D: score=2 
    LASP1Q148471, 3, ENSP000003252404EBI-444225,EBI-742828 I2D: score=3 STRING: ENSP00000325240
    LATS1O958351, 3, ENSP000002533394EBI-444225,EBI-444209 I2D: score=3 STRING: ENSP00000253339
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8940160
    GO:0007267cell-cell signaling TAS8940160
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with ZYX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZYX

    6 Novoseek inferred chemical compound relationships for ZYX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 70.9 4 11395501 (1), 19173742 (1)
    proline 34.1 1 9296389 (1)
    phosphotyrosine 30 1 8748369 (1)
    zinc 28.5 3 9394617 (1), 1469049 (1)
    tyrosine 21.8 1 14576354 (1)
    fibrinogen 0 1 15120620 (1)



    Find genes that share compounds with ZYX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZYX gene (2 alternative transcripts): 
    NM_001010972.1  NM_003461.4  

    Unigene Cluster for ZYX:

    Zyxin
    Hs.490415  [show with all ESTs]
    Unigene Representative Sequence: BC073825
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322764(uc011ktd.2 uc003wcw.3 uc003wcx.3 uc011kte.2)
    ENST00000449630 ENST00000468083 ENST00000457235 ENST00000354434 ENST00000392910(uc011ktf.2)
    ENST00000477373 ENST00000436448 ENST00000446634 ENST00000497119 ENST00000449423

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZYX (see all 18):
    hsa-miR-875-3p hsa-miR-15a hsa-miR-1205 hsa-miR-570 hsa-miR-103a hsa-miR-424 hsa-miR-323-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZYX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZYX
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZYX (NM_003461)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZYX
    Primer
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    OriGene qPCR primer pairs and template standards for ZYX
    OriGene qSTAR qPCR primer pairs in human, mouse for ZYX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZYX
      QuantiTect SYBR Green Assays in human, mouse, rat ZYX
      QuantiFast Probe-based Assays in human, mouse, rat ZYX

    Additional mRNA sequence: 

    AK130138.1 AK298925.1 AK299005.1 AK302309.1 AK316227.1 BC002323.2 BC008743.2 BC009360.2 
    BC010031.2 BC017183.2 BC073825.1 CR457431.1 U15158.1 X94991.1 X95735.1 

    Selected DOTS entries (see all 25):

    DT.449659  DT.100045554  DT.86838554  DT.97864738  DT.100674451  DT.97864739  DT.75130220  DT.40201031 
    DT.100674454  DT.100674443  DT.121071327  DT.121071344  DT.454463  DT.92035875  DT.100674444  DT.87016730 
    DT.92458526  DT.95261771  DT.97864737  DT.100638373  DT.100642216  DT.121071355  DT.100711751  DT.100840804 

    Selected AceView cDNA sequences (see all 640):

    AA454693 F27828 BQ948112 BF724176 CD365050 BQ919315 BM835378 CN480494 
    F37360 AI871793 AI682549 BQ923496 NM_003461 AA699474 BM791256 AI609066 
    BQ067626 BM691452 BM820270 BQ937239 AA558974 BC008743 BM558992 BU182647 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZYX (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -                 -     -                                   -     -                                                         
    SP2:                          -     -                 -     -                                   -     -                                                         
    SP3:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP4:                                                                                                                                -                           
    SP5:                          -     -                                                                                                                           


    ECgene alternative splicing isoforms for ZYX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ZYX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCAAGTT
    ZYX Expression
    About this image


    ZYX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Hair (Integumentary System)
             Outer Root Sheath Cells Outer Root Sheath
     
     Liver (Hepatobiliary System)
             Liver Lobule
    ZYX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZYX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490415
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZYX: 
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZYX
    OriGene qSTAR qPCR primer pairs in human, mouse for ZYX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZYX
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    QuantiFast Probe-based Assays in human, mouse, rat ZYX
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZYX gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zyx1 , 5 zyxin1, 5 84.82(n)1
    88.26(a)1
      6 (20.64 cM)5
    227931  NM_011777.21  NP_035907.11 
     423498285 
    chicken
    (Gallus gallus)
    Aves ZYX6
    Gallus gallus zyxin (ZYX), mRNA.
    53(a)
    1 ↔ 1
    1(77014769-77026185)
    lizard
    (Anolis carolinensis)
    Reptilia ZYX6
    zyxin
    50(a)
    1 ↔ 1
    GL343391.1(635643-673054)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30572 Xenopus laevis transcribed sequence with weak similarity more 76.49(n)    BJ068010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zyx6
    zyxin
    36(a)
    1 ↔ 1
    16(19364152-19409427) ENSDARG00000075733
    worm
    (Caenorhabditis elegans)
    Secernentea zyx-13 LIM domain containing proteins 47(a)   II(13057045-13070542)   --


    ENSEMBL Gene Tree for ZYX (if available)
    TreeFam Gene Tree for ZYX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZYX gene
    LPP2  FBLIM12  TRIP62  ABLIM32  WTIP2  AJUBA2  DMTN2  ABLIM22  
    LIMD12  ABLIM12  
    8 SIMAP similar genes for ZYX using alignment to 10 protein entries:     ZYX_HUMAN (see all proteins):
    LIMS1    LHX8    LIMD1    FBLIM1    PDLIM5    LPP
    CRIP1    LHX4

    Find genes that share paralogs with ZYX           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZYX
    PGOHUM00000249513


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZYX (see all 280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410610561,2
    --143079601(+) GGGCCC/TTTTCT 2 -- int10--------
    rs1931267731,2
    C--143079636(+) TTGGGA/GGTGGG 2 -- int10--------
    rs1431341661,2
    C--143079640(+) GGGTGA/GGGGGA 2 -- int10--------
    rs1482363391,2
    C--143079643(+) TGGGGA/GGATAG 2 -- int10--------
    rs2002126861,2
    --143079692(+) CCAGGA/GAGAAG 4 K E mis10--------
    rs1113477041,2
    C--143079781(+) CGGGTA/GAGGGA 2 -- int10--------
    rs64645461,2
    C,F,A,H--143079806(+) AAGCAG/AGGCTC 2 -- int123Minor allele frequency- A:0.31NS EA NA WA CSA 2352
    rs1856190511,2
    C--143079808(+) GCAGGG/TCTCAG 2 -- int10--------
    rs1507913281,2
    C--143079825(+) AGAGAC/TTGGGC 2 -- int10--------
    rs1886309081,2
    C--143079854(+) GTGTCC/TTCCTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZYX (143078173 - 143088204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZYX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517520CNV Loss19592680
    nsv482115CNV Gain20164927

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZYX
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602002    OMIM disorders: --

    1 disease for ZYX:    
    About MalaCards
    tetraploidy


    Find genes that share disorders with ZYX           About GenesLikeMe

    5 Novoseek inferred disease relationships for ZYX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoma 48.4 5 11433529 (1), 9598321 (1), 15465019 (1), 19701494 (1)
    warts 26.7 1 15122335 (1)
    ewings sarcoma 19.5 3 15748890 (2), 15184883 (1)
    leukemia 0 2 12659632 (1), 16959042 (1)
    tumors 0 10 16680155 (3), 15748890 (3), 17889706 (1), 10831611 (1) (see all 6)

    Genetic Association Database (GAD): ZYX
    Human Genome Epidemiology (HuGE) Navigator: ZYX (3 documents)

    Export disorders for ZYX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZYX gene, integrated from 10 sources (see all 176):
    (articles sorted by number of sources associating them with ZYX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human zyxin. (PubMed id 8940160)1, 2, 3, 9 Macalma T.... Beckerle M.C. (J. Biol. Chem. 1996)
    2. A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. (PubMed id 8917469)1, 2, 3 Zumbrunn J. and Trueb B. (Eur. J. Biochem. 1996)
    3. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. (PubMed id 10801818)1, 2, 9 Drees B....Golsteyn R.M. (J. Biol. Chem. 2000)
    4. Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation. (PubMed id 11689660)1, 2, 9 Degenhardt Y.Y. and Silverstein S. (J. Virol. 2001)
    5. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PubMed id 12695497)1, 2, 9 Garvalov B.K.... Way M. (J. Cell Biol. 2003)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The LIM-domain protein zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo. (PubMed id 18297730)1, 2 Martynova N.Y.... Zaraisky A.G. (Dev. Dyn. 2008)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7791 HGNC: 13200 AceView: ZYX Ensembl:ENSG00000159840 euGenes: HUgn7791
    ECgene: ZYX Kegg: 7791 H-InvDB: ZYX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZYX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZYX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZYX gene:
    Search GeneIP for patents involving ZYX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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