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Aliases for ZYX Gene

Aliases for ZYX Gene

  • Zyxin 2 3 3 5
  • Zyxin-2 3 4
  • ESP-2 3
  • HED-2 3

External Ids for ZYX Gene

Previous GeneCards Identifiers for ZYX Gene

  • GC07P141404
  • GC07P142472
  • GC07P142549
  • GC07P142595
  • GC07P142791
  • GC07P143078
  • GC07P137415
  • GC07P143381

Summaries for ZYX Gene

Entrez Gene Summary for ZYX Gene

  • Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZYX Gene

ZYX (Zyxin) is a Protein Coding gene. Diseases associated with ZYX include Vaccinia and Ewing Sarcoma. Among its related pathways are Adhesion and Focal Adhesion. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot for ZYX Gene

  • Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Gene Wiki entry for ZYX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYX Gene

Genomics for ZYX Gene

Regulatory Elements for ZYX Gene

Enhancers for ZYX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143378 1.5 FANTOM5 Ensembl ENCODE 50.3 +7.9 7866 15.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZYX EPHA1-AS1 EPHA1 CLCN1 HINT1P1 OR2A1 FAM131B LOC100507507 TAS2R60 ARHGEF35
GH07F143394 0.7 Ensembl ENCODE 11.9 +17.3 17272 1.6 ELF3 TBP ARID4B THRB ZNF48 RAD21 RARA YY1 THAP11 MCM3 ZYX TAS2R60 EPHA1-AS1 MIR6892
GH07F143345 1.3 Ensembl ENCODE 11.6 -32.5 -32545 1.3 ATF1 GLI4 ZNF2 ZNF48 GLIS2 KLF7 KDM4B JUNB NFIL3 ZNF610 CLCN1 HINT1P1 ZYX LOC100507507 LOC105375545 RN7SL535P CASP2 TMEM139 EPHA1 EPHA1-AS1
GH07F143305 0.4 ENCODE 11.4 -72.7 -72657 1.0 CTCF CBX3 TBL1XR1 ARID4B ZNF2 RAD21 ZNF121 GATA3 POLR2A SMC3 TMEM139 GSTK1 ZYX LOC100507507 FAM131B EPHA1 EPHA1-AS1 RN7SL481P HINT1P1
GH07F143300 1.1 Ensembl ENCODE 11.4 -77.1 -77102 1.8 TAL1 BHLHE40 MAX MNT DPF2 GATA3 CTBP1 POLR2A IKZF1 FOSL2 GSTK1 LOC100507507 ZYX FAM131B CASP2 RN7SL481P HINT1P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZYX on UCSC Golden Path with GeneCards custom track

Genomic Location for ZYX Gene

Chromosome:
7
Start:
143,378,329 bp from pter
End:
143,391,111 bp from pter
Size:
12,783 bases
Orientation:
Plus strand

Genomic View for ZYX Gene

Genes around ZYX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYX Gene

Proteins for ZYX Gene

  • Protein details for ZYX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15942-ZYX_HUMAN
    Recommended name:
    Zyxin
    Protein Accession:
    Q15942
    Secondary Accessions:
    • A4D2G6
    • B4DQX7
    • Q6I9S4

    Protein attributes for ZYX Gene

    Size:
    572 amino acids
    Molecular mass:
    61277 Da
    Quaternary structure:
    • Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2).

    Alternative splice isoforms for ZYX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZYX Gene

Post-translational modifications for ZYX Gene

  • Ubiquitination at Lys 265
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZYX (Zyxin)
  • Abcam antibodies for ZYX
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZYX

No data available for DME Specific Peptides for ZYX Gene

Domains & Families for ZYX Gene

Gene Families for ZYX Gene

Protein Domains for ZYX Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15942

UniProtKB/Swiss-Prot:

ZYX_HUMAN :
  • Contains 3 LIM zinc-binding domains.
  • Belongs to the zyxin/ajuba family.
Domain:
  • Contains 3 LIM zinc-binding domains.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with ZYX: view

Function for ZYX Gene

Molecular function for ZYX Gene

GENATLAS Biochemistry:
zyxin component of cell junction matrix,concentrated at adhesion plaques and along actin-filament bundles,ubiquitous but most prominent in blood cells and tissues rich in smooth muscle and endothelial cells,involved in the spatial control of actin assembly and in communication between the adhesive membrane and the cell nucleus
UniProtKB/Swiss-Prot Function:
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Gene Ontology (GO) - Molecular Function for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10831611
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZYX: view
genes like me logo Genes that share phenotypes with ZYX: view

Animal Models for ZYX Gene

MGI Knock Outs for ZYX:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZYX Gene

Localization for ZYX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZYX Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZYX Gene COMPARTMENTS Subcellular localization image for ZYX gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 18297730
GO:0005634 nucleus IEA,IDA 24036928
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS 8940160
genes like me logo Genes that share ontologies with ZYX: view

Pathways & Interactions for ZYX Gene

genes like me logo Genes that share pathways with ZYX: view

Pathways by source for ZYX Gene

SIGNOR curated interactions for ZYX Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8940160
GO:0007160 cell-matrix adhesion IC 24036928
GO:0007165 signal transduction TAS 8940160
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928
GO:0007229 integrin-mediated signaling pathway IMP 24036928
genes like me logo Genes that share ontologies with ZYX: view

Drugs & Compounds for ZYX Gene

(3) Drugs for ZYX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ZYX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZYX: view

Transcripts for ZYX Gene

Unigene Clusters for ZYX Gene

Zyxin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZYX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ZYX Gene

GeneLoc Exon Structure for
ZYX
ECgene alternative splicing isoforms for
ZYX

Expression for ZYX Gene

mRNA expression in normal human tissues for ZYX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYX Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for ZYX Gene

This gene is overexpressed in Platelet (14.3), Bone marrow stromal cell (10.1), and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZYX Gene



Protein tissue co-expression partners for ZYX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZYX Gene:

ZYX

SOURCE GeneReport for Unigene cluster for ZYX Gene:

Hs.490415
genes like me logo Genes that share expression patterns with ZYX: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZYX Gene

Orthologs for ZYX Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZYX 34 35
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia ZYX 34 35
  • 87.22 (n)
dog
(Canis familiaris)
Mammalia ZYX 34 35
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Zyx 34 16 35
  • 84.82 (n)
rat
(Rattus norvegicus)
Mammalia Zyx 34
  • 84.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZYX 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZYX 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZYX 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7234 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3057 34
zebrafish
(Danio rerio)
Actinopterygii zyx 35
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Zyx102EF 36
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea zyx-1 36 35
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8432 34
Species where no ortholog for ZYX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZYX Gene

ENSEMBL:
Gene Tree for ZYX (if available)
TreeFam:
Gene Tree for ZYX (if available)

Paralogs for ZYX Gene

Paralogs for ZYX Gene

Pseudogenes.org Pseudogenes for ZYX Gene

genes like me logo Genes that share paralogs with ZYX: view

Variants for ZYX Gene

Sequence variations from dbSNP and Humsavar for ZYX Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10266621 -- 143,389,739(+) TTCCT(C/T)CACCT intron-variant
rs10808025 -- 143,381,835(+) GCAGT(C/G)GTTTC intron-variant, upstream-variant-2KB
rs111335084 -- 143,390,971(+) GCACC(C/T)GCGCC downstream-variant-500B, utr-variant-3-prime
rs111347704 -- 143,382,688(+) CGGGT(A/G)AGGGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111378727 -- 143,386,761(+) GTGGA(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZYX Gene

Variant ID Type Subtype PubMed ID
nsv1075065 CNV deletion 25765185
nsv482115 CNV gain 20164927
nsv517520 CNV loss 19592680
nsv608681 CNV loss 21841781
nsv949967 CNV deletion 24416366

Variation tolerance for ZYX Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZYX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZYX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYX Gene

Disorders for ZYX Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZYX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vaccinia
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search ZYX in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZYX

Genetic Association Database (GAD)
ZYX
Human Genome Epidemiology (HuGE) Navigator
ZYX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZYX
genes like me logo Genes that share disorders with ZYX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZYX Gene

Publications for ZYX Gene

  1. Molecular characterization of human zyxin. (PMID: 8940160) Macalma T. … Beckerle M.C. (J. Biol. Chem. 1996) 2 3 4 22 64
  2. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PMID: 12695497) Garvalov B.K. … Way M. (J. Cell Biol. 2003) 3 4 22 64
  3. Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation. (PMID: 11689660) Degenhardt Y.Y. … Silverstein S. (J. Virol. 2001) 3 4 22 64
  4. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. (PMID: 10801818) Drees B. … Golsteyn R.M. (J. Biol. Chem. 2000) 3 4 22 64
  5. A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. (PMID: 8917469) Zumbrunn J. … Trueb B. (Eur. J. Biochem. 1996) 2 3 4 64

Products for ZYX Gene

Sources for ZYX Gene

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