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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZYX Gene

protein-coding GIFtS: 65
GCID: GC07P143078

zyxin

Explore 18 diseases affiliated with
ZYX via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zyxin¹
ESP-2²
HED-2²
Zyxin-2³
Zyxin-2³

External Ids:	HGNC: 13200¹	Entrez Gene: 7791²	Ensembl: ENSG00000159840⁷	OMIM: 602002⁵	UniProtKB: Q15942³

Export aliases for ZYX gene to outside databases

Previous GC identifers: GC07P141404 GC07P142472 GC07P142549 GC07P142595 GC07P142791 GC07P137415

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZYX:

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein

complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal

adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its

C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction

pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in

the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the

cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode

the same isoform. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942

Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP

family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal

transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

Gene Wiki entry for ZYX (Zyxin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZYX gene promoter:
SRF CP2 Ik-2 p53 SRF (504 AA) NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ZYX promoter sequence

Search SABiosciences Chromatin IP Primers for ZYX

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZYX

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q32

ZYX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZYX gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P143078: view genomic region (about GC identifiers)

Start:	143,078,173 bp from pter	End:	143,088,204 bp from pter
Size:	10,032 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 142,480,492-142,490,336

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942 (See protein sequence)

Recommended Name: Zyxin

Size: 572 amino acids; 61277 Da

Subunit: Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16,

or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM

domain of TES. Interacts with NEBL (isoform 2)

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with

the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1

Secondary accessions: A4D2G6 Q6I9S4

Explore the universe of human proteins at neXtProt for ZYX: NX_Q15942

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15942

ZYX Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001010972.1 NP_003452.1

ENSEMBL proteins:

ENSP00000324422 ENSP00000413467 ENSP00000400537 ENSP00000346417 ENSP00000376642

ENSP00000411230 ENSP00000403714 ENSP00000394158

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): ZYX Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ZYX
	GenScript Custom Purified and Recombinant Proteins Services for ZYX
	Novus Biologicals ZYX Protein Novus Biologicals ZYX Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ZYX

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IDA	18297730
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	TAS	8940160
GO:0005887	integral to plasma membrane	TAS	8940160

ZYX for ontologies About GeneDecksing

ZYX Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ZYX
	R&D Systems Antibodies for ZYX (Zyxin)
	Cell Signaling Technology (CST) Antibodies for ZYX (zyxin)
	OriGene Antibodies (see all 2): ZYX OriGene Custom Antibody Services for ZYX
	GenScript Custom Superior Antibodies Services for ZYX
	Novus Biologicals ZYX Antibodies
	Abcam antibodies for ZYX
	Uscn Antibodies for ZYX
	ThermoFisher Antibodies for ZYX

Assay Products for ZYX:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZYX
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ZYX

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZYX for domains About GeneDecksing

1 InterPro domain/family:

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry Q15942

ProtoNet protein and cluster: Q15942

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942

Similarity: Belongs to the zyxin/ajuba family

Similarity: Contains 3 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZYX_HUMAN, Q15942

Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP

family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal

transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

Genatlas biochemistry entry for ZYX:

zyxin component of cell junction matrix,concentrated at adhesion plaques and along actin-filament bundles,ubiquitous

but most prominent in blood cells and tissues rich in smooth muscle and endothelial cells,involved in the spatial

control of actin assembly and in communication between the adhesive membrane and the cell nucleus

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ZYX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZYX
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ZYX (see all 18):
		hsa-miR-875-3p hsa-miR-15a hsa-miR-1205 hsa-miR-570 hsa-miR-103a hsa-miR-424 hsa-miR-323-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: ZYX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZYX (see all 7) OriGene shRNA RFP: ZYX OriGene siRNA: ZYX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZYX

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ZYX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZYX (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZYX (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ZYX (NM_003461)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZYX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZYX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZYX
		Search LifeMap BioReagents cell lines for ZYX

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYX

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10831611
GO:0008270	zinc ion binding	IEA	--

ZYX for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZYX:

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-out Zyx^tm1Mbk for ZYX
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Zyx):

cellular

normal

ZYX for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion Integrin-mediated cell adhesion and migration

1.00

Cell adhesion_Integrin-mediated cell adhesion and migration

1.00

Adhesion

Adhesion

1.00

E-cadherin signaling in keratinocytes

E-cadherin signaling in keratinocytes

1.00

Stabilization and expansion of the E-cadherin adherens junction

Stabilization and expansion of the E-cadherin adherens junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ZYX

Cell adhesion Integrin-mediated cell adhesion and migration

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ZYX

	Remodeling of Adherens Junctions
	Germ Cell-Sertoli Cell Junction Dynamics
	Epithelial Adherens Junctions

1 Cell Signaling Technology (CST) Pathway for ZYX

Adhesion

1 GeneGo (Thomson Reuters) Pathway for ZYX

Cell adhesion Integrin-mediated cell adhesion and migration

4 BioSystems Pathways for ZYX

	Integrin-mediated cell adhesion
	Focal Adhesion
	E-cadherin signaling in keratinocytes
	Stabilization and expansion of the E-cadherin adherens junction

1 Kegg Pathway (Kegg details for ZYX):

Focal adhesion

ZYX for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ZYX

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for ZYX (Q15942^{1, 2, 3} ENSP00000324422⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²^,³, ENSP00000244769⁴	MINT-2864284 I2D: score=3 STRING: ENSP00000244769
HIPK3	Q9H422²^,³	MINT-61743 I2D: score=3
RGS2	P41220²^,³	MINT-8269032 I2D: score=2
LATS1	O95835¹^,³, ENSP00000253339⁴	EBI-444225,EBI-444209 I2D: score=3 STRING: ENSP00000253339
RABEPK	Q7Z6M1²^,³, ENSP00000362639⁴	MINT-8267863 I2D: score=2 STRING: ENSP00000362639

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	8940160
GO:0007267	cell-cell signaling	TAS	8940160
GO:0019048	virus-host interaction	IEA	--
GO:0044419	interspecies interaction between organisms	--	--

ZYX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ZYX for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZYX
6 Novoseek chemical compound relationships for ZYX gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leptomycin b	70.9	4	11395501 (1), 19173742 (1)
proline	34.1	1	9296389 (1)
phosphotyrosine	30	1	8748369 (1)
zinc	28.5	3	9394617 (1), 1469049 (1)
tyrosine	21.8	1	14576354 (1)
fibrinogen	0	1	15120620 (1)

Search CenterWatch for drugs/clinical trials and news about ZYX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZYX gene (2 alternative transcripts):

NM_001010972.1 NM_003461.4

Unigene Cluster for ZYX:

Zyxin

Hs.490415 [show with all ESTs]

Unigene Representative Sequence: BC073825

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000322764(uc011ktd.2 uc003wcw.3 uc003wcx.3 uc011kte.2)

ENST00000449630 ENST00000468083 ENST00000457235 ENST00000354434 ENST00000392910(uc011ktf.2)

ENST00000477373 ENST00000436448 ENST00000446634 ENST00000497119 ENST00000449423

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ZYX Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZYX
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ZYX (see all 18):
		hsa-miR-875-3p hsa-miR-15a hsa-miR-1205 hsa-miR-570 hsa-miR-103a hsa-miR-424 hsa-miR-323-5p hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: ZYX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZYX (see all 7) OriGene shRNA RFP: ZYX OriGene siRNA: ZYX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZYX

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZYX (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZYX (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ZYX (NM_003461)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZYX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZYX

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZYX Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZYX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZYX

Additional cDNA sequence:

AK130138.1 AK298925.1 AK299005.1 AK302309.1 AK316227.1 BC002323.2 BC008743.2 BC009360.2

BC010031.2 BC017183.2 BC073825.1 CR457431.1 U15158.1 X94991.1 X95735.1

24/25 DOTS entries (see all 25):

DT.449659 DT.100045554 DT.86838554 DT.97864738 DT.100674451 DT.97864739 DT.75130220 DT.40201031

DT.100674454 DT.100674443 DT.121071327 DT.121071344 DT.454463 DT.92035875 DT.100674444 DT.87016730

DT.92458526 DT.95261771 DT.97864737 DT.100638373 DT.100642216 DT.121071355 DT.100711751 DT.100840804

24/640 AceView cDNA sequences (see all 640):

BG059688 AA699474 F37360 BE301628 NM_003461 AI922615 AA454693 AI871793

AI682549 AA688306 BQ923496 BM835378 BC008743 BE018146 CN480494 AI609066

BU182647 AL547317 X94991 AA558974 BM811312 H24989 AA434106 BU188721

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZYX (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:									-		-						-		-												-		-
SP2:									-		-						-		-												-		-
SP3:							-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP4:																																											-
SP5:									-		-

ECgene alternative splicing isoforms for ZYX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZYX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCAAGTT

About this image

ZYX expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZYX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZYX

SOURCE GeneReport for Unigene cluster: Hs.490415

SABiosciences Expression via Pathway-Focused PCR Arrays including ZYX:

Adherens Junctions in human mouse rat

Focal Adhesions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZYX Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZYX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZYX

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZYX gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZYX¹	zyxin	62.96(n) 60.16(a)		418300 NM_001004386.1 NP_001004386.1
lizard (Anolis carolinensis)	Reptilia	ZYX⁶	--	49(a)	1 ↔ 1	GL343391.1(635652-658597)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3057²	Xenopus laevis transcribed sequence with weak similarity more	76.49(n)		BJ068010.1
zebrafish (Danio rerio)	Actinopterygii	zyx¹	zyxin	53.18(n) 46.21(a)		564246 NM_001109824.1 NP_001103294.1
worm (Caenorhabditis elegans)	Secernentea	zyx-1³	LIM domain containing proteins	47(a)		II(13057045-13070542) --

ENSEMBL Gene Tree for ZYX (if available)
TreeFam Gene Tree for ZYX (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZYX gene

LPP² FBLIM1² TRIP6² AJUBA² WTIP² LIMD1²

11 SIMAP similar genes for ZYX using alignment to 10 protein entries: ZYX_HUMAN (see all proteins):

LIMS1 LHX8 LIMD1 LHX6 FBLIM1 LDB3

PDLIM5 LPP CRIP1 LHX4 ABLIM1

ZYX for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZYX
PGOHUM00000249513

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11552741^1,2	C,H	--	142480915(+)	`CTTCCG/TGCCCG`	1	--	us2k¹ ese³		1		NS	180
rs17551528^1,2	F	--	142481340(+)	`CGCCCTGCG CCC/-CTCCT`	1	--	us2k¹		2		MN EA	1252
rs113258845^1,2	C	--	142481470(+)	`TACCCA/C/GAGACT`	1	--	us2k¹		1		CSA	1
rs182393151^1,2		--	143076419(+)	`AACATA/GTCTTC`	3	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs117421621^1,2		--	143076451(+)	`TTGAGC/TGTGTC`	3	--	us2k¹ nc-transcript-variant		1		EA	120
rs186072119^1,2		--	143076525(+)	`TACTGA/GTGGTG`	3	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs142401430^1,2		--	143076607(+)	`ATAATC/TAAAGA`	3	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs151287781^1,2		--	143076612(+)	`TAAAGA/TCTTAA`	3	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs4726615^1,2	C,F,A,H,	--	143076781(+)	`TATAGA/CGCATA`	3	--	us2k¹ nc-transcript-variant		21		NA NS EA WA CSA	1441
rs190972651^1,2		--	143076792(+)	`CAGCTA/GTGACA`	3	--	us2k¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZYX (143078173 - 143088204 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZYX
2 CNVs: 52138 52139

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZYX for disorders           About GeneDecksing

OMIM gene information: 602002    OMIM disorders: --

18 diseases for ZYX:    About MalaCards

lipoma tetraploidy wilms tumor laryngitis

laryngeal carcinoma epididymitis vaccinia acute leukemia

sarcoma hepatocellular carcinoma ovarian cancer infertility

leukemia breast cancer ataxia carcinoma

melanoma neuronitis

5 Novoseek disease relationships for ZYX gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipoma	48.4	5	11433529 (1), 9598321 (1), 15465019 (1), 19701494 (1)
warts	26.7	1	15122335 (1)
ewings sarcoma	19.5	3	15748890 (2), 15184883 (1)
leukemia	0	2	12659632 (1), 16959042 (1)
tumors	0	10	16680155 (3), 15748890 (3), 17889706 (1), 10831611 (1) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: ZYX (3 documents)

Export disorders for ZYX gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZYX gene, integrated from 9 sources (see all 167):
(articles sorted by number of sources associating them with ZYX)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of human zyxin. (PubMed id 8940160)^{1, 2, 3, 9} Macalma T....Beckerle M.C. (1996)
A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. (PubMed id 8917469)^{1, 2, 3} Zumbrunn J. and Trueb B. (1996)
Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. (PubMed id 10801818)^{1, 2, 9} Drees B....Golsteyn R.M. (2000)
Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation. (PubMed id 11689660)^{1, 2, 9} Degenhardt Y.Y. and Silverstein S. (2001)
The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PubMed id 12695497)^{1, 2, 9} Garvalov B.K.... Way M. (2003)
The LIM-domain protein zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo. (PubMed id 18297730)^{1, 2} Martynova N.Y.... Zaraisky A.G. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7791	HGNC: 13200	AceView: ZYX	Ensembl:ENSG00000159840	euGenes: HUgn7791
ECgene: ZYX	Kegg: 7791	H-InvDB: ZYX

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZYX	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ZYX	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ZYX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZYX gene:
Search GeneIP for patents involving ZYX

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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