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Aliases for ZYG11B Gene

Aliases for ZYG11B Gene

  • Zyg-11 Family Member B, Cell Cycle Regulator 2 3 5
  • Zyg-11 Homolog B (C. Elegans) 2
  • Zyg-11 Homolog (C. Elegans) 2
  • Zyg-11 Homolog B 3
  • KIAA1730 4
  • ZYG11 3

External Ids for ZYG11B Gene

Previous HGNC Symbols for ZYG11B Gene

  • ZYG11

Previous GeneCards Identifiers for ZYG11B Gene

  • GC01P052904
  • GC01P052964
  • GC01P053192
  • GC01P051337

Summaries for ZYG11B Gene

GeneCards Summary for ZYG11B Gene

ZYG11B (Zyg-11 Family Member B, Cell Cycle Regulator) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ZER1.

UniProtKB/Swiss-Prot for ZYG11B Gene

  • Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYG11B Gene

Genomics for ZYG11B Gene

Regulatory Elements for ZYG11B Gene

Enhancers for ZYG11B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZYG11B on UCSC Golden Path with GeneCards custom track

Promoters for ZYG11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZYG11B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZYG11B Gene

52,726,459 bp from pter
52,827,342 bp from pter
100,884 bases
Plus strand

Genomic View for ZYG11B Gene

Genes around ZYG11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYG11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYG11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11B Gene

Proteins for ZYG11B Gene

  • Protein details for ZYG11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein zyg-11 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q8N2X3
    • Q9H8L8

    Protein attributes for ZYG11B Gene

    744 amino acids
    Molecular mass:
    83921 Da
    Quaternary structure:
    • Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.
    • Sequence=BAB21821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZYG11B Gene


neXtProt entry for ZYG11B Gene

Proteomics data for ZYG11B Gene at MOPED

Post-translational modifications for ZYG11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZYG11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZYG11B Gene

Domains & Families for ZYG11B Gene

Gene Families for ZYG11B Gene

Protein Domains for ZYG11B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zyg-11 family.
  • Contains 2 ARM repeats.
  • Belongs to the zyg-11 family.
  • Contains 2 ARM repeats.
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ZYG11B: view

Function for ZYG11B Gene

Molecular function for ZYG11B Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

Gene Ontology (GO) - Molecular Function for ZYG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZYG11B: view
genes like me logo Genes that share phenotypes with ZYG11B: view

Animal Model Products

miRNA for ZYG11B Gene

miRTarBase miRNAs that target ZYG11B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZYG11B Gene

Localization for ZYG11B Gene

Subcellular locations from

Jensen Localization Image for ZYG11B Gene COMPARTMENTS Subcellular localization image for ZYG11B gene
Compartment Confidence
cytoskeleton 2
cytosol 2
golgi apparatus 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZYG11B Gene

Pathways & Interactions for ZYG11B Gene

SuperPathways for ZYG11B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZYG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with ZYG11B: view

No data available for Pathways by source and SIGNOR curated interactions for ZYG11B Gene

Drugs & Compounds for ZYG11B Gene

No Compound Related Data Available

Transcripts for ZYG11B Gene

mRNA/cDNA for ZYG11B Gene

Unigene Clusters for ZYG11B Gene

Zyg-11 family member B, cell cycle regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: -
SP4: -

Relevant External Links for ZYG11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZYG11B Gene

mRNA expression in normal human tissues for ZYG11B Gene

mRNA differential expression in normal tissues according to GTEx for ZYG11B Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for ZYG11B Gene

This gene is overexpressed in Fetal Brain (13.4), Frontal cortex (9.0), Lymph node (7.3), Spleen (6.8), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZYG11B Gene

SOURCE GeneReport for Unigene cluster for ZYG11B Gene Hs.476280

genes like me logo Genes that share expression patterns with ZYG11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZYG11B Gene

Orthologs for ZYG11B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZYG11B 35
  • 94.27 (n)
  • 99.06 (a)
ZYG11B 36
  • 99 (a)
(Canis familiaris)
Mammalia ZYG11B 35
  • 95.01 (n)
  • 99.32 (a)
ZYG11B 36
  • 99 (a)
(Mus musculus)
Mammalia Zyg11b 35
  • 89.25 (n)
  • 98.12 (a)
Zyg11b 16
Zyg11b 36
  • 98 (a)
(Pan troglodytes)
Mammalia ZYG11B 35
  • 99.82 (n)
  • 100 (a)
ZYG11B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zyg11b 35
  • 89.78 (n)
  • 98.09 (a)
(Monodelphis domestica)
Mammalia ZYG11B 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia ZYG11B 36
  • 62 (a)
(Gallus gallus)
Aves ZYG11B 35
  • 81.5 (n)
  • 94.42 (a)
ZYG11B 36
  • 94 (a)
(Anolis carolinensis)
Reptilia ZYG11B 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496980 35
  • 75.05 (n)
  • 85.25 (a)
(Danio rerio)
Actinopterygii zyg11 35
  • 66.3 (n)
  • 71.88 (a)
si:ch1073-82l19.1 36
  • 51 (a)
zyg11 36
  • 70 (a)
(Caenorhabditis elegans)
Secernentea zyg-11 35
  • 46.48 (n)
  • 36.02 (a)
zyg-11 36
  • 22 (a)
Species with no ortholog for ZYG11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZYG11B Gene

Gene Tree for ZYG11B (if available)
Gene Tree for ZYG11B (if available)

Paralogs for ZYG11B Gene

Paralogs for ZYG11B Gene

(1) SIMAP similar genes for ZYG11B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZYG11B: view

Variants for ZYG11B Gene

Sequence variations from dbSNP and Humsavar for ZYG11B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs269298 -- 52,726,515(+) ACGCT(C/T)CTAGC utr-variant-5-prime
rs475969 -- 52,826,935(-) TTTTA(A/T)TAAAG utr-variant-3-prime
rs476683 -- 52,787,014(-) ctccc(A/G)ggttc intron-variant
rs479581 -- 52,812,845(+) cctca(C/G)cctcc intron-variant
rs482189 -- 52,816,875(-) GGAGG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZYG11B Gene

Variant ID Type Subtype PubMed ID
dgv50e1 CNV Complex 17122850
nsv871800 CNV Loss 21882294
nsv829859 CNV Loss 17160897
esv1751396 CNV Insertion 17803354
nsv866 CNV Loss 18451855
esv6479 CNV Gain 19470904

Variation tolerance for ZYG11B Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZYG11B Gene

Disorders for ZYG11B Gene

Relevant External Links for ZYG11B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZYG11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZYG11B Gene

Publications for ZYG11B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZYG11B Gene

Sources for ZYG11B Gene