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ZYG11B Gene

protein-coding   GIFtS: 47
GCID: GC01P053192

Zyg-11 Family Member B, Cell Cycle Regulator

(Previous names: zyg-11 homolog (C. elegans), zyg-11 homolog B (C. elegans))
(Previous symbol: ZYG11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zyg-11 Family Member B, Cell Cycle Regulator1 2     Protein Zyg-11 Homolog B2
ZYG111 2     Zyg-11 Homolog B2
Zyg-11 Homolog (C. Elegans)1     KIAA17303
Zyg-11 Homolog B (C. Elegans)1     

External Ids:    HGNC: 258201   Entrez Gene: 796992   Ensembl: ENSG000001623787   UniProtKB: Q9C0D33   

Export aliases for ZYG11B gene to outside databases

Previous GC identifers: GC01P052904 GC01P052964 GC01P051337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZYG11B Gene:
ZYG11B (zyg-11 family member B, cell cycle regulator) is a protein-coding gene. An important paralog of this gene is ZER1.

UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3
Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZYG11B gene promoter:
         HNF-1A   Evi-1   YY1   POU2F1   POU2F1a   POU2F1b   POU2F1c   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZYG11B promoter sequence
   Search Chromatin IP Primers for ZYG11B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZYG11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

ZYG11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZYG11B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P053192:  view genomic region     (about GC identifiers)

Start:
53,192,126 bp from pter      End:
53,293,014 bp from pter
Size:
100,889 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3 (See protein sequence)
Recommended Name: Protein zyg-11 homolog B  
Size: 744 amino acids; 83921 Da
Subunit: Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin
BC
Sequence caution: Sequence=BAB21821.1; Type=Erroneous initiation;
Secondary accessions: Q8N2X3 Q9H8L8
Alternative splicing: 2 isoforms:  Q9C0D3-1   Q9C0D3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZYG11B: NX_Q9C0D3

Explore proteomics data for ZYG11B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZYG11B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078922.1  
    ENSEMBL proteins: 
     ENSP00000294353   ENSP00000400522   ENSP00000441315  

    ZYG11B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZYG11B

     
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    antibodies-online proteins for ZYG11B (4 products) 

     
    antibodies-online peptides for ZYG11B

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    antibodies-online antibodies for ZYG11B (9 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZYG11: ZYG11 cell cycle regulator family

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR001611 Leu-rich_rpt
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9C0D3

    ProtoNet protein and cluster: Q9C0D3

    UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3
    Similarity: Belongs to the zyg-11 family
    Similarity: Contains 2 ARM repeats
    Similarity: Contains 3 LRR (leucine-rich) repeats


    Find genes that share domains with ZYG11B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZY11B_HUMAN, Q9C0D3
    Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with ZYG11B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZYG11B:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZYG11B

    miRNA
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    miRTarBase miRNAs that target ZYG11B:
    hsa-mir-21-5p (MIRT031006)

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    Selected qRT-PCR Assays for microRNAs that regulate ZYG11B (see all 103):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-517a hsa-miR-200a hsa-miR-30d hsa-miR-3653 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidZYG11B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZYG11B (NM_024646)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYG11B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ZYG11B: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ZYG11B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZYG11B (Q9C0D32, 3 ENSP000002943534) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL2Q136172, 3, ENSP000003638804MINT-4507579 I2D: score=5 STRING: ENSP00000363880
    TCEB1Q153692, 3, ENSP000002848114MINT-4507555 I2D: score=5 STRING: ENSP00000284811
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    YWHAZP631043I2D: score=1 
    ENSG00000234000ENSP000004124564STRING: ENSP00000412456
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZYG11B (ZY11B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZYG11B gene: 
    NM_024646.2  

    Unigene Cluster for ZYG11B:

    Zyg-11 family member B, cell cycle regulator
    Hs.476280  [show with all ESTs]
    Unigene Representative Sequence: NM_024646
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294353(uc001cuj.3 uc010onj.2 uc009vzh.3) ENST00000443756
    ENST00000545132(uc009vzg.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat ZYG11B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZYG11B (see all 103):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-26a-2* hsa-miR-517a hsa-miR-200a hsa-miR-30d hsa-miR-3653 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidZYG11B 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZYG11B
      QuantiTect SYBR Green Assays in human, mouse, rat ZYG11B
      QuantiFast Probe-based Assays in human, mouse, rat ZYG11B

    Additional mRNA sequence: 

    AB051517.1 AK023518.1 AK025056.1 AK056645.1 AK095643.1 AK296460.1 BC029832.1 BX647643.1 

    8 DOTS entries:

    DT.114040  DT.100748751  DT.100817447  DT.100817444  DT.121431412  DT.97791975  DT.424044  DT.95265734 

    Selected AceView cDNA sequences (see all 207):

    BM716545 AA628780 CB321863 BI492777 CD674672 AI245091 BI039406 AI291586 
    AI242322 AW673221 AK056645 BX500188 BQ029127 AL599990 BI039415 BC029832 
    BU689142 AA767175 BG575347 BG059880 AI433668 CB048353 AI868839 BQ026867 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11B    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                            -                                 
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:              -                                                                                                               


    ECgene alternative splicing isoforms for ZYG11B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZYG11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTATTTTA
    ZYG11B Expression
    About this image

    ZYG11B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZYG11B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476280
        Pathway & Disease-focused RT2 Profiler PCR Array including ZYG11B: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZYG11B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zyg11b1 , 5 zyg-ll homolog B (C. elegans)5
    zyg-ll family member B, cell cycle regulator1
    89.25(n)1
    98.12(a)1
      4 (50.35 cM)5
    4148721  NM_001033634.31  NP_001028806.21 
     1082297245 
    chicken
    (Gallus gallus)
    Aves ZYG11B1 zyg-11 homolog B (C. elegans) 81.5(n)
    94.42(a)
      424645  XM_422479.4  XP_422479.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZYG11B6
    zyg-11 family member B, cell cycle regulator
    92(a)
    1 ↔ 1
    4(114784571-114817459)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004969801 protein zyg-11 homolog 75.05(n)
    85.25(a)
      100496980  XM_002931422.2  XP_002931468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zyg111 zyg-11 homolog (C. elegans) 66.3(n)
    71.88(a)
      555349  NM_001040332.2  NP_001035422.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-111 zyg-11 46.48(n)
    36.02(a)
      174284  NM_063276.4  NP_495677.1 


    ENSEMBL Gene Tree for ZYG11B (if available)
    TreeFam Gene Tree for ZYG11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZYG11B gene
    ZER12  ZYG11A2  
    1 SIMAP similar gene for ZYG11B using alignment to 3 protein entries:     ZY11B_HUMAN (see all proteins):
    ZYG11A

    Find genes that share paralogs with ZYG11B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZYG11B (see all 2250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446947941,2
    --53190144(+) ACTTGA/TGCCTA 1 -- us2k10--------
    rs1481849741,2
    C--53190312(+) TGAGCC/TGTGAT 1 -- us2k10--------
    rs798227441,2
    C--53190358(+) AACTTA/GTCTCA 1 -- us2k10--------
    rs3778081,2
    C,F,A,H--53190359(-) ttgagC/Acaagt 1 -- us2k14Minor allele frequency- A:0.50NA 8
    rs755977281,2
    C,F--53190360(+) CTTGTC/TTCAAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1476963681,2
    C--53190362(+) GTCTC-/AATA  
            
    AATAA
    1 -- us2k10--------
    rs558383431,2
    C--53190364(+) ATAAA-/TAAA  
            
    AGAAA
    1 -- us2k10--------
    rs1411699741,2
    C--53190618(+) TTTAGC/GACAGA 1 -- us2k10--------
    rs353584061,2
    C,F--53190659(+) GCTAAA/CAGACA 1 -- us2k16Minor allele frequency- C:0.12NA WA EA 364
    rs1906658801,2
    C--53190871(+) AAATAA/GTTATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZYG11B (53192126 - 53293014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZYG11B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1751396CNV Insertion17803354
    nsv829859CNV Loss17160897
    nsv866CNV Loss18451855
    nsv871800CNV Loss21882294
    esv6479CNV Gain19470904
    dgv50e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZYG11B
    DNA2.0 Custom Variant and Variant Library Synthesis for ZYG11B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZYG11B           About GenesLikeMe

    Genetic Association Database (GAD): ZYG11B

    Export disorders for ZYG11B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZYG11B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZYG11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PubMed id 17304241)1, 2 Vasudevan S.... Kipreos E.T. (EMBO Rep. 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79699 HGNC: 25820 AceView: FLJ13456 Ensembl:ENSG00000162378 euGenes: HUgn79699
    ECgene: ZYG11B H-InvDB: ZYG11B

    (According to HUGE)
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    HUGE: KIAA1730

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZYG11B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZYG11B gene:
    Search GeneIP for patents involving ZYG11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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