ZYG11B Gene
protein-coding GIFtS: 44
GCID: GC01P053192
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zyg-11 family member B, cell cycle regulator(Previous names: zyg-11 homolog (C. elegans), zyg-11 homolog B (C. elegans)...)
(Previous symbol: ZYG11)
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Aliases
for ZYG11B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zyg-11 Family Member B, Cell Cycle Regulator1 2 | | Zyg-11 Homolog B (C. Elegans)1 | | ZYG111 2 | | Protein Zyg-11 Homolog B2 | | FLJ134561 | | Zyg-11 Homolog B2 | | Zyg-11 Homolog (C. Elegans)1 | | KIAA17303 |
Export aliases for ZYG11B gene to outside databasesPrevious GC identifers: GC01P052904 GC01P052964 GC01P051337 |
Summaries
for ZYG11B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC
|
Genomic Views
for ZYG11B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZYG11B gene promoter:
HNF-1A Evi-1 YY1 POU2F1 POU2F1a POU2F1b POU2F1c Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZYG11B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZYG11B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3ZYG11B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P053192: view genomic region
(about GC identifiers)
Start:
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53,192,126 bp from pter |
End:
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53,293,014 bp from pter |
Size:
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100,889 bases |
Orientation:
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plus strand |
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Proteins
for ZYG11B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3 (See
protein sequence)Recommended Name: Protein zyg-11 homolog B Size: 744 amino acids; 83921 Da
Subunit: Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC
Sequence caution: Sequence=BAB21821.1; Type=Erroneous initiation;
Secondary accessions: Q8N2X3 Q9H8L8Alternative splicing: 2 isoforms: Q9C0D3-1 Q9C0D3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZYG11B: NX_Q9C0D3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0D3
ZYG11B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078922.1
ENSEMBL proteins: ENSP00000294353 ENSP00000400522 ENSP00000441315
Human Recombinant Protein Products:
ZYG11B Antibody Products:
Assay Products for ZYG11B: |
Protein
Domains /
Families
for ZYG11B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZYG11B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0D3ProtoNet protein and cluster: Q9C0D3 UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3Similarity: Belongs to the zyg-11 familySimilarity: Contains 2 ARM repeatsSimilarity: Contains 3 LRR (leucine-rich) repeats |
Function
for ZYG11B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZY11B_HUMAN, Q9C0D3Function: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZYG11B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZYG11B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYG11B |
3 GenomeRNAi human phenotypes for ZYG11B:
|
Pathways & Interactions
for ZYG11B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZYG11B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for ZYG11B (Q9C0D32, 3 ENSP000002943534) via UniProtKB, MINT, STRING, and/or I2D (see all 34)About this table
|
Drugs & Compounds
for ZYG11B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZYG11B
Search CenterWatch for drugs/clinical trials and news about ZYG11B / ZY11B
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Transcripts
for ZYG11B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZYG11B gene: NM_024646.2 Unigene Cluster for ZYG11B: Zyg-11 family member B, cell cycle regulator Hs.476280 [show with all ESTs]Unigene Representative Sequence: NM_0246463 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294353(uc001cuj.3 uc010onj.2 uc009vzh.3) ENST00000443756
ENST00000545132(uc009vzg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZYG11B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZYG11B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZYG11B (NM_024646) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZYG11B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZYG11B |
Additional cDNA sequence: AB051517.1 AK023518.1 AK025056.1 AK056645.1 AK095643.1 AK296460.1 BC029832.1 BX647643.1 8 DOTS entries: DT.114040 DT.100748751 DT.100817447 DT.100817444 DT.121431412 DT.97791975 DT.424044 DT.95265734 24/207 AceView cDNA sequences (see all 207): AI245091 BI039406 AK056645 AI291586 AI242322 AL599990 AW673221 BC029832 H65852 AW021848 CD674672 AA628780 BI492777 Z40634 BM716545 Z42566 CA435801 AA127250 AL703364 AI433668 BG575347 AI868839 CB048353 BM666475
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZYG11B
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Expression
for ZYG11B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZYG11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTATTTTA
About this image
See ZYG11B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZYG11B
SOURCE GeneReport for Unigene cluster: Hs.476280
SABiosciences Expression via Pathway-Focused PCR Array including ZYG11B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZYG11B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZYG11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZYG11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZYG11B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYG11B |
Orthologs
for ZYG11B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZYG11B gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for ZYG11B (if available)
TreeFam Gene Tree for ZYG11B (if available) |
Paralogs
for ZYG11B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZYG11B gene
- ZER12 ZYG11A2
1 SIMAP similar gene for ZYG11B using alignment to 3 protein entries: ZY11B_HUMAN (see all proteins):ZYG11A
ZYG11B for paralogs About GeneDecksing
|
Genomic Variants
for ZYG11B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZYG11B (53192126 - 53293014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZYG11B
2 CNVs: 4225 3290
1 Indel: 59929 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZYG11B |
|
Disorders
/ Diseases
for ZYG11B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZYG11B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZYG11B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZYG11B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PubMed id 17304241)1, 2 Vasudevan S.... Kipreos E.T. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for ZYG11B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZYG11B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZYG11B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZYG11B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZYG11B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZYG11B gene:
Search GeneIP for patents involving ZYG11B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZYG11B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZYG11B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZYG11B | | | OriGene Protein Over-expression Lysate for ZYG11B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZYG11B | | OriGene 3'-UTR Clone for ZYG11B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZYG11B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZYG11B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for ZYG11B |
| |  |  |  |  | | | | |
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 | | | ZYG11B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYG11B |
|  |  |  | | | | Search ThermoFisher Antibodies for ZYG11B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZYG11B |
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