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Aliases for ZYG11A Gene

Aliases for ZYG11A Gene

  • Zyg-11 Family Member A, Cell Cycle Regulator 2 3 5
  • ZYG11 3 4
  • ZYG-11A Early Embryogenesis Protein 3
  • Zyg-11 Homolog A (C. Elegans) 2
  • Zyg-11 Homolog A 3

External Ids for ZYG11A Gene

Previous GeneCards Identifiers for ZYG11A Gene

  • GC01P053022
  • GC01P053080
  • GC01P053308
  • GC01P051424

Summaries for ZYG11A Gene

GeneCards Summary for ZYG11A Gene

ZYG11A (Zyg-11 Family Member A, Cell Cycle Regulator) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ZER1.

UniProtKB/Swiss-Prot for ZYG11A Gene

  • Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYG11A Gene

Genomics for ZYG11A Gene

Regulatory Elements for ZYG11A Gene

Enhancers for ZYG11A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZYG11A on UCSC Golden Path with GeneCards custom track

Promoters for ZYG11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZYG11A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZYG11A Gene

52,842,511 bp from pter
52,894,998 bp from pter
52,488 bases
Plus strand

Genomic View for ZYG11A Gene

Genes around ZYG11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYG11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11A Gene

Proteins for ZYG11A Gene

  • Protein details for ZYG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein zyg-11 homolog A
    Protein Accession:
    Secondary Accessions:
    • A6NCK5

    Protein attributes for ZYG11A Gene

    759 amino acids
    Molecular mass:
    85808 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZYG11A Gene


neXtProt entry for ZYG11A Gene

Proteomics data for ZYG11A Gene at MOPED

Post-translational modifications for ZYG11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZYG11A Gene

No data available for DME Specific Peptides for ZYG11A Gene

Domains & Families for ZYG11A Gene

Gene Families for ZYG11A Gene

Protein Domains for ZYG11A Gene


Suggested Antigen Peptide Sequences for ZYG11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zyg-11 family.
  • Contains 3 LRR (leucine-rich) repeats.
  • Belongs to the zyg-11 family.
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ZYG11A: view

Function for ZYG11A Gene

Molecular function for ZYG11A Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.
genes like me logo Genes that share phenotypes with ZYG11A: view

Animal Model Products

miRNA for ZYG11A Gene

miRTarBase miRNAs that target ZYG11A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZYG11A Gene

Localization for ZYG11A Gene

Subcellular locations from

Jensen Localization Image for ZYG11A Gene COMPARTMENTS Subcellular localization image for ZYG11A gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZYG11A Gene

Pathways & Interactions for ZYG11A Gene

SuperPathways for ZYG11A Gene

No Data Available

Interacting Proteins for ZYG11A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000360583 for ZYG11A Gene via STRING

Gene Ontology (GO) - Biological Process for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with ZYG11A: view

No data available for Pathways by source and SIGNOR curated interactions for ZYG11A Gene

Drugs & Compounds for ZYG11A Gene

No Compound Related Data Available

Transcripts for ZYG11A Gene

mRNA/cDNA for ZYG11A Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZYG11A Gene

Zyg-11 family member A, cell cycle regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11A Gene

No ASD Table

Relevant External Links for ZYG11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZYG11A Gene

mRNA expression in normal human tissues for ZYG11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYG11A Gene

This gene is overexpressed in Testis (x11.8), Thyroid (x6.3), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for ZYG11A Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZYG11A Gene

SOURCE GeneReport for Unigene cluster for ZYG11A Gene Hs.658458

genes like me logo Genes that share expression patterns with ZYG11A: view

Protein tissue co-expression partners for ZYG11A Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZYG11A Gene

Orthologs for ZYG11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZYG11A 35
  • 88.34 (n)
  • 84.9 (a)
ZYG11A 36
  • 85 (a)
(Canis familiaris)
Mammalia ZYG11A 35
  • 91.31 (n)
  • 90.76 (a)
ZYG11A 36
  • 91 (a)
(Mus musculus)
Mammalia Zyg11a 35
  • 79.95 (n)
  • 74.29 (a)
Zyg11a 16
Zyg11a 36
  • 73 (a)
(Pan troglodytes)
Mammalia ZYG11A 35
  • 99.34 (n)
  • 98.95 (a)
ZYG11A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zyg11a 35
  • 78.22 (n)
  • 72.2 (a)
(Monodelphis domestica)
Mammalia ZYG11A 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 55 (a)
(Anolis carolinensis)
Reptilia ZYG11A 36
  • 55 (a)
(Danio rerio)
Actinopterygii si:ch1073-82l19.1 36
  • 42 (a)
zyg11 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea zyg-11 36
  • 20 (a)
Species with no ortholog for ZYG11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZYG11A Gene

Gene Tree for ZYG11A (if available)
Gene Tree for ZYG11A (if available)

Paralogs for ZYG11A Gene

Paralogs for ZYG11A Gene

(1) SIMAP similar genes for ZYG11A Gene using alignment to 1 proteins: Pseudogenes for ZYG11A Gene

genes like me logo Genes that share paralogs with ZYG11A: view

Variants for ZYG11A Gene

Sequence variations from dbSNP and Humsavar for ZYG11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs473340 -- 52,845,391(-) gaggc(A/G)gaggt intron-variant
rs475832 -- 52,855,063(-) ccaaa(C/G)tggtg intron-variant
rs476108 -- 52,851,679(-) ctcac(A/G)cctat intron-variant
rs479569 -- 52,886,735(+) AGAGA(C/T)GGGGG intron-variant
rs480299 -- 52,854,602(-) AATCG(A/C)TCGGC reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZYG11A Gene

Variant ID Type Subtype PubMed ID
nsv871800 CNV Loss 21882294
nsv829859 CNV Loss 17160897
nsv866 CNV Loss 18451855
esv2668074 CNV Deletion 23128226
esv24261 CNV Loss 19812545

Variation tolerance for ZYG11A Gene

Gene Damage Index Score: 3.83; 58.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZYG11A Gene

Disorders for ZYG11A Gene

Relevant External Links for ZYG11A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZYG11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZYG11A Gene

Publications for ZYG11A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZYG11A Gene

Sources for ZYG11A Gene