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Aliases for ZYG11A Gene

Aliases for ZYG11A Gene

  • Zyg-11 Family Member A, Cell Cycle Regulator 2 3 5
  • ZYG11 3 4
  • ZYG-11A Early Embryogenesis Protein 3
  • Zyg-11 Homolog A (C. Elegans) 2
  • Protein Zyg-11 Homolog A 3
  • Zyg-11 Homolog A 3

External Ids for ZYG11A Gene

Previous GeneCards Identifiers for ZYG11A Gene

  • GC01P053022
  • GC01P053080
  • GC01P053308
  • GC01P051424

Summaries for ZYG11A Gene

GeneCards Summary for ZYG11A Gene

ZYG11A (Zyg-11 Family Member A, Cell Cycle Regulator) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ZYG11B.

UniProtKB/Swiss-Prot for ZYG11A Gene

  • Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYG11A Gene

Genomics for ZYG11A Gene

Regulatory Elements for ZYG11A Gene

Enhancers for ZYG11A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F052926 1 ENCODE 11.3 +85.0 85008 1.8 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 ZNF207 ZNF263 ECHDC2 ZYG11A COA7 SLC1A7 MIR1273F SCP2
GH01F053393 1 Ensembl ENCODE 11.2 +551.3 551296 0.8 ZNF263 CTCF ZNF654 NRF1 TRIM22 REST ZBTB40 RAD21 ZFHX2 IKZF1 LRP8 ENSG00000228838 LOC105378728 LINC01771 ZYG11A ENSG00000230138 LOC105378733
GH01F053139 1 Ensembl ENCODE 5.2 +297.8 297790 1.9 BCOR ZMYM3 ZNF175 ZIC2 ZBTB40 ZNF664 ZFHX2 ADNP TRIM24 FOS SLC1A7 PODN ZYG11A GC01P053132
GH01F052725 1.1 ENCODE 4.3 -115.8 -115820 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 SP3 KAT8 SMARCA4 MAGOH RPS13P2 ECHDC2 ENSG00000230953 ENSG00000266993 ZYG11B ZYG11A GC01P052729
GH01F052842 1.1 ENCODE 0.8 +1.3 1324 3.4 PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 ZNF143 ZNF207 KLF13 SP3 MXD4 ZCCHC11 MAGOH ECHDC2 ENSG00000272100 ENSG00000230953 ZYG11B ORC1 ZYG11A PIR36649
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZYG11A on UCSC Golden Path with GeneCards custom track

Promoters for ZYG11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000536624 789 2200 PKNOX1 ATF1 CREB3L1 SIN3A FEZF1 BRCA1 ZNF2 GTF3C2 GLIS2 ZNF143

Genomic Location for ZYG11A Gene

Chromosome:
1
Start:
52,842,511 bp from pter
End:
52,894,998 bp from pter
Size:
52,488 bases
Orientation:
Plus strand

Genomic View for ZYG11A Gene

Genes around ZYG11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYG11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11A Gene

Proteins for ZYG11A Gene

  • Protein details for ZYG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WRX3-ZY11A_HUMAN
    Recommended name:
    Protein zyg-11 homolog A
    Protein Accession:
    Q6WRX3
    Secondary Accessions:
    • A6NCK5

    Protein attributes for ZYG11A Gene

    Size:
    759 amino acids
    Molecular mass:
    85808 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZYG11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZYG11A Gene

Post-translational modifications for ZYG11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZYG11A Gene

Domains & Families for ZYG11A Gene

Gene Families for ZYG11A Gene

Protein Domains for ZYG11A Gene

Suggested Antigen Peptide Sequences for ZYG11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6WRX3

UniProtKB/Swiss-Prot:

ZY11A_HUMAN :
  • Belongs to the zyg-11 family.
  • Contains 3 LRR (leucine-rich) repeats.
Family:
  • Belongs to the zyg-11 family.
Similarity:
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ZYG11A: view

Function for ZYG11A Gene

Molecular function for ZYG11A Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

Gene Ontology (GO) - Molecular Function for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZYG11A: view
genes like me logo Genes that share phenotypes with ZYG11A: view

Animal Model Products

miRNA for ZYG11A Gene

miRTarBase miRNAs that target ZYG11A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZYG11A Gene

Localization for ZYG11A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZYG11A gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with ZYG11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZYG11A Gene

Pathways & Interactions for ZYG11A Gene

SuperPathways for ZYG11A Gene

No Data Available

Interacting Proteins for ZYG11A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360583%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000444856%0d%0a9606.ENSP00000284811%0d%0a9606.ENSP00000264414%0d%0a
Selected Interacting proteins: ENSP00000360583 for ZYG11A Gene via STRING

Gene Ontology (GO) - Biological Process for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051438 regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZYG11A: view

No data available for Pathways by source and SIGNOR curated interactions for ZYG11A Gene

Transcripts for ZYG11A Gene

mRNA/cDNA for ZYG11A Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZYG11A Gene

Zyg-11 family member A, cell cycle regulator:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11A Gene

No ASD Table

Relevant External Links for ZYG11A Gene

GeneLoc Exon Structure for
ZYG11A
ECgene alternative splicing isoforms for
ZYG11A

Expression for ZYG11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZYG11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYG11A Gene

This gene is overexpressed in Testis (x11.8), Thyroid (x6.3), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for ZYG11A Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZYG11A Gene



Protein tissue co-expression partners for ZYG11A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZYG11A Gene:

ZYG11A

SOURCE GeneReport for Unigene cluster for ZYG11A Gene:

Hs.658458
genes like me logo Genes that share expression patterns with ZYG11A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZYG11A Gene

Orthologs for ZYG11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZYG11A 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia ZYG11A 34 35
  • 91.31 (n)
cow
(Bos Taurus)
Mammalia ZYG11A 34 35
  • 88.34 (n)
mouse
(Mus musculus)
Mammalia Zyg11a 34 16 35
  • 79.95 (n)
rat
(Rattus norvegicus)
Mammalia Zyg11a 34
  • 78.22 (n)
oppossum
(Monodelphis domestica)
Mammalia ZYG11A 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZYG11A 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zyg11 35
  • 51 (a)
ManyToMany
si:ch1073-82l19.1 35
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-11 35
  • 20 (a)
OneToMany
Species where no ortholog for ZYG11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZYG11A Gene

ENSEMBL:
Gene Tree for ZYG11A (if available)
TreeFam:
Gene Tree for ZYG11A (if available)

Paralogs for ZYG11A Gene

Paralogs for ZYG11A Gene

(1) SIMAP similar genes for ZYG11A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZYG11A Gene

genes like me logo Genes that share paralogs with ZYG11A: view

Variants for ZYG11A Gene

Sequence variations from dbSNP and Humsavar for ZYG11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10581739 -- 52,885,678(+) CCACA(-/TT)GTTAA intron-variant
rs10670232 -- 52,846,308(+) AAATT(-/TATATATATATATATATATATATA/TATTTA)TTTAT intron-variant
rs10682296 -- 52,880,087(+) TTTTT(-/TT)GAGAG intron-variant
rs10788945 -- 52,857,820(+) CCAGA(A/C)TTTTT intron-variant
rs111252162 -- 52,875,160(+) ATATC(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZYG11A Gene

Variant ID Type Subtype PubMed ID
esv24261 CNV loss 19812545
esv2668074 CNV deletion 23128226
esv3586055 CNV loss 21293372
nsv1001535 CNV gain 25217958
nsv1122345 CNV deletion 24896259
nsv1125462 CNV tandem duplication 24896259
nsv829859 CNV loss 17160897
nsv866 CNV deletion 18451855

Variation tolerance for ZYG11A Gene

Gene Damage Index Score: 3.83; 58.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZYG11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZYG11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYG11A Gene

Disorders for ZYG11A Gene

Relevant External Links for ZYG11A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZYG11A

No disorders were found for ZYG11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZYG11A Gene

Publications for ZYG11A Gene

  1. ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. (PMID: 26771237) Wang X. … Ren B. (Oncotarget 2016) 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZYG11A Gene

Sources for ZYG11A Gene

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