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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZYG11A Gene

protein-coding   GIFtS: 39
GCID: GC01P053308

zyg-11 family member A, cell cycle regulator

(Previous name: zyg-11 homolog A (C. elegans) )
  Search for ZYG11A
in
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 Human Malady Compendium 
Biological research products
for ZYG11A    

Aliases
for ZYG11A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zyg-11 Family Member A, Cell Cycle Regulator1 2
ZYG111 2 3
Zyg-11 Homolog A (C. Elegans)1
Protein Zyg-11 Homolog A2
Zyg-11 Homolog A2
ZYG-11A Early Embryogenesis Protein2

External Ids:    HGNC: 320581   Entrez Gene: 4405902   Ensembl: ENSG000002039957   UniProtKB: Q6WRX33   

Export aliases for ZYG11A gene to outside databases

Previous GC identifers: GC01P053022 GC01P053080 GC01P051424


Summaries
for ZYG11A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZY11A_HUMAN, Q6WRX3
Function: Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC (By
similarity)




Genomic Views
for ZYG11A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZYG11A gene promoter:
         Nkx3-1   Nkx3-1 v4   HTF   Nkx2-5   Nkx3-1 v1   Evi-1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZYG11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZYG11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

ZYG11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZYG11A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P053308:  view genomic region     (about GC identifiers)

Start:
 53,308,183 bp from pter      End:
 53,360,670 bp from pter
Size:
 52,488 bases      Orientation:
 plus strand

Proteins
for ZYG11A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZY11A_HUMAN, Q6WRX3 (See protein sequence)
Recommended Name: Protein zyg-11 homolog A  
Size: 759 amino acids; 85808 Da
Secondary accessions: A6NCK5
Alternative splicing: 2 isoforms:  Q6WRX3-1   Q6WRX3-2   

Explore the universe of human proteins at neXtProt for ZYG11A: NX_Q6WRX3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6WRX3

    • ZYG11A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001004339.2  
    ENSEMBL proteins: 
     ENSP00000360587   ENSP00000360583  

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    Protein Domains /
    Families
    for ZYG11A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZYG11A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6WRX3

    ProtoNet protein and cluster: Q6WRX3

    UniProtKB/Swiss-Prot: ZY11A_HUMAN, Q6WRX3
    Similarity: Belongs to the zyg-11 family
    Similarity: Contains 3 LRR (leucine-rich) repeats


    Function
    for ZYG11A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZY11A_HUMAN, Q6WRX3
    Function: Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC (By
    similarity)

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    1 GenomeRNAi human phenotype for ZYG11A:
     Elongated cells 


    Pathways & Interactions
    for ZYG11A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZYG11A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZYG11A (ENSP000003605834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL11A1ENSP000003511634STRING: ENSP00000351163
    SCP2ENSP000003605694STRING: ENSP00000360569
    UBIAD1ENSP000003660064STRING: ENSP00000366006
    --ENSP000003728604STRING: ENSP00000372860
    About this table

    Drugs & Compounds
    for ZYG11A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZYG11A
    Search CenterWatch for drugs/clinical trials and news about ZYG11A / ZY11A 

    Transcripts
    for ZYG11A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ZYG11A gene: 
    NM_001004339.2  

    Unigene Cluster for ZYG11A:

    Zyg-11 family member A, cell cycle regulator
    Hs.658458  [show with all ESTs]
    Unigene Representative Sequence: NM_001004339
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371532(uc001cul.2) ENST00000371528(uc001cuk.2)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AY271826.1 BC119789.1 BC119815.1 

    2 DOTS entries:

    DT.40268250  DT.102837165 

    4 AceView cDNA sequences:

    BP872266 AY271826 NM_001004339 AA176176 

    GeneLoc Exon Structure


    Expression
    for ZYG11A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZYG11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTCCAAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZYG11A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZYG11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZYG11A

    SOURCE GeneReport for Unigene cluster: Hs.658458
        SABiosciences Custom PCR Arrays for ZYG11A
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZYG11A

    Orthologs
    for ZYG11A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZYG11A gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZYG11B6
    		 Uncharacterized protein
    		 64(a)
    		 1 → many
    		 8(25259573-25273393)
    lizard
    (Anolis carolinensis)    		 Reptilia ZYG11B6
    		 --
    		 64(a)
    		 1 → many
    		 4(114796454-114814356)
    zebrafish
    (Danio rerio)    		 Actinopterygii zyg116
    wu:fi26e046
    		 wu:fi26e04
    		 52(a)
    43(a)
    		 many ↔ many
    many ↔ many
    		 20(16214145-16242343)
    2(3508171-3530580)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 34(a)
    		 1 → many
    		 GroupUn.1142(1840-5205)
    worm
    (Caenorhabditis elegans)    		 Secernentea zyg-116
    		 Early embryogenesis protein zyg-11
    		 24(a)
    		 1 → many
    		 II(8017629-8020708)


    ENSEMBL Gene Tree for ZYG11A (if available)
    TreeFam Gene Tree for ZYG11A (if available) 

    Paralogs
    for ZYG11A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZYG11A gene
    ZYG11B2  ZER12  
    1 SIMAP similar gene for ZYG11A using alignment to 1 protein entry:     ZY11A_HUMAN:
    ZYG11B

    ZYG11A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZYG11A
    PGOHUM00000236293


    Genomic Variants
    for ZYG11A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/957 NCBI SNPs in ZYG11A are shown (see all 957)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873166981,2
    		--53306302(+) TAAATA/TAAATA 1 -- us2k10--------
    rs1399337761,2
    		--53306601(+) CTTATA/GAGAAC 1 -- us2k10--------
    rs761370981,2
    		--53306622(+) AGGTTC/TTATAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1914203241,2
    		--53306776(+) CCCAAA/GAATTC 1 -- us2k10--------
    rs1838970621,2
    		--53306858(+) TTTCAA/TTAAAT 1 -- us2k10--------
    rs1154872701,2
    		F,--53306865(+) AAATCC/ACTTCA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1878341531,2
    		--53306885(+) TGTTTG/TTGCGT 1 -- us2k10--------
    rs782546741,2
    		C--53306952(+) AAAGCA/GTATTG 1 -- us2k10--------
    rs1121673441,2
    		C,F,--53306968(+) GGCACG/AGTGGC 1 -- us2k14Minor allele frequency- A:0.12WA CSA 124
    rs1500053031,2
    		--53306975(+) TGGCTC/TACGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZYG11A (53308183 - 53360670 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZYG11A
         2 CNVs: 4225 63725

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    Disorders / Diseases
    for ZYG11A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ZYG11A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZYG11A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZYG11A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for ZYG11A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZYG11A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440590 HGNC: 32058 AceView: LOC440590 Ensembl:ENSG00000203995 euGenes: HUgn440590
    ECgene: ZYG11A H-InvDB: ZYG11A

    Other Databases showing ZYG11A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZYG11A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZYG11A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZYG11A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZYG11A gene:
    Search GeneIP for patents involving ZYG11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZYG11A gene

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    About This Section

     
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