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Aliases for ZYG11A Gene

Aliases for ZYG11A Gene

  • Zyg-11 Family Member A, Cell Cycle Regulator 2 3
  • ZYG11 3 4
  • ZYG-11A Early Embryogenesis Protein 3
  • Zyg-11 Homolog A (C. Elegans) 2
  • Protein Zyg-11 Homolog A 3
  • Zyg-11 Homolog A 3

External Ids for ZYG11A Gene

Previous GeneCards Identifiers for ZYG11A Gene

  • GC01P053022
  • GC01P053080
  • GC01P053308
  • GC01P051424

Summaries for ZYG11A Gene

GeneCards Summary for ZYG11A Gene

ZYG11A (Zyg-11 Family Member A, Cell Cycle Regulator) is a Protein Coding gene. An important paralog of this gene is ZER1.

UniProtKB/Swiss-Prot for ZYG11A Gene

  • Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYG11A Gene

Genomics for ZYG11A Gene

Regulatory Elements for ZYG11A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZYG11A Gene

52,842,511 bp from pter
52,894,998 bp from pter
52,488 bases
Plus strand

Genomic View for ZYG11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZYG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11A Gene

Proteins for ZYG11A Gene

  • Protein details for ZYG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein zyg-11 homolog A
    Protein Accession:
    Secondary Accessions:
    • A6NCK5

    Protein attributes for ZYG11A Gene

    759 amino acids
    Molecular mass:
    85808 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZYG11A Gene


neXtProt entry for ZYG11A Gene

Proteomics data for ZYG11A Gene at MOPED

Post-translational modifications for ZYG11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZYG11A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZYG11A Gene

Domains for ZYG11A Gene

Gene Families for ZYG11A Gene

  • ZYG11 :ZYG11 cell cycle regulator family

Protein Domains for ZYG11A Gene


Suggested Antigen Peptide Sequences for ZYG11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6WRX3
  • Belongs to the zyg-11 family.
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ZYG11A: view

Function for ZYG11A Gene

Molecular function for ZYG11A Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

Gene Ontology (GO) - Molecular Function for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with ZYG11A: view

Phenotypes for ZYG11A Gene

GenomeRNAi human phenotypes for ZYG11A:
genes like me logo Genes that share phenotypes with ZYG11A: view

Animal Model Products

miRNA for ZYG11A Gene

miRTarBase miRNAs that target ZYG11A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZYG11A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZYG11A Gene

Localization for ZYG11A Gene

Subcellular locations from

Jensen Localization Image for ZYG11A Gene COMPARTMENTS Subcellular localization image for ZYG11A gene
Compartment Confidence
cytosol 3
cytoskeleton 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZYG11A Gene

Pathways for ZYG11A Gene

SuperPathways for ZYG11A Gene

No Data Available

Interacting Proteins for ZYG11A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000360583 for ZYG11A Gene via STRING

Gene Ontology (GO) - Biological Process for ZYG11A Gene


No data available for Pathways by source for ZYG11A Gene

Transcripts for ZYG11A Gene

mRNA/cDNA for ZYG11A Gene

(4) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(11) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZYG11A Gene

Zyg-11 family member A, cell cycle regulator:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZYG11A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11A Gene

No ASD Table

Relevant External Links for ZYG11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZYG11A Gene

mRNA expression in normal human tissues for ZYG11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYG11A Gene

This gene is overexpressed in Testis (11.8), Thyroid (6.3), and Liver (4.0).

Protein differential expression in normal tissues for ZYG11A Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZYG11A Gene

SOURCE GeneReport for Unigene cluster for ZYG11A Gene Hs.658458

genes like me logo Genes that share expressions with ZYG11A: view

Expression partners for ZYG11A Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZYG11A Gene

Orthologs for ZYG11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZYG11A 35
  • 88.34 (n)
  • 84.9 (a)
ZYG11A 36
  • 85 (a)
(Canis familiaris)
Mammalia ZYG11A 35
  • 91.31 (n)
  • 90.76 (a)
ZYG11A 36
  • 91 (a)
(Mus musculus)
Mammalia Zyg11a 35
  • 79.95 (n)
  • 74.29 (a)
Zyg11a 16
Zyg11a 36
  • 73 (a)
(Pan troglodytes)
Mammalia ZYG11A 35
  • 99.34 (n)
  • 98.95 (a)
ZYG11A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zyg11a 35
  • 78.22 (n)
  • 72.2 (a)
(Monodelphis domestica)
Mammalia ZYG11A 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 55 (a)
(Anolis carolinensis)
Reptilia ZYG11A 36
  • 55 (a)
(Danio rerio)
Actinopterygii si:ch1073-82l19.1 36
  • 42 (a)
zyg11 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea zyg-11 36
  • 20 (a)
Species with no ortholog for ZYG11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZYG11A Gene

Gene Tree for ZYG11A (if available)
Gene Tree for ZYG11A (if available)

Paralogs for ZYG11A Gene

Paralogs for ZYG11A Gene

Selected SIMAP similar genes for ZYG11A Gene using alignment to 1 proteins: Pseudogenes for ZYG11A Gene

genes like me logo Genes that share paralogs with ZYG11A: view

Variants for ZYG11A Gene

Sequence variations from dbSNP and Humsavar for ZYG11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs473340 -- 52,845,391(-) gaggc(A/G)gaggt intron-variant
rs475832 -- 52,855,063(-) ccaaa(C/G)tggtg intron-variant
rs476108 -- 52,851,679(-) ctcac(A/G)cctat intron-variant
rs479569 -- 52,886,735(+) AGAGA(C/T)GGGGG intron-variant
rs480299 -- 52,854,602(-) AATCG(A/C)TCGGC reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZYG11A Gene

Variant ID Type Subtype PubMed ID
nsv871800 CNV Loss 21882294
nsv829859 CNV Loss 17160897
nsv866 CNV Loss 18451855
esv2668074 CNV Deletion 23128226
esv24261 CNV Loss 19812545

Relevant External Links for ZYG11A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYG11A Gene

Disorders for ZYG11A Gene

No disorders were found for ZYG11A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZYG11A Gene

Publications for ZYG11A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for ZYG11A Gene

Sources for ZYG11A Gene

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