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Aliases for ZXDC Gene

Aliases for ZXDC Gene

  • ZXD Family Zinc Finger C 2 3
  • ZXD-Like Zinc Finger Protein 3 4
  • ZXDL 3 4
  • Zinc Finger Protein ZXDC 3
  • SERH2790 3

External Ids for ZXDC Gene

Previous GeneCards Identifiers for ZXDC Gene

  • GC03M127640
  • GC03M126156
  • GC03M123536

Summaries for ZXDC Gene

GeneCards Summary for ZXDC Gene

ZXDC (ZXD Family Zinc Finger C) is a Protein Coding gene. Diseases associated with ZXDC include rectum adenocarcinoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and C2H2 zinc finger domain binding. An important paralog of this gene is GTF3A.

UniProtKB/Swiss-Prot for ZXDC Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDC Gene

Genomics for ZXDC Gene

Regulatory Elements for ZXDC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZXDC Gene

Start:
126,437,601 bp from pter
End:
126,475,930 bp from pter
Size:
38,330 bases
Orientation:
Minus strand

Genomic View for ZXDC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZXDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDC Gene

Proteins for ZXDC Gene

  • Protein details for ZXDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2QGD7-ZXDC_HUMAN
    Recommended name:
    Zinc finger protein ZXDC
    Protein Accession:
    Q2QGD7
    Secondary Accessions:
    • C5J0H9
    • Q6DKI8
    • Q7L3L1
    • Q8NAU2

    Protein attributes for ZXDC Gene

    Size:
    858 amino acids
    Molecular mass:
    89988 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDA and CIITA.
    SequenceCaution:
    • Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZXDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZXDC Gene

Proteomics data for ZXDC Gene at MOPED

Post-translational modifications for ZXDC Gene

  • Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZXDC Gene

No data available for DME Specific Peptides for ZXDC Gene

Domains for ZXDC Gene

Gene Families for ZXDC Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZXDC Gene

Suggested Antigen Peptide Sequences for ZXDC Gene

Graphical View of Domain Structure for InterPro Entry

Q2QGD7

UniProtKB/Swiss-Prot:

ZXDC_HUMAN :
  • Q2QGD7
Family:
  • Belongs to the ZXD family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZXDC: view

Function for ZXDC Gene

Molecular function for ZXDC Gene

UniProtKB/Swiss-Prot Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Gene Ontology (GO) - Molecular Function for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 17493635
GO:0005515 protein binding IPI 16600381
GO:0030275 LRR domain binding IPI 16600381
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZXDC: view

Phenotypes for ZXDC Gene

GenomeRNAi human phenotypes for ZXDC:
genes like me logo Genes that share phenotypes with ZXDC: view

Animal Model Products

CRISPR Products

miRNA for ZXDC Gene

miRTarBase miRNAs that target ZXDC

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZXDC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZXDC Gene

Localization for ZXDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZXDC Gene COMPARTMENTS Subcellular localization image for ZXDC gene
Compartment Confidence
nucleus 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZXDC: view

Pathways for ZXDC Gene

SuperPathways for ZXDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 16600381
genes like me logo Genes that share ontologies with ZXDC: view

No data available for Pathways by source for ZXDC Gene

Transcripts for ZXDC Gene

Unigene Clusters for ZXDC Gene

ZXD family zinc finger C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZXDC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6:

Relevant External Links for ZXDC Gene

GeneLoc Exon Structure for
ZXDC
ECgene alternative splicing isoforms for
ZXDC

Expression for ZXDC Gene

mRNA expression in normal human tissues for ZXDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZXDC Gene

SOURCE GeneReport for Unigene cluster for ZXDC Gene Hs.440049

mRNA Expression by UniProt/SwissProt for ZXDC Gene

Q2QGD7-ZXDC_HUMAN
Tissue specificity: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.
genes like me logo Genes that share expressions with ZXDC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZXDC Gene

Orthologs for ZXDC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZXDC 35
  • 99.46 (n)
  • 99.42 (a)
ZXDC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZXDC 35
  • 75.61 (n)
  • 71.39 (a)
ZXDC 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZXDC 35
  • 82.49 (n)
  • 81.04 (a)
ZXDC 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zxdc 35
  • 81.21 (n)
  • 77.17 (a)
Zxdc 16
Zxdc 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zxdc 35
  • 80.89 (n)
  • 77.92 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 60 (a)
OneToMany
ZXDC 35
  • 67.84 (n)
  • 65.6 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zxdc 35
  • 66.37 (n)
  • 64.07 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-156n14.3 35
  • 58.3 (n)
  • 56.05 (a)
wufd99c07 35
ZXDC 36
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9609 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 36
  • 6 (a)
ManyToMany
SWI5 36
  • 6 (a)
ManyToMany
Species with no ortholog for ZXDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDC Gene

ENSEMBL:
Gene Tree for ZXDC (if available)
TreeFam:
Gene Tree for ZXDC (if available)

Paralogs for ZXDC Gene

Paralogs for ZXDC Gene

genes like me logo Genes that share paralogs with ZXDC: view

Variants for ZXDC Gene

Sequence variations from dbSNP and Humsavar for ZXDC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3230 -- 126,461,245(+) CCCCA(A/G)TCTTC utr-variant-3-prime, intron-variant
rs3231 -- 126,461,278(+) GGAGC(C/T)ACAGG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs7131 -- 126,437,817(+) TCCCC(C/G)GAAAA utr-variant-3-prime, nc-transcript-variant
rs12957 -- 126,451,852(+) ACCCG(G/T)GCAGG intron-variant
rs15058 -- 126,437,733(-) GAGCT(C/T)GGGGG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZXDC Gene

Variant ID Type Subtype PubMed ID
nsv877432 CNV Loss 21882294
nsv877436 CNV Loss 21882294
nsv829717 CNV Loss 17160897
esv993756 CNV Insertion 20482838
nsv236874 CNV Loss 16902084
dgv5246n71 CNV Loss 21882294
esv27826 CNV Loss 19812545

Relevant External Links for ZXDC Gene

HapMap Linkage Disequilibrium report
ZXDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDC Gene

Disorders for ZXDC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZXDC Gene including...

Search for ZXDC Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZXDC Gene

Relevant External Links for ZXDC

Genetic Association Database (GAD)
ZXDC
Human Genome Epidemiology (HuGE) Navigator
ZXDC
genes like me logo Genes that share disorders with ZXDC: view

No data available for UniProtKB/Swiss-Prot for ZXDC Gene

Publications for ZXDC Gene

  1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PMID: 19777325) Aleksandrova A. … Fontes J.D. (Mol. Cell. Biochem. 2010) 3 4 23
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription. (PMID: 16600381) Al-Kandari W. … Fontes J.D. (Mol. Immunol. 2007) 3 4

Products for ZXDC Gene

Sources for ZXDC Gene

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