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Aliases for ZXDC Gene

Aliases for ZXDC Gene

  • ZXD Family Zinc Finger C 2 3 5
  • ZXD-Like Zinc Finger Protein 3 4
  • ZXDL 3 4
  • Zinc Finger Protein ZXDC 3
  • SERH2790 3

External Ids for ZXDC Gene

Previous GeneCards Identifiers for ZXDC Gene

  • GC03M127640
  • GC03M126156
  • GC03M123536

Summaries for ZXDC Gene

GeneCards Summary for ZXDC Gene

ZXDC (ZXD Family Zinc Finger C) is a Protein Coding gene. Diseases associated with ZXDC include Moyamoya Disease 1 and Cerebral Arterial Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding. An important paralog of this gene is ZXDB.

UniProtKB/Swiss-Prot for ZXDC Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Additional gene information for ZXDC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDC Gene

Genomics for ZXDC Gene

GeneHancer (GH) Regulatory Elements for ZXDC Gene

Promoters and enhancers for ZXDC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I126471 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 569.2 +1.3 1281 5.6 HDGF CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS ZXDC OR7E29P PIR31332
GH03I125645 Enhancer 0.8 ENCODE 40.9 +828.6 828584 3 PKNOX1 FOXA2 ZNF493 ZFP64 RAD21 ZNF213 ZNF138 FOS ZNF202 ZNF680 ZNF148 ZXDC UMPS OR7E29P ENSG00000242001 FAM86JP LOC101927056 LOC100419878 SLC41A3 ENSG00000243072
GH03I126464 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.7 +10.3 10324 2.8 ELF3 FOXA2 ARID4B ZNF48 RAD21 RARA YY1 RXRA SP5 REST ZXDC PIR31332
GH03I126212 Enhancer 1 Ensembl ENCODE 24.4 +262.7 262707 1.6 HDGF ARID4B SIN3A YBX1 ZBTB7B ZNF48 RAD21 ZNF366 E2F8 ZNF207 LOC105374086 ZXDC ZNF148 ALDH1L1 ALG1L GC03P126153
GH03I126467 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 18.4 +7.9 7865 1.8 MXI1 FOXA2 TAF1 MAX CEBPG RAD21 YY1 POLR2A HNF4G GATAD2A ZXDC PIR31332
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZXDC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZXDC gene promoter:

Genomic Locations for ZXDC Gene

Genomic Locations for ZXDC Gene
chr3:126,437,601-126,475,933
(GRCh38/hg38)
Size:
38,333 bases
Orientation:
Minus strand
chr3:126,156,444-126,194,762
(GRCh37/hg19)

Genomic View for ZXDC Gene

Genes around ZXDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZXDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZXDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDC Gene

Proteins for ZXDC Gene

  • Protein details for ZXDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2QGD7-ZXDC_HUMAN
    Recommended name:
    Zinc finger protein ZXDC
    Protein Accession:
    Q2QGD7
    Secondary Accessions:
    • C5J0H9
    • Q6DKI8
    • Q7L3L1
    • Q8NAU2

    Protein attributes for ZXDC Gene

    Size:
    858 amino acids
    Molecular mass:
    89988 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDA and CIITA.
    SequenceCaution:
    • Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZXDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZXDC Gene

Post-translational modifications for ZXDC Gene

  • Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.

Other Protein References for ZXDC Gene

No data available for DME Specific Peptides for ZXDC Gene

Domains & Families for ZXDC Gene

Gene Families for ZXDC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZXDC Gene

Suggested Antigen Peptide Sequences for ZXDC Gene

Graphical View of Domain Structure for InterPro Entry

Q2QGD7

UniProtKB/Swiss-Prot:

ZXDC_HUMAN :
  • Belongs to the ZXD family.
Family:
  • Belongs to the ZXD family.
genes like me logo Genes that share domains with ZXDC: view

Function for ZXDC Gene

Molecular function for ZXDC Gene

UniProtKB/Swiss-Prot Function:
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Phenotypes From GWAS Catalog for ZXDC Gene

Gene Ontology (GO) - Molecular Function for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA binding transcription factor activity IMP 17493635
GO:0005515 protein binding IPI 16600381
GO:0030275 LRR domain binding IPI 16600381
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZXDC: view

Phenotypes for ZXDC Gene

genes like me logo Genes that share phenotypes with ZXDC: view

miRNA for ZXDC Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZXDC Gene

Localization for ZXDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZXDC gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZXDC: view

Pathways & Interactions for ZXDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 16600381
genes like me logo Genes that share ontologies with ZXDC: view

No data available for Pathways by source and SIGNOR curated interactions for ZXDC Gene

Drugs & Compounds for ZXDC Gene

No Compound Related Data Available

Transcripts for ZXDC Gene

Unigene Clusters for ZXDC Gene

ZXD family zinc finger C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6:

Relevant External Links for ZXDC Gene

GeneLoc Exon Structure for
ZXDC
ECgene alternative splicing isoforms for
ZXDC

Expression for ZXDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZXDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZXDC Gene

This gene is overexpressed in Plasma (35.1) and Pancreatic juice (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZXDC Gene



Protein tissue co-expression partners for ZXDC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZXDC Gene:

ZXDC

SOURCE GeneReport for Unigene cluster for ZXDC Gene:

Hs.440049

mRNA Expression by UniProt/SwissProt for ZXDC Gene:

Q2QGD7-ZXDC_HUMAN
Tissue specificity: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.

Evidence on tissue expression from TISSUES for ZXDC Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(3.6)
  • Lung(2.8)
genes like me logo Genes that share expression patterns with ZXDC: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZXDC Gene

Orthologs for ZXDC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZXDC 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia ZXDC 33 34
  • 82.49 (n)
mouse
(Mus musculus)
Mammalia Zxdc 33 16 34
  • 81.21 (n)
rat
(Rattus norvegicus)
Mammalia Zxdc 33
  • 80.89 (n)
cow
(Bos Taurus)
Mammalia ZXDC 33 34
  • 75.61 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZXDC 33
  • 67.84 (n)
-- 34
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zxdc 33
  • 66.37 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-156n14.3 33
  • 58.3 (n)
ZXDC 34
  • 31 (a)
OneToMany
wufd99c07 33
fruit fly
(Drosophila melanogaster)
Insecta CG9609 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 34
  • 6 (a)
ManyToMany
SWI5 34
  • 6 (a)
ManyToMany
Species where no ortholog for ZXDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDC Gene

ENSEMBL:
Gene Tree for ZXDC (if available)
TreeFam:
Gene Tree for ZXDC (if available)

Paralogs for ZXDC Gene

Paralogs for ZXDC Gene

genes like me logo Genes that share paralogs with ZXDC: view

Variants for ZXDC Gene

Sequence variations from dbSNP and Humsavar for ZXDC Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000057859 -- 126,451,245(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000128586 -- 126,457,134(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000222175 -- 126,468,034(-) G/A intron_variant
rs1000264833 -- 126,473,093(-) C/T intron_variant
rs1000319989 -- 126,461,308(-) T/C 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZXDC Gene

Variant ID Type Subtype PubMed ID
esv27826 CNV loss 19812545
esv3597682 CNV loss 21293372
esv993756 CNV insertion 20482838
nsv1074620 CNV deletion 25765185
nsv1144047 CNV deletion 24896259
nsv236874 CNV deletion 16902084
nsv591507 CNV loss 21841781
nsv591508 CNV gain+loss 21841781
nsv829717 CNV loss 17160897

Variation tolerance for ZXDC Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZXDC Gene

Human Gene Mutation Database (HGMD)
ZXDC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZXDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDC Gene

Disorders for ZXDC Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZXDC Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
moyamoya disease 1
  • mymy1
cerebral arterial disease
  • cerebral arterial diseases
- elite association - COSMIC cancer census association via MalaCards
Search ZXDC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZXDC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZXDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZXDC Gene

Publications for ZXDC Gene

  1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PMID: 19777325) Aleksandrova A … Fontes JD (Molecular and cellular biochemistry 2010) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. (PMID: 17696781) Jambunathan S … Fontes JD (Biological chemistry 2007) 3 4 58
  4. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PMID: 17493635) Al-Kandari W … Fontes JD (Journal of molecular biology 2007) 3 4 58
  5. ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription. (PMID: 16600381) Al-Kandari W … Fontes JD (Molecular immunology 2007) 3 4 58

Products for ZXDC Gene

Sources for ZXDC Gene

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