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Aliases for ZXDC Gene

Aliases for ZXDC Gene

  • ZXD Family Zinc Finger C 2 3 5
  • ZXD-Like Zinc Finger Protein 3 4
  • ZXDL 3 4
  • Zinc Finger Protein ZXDC 3
  • SERH2790 3

External Ids for ZXDC Gene

Previous GeneCards Identifiers for ZXDC Gene

  • GC03M127640
  • GC03M126156
  • GC03M123536

Summaries for ZXDC Gene

GeneCards Summary for ZXDC Gene

ZXDC (ZXD Family Zinc Finger C) is a Protein Coding gene. Diseases associated with ZXDC include Cerebral Arterial Disease. GO annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding. An important paralog of this gene is ZXDA.

UniProtKB/Swiss-Prot for ZXDC Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDC Gene

Genomics for ZXDC Gene

Regulatory Elements for ZXDC Gene

Enhancers for ZXDC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G126464 1.4 Ensembl ENCODE dbSUPER 21.7 +10.3 10325 2.8 ELF3 FOXA2 ARID4B ZNF48 RAD21 YY1 RARA CREM SP5 PPARG ZXDC PIR31332
GH03G126471 1.4 ENCODE dbSUPER 19.2 +1.3 1281 5.6 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF143 FOS ZXDC LOC101927056 OR7E29P PIR31332
GH03G126467 1.3 FANTOM5 ENCODE dbSUPER 18.4 +7.9 7866 1.8 MXI1 TAF1 MAX CEBPG RAD21 YY1 RARA HNF4G NR2F6 GATAD2A ZXDC PIR31332
GH03G126461 0.8 dbSUPER 21.7 +13.8 13773 2.3 TBP ARID4B YY1 ZNF335 GLIS2 SCRT2 SP3 KLF11 NFYC ZNF398 ZXDC UROC1 CHST13 PIR31332
GH03G126486 1 Ensembl ENCODE 14.7 -11.5 -11455 1.2 CTCF FOXA2 TFE3 NFIA MXD4 MAX ZEB2 TEAD3 ZEB1 MXD3 ZXDC UROC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZXDC on UCSC Golden Path with GeneCards custom track

Promoters for ZXDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000306000 233 1801 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B YY1 GTF3C2 GLIS2 ZNF143
ENSR00000157845 1733 401 SCRT1 ZNF362 SCRT2 IKZF1 PRDM10 ZNF384 ZNF18

Genomic Location for ZXDC Gene

126,437,601 bp from pter
126,475,933 bp from pter
38,333 bases
Minus strand

Genomic View for ZXDC Gene

Genes around ZXDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZXDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZXDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDC Gene

Proteins for ZXDC Gene

  • Protein details for ZXDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZXDC
    Protein Accession:
    Secondary Accessions:
    • C5J0H9
    • Q6DKI8
    • Q7L3L1
    • Q8NAU2

    Protein attributes for ZXDC Gene

    858 amino acids
    Molecular mass:
    89988 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDA and CIITA.
    • Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZXDC Gene


neXtProt entry for ZXDC Gene

Post-translational modifications for ZXDC Gene

  • Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZXDC Gene

No data available for DME Specific Peptides for ZXDC Gene

Domains & Families for ZXDC Gene

Gene Families for ZXDC Gene

Protein Domains for ZXDC Gene

Suggested Antigen Peptide Sequences for ZXDC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZXD family.
  • Belongs to the ZXD family.
genes like me logo Genes that share domains with ZXDC: view

Function for ZXDC Gene

Molecular function for ZXDC Gene

UniProtKB/Swiss-Prot Function:
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Gene Ontology (GO) - Molecular Function for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IMP 17493635
GO:0005515 protein binding IPI 16600381
GO:0030275 LRR domain binding IPI 16600381
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZXDC: view

Phenotypes for ZXDC Gene

genes like me logo Genes that share phenotypes with ZXDC: view

Animal Model Products

CRISPR Products

miRNA for ZXDC Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZXDC Gene

Localization for ZXDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZXDC gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZXDC: view

Pathways & Interactions for ZXDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 16600381
genes like me logo Genes that share ontologies with ZXDC: view

No data available for Pathways by source and SIGNOR curated interactions for ZXDC Gene

Drugs & Compounds for ZXDC Gene

No Compound Related Data Available

Transcripts for ZXDC Gene

Unigene Clusters for ZXDC Gene

ZXD family zinc finger C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - -
SP3: -
SP5: - -

Relevant External Links for ZXDC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZXDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZXDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZXDC Gene

This gene is overexpressed in Plasma (35.1) and Pancreatic juice (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZXDC Gene

Protein tissue co-expression partners for ZXDC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZXDC Gene:


SOURCE GeneReport for Unigene cluster for ZXDC Gene:


mRNA Expression by UniProt/SwissProt for ZXDC Gene:

Tissue specificity: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.

Evidence on tissue expression from TISSUES for ZXDC Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(3.6)
  • Lung(2.8)
genes like me logo Genes that share expression patterns with ZXDC: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZXDC Gene

Orthologs for ZXDC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZXDC 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia ZXDC 34 35
  • 82.49 (n)
(Mus musculus)
Mammalia Zxdc 34 16 35
  • 81.21 (n)
(Rattus norvegicus)
Mammalia Zxdc 34
  • 80.89 (n)
(Bos Taurus)
Mammalia ZXDC 34 35
  • 75.61 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
(Gallus gallus)
Aves ZXDC 34
  • 67.84 (n)
-- 35
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zxdc 34
  • 66.37 (n)
(Danio rerio)
Actinopterygii si:dkey-156n14.3 34
  • 58.3 (n)
  • 31 (a)
wufd99c07 34
fruit fly
(Drosophila melanogaster)
Insecta CG9609 35
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 35
  • 6 (a)
SWI5 35
  • 6 (a)
Species where no ortholog for ZXDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDC Gene

Gene Tree for ZXDC (if available)
Gene Tree for ZXDC (if available)

Paralogs for ZXDC Gene

Paralogs for ZXDC Gene

genes like me logo Genes that share paralogs with ZXDC: view

Variants for ZXDC Gene

Sequence variations from dbSNP and Humsavar for ZXDC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000057859 -- 126,451,245(+) CATGC(A/G)TATGT intron-variant
rs1000128586 -- 126,457,134(+) TGGAA(A/C)AGGGA intron-variant
rs1000222175 -- 126,468,034(+) CTGCT(A/G)GCTTT intron-variant
rs1000264833 -- 126,473,093(+) AGTAT(C/T)AGCCC intron-variant
rs1000319989 -- 126,461,308(+) AGCAT(C/T)TAGCC intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZXDC Gene

Variant ID Type Subtype PubMed ID
esv27826 CNV loss 19812545
esv3597682 CNV loss 21293372
esv993756 CNV insertion 20482838
nsv1074620 CNV deletion 25765185
nsv1144047 CNV deletion 24896259
nsv236874 CNV deletion 16902084
nsv591507 CNV loss 21841781
nsv591508 CNV gain+loss 21841781
nsv829717 CNV loss 17160897

Variation tolerance for ZXDC Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZXDC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDC Gene

Disorders for ZXDC Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZXDC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral arterial disease
  • cerebral arterial diseases
- elite association - COSMIC cancer census association via MalaCards
Search ZXDC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZXDC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZXDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZXDC Gene

Publications for ZXDC Gene

  1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PMID: 19777325) Aleksandrova A. … Fontes J.D. (Mol. Cell. Biochem. 2010) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription. (PMID: 16600381) Al-Kandari W. … Fontes J.D. (Mol. Immunol. 2007) 3 4 64
  4. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PMID: 17493635) Al-Kandari W. … Fontes J.D. (J. Mol. Biol. 2007) 3 4 64
  5. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. (PMID: 17696781) Jambunathan S. … Fontes J.D. (Biol. Chem. 2007) 3 4 64

Products for ZXDC Gene

Sources for ZXDC Gene

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