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ZXDC Gene

protein-coding   GIFtS: 52
GCID: GC03M126156

ZXD Family Zinc Finger C

  See ZXDC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZXD Family Zinc Finger C1 2
ZXDL2 3
ZXD-Like Zinc Finger Protein2 3
SERH27902
Zinc Finger Protein ZXDC2

External Ids:    HGNC: 281601   Entrez Gene: 793642   Ensembl: ENSG000000704767   UniProtKB: Q2QGD73   

Export aliases for ZXDC gene to outside databases

Previous GC identifers: GC03M127640 GC03M123536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZXDC Gene:
ZXDC (ZXD family zinc finger C) is a protein-coding gene. Diseases associated with ZXDC include rectum adenocarcinoma. GO annotations related to this gene include C2H2 zinc finger domain binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZXDA.

UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZXDC gene promoter:
         USF1   Tal-1beta   Egr-4   E47   PPAR-gamma1   E2F   COMP1   USF-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZXDC promoter sequence
   Search Chromatin IP Primers for ZXDC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZXDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

ZXDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZXDC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126156:  view genomic region     (about GC identifiers)

Start:
126,156,444 bp from pter      End:
126,194,762 bp from pter
Size:
38,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7 (See protein sequence)
Recommended Name: Zinc finger protein ZXDC  
Size: 858 amino acids; 89988 Da
Subunit: Self-associates. Interacts with ZXDA and CIITA
Sequence caution: Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C5J0H9 Q6DKI8 Q7L3L1 Q8NAU2
Alternative splicing: 3 isoforms:  Q2QGD7-1   Q2QGD7-2   Q2QGD7-3   (Doesn't interact with CIITA. Represses MHC class II transcription possibly via dominant-negative association with isoform 1)

Explore the universe of human proteins at neXtProt for ZXDC: NX_Q2QGD7

Explore proteomics data for ZXDC at MOPED

Post-translational modifications: 

  • Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional
    activation domain1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZXDC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035743.1  NP_079388.3  

    ENSEMBL proteins: 
     ENSP00000374359   ENSP00000426532   ENSP00000337694  

    ZXDC Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for ZXDC

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    antibodies-online antibodies for ZXDC (7 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q2QGD7

    ProtoNet protein and cluster: Q2QGD7

    UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
    Similarity: Belongs to the ZXD family
    Similarity: Contains 10 C2H2-type zinc fingers


    Find genes that share domains with ZXDC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZXDC_HUMAN, Q2QGD7
    Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IMP17493635
    GO:0005515protein binding IPI16600381
    GO:0030275LRR domain binding IPI16600381
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZXDC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZXDC:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZXDC
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    miRNA
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    miRTarBase miRNAs that target ZXDC:
    hsa-mir-181b-5p (MIRT047258), hsa-mir-192-5p (MIRT026669)

    Block miRNA regulation of human, mouse, rat ZXDC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZXDC (see all 33):
    hsa-miR-142-5p hsa-miR-134 hsa-miR-548l hsa-miR-877* hsa-miR-223 hsa-miR-3118 hsa-miR-3136-5p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidZXDC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZXDC

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZXDC_HUMAN, Q2QGD7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZXDC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZXDC
    Interactions:

        GeneGlobe Interaction Network for ZXDC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ZXDC (Q2QGD71, 2, 3 ENSP000003743594) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271729 I2D: score=2 
    SMN2Q166372, 3MINT-8271729 I2D: score=2 
    SH3GL2Q999622, 3MINT-8270649 I2D: score=2 
    TK1P041832, 3MINT-8274434 I2D: score=2 
    CIITAP330761, 3, ENSP000003163284EBI-1538838,EBI-1538819 I2D: score=2 STRING: ENSP00000316328
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045893positive regulation of transcription, DNA-templated IMP16600381

    Find genes that share ontologies with ZXDC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZXDC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZXDC gene (2 alternative transcripts): 
    NM_001040653.3  NM_025112.4  

    Unigene Cluster for ZXDC:

    ZXD family zinc finger C
    Hs.440049  [show with all ESTs]
    Unigene Representative Sequence: NM_001040653
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514463 ENST00000389709(uc003eiv.3 uc010hsh.3) ENST00000515545
    ENST00000336332(uc003eix.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat ZXDC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZXDC (see all 33):
    hsa-miR-142-5p hsa-miR-134 hsa-miR-548l hsa-miR-877* hsa-miR-223 hsa-miR-3118 hsa-miR-3136-5p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidZXDC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZXDC
    Predesigned siRNA for gene silencing in human, mouse, rat ZXDC
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZXDC (NM_025112)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZXDC
    Primer
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    OriGene qPCR primer pairs and template standards for ZXDC
    OriGene qSTAR qPCR primer pairs in human, mouse for ZXDC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZXDC
      QuantiTect SYBR Green Assays in human, mouse, rat ZXDC
      QuantiFast Probe-based Assays in human, mouse, rat ZXDC

    Additional mRNA sequence: 

    AF131763.1 AK023923.1 AK092101.1 AK095149.1 AY277596.1 AY936556.1 BC002940.2 BC012729.2 
    BC063713.1 BC073859.1 BC110644.1 BC115413.1 DQ079590.1 FJ980275.1 

    15 DOTS entries:

    DT.100752072  DT.313878  DT.92428958  DT.97766469  DT.92428953  DT.215466  DT.91900808  DT.120887725 
    DT.120887723  DT.100690925  DT.120887759  DT.75180464  DT.120844364  DT.91859757  DT.91864990 

    Selected AceView cDNA sequences (see all 255):

    F05240 AA478927 BE409746 AA574187 AA430663 AU141720 AK023923 BG740303 
    BC063713 AA939161 BM712659 BI792805 AA402554 BE219901 F34761 BM762574 
    AW131875 AI745653 NM_025112 AI424542 BE383720 BQ050465 BF594386 CB123916 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZXDC (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                                              -     -           -     -                           
    SP2:                                                                    -     -     -     -                           
    SP3:        -                                                                                                         
    SP4:                                                                                                                  
    SP5:                                                              -     -                                             


    ECgene alternative splicing isoforms for ZXDC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZXDC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGGAGC
    ZXDC Expression
    About this image


    ZXDC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Placenta (Extraembryonic Tissues)
    ZXDC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZXDC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440049

    UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
    Tissue specificity: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and
    stomach, and at low levels in lung, muscle, placenta, small intestine and spleen

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    QuantiFast Probe-based Assays in human, mouse, rat ZXDC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZXDC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZXDC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zxdc1 , 5 ZXD family zinc finger C1, 5 81.21(n)1
    77.17(a)1
      6 (40.16 cM)5
    802921  NM_173002.31  NP_766590.11 
     903694925 
    chicken
    (Gallus gallus)
    Aves ZXDC1 ZXD family zinc finger C 67.84(n)
    65.6(a)
      416034  XM_414374.4  XP_414374.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    1 → many
    2(169122892-169230882)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zxdc1 ZXD family zinc finger C 66.37(n)
    64.07(a)
      100495694  XM_002938232.2  XP_002938278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd99c072 Transcribed sequence with moderate similarity to protein more 75.53(n)    57059664 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96096
    --
    23(a)
    1 → many
    X(16679398-16681011)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ACE26
    SWI56
    Transcription factor required for septum destructi...
    Transcription factor that activates transcription ...
    6(a)
    6(a)
    many ↔ many
    many ↔ many
    XII(404510-406822) YLR131C
    IV(748613-750742) YDR146C


    ENSEMBL Gene Tree for ZXDC (if available)
    TreeFam Gene Tree for ZXDC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZXDC gene
    ZXDA2  GTF3A2  ZXDB2  
    18 SIMAP similar genes for ZXDC using alignment to 2 protein entries:     ZXDC_HUMAN (see all proteins):
    DKFZp547N024    TRG13    ZXDA    ZXDB    DKFZp686O1631    kr-znf3
    ZNF    KLF1    DKFZp434J0650    A-328A3.4    KLF16    ZFS-5
    ZNF808    DKFZp686N0199    DKFZp666C237    GTF3A    ZFS-2    ZNF78L1

    Find genes that share paralogs with ZXDC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZXDC (see all 890)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs67690631,2
    C,F,H--126156066(+) TTTGTC/TGACGA 1 -- int16Minor allele frequency- T:0.05NS EA WA 536
    rs37325401,2
    C,F,A--126156156(+) ACTTGG/ATGTCA 1 -- int115Minor allele frequency- A:0.39EA NA WA CSA 1769
    rs1931240111,2
    --126156214(+) TCTGAC/GAATCA 1 -- int10--------
    rs1385784081,2
    C--126156222(+) CAAAA-/AA    
       AAAAC
    CAGCC
    1 -- int10--------
    rs112999921,2
    C--126156262(+) AAGGC-/A/AA  
            
    AAAAA
    1 -- int11CSA 2
    rs613424681,2
    C--126156277(+) AAAAA-/A/A   
       A
    /AAA
    GTCAT
    2 -- int1 cds12NA 4
    rs799607971,2
    C,F--126156306(+) CATTGC/TTAAGT 1 -- int12Minor allele frequency- T:0.03NA EA 240
    rs67692921,2
    C,F,H--126156363(+) TTTTAC/TAAGAC 1 -- int110Minor allele frequency- T:0.10NS EA WA NA 1210
    rs1383214931,2
    --126156399(+) CTGACA/GTATTA 1 -- int10--------
    rs1839590781,2
    --126156405(+) TATTAC/TGTGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZXDC (126156444 - 126194762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZXDC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv993756CNV Insertion20482838
    esv27826CNV Loss19812545
    dgv5246n71CNV Loss21882294
    nsv877432CNV Loss21882294
    nsv236874CNV Loss16902084
    nsv829717CNV Loss17160897
    nsv877436CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZXDC
    DNA2.0 Custom Variant and Variant Library Synthesis for ZXDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZXDC:    
    About MalaCards
    rectum adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for ZXDC:
    Rectum adenocarcinoma

    Find genes that share disorders with ZXDC           About GenesLikeMe

    Genetic Association Database (GAD): ZXDC
    Human Genome Epidemiology (HuGE) Navigator: ZXDC (1 document)

    Export disorders for ZXDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZXDC gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ZXDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PubMed id 19777325)1, 2, 9 Aleksandrova A.... Fontes J.D. (Mol. Cell. Biochem. 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. (PubMed id 17696781)1, 2 Jambunathan S. and Fontes J.D. (Biol. Chem. 2007)
    4. ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription. (PubMed id 16600381)1, 2 Al-Kandari W.... Fontes J.D. (Mol. Immunol. 2007)
    5. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PubMed id 17493635)1, 2 Al-Kandari W.... Fontes J.D. (J. Mol. Biol. 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    9. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    10. The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. (PubMed id 23954399)1 Ramsey J.E. and Fontes J.D. (Mol. Immunol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79364 HGNC: 28160 AceView: MGC11349 Ensembl:ENSG00000070476 euGenes: HUgn79364
    ECgene: ZXDC H-InvDB: ZXDC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZXDC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZXDC gene:
    Search GeneIP for patents involving ZXDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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