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Aliases for ZXDC Gene

Aliases for ZXDC Gene

  • ZXD Family Zinc Finger C 2 3 5
  • ZXD-Like Zinc Finger Protein 3 4
  • ZXDL 3 4
  • SERH2790 3

External Ids for ZXDC Gene

Previous GeneCards Identifiers for ZXDC Gene

  • GC03M127640
  • GC03M126156
  • GC03M123536

Summaries for ZXDC Gene

GeneCards Summary for ZXDC Gene

ZXDC (ZXD Family Zinc Finger C) is a Protein Coding gene. Diseases associated with ZXDC include Rectum Adenocarcinoma. GO annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding. An important paralog of this gene is GTF3A.

UniProtKB/Swiss-Prot for ZXDC Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDC Gene

Genomics for ZXDC Gene

Regulatory Elements for ZXDC Gene

Enhancers for ZXDC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZXDC on UCSC Golden Path with GeneCards custom track

Promoters for ZXDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZXDC on UCSC Golden Path with GeneCards custom track

Genomic Location for ZXDC Gene

126,437,601 bp from pter
126,475,933 bp from pter
38,333 bases
Minus strand

Genomic View for ZXDC Gene

Genes around ZXDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZXDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZXDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDC Gene

Proteins for ZXDC Gene

  • Protein details for ZXDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZXDC
    Protein Accession:
    Secondary Accessions:
    • C5J0H9
    • Q6DKI8
    • Q7L3L1
    • Q8NAU2

    Protein attributes for ZXDC Gene

    858 amino acids
    Molecular mass:
    89988 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDA and CIITA.
    • Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZXDC Gene


neXtProt entry for ZXDC Gene

Proteomics data for ZXDC Gene at MOPED

Post-translational modifications for ZXDC Gene

  • Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZXDC Gene

No data available for DME Specific Peptides for ZXDC Gene

Domains & Families for ZXDC Gene

Gene Families for ZXDC Gene

Protein Domains for ZXDC Gene

Suggested Antigen Peptide Sequences for ZXDC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZXD family.
  • Contains 10 C2H2-type zinc fingers.
  • Belongs to the ZXD family.
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZXDC: view

Function for ZXDC Gene

Molecular function for ZXDC Gene

UniProtKB/Swiss-Prot Function:
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Gene Ontology (GO) - Molecular Function for ZXDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16600381
GO:0070742 C2H2 zinc finger domain binding IPI 17493635
genes like me logo Genes that share ontologies with ZXDC: view

Phenotypes for ZXDC Gene

GenomeRNAi human phenotypes for ZXDC:
genes like me logo Genes that share phenotypes with ZXDC: view

Animal Model Products

miRNA for ZXDC Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZXDC Gene

Localization for ZXDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDC Gene

Subcellular locations from

Jensen Localization Image for ZXDC Gene COMPARTMENTS Subcellular localization image for ZXDC gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZXDC Gene

Pathways & Interactions for ZXDC Gene

SuperPathways for ZXDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDC Gene


No data available for Pathways by source and SIGNOR curated interactions for ZXDC Gene

Drugs & Compounds for ZXDC Gene

No Compound Related Data Available

Transcripts for ZXDC Gene

Unigene Clusters for ZXDC Gene

ZXD family zinc finger C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - -
SP3: -
SP5: - -

Relevant External Links for ZXDC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZXDC Gene

mRNA expression in normal human tissues for ZXDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZXDC Gene

This gene is overexpressed in Plasma (35.1) and Pancreatic juice (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZXDC Gene

SOURCE GeneReport for Unigene cluster for ZXDC Gene Hs.440049

mRNA Expression by UniProt/SwissProt for ZXDC Gene

Tissue specificity: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.
genes like me logo Genes that share expression patterns with ZXDC: view

Protein tissue co-expression partners for ZXDC Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ZXDC Gene

Orthologs for ZXDC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZXDC 35
  • 75.61 (n)
  • 71.39 (a)
  • 65 (a)
(Canis familiaris)
Mammalia ZXDC 35
  • 82.49 (n)
  • 81.04 (a)
  • 79 (a)
(Mus musculus)
Mammalia Zxdc 35
  • 81.21 (n)
  • 77.17 (a)
Zxdc 16
Zxdc 36
  • 75 (a)
(Pan troglodytes)
Mammalia ZXDC 35
  • 99.46 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Zxdc 35
  • 80.89 (n)
  • 77.92 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
(Gallus gallus)
Aves ZXDC 35
  • 67.84 (n)
  • 65.6 (a)
-- 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zxdc 35
  • 66.37 (n)
  • 64.07 (a)
(Danio rerio)
Actinopterygii si:dkey-156n14.3 35
  • 58.3 (n)
  • 56.05 (a)
wufd99c07 35
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9609 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 36
  • 6 (a)
SWI5 36
  • 6 (a)
Species with no ortholog for ZXDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDC Gene

Gene Tree for ZXDC (if available)
Gene Tree for ZXDC (if available)

Paralogs for ZXDC Gene

Paralogs for ZXDC Gene

genes like me logo Genes that share paralogs with ZXDC: view

Variants for ZXDC Gene

Sequence variations from dbSNP and Humsavar for ZXDC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs16837497 - 126,461,977(+) CCATC(A/G)GCCCT nc-transcript-variant, reference, missense
rs3230 -- 126,461,245(+) CCCCA(A/G)TCTTC intron-variant, utr-variant-3-prime
rs3231 -- 126,461,278(+) GGAGC(C/T)ACAGG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs7131 -- 126,437,817(+) TCCCC(C/G)GAAAA nc-transcript-variant, utr-variant-3-prime
rs12957 -- 126,451,852(+) ACCCG(G/T)GCAGG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZXDC Gene

Variant ID Type Subtype PubMed ID
nsv877432 CNV Loss 21882294
nsv877436 CNV Loss 21882294
nsv829717 CNV Loss 17160897
esv993756 CNV Insertion 20482838
nsv236874 CNV Loss 16902084
dgv5246n71 CNV Loss 21882294
esv27826 CNV Loss 19812545

Variation tolerance for ZXDC Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZXDC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDC Gene

Disorders for ZXDC Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZXDC Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectum adenocarcinoma
  • adenocarcinoma of rectum
- elite association - COSMIC cancer census association via MalaCards
Search ZXDC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZXDC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZXDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZXDC Gene

Publications for ZXDC Gene

  1. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PMID: 19777325) Aleksandrova A. … Fontes J.D. (Mol. Cell. Biochem. 2010) 3 4 23 67
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZXDC Gene

Sources for ZXDC Gene