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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZXDC Gene

protein-coding   GIFtS: 50
GCID: GC03M126156

ZXD family zinc finger C

 Explore 2 diseases affiliated with
ZXDC via our new
 Human Malady Compendium 
Biological research products
for ZXDC
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ZXD Family Zinc Finger C1 2     MGC113491
ZXDL2 3     SERH27902
ZXD-Like Zinc Finger Protein2 3     Zinc Finger Protein ZXDC2
FLJ138611     

External Ids:    HGNC: 281601   Entrez Gene: 793642   Ensembl: ENSG000000704767   UniProtKB: Q2QGD73   

Export aliases for ZXDC gene to outside databases

Previous GC identifers: GC03M127640 GC03M123536


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZXDC gene promoter:
         USF1   Tal-1beta   Egr-4   E47   PPAR-gamma1   E2F   COMP1   USF-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZXDC promoter sequence
   Search SABiosciences Chromatin IP Primers for ZXDC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZXDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

ZXDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZXDC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126156:  view genomic region     (about GC identifiers)

Start:
126,156,444 bp from pter      End:
126,194,762 bp from pter
Size:
38,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7 (See protein sequence)
Recommended Name: Zinc finger protein ZXDC  
Size: 858 amino acids; 89988 Da
Subunit: Self-associates. Interacts with ZXDA and CIITA
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAC03805.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7L3L1 Q8NAU2
Alternative splicing: 2 isoforms:  Q2QGD7-1   Q2QGD7-2   

Explore the universe of human proteins at neXtProt for ZXDC: NX_Q2QGD7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q2QGD7

  • ZXDC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035743.1  NP_079388.3  

    ENSEMBL proteins: 
     ENSP00000374359   ENSP00000426532   ENSP00000337694  

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    Uscn Proteins for ZXDC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--


    ZXDC for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZXDC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q2QGD7

    ProtoNet protein and cluster: Q2QGD7

    UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
    Similarity: Belongs to the ZXD family
    Similarity: Contains 10 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
    Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes

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    hsa-miR-142-5p hsa-miR-134 hsa-miR-548l hsa-miR-877* hsa-miR-223 hsa-miR-3118 hsa-miR-3136-5p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidZXDC 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IMP17493635
    GO:0005515protein binding IPI17493635
    GO:0008270zinc ion binding IEA--
    GO:0030275LRR domain binding IPI16600381


    ZXDC for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZXDC:
     Proliferating cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZXDC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/12 Interacting proteins for ZXDC (Q2QGD71, 2, 3 ENSP000003743594) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271729 I2D: score=2 
    SMN2Q166372, 3MINT-8271729 I2D: score=2 
    SH3GL2Q999622, 3MINT-8270649 I2D: score=2 
    TK1P041832, 3MINT-8274434 I2D: score=2 
    CIITAP330761, 3, ENSP000003163284EBI-1538838,EBI-1538819 I2D: score=2 STRING: ENSP00000316328
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IMP16600381


    ZXDC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZXDC
    Search CenterWatch for drugs/clinical trials and news about ZXDC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZXDC gene (2 alternative transcripts): 
    NM_001040653.2  NM_025112.4  

    Unigene Clusters for ZXDC:

    ZXD family zinc finger C
    Hs.440049  [show with all ESTs], Hs.711046  [show with all ESTs]
    Unigene Representative Sequences: NM_001040653, AK093796
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514463 ENST00000389709(uc003eiv.3 uc010hsh.3) ENST00000515545
    ENST00000336332(uc003eix.2)

    miRNA
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    OriGene 3'-UTR Clone: ZXDC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZXDC
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ZXDC (see all 33):
    hsa-miR-142-5p hsa-miR-134 hsa-miR-548l hsa-miR-877* hsa-miR-223 hsa-miR-3118 hsa-miR-3136-5p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidZXDC 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK093796.1 AY358102.1 

    16 DOTS entries:

    DT.100752072  DT.313878  DT.92428958  DT.97766469  DT.92428953  DT.215466  DT.91900808  DT.91926388 
    DT.120887725  DT.120887723  DT.100690925  DT.120887759  DT.75180464  DT.120844364  DT.91859757  DT.91864990 

    24/255 AceView cDNA sequences (see all 255):

    BC002940 BI792964 AA913123 CK820990 AI658735 AI797094 AW131875 BG740303 
    BE869868 BE383720 CB123916 BQ669903 AA339230 AA574187 BE501211 AA430663 
    BE219901 BQ050465 AI424542 BG392535 F05240 AI745653 AK023923 NM_025112 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZXDC (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                                              -     -           -     -                           
    SP2:                                                                    -     -     -     -                           
    SP3:        -                                                                                                         
    SP4:                                                                                                                  
    SP5:                                                              -     -                                             


    ECgene alternative splicing isoforms for ZXDC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZXDC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGATGGAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZXDC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZXDC

    SOURCE GeneReport for Unigene clusters: Hs.440049 Hs.711046

    UniProtKB/Swiss-Prot: ZXDC_HUMAN, Q2QGD7
    Tissue specificity: Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and
    stomach, and at low levels in lung, muscle, placenta, small intestine and spleen

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZXDC gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zxdc1 , 5 ZXD family zinc finger C1, 5 82.4(n)1
    78.95(a)1
      6 (40.16 cM)5
    802921  NM_173002.31  NP_766590.11 
     903694925 
    chicken
    (Gallus gallus)
    Aves ZXDC1 ZXD family zinc finger C 67.89(n)
    65.6(a)
      416034  XM_414374.3  XP_414374.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    59(a)
    1 → many
    2(169212567-169230471)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd99c072 Transcribed sequence with moderate similarity to protein more 75.53(n)    57059664 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    12(a)
    1 → many
    Group5.21(38592-44978)


    ENSEMBL Gene Tree for ZXDC (if available)
    TreeFam Gene Tree for ZXDC (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZXDC gene
    ZXDA2  GTF3A2  ZXDB2  
    18/24 SIMAP similar genes for ZXDC using alignment to 4 protein entries:     ZXDC_HUMAN (see all proteins) (see all similar genes):
    DKFZp547N024    TRG13    ZXDA    ZXDB    DKFZp686O1631    kr-znf3
    KLF16    ZNF    KLF1    DKFZp434J0650    A-328A3.4    ZFS-5
    GTF3A    KLF7    ZNF808    DKFZp666C237    ZFS-2    DKFZp686N0199

    ZXDC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/728 NCBI SNPs in ZXDC are shown (see all 728    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs67690631,2
    C,F,H,--126156066(+) TTTGTC/TGACGA 1 -- int16Minor allele frequency- T:0.05NS EA WA 536
    rs37325401,2
    C,F,A,--126156156(+) ACTTGG/ATGTCA 1 -- int115Minor allele frequency- A:0.39EA NA WA CSA 1769
    rs1931240111,2
    --126156214(+) TCTGAC/GAATCA 1 -- int10--------
    rs1385784081,2
    C,--126156222(+) CAAAA-/AA    
       AAAAC
    CAGCC
    1 -- int10--------
    rs799607971,2
    F,--126156306(+) CATTGC/TTAAGT 1 -- int12Minor allele frequency- T:0.03NA EA 240
    rs67692921,2
    C,F,H,--126156363(+) TTTTAC/TAAGAC 1 -- int110Minor allele frequency- T:0.10NS EA WA NA 1210
    rs1383214931,2
    --126156399(+) CTGACA/GTATTA 1 -- int10--------
    rs1839590781,2
    --126156405(+) TATTAC/TGTGCA 1 -- int10--------
    rs1382318511,2
    C,--126156561(+) TTTAA-/CTCTACC 1 -- ut310--------
    rs150581,2
    C,F,H,--126156576(-) GAGCTC/TGGGGG 1 -- ut3112Minor allele frequency- T:0.04MN NS EA NA 1142

    HapMap Linkage Disequilibrium report for ZXDC (126156444 - 126194762 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ZXDC
         3 CNVs: 68449 5213 6208
         1 Indel: 68450

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZXDC
    DNA2.0 Custom Variant and Variant Library Synthesis for ZXDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZXDC for disorders           About GeneDecksing

    2 diseases for ZXDC:    About MalaCards
    rectum adenocarcinoma    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for ZXDC:
    Rectum adenocarcinoma
    Human Genome Epidemiology (HuGE) Navigator: ZXDC (1 document)

    Export disorders for ZXDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZXDC gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZXDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription. (PubMed id 16600381)1, 2 Al-Kandari W.... Fontes J.D. (2007)
    2. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PubMed id 17493635)1, 2 Al-Kandari W.... Fontes J.D. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    6. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PubMed id 19777325)1, 9 Aleksandrova A....Fontes J.D. (2010)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. (PubMed id 17696781)1 Jambunathan S. and Fontes J.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79364 HGNC: 28160 AceView: MGC11349 Ensembl:ENSG00000070476 euGenes: HUgn79364
    ECgene: ZXDC H-InvDB: ZXDC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZXDC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZXDC gene:
    Search GeneIP for patents involving ZXDC

    GeneCards and IP:
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