ZXDB Gene
protein-coding GIFtS: 43
GCID: GC0XP057634
|
|
zinc finger, X-linked, duplicated B
| |
Aliases
for ZXDB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, X-Linked, Duplicated B1 2 | | ZNF9051 2 | | DJ83L6.11 | | Zinc Finger X-Linked Protein ZXDB2 |
Export aliases for ZXDB gene to outside databasesPrevious GC identifers: GC0XU990242 GC0XP055586 GC0XP056223 GC0XM056901 GC0XP056585 GC0XP057484 GC0XP054679 |
Summaries
for ZXDB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZXDB:
The ZXDB gene is one of a pair of duplicated zinc finger genes on chromosome Xp11.21 (Greig et al., 1993 (PubMed8268913)); see also ZXDA (MIM 300235).(supplied by OMIM, Jul 2010)
UniProtKB/Swiss-Prot: ZXDB_HUMAN, P98169Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes (By similarity)
|
Genomic Views
for ZXDB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZXDB gene promoter:
AREB6 PPAR-gamma1 Pax-5 AML1a Nkx2-2 Lmo2 ARP-1 PPAR-gamma2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZXDB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZXDB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.1ZXDB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP057634: view genomic region
(about GC identifiers)
Start:
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57,618,269 bp from pter |
End:
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57,623,910 bp from pter |
Size:
|
5,642 bases |
Orientation:
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plus strand |
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Proteins
for ZXDB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZXDB_HUMAN, P98169 (See
protein sequence)Recommended Name: Zinc finger X-linked protein ZXDB Size: 803 amino acids; 84792 Da
Subunit: Self-associates. Interacts with ZXDC and CIITA (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: A8K151 Q9UBB3Explore the universe of human proteins at neXtProt for ZXDB: NX_P98169
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P98169
ZXDB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009088.1
ENSEMBL proteins: ENSP00000364023
Human Recombinant Protein Products for ZXDB:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
ZXDB for ontologies About GeneDecksing
ZXDB Antibody Products:
Assay Products for ZXDB: |
Protein
Domains /
Families
for ZXDB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZXDB for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P98169ProtoNet protein and cluster: P98169 UniProtKB/Swiss-Prot: ZXDB_HUMAN, P98169Similarity: Belongs to the ZXD familySimilarity: Contains 10 C2H2-type zinc fingers |
Function
for ZXDB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZXDB_HUMAN, P98169Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes (By similarity) Genatlas biochemistry entry for ZXDB:zinc finger protein (C2H2 type),X linked,duplicated B
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZXDB for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZXDB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZXDB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZXDB (NM_007157) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZXDB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZXDB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZXDB |
|
Pathways & Interactions
for ZXDB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZXDB
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZXDB (ENSP000003640234) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZXDB for ontologies About GeneDecksing
|
Drugs & Compounds
for ZXDB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZXDB
Search CenterWatch for drugs/clinical trials and news about ZXDB
|
Transcripts
for ZXDB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZXDB gene: NM_007157.3 Unigene Cluster for ZXDB: Zinc finger, X-linked, duplicated B Hs.156257 [show with all ESTs]Unigene Representative Sequence: NM_0071571 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000374888(uc004dvd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZXDB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZXDB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZXDB (NM_007157) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZXDB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZXDB |
Additional cDNA sequence: AJ227869.1 AK124513.1 AK289766.1 L14788.1 3 DOTS entries: DT.95120992 DT.109565 DT.101981193 24/48 AceView cDNA sequences (see all 48): BG563527 BE677308 AW150690 AA400675 AI868484 AA400709 BU076306 AI335812 BE044323 BM701206 CA433211 AI360269 L14788 BM674105 NM_007157 Z41985 AK124513 BG027131 BM715753 BM069614 BU165593 AI335006 BF222566 AW952243
GeneLoc Exon Structure
|
Expression
for ZXDB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZXDB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGATGTCTG
About this image
See ZXDB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZXDB
SOURCE GeneReport for Unigene cluster: Hs.156257
UniProtKB/Swiss-Prot: ZXDB_HUMAN, P98169Tissue specificity: May be expressed in brain, heart, kidney, liver, lung, muscle and placenta
SABiosciences Custom PCR Arrays for ZXDB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZXDB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZXDB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZXDB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZXDB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZXDB |
Orthologs
for ZXDB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZXDB gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZXDC6 |
Uncharacterized protein |
53(a) |
1 → many |
12(10959085-10967883) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
49(a) |
1 → many |
2(169212567-169230471) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-156n14.36 |
si:dkey-156n14.3 |
28(a) |
1 → many |
6(23710138-23727533) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
13(a) |
1 → many |
Group5.21(38592-44978) |
ENSEMBL Gene Tree for ZXDB (if available)
TreeFam Gene Tree for ZXDB (if available) |
Paralogs
for ZXDB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZXDB gene
- ZXDA2 GTF3A2 ZXDC2
4 SIMAP similar genes for ZXDB using alignment to 1 protein entry: ZXDB_HUMAN:ZXDA ZXDC ZNF32 ZNF323
ZXDB for paralogs About GeneDecksing
|
Genomic Variants
for ZXDB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZXDB (57618269 - 57623910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZXDB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZXDB |
|
Disorders
/ Diseases
for ZXDB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZXDB for disorders About GeneDecksing
OMIM gene information: 300236
OMIM disorders: --
1  disease for ZXDB: About MalaCardsx inactivation
1 disease from the University of Copenhagen DISEASES database for ZXDB:Turner syndrome Export disorders for ZXDB gene to outside databases
|
Publications
for ZXDB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZXDB gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZXDB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. (PubMed id 8268913)1, 2, 3 Greig G.M.... Willard H.F. (1993)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for ZXDB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZXDB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZXDB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZXDB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZXDB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZXDB gene:
Search GeneIP for patents involving ZXDB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZXDB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZXDB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZXDB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZXDB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZXDB | | OriGene 3'-UTR Clone for ZXDB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZXDB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZXDB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZXDB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZXDB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZXDB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZXDB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZXDB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZXDB |
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 |  |  |  | |
| | | | Search Tocris compounds for ZXDB |
| |  |  |  |  | | | | |
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 |
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 | | | ZXDB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZXDB |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZXDB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZXDB |
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