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Aliases for ZXDA Gene

Aliases for ZXDA Gene

  • Zinc Finger, X-Linked, Duplicated A 2 3 5
  • Zinc Finger Protein 896 2 3
  • ZNF896 3

External Ids for ZXDA Gene

Previous GeneCards Identifiers for ZXDA Gene

  • GC0XM054714
  • GC0XM055912
  • GC0XM056539
  • GC0XM056902
  • GC0XM056900
  • GC0XM057817
  • GC0XM057949
  • GC0XM054990

Summaries for ZXDA Gene

Entrez Gene Summary for ZXDA Gene

  • This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]

GeneCards Summary for ZXDA Gene

ZXDA (Zinc Finger, X-Linked, Duplicated A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding. An important paralog of this gene is GTF3A.

UniProtKB/Swiss-Prot for ZXDA Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDA Gene

Genomics for ZXDA Gene

Regulatory Elements for ZXDA Gene

Promoters for ZXDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZXDA on UCSC Golden Path with GeneCards custom track

Genomic Location for ZXDA Gene

Chromosome:
X
Start:
57,905,430 bp from pter
End:
57,910,820 bp from pter
Size:
5,391 bases
Orientation:
Minus strand

Genomic View for ZXDA Gene

Genes around ZXDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZXDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZXDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDA Gene

Proteins for ZXDA Gene

  • Protein details for ZXDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98168-ZXDA_HUMAN
    Recommended name:
    Zinc finger X-linked protein ZXDA
    Protein Accession:
    P98168
    Secondary Accessions:
    • Q9UJP7

    Protein attributes for ZXDA Gene

    Size:
    799 amino acids
    Molecular mass:
    84771 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDC and CIITA.
    SequenceCaution:
    • Sequence=AAC37521.1; Type=Frameshift; Positions=753; Evidence={ECO:0000305};

neXtProt entry for ZXDA Gene

Proteomics data for ZXDA Gene at MOPED

Post-translational modifications for ZXDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZXDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZXDA Gene

Domains & Families for ZXDA Gene

Gene Families for ZXDA Gene

Protein Domains for ZXDA Gene

Suggested Antigen Peptide Sequences for ZXDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P98168

UniProtKB/Swiss-Prot:

ZXDA_HUMAN :
  • Belongs to the ZXD family.
  • Contains 10 C2H2-type zinc fingers.
Family:
  • Belongs to the ZXD family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZXDA: view

Function for ZXDA Gene

Molecular function for ZXDA Gene

GENATLAS Biochemistry:
zinc finger protein (C2H2 type),X linked,duplicated A
UniProtKB/Swiss-Prot Function:
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Gene Ontology (GO) - Molecular Function for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 17493635
genes like me logo Genes that share ontologies with ZXDA: view

Phenotypes for ZXDA Gene

genes like me logo Genes that share phenotypes with ZXDA: view

Animal Model Products

CRISPR Products

miRNA for ZXDA Gene

miRTarBase miRNAs that target ZXDA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZXDA Gene

Localization for ZXDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZXDA Gene COMPARTMENTS Subcellular localization image for ZXDA gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZXDA Gene

Pathways & Interactions for ZXDA Gene

SuperPathways for ZXDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZXDA Gene

Drugs & Compounds for ZXDA Gene

No Compound Related Data Available

Transcripts for ZXDA Gene

mRNA/cDNA for ZXDA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZXDA Gene

Zinc finger, X-linked, duplicated A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDA Gene

No ASD Table

Relevant External Links for ZXDA Gene

GeneLoc Exon Structure for
ZXDA
ECgene alternative splicing isoforms for
ZXDA

Expression for ZXDA Gene

mRNA expression in normal human tissues for ZXDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZXDA Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZXDA Gene



SOURCE GeneReport for Unigene cluster for ZXDA Gene Hs.550094

mRNA Expression by UniProt/SwissProt for ZXDA Gene

P98168-ZXDA_HUMAN
Tissue specificity: May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.
genes like me logo Genes that share expression patterns with ZXDA: view

Protein tissue co-expression partners for ZXDA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZXDA Gene

Orthologs for ZXDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZXDA 35
  • 98.83 (n)
  • 98.12 (a)
ZXDA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zxdb 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZXDC 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9609 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 36
  • 8 (a)
ManyToMany
SWI5 36
  • 7 (a)
ManyToMany
Species with no ortholog for ZXDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDA Gene

ENSEMBL:
Gene Tree for ZXDA (if available)
TreeFam:
Gene Tree for ZXDA (if available)

Paralogs for ZXDA Gene

Paralogs for ZXDA Gene

(4) SIMAP similar genes for ZXDA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZXDA: view

Variants for ZXDA Gene

Sequence variations from dbSNP and Humsavar for ZXDA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1057327 - 57,909,295(-) AACTC(A/G/T)GCGCC reference, missense
rs1057325 -- 57,909,344(-) AACTC(A/G)TTCAA reference, synonymous-codon
rs1057326 -- 57,909,335(-) AAATG(C/T)GAGGT reference, synonymous-codon
rs1057329 -- 57,909,134(-) AGCAA(A/G)CAATA reference, synonymous-codon
rs1057330 -- 57,909,035(-) TTCAC(C/T)AGCAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZXDA Gene

Variant ID Type Subtype PubMed ID
nsv518933 CNV Gain 19592680

Variation tolerance for ZXDA Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.30; 81.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZXDA Gene

HapMap Linkage Disequilibrium report
ZXDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDA Gene

Disorders for ZXDA Gene

Relevant External Links for ZXDA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZXDA

No disorders were found for ZXDA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZXDA Gene

Publications for ZXDA Gene

  1. Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. (PMID: 8268913) Greig G.M. … Willard H.F. (Hum. Mol. Genet. 1993) 2 3 4 67
  2. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PMID: 17493635) Al-Kandari W. … Fontes J.D. (J. Mol. Biol. 2007) 3 23
  3. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  4. An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription. (PMID: 19777325) Aleksandrova A. … Fontes J.D. (Mol. Cell. Biochem. 2010) 3
  5. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3

Products for ZXDA Gene

Sources for ZXDA Gene

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