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Aliases for ZXDA Gene

Aliases for ZXDA Gene

  • Zinc Finger, X-Linked, Duplicated A 2 3
  • Zinc Finger Protein 896 2 3
  • Zinc Finger X-Linked Protein ZXDA 3
  • ZNF896 3

External Ids for ZXDA Gene

Previous GeneCards Identifiers for ZXDA Gene

  • GC0XM054714
  • GC0XM055912
  • GC0XM056539
  • GC0XM056902
  • GC0XM056900
  • GC0XM057817
  • GC0XM057949
  • GC0XM054990

Summaries for ZXDA Gene

Entrez Gene Summary for ZXDA Gene

  • This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]

GeneCards Summary for ZXDA Gene

ZXDA (Zinc Finger, X-Linked, Duplicated A) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and C2H2 zinc finger domain binding. An important paralog of this gene is GTF3A.

UniProtKB/Swiss-Prot for ZXDA Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDA Gene

Genomics for ZXDA Gene

Regulatory Elements for ZXDA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZXDA Gene

Start:
57,905,430 bp from pter
End:
57,910,820 bp from pter
Size:
5,391 bases
Orientation:
Minus strand

Genomic View for ZXDA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZXDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDA Gene

Proteins for ZXDA Gene

  • Protein details for ZXDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98168-ZXDA_HUMAN
    Recommended name:
    Zinc finger X-linked protein ZXDA
    Protein Accession:
    P98168
    Secondary Accessions:
    • Q9UJP7

    Protein attributes for ZXDA Gene

    Size:
    799 amino acids
    Molecular mass:
    84771 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDC and CIITA.
    SequenceCaution:
    • Sequence=AAC37521.1; Type=Frameshift; Positions=753; Evidence={ECO:0000305};

neXtProt entry for ZXDA Gene

Proteomics data for ZXDA Gene at MOPED

Post-translational modifications for ZXDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZXDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZXDA Gene

Domains for ZXDA Gene

Gene Families for ZXDA Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZXDA Gene

Suggested Antigen Peptide Sequences for ZXDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P98168

UniProtKB/Swiss-Prot:

ZXDA_HUMAN :
  • P98168
Family:
  • Belongs to the ZXD family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZXDA: view

Function for ZXDA Gene

Molecular function for ZXDA Gene

GENATLAS Biochemistry: zinc finger protein (C2H2 type),X linked,duplicated A
UniProtKB/Swiss-Prot Function: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Gene Ontology (GO) - Molecular Function for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 17493635
GO:0005515 protein binding IPI 17493635
GO:0046872 metal ion binding IEA --
GO:0070742 C2H2 zinc finger domain binding IPI 17493635
genes like me logo Genes that share ontologies with ZXDA: view

Animal Model Products

CRISPR Products

miRNA for ZXDA Gene

miRTarBase miRNAs that target ZXDA

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZXDA Gene

Localization for ZXDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZXDA Gene COMPARTMENTS Subcellular localization image for ZXDA gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZXDA: view

Pathways for ZXDA Gene

SuperPathways for ZXDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 17493635
genes like me logo Genes that share ontologies with ZXDA: view

No data available for Pathways by source for ZXDA Gene

Transcripts for ZXDA Gene

mRNA/cDNA for ZXDA Gene

(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZXDA Gene

Zinc finger, X-linked, duplicated A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZXDA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZXDA
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDA Gene

No ASD Table

Relevant External Links for ZXDA Gene

GeneLoc Exon Structure for
ZXDA
ECgene alternative splicing isoforms for
ZXDA

Expression for ZXDA Gene

mRNA expression in normal human tissues for ZXDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZXDA Gene

SOURCE GeneReport for Unigene cluster for ZXDA Gene Hs.550094

mRNA Expression by UniProt/SwissProt for ZXDA Gene

P98168-ZXDA_HUMAN
Tissue specificity: May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.
genes like me logo Genes that share expressions with ZXDA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZXDA Gene

Orthologs for ZXDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZXDA 35
  • 98.83 (n)
  • 98.12 (a)
ZXDA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zxdb 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZXDC 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9609 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 36
  • 8 (a)
ManyToMany
SWI5 36
  • 7 (a)
ManyToMany
Species with no ortholog for ZXDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDA Gene

ENSEMBL:
Gene Tree for ZXDA (if available)
TreeFam:
Gene Tree for ZXDA (if available)

Paralogs for ZXDA Gene

Paralogs for ZXDA Gene

Selected SIMAP similar genes for ZXDA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZXDA: view

Variants for ZXDA Gene

Sequence variations from dbSNP and Humsavar for ZXDA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1057325 -- 57,909,344(-) AACTC(A/G)TTCAA synonymous-codon, reference
rs1057326 -- 57,909,335(-) AAATG(C/T)GAGGT synonymous-codon, reference
rs1057327 - 57,909,295(-) AACTC(A/G)GCGCC missense, reference
rs1057329 -- 57,909,134(-) AGCAA(A/G)CAATA synonymous-codon, reference
rs1057330 -- 57,909,035(-) TTCAC(C/T)AGCAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZXDA Gene

Variant ID Type Subtype PubMed ID
nsv518933 CNV Gain 19592680

Relevant External Links for ZXDA Gene

HapMap Linkage Disequilibrium report
ZXDA
Locus Specific Mutation Databases (LSDB)
ZXDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDA Gene

Disorders for ZXDA Gene

(1) University of Copenhagen DISEASES for ZXDA Gene

genes like me logo Genes that share disorders with ZXDA: view

No data available for UniProtKB/Swiss-Prot for ZXDA Gene

Publications for ZXDA Gene

  1. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PMID: 17493635) Al-Kandari W. … Fontes J.D. (J. Mol. Biol. 2007) 3 4 23
  2. Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. (PMID: 8268913) Greig G.M. … Willard H.F. (Hum. Mol. Genet. 1993) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3

Products for ZXDA Gene

Sources for ZXDA Gene

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