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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZWINT Gene

protein-coding   GIFtS: 58
GCID: GC10M058116

ZW10 Interacting Kinetochore Protein

(Previous name: ZW10 interactor)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZW10 Interacting Kinetochore Protein1 2     ZWINT12
ZW10 Interactor1 2     Human ZW10 Interacting Protein-12
ZW10-Interacting Protein 12 3     ZW10 Interactor, Kinetochore Protein2
HZwint-12     zwint-12
KNTC2AP2     Zwint-13

External Ids:    HGNC: 131951   Entrez Gene: 111302   Ensembl: ENSG000001229527   OMIM: 6091775   UniProtKB: O952293   

Export aliases for ZWINT gene to outside databases

Previous GC identifers: GC10M056945 GC10M057122 GC10M058009 GC10M057461 GC10M057787 GC10M052100


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZWINT Gene:
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known.
It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and
kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable
on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ZWINT Gene: 
ZWINT (ZW10 interacting kinetochore protein) is a protein-coding gene. Diseases associated with ZWINT include roberts syndrome, and alzheimer's disease, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include protein binding and protein N-terminus binding.

UniProtKB/Swiss-Prot: ZWINT_HUMAN, O95229
Function: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity.
Required to target ZW10 to the kinetochore at prometaphase

Gene Wiki entry for ZWINT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZWINT
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZWINT promoter sequence
   Search SABiosciences Chromatin IP Primers for ZWINT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZWINT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21-q22   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q21-q22

ZWINT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZWINT gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M058116:  view genomic region     (about GC identifiers)

Start:
58,116,989 bp from pter      End:
58,121,036 bp from pter
Size:
4,048 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZWINT_HUMAN, O95229 (See protein sequence)
Recommended Name: ZW10 interactor  
Size: 277 amino acids; 31293 Da
Subunit: Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during
mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late
prophase to anaphase
Secondary accessions: A6NNV6 Q0D2I3 Q9BWD0
Alternative splicing: 2 isoforms:  O95229-1   O95229-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZWINT: NX_O95229

Explore proteomics data for ZWINT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95229

  • ZWINT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZWINT Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001005413.1  NP_008988.2  NP_127490.1  

    ENSEMBL proteins: 
     ENSP00000363055   ENSP00000322850   ENSP00000473330   ENSP00000354921   ENSP00000378801  
    Reactome Protein details: O95229
    Human Recombinant Protein Products for ZWINT: 
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    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA11682612
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11682612
    GO:0005829cytosol TAS--

    ZWINT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O95229


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZWINT_HUMAN, O95229
    Function: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity.
    Required to target ZW10 to the kinetochore at prometaphase

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15502821
    GO:0047485protein N-terminus binding IPI15485811
         
    ZWINT for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZWINT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/9        Reactome Pathways for ZWINT (see all 9)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    ZWINT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZWINT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for ZWINT (O952291, 2, 3 ENSP000003630554) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHAXQ9H8142, 3, ENSP000002975404MINT-8277444 I2D: score=2 STRING: ENSP00000297540
    NDC80O147771, 3, ENSP000002615974EBI-1001132,EBI-715849 I2D: score=4 STRING: ENSP00000261597
    ZW10O432641, 3, ENSP000002001354EBI-1001132,EBI-1001217 I2D: score=2 STRING: ENSP00000200135
    BECN1Q144572, 3, ENSP000003552314MINT-8304305 I2D: score=3 STRING: ENSP00000355231
    DSN1Q9H4103, ENSP000003628504I2D: score=4 STRING: ENSP00000362850
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IDA15485811
    GO:0000278mitotic cell cycle TAS--
    GO:0007049cell cycle NAS15504738
    GO:0007051spindle organization NAS15504738
    GO:0007093mitotic cell cycle checkpoint IDA15485811

    ZWINT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZWINT

    Search CenterWatch for drugs/clinical trials and news about ZWINT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZWINT gene (4 alternative transcripts): 
    NM_001005413.1  NM_007057.3  NM_032997.2  NM_001005414.1  

    Unigene Cluster for ZWINT:

    ZW10 interactor, kinetochore protein
    Hs.591363  [show with all ESTs]
    Unigene Representative Sequence: NM_032997
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373944(uc001jjx.1) ENST00000494312(uc009xoy.1) ENST00000318387
    ENST00000489649 ENST00000460654 ENST00000361148 ENST00000478181 ENST00000467523
    ENST00000395405(uc001jjy.1 uc001jka.1)

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    hsa-miR-571
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    Additional mRNA sequence: 

    AF067656.1 AK225509.1 AK293416.1 AK298148.1 BC000411.1 BC016357.2 BC020979.1 BC110399.1 

    11 DOTS entries:

    DT.214993  DT.100801012  DT.100801018  DT.101984029  DT.121299465  DT.121299457  DT.100029156  DT.92437637 
    DT.100801008  DT.100801017  DT.95171864 

    24/231 AceView cDNA sequences (see all 231):

    AL557130 BG505059 BC016357 BU183970 AA564001 BG391722 CR624092 CB242187 
    AI375629 AA573448 AI888810 BG678593 BI259219 CA431155 BM562031 BX105168 
    BI859295 BU155152 BC020979 AA706948 CR595414 AA394261 CA443208 BM699136 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZWINT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                                          
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for ZWINT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZWINT expression in normal human tissues (normalized intensities)      ZWINT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCAAATG
    ZWINT Expression
    About this image


    ZWINT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Thalamus
             Human Cerebellar Astrocytes   
             Septum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cmps   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See ZWINT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZWINT

    SOURCE GeneReport for Unigene cluster: Hs.591363
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZWINT gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zwint1 , 5 ZW10 interactor1, 5 71.14(n)1
    58.87(a)1
      10 (37.15 cM)5
    526961  NM_025635.31  NP_079911.11 
     726548455 
    lizard
    (Anolis carolinensis)
    Reptilia ZWINT6
    Uncharacterized protein
    30(a)
    1 ↔ 1
    2(69547239-69559169)


    ENSEMBL Gene Tree for ZWINT (if available)
    TreeFam Gene Tree for ZWINT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/184 SNPs in ZWINT are shown (see all 184)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898495831,2
    --58116701(+) CCACAC/TAAAGA 3 -- ds50010--------
    rs1473608521,2
    --58116773(+) AGTATA/GTAAGA 3 -- ds50010--------
    rs767464551,2
    C,F--58116821(+) CATAGT/CTGGAG 3 -- ds50013Minor allele frequency- C:0.04WA NA EA 358
    rs1819478811,2
    --58116826(+) TTGGAA/GATTTG 3 -- ds50010--------
    rs1860732181,2
    --58116958(+) ACCTAG/TGTGAA 3 -- ds50010--------
    rs2021887271,2
    C--58117040(+) TAAAC-/GATATGAT 3 -- ds50010--------
    rs1487909901,2
    --58117058(+) GACCAA/TATTAA 3 -- ds50010--------
    rs110053261,2
    C,F,A,H--58117124(+) TATGAA/GTCAAT 3 -- ds5001 ese320Minor allele frequency- G:0.23NS EA NA WA 2324
    rs1897483071,2
    --58117251(+) AATACA/GTGAGT 3 -- ut310--------
    rs1808001961,2
    --58117273(+) TAAAAA/GTAAGA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZWINT (58116989 - 58121036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZWINT:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv727n71CNV Gain21882294
    nsv831883CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609177    OMIM disorders: --

    4 diseases for ZWINT:    About MalaCards
    roberts syndrome    alzheimer's disease    breast cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ZWINT:
    Roberts syndrome

    ZWINT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZWINT
    Human Genome Epidemiology (HuGE) Navigator: ZWINT (2 documents)

    Export disorders for ZWINT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZWINT gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with ZWINT)
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    1. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. (PubMed id 15485811)1, 2, 9 Wang H.... Yao X. (2004)
    2. HZwint-1, a novel human kinetochore component that interacts with HZW10. (PubMed id 10806105)1, 2, 9 Starr D.A....Goldberg M.L. (2000)
    3. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PubMed id 16732327)1, 2, 9 Lin Y.-T.... Lee W.-H. (2006)
    4. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. (PubMed id 15094189)1, 2, 9 Musio A....Vezzoni P. (2004)
    5. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: A Swedish prospective case-control study. (PubMed id 19008095)1, 4 Brendle A....Forsti A. (2008)
    6. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (2007)
    7. ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PubMed id 15824131)1, 2 Kops G.J.P.L.... Cleveland D.W. (2005)
    8. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PubMed id 15502821)1, 2 Obuse C....Yanagida M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. (PubMed id 11682612)1, 9 Van Hooser A.A....Brinkley B.R. (2001)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11130 HGNC: 13195 AceView: ZWINT Ensembl:ENSG00000122952 euGenes: HUgn11130
    ECgene: ZWINT H-InvDB: ZWINT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZWINT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZWINT gene:
    Search GeneIP for patents involving ZWINT

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