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Aliases for ZWINT Gene

Aliases for ZWINT Gene

  • ZW10 Interacting Kinetochore Protein 2 3 5
  • SNAP25 Interacting Protein Of 30 KDa 2 3
  • ZW10 Interactor 2 3
  • Zwint-1 3 4
  • ZW10 Interactor, Kinetochore Protein 3
  • Human ZW10 Interacting Protein-1 3
  • ZW10-Interacting Protein 1 4
  • HZwint-1 3
  • KNTC2AP 3
  • ZWINT1 3
  • SIP30 3

External Ids for ZWINT Gene

Previous GeneCards Identifiers for ZWINT Gene

  • GC10M056945
  • GC10M057122
  • GC10M058009
  • GC10M057461
  • GC10M057787
  • GC10M058116
  • GC10M052100

Summaries for ZWINT Gene

Entrez Gene Summary for ZWINT Gene

  • This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZWINT Gene

ZWINT (ZW10 Interacting Kinetochore Protein) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Cell Cycle, Mitotic. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot for ZWINT Gene

  • Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Gene Wiki entry for ZWINT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZWINT Gene

Genomics for ZWINT Gene

Regulatory Elements for ZWINT Gene

Enhancers for ZWINT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F056359 0.2 ENCODE 12.8 +0.3 286 2.5 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GATA2 ZNF207 ZWINT GC10P056305
GH10F057101 0.6 ENCODE 5.1 -741.5 -741480 1.9 ZWINT GC10P057081 GC10P057280
GH10F056370 0.6 ENCODE 0.4 -9.6 -9573 0.2 ATF1 PKNOX1 CBX3 ZNF644 CHAMP1 CCNT2 NCOR1 CBX5 ZNF547 ZNF169 ZWINT GC10M056621 PIR52345
GH10F056317 0.4 ENCODE 0.2 +43.5 43498 0.1 GC10P056305 ZWINT
GH10F056319 0.9 ENCODE 0.2 +41.7 41712 1.1 TBL1XR1 CBX5 EED ETV6 FOS CREM SRF MTA2 HLF CBFB GC10P056305 ZWINT
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZWINT on UCSC Golden Path with GeneCards custom track

Promoters for ZWINT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001760467 -298 2001 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GATA2 ZNF143

Genomic Location for ZWINT Gene

Chromosome:
10
Start:
56,357,228 bp from pter
End:
56,361,302 bp from pter
Size:
4,075 bases
Orientation:
Minus strand

Genomic View for ZWINT Gene

Genes around ZWINT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZWINT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZWINT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZWINT Gene

Proteins for ZWINT Gene

  • Protein details for ZWINT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95229-ZWINT_HUMAN
    Recommended name:
    ZW10 interactor
    Protein Accession:
    O95229
    Secondary Accessions:
    • A6NNV6
    • Q0D2I3
    • Q9BWD0

    Protein attributes for ZWINT Gene

    Size:
    277 amino acids
    Molecular mass:
    31293 Da
    Quaternary structure:
    • Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1.

    Alternative splice isoforms for ZWINT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZWINT Gene

Post-translational modifications for ZWINT Gene

  • Ubiquitination at Lys 93, Lys 100, Lys 111, Lys 116, Lys 141, Lys 162, and Lys 196
  • Modification sites at PhosphoSitePlus

Other Protein References for ZWINT Gene

Antibody Products

  • Abcam antibodies for ZWINT
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZWINT

No data available for DME Specific Peptides for ZWINT Gene

Domains & Families for ZWINT Gene

Protein Domains for ZWINT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZWINT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZWINT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZWINT Gene

Function for ZWINT Gene

Molecular function for ZWINT Gene

UniProtKB/Swiss-Prot Function:
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Gene Ontology (GO) - Molecular Function for ZWINT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15502821
GO:0047485 protein N-terminus binding IPI 15485811
genes like me logo Genes that share ontologies with ZWINT: view
genes like me logo Genes that share phenotypes with ZWINT: view

Animal Model Products

miRNA for ZWINT Gene

miRTarBase miRNAs that target ZWINT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZWINT Gene

Localization for ZWINT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZWINT Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZWINT Gene COMPARTMENTS Subcellular localization image for ZWINT gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZWINT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 11682612
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZWINT: view

Pathways & Interactions for ZWINT Gene

genes like me logo Genes that share pathways with ZWINT: view

Pathways by source for ZWINT Gene

Gene Ontology (GO) - Biological Process for ZWINT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 15485811
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007093 mitotic cell cycle checkpoint IEA,IDA 15485811
genes like me logo Genes that share ontologies with ZWINT: view

No data available for SIGNOR curated interactions for ZWINT Gene

Transcripts for ZWINT Gene

Unigene Clusters for ZWINT Gene

ZW10 interactor, kinetochore protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZWINT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for ZWINT Gene

GeneLoc Exon Structure for
ZWINT
ECgene alternative splicing isoforms for
ZWINT

Expression for ZWINT Gene

mRNA expression in normal human tissues for ZWINT Gene

mRNA differential expression in normal tissues according to GTEx for ZWINT Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for ZWINT Gene

This gene is overexpressed in Testis (42.3) and Fetal ovary (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZWINT Gene



Protein tissue co-expression partners for ZWINT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZWINT Gene:

ZWINT

SOURCE GeneReport for Unigene cluster for ZWINT Gene:

Hs.591363
genes like me logo Genes that share expression patterns with ZWINT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZWINT Gene

Orthologs for ZWINT Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZWINT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZWINT 34 35
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC477579 34
  • 79.4 (n)
ZWINT 35
  • 63 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101904477 34
  • 78.84 (n)
-- 35
  • 69 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zwint 34 16 35
  • 72.06 (n)
rat
(Rattus norvegicus)
Mammalia Zwint 34
  • 70.57 (n)
lizard
(Anolis carolinensis)
Reptilia ZWINT 35
  • 32 (a)
OneToOne
Species where no ortholog for ZWINT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZWINT Gene

ENSEMBL:
Gene Tree for ZWINT (if available)
TreeFam:
Gene Tree for ZWINT (if available)

Paralogs for ZWINT Gene

No data available for Paralogs for ZWINT Gene

Variants for ZWINT Gene

Sequence variations from dbSNP and Humsavar for ZWINT Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1056474 -- 56,357,028(-) CTTTA(A/T)AGTTC downstream-variant-500B
rs11005326 -- 56,357,363(+) TATGA(A/G)TCAAT downstream-variant-500B, utr-variant-3-prime
rs11005327 -- 56,358,052(+) AATAC(A/G)CAACT nc-transcript-variant, utr-variant-3-prime
rs11005328 -- 56,361,227(+) CTCCG(A/C)TGCCT nc-transcript-variant, reference, missense
rs11005329 -- 56,361,271(+) CCACA(A/G)TCCCT nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZWINT Gene

Variant ID Type Subtype PubMed ID
dgv864n100 CNV gain 25217958
esv3623381 CNV gain 21293372
esv3623382 CNV gain 21293372
esv3891822 CNV loss 25118596
nsv1035842 CNV loss 25217958
nsv831883 CNV gain+loss 17160897

Variation tolerance for ZWINT Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZWINT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZWINT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZWINT Gene

Disorders for ZWINT Gene

Relevant External Links for ZWINT

Genetic Association Database (GAD)
ZWINT
Human Genome Epidemiology (HuGE) Navigator
ZWINT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZWINT

No disorders were found for ZWINT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZWINT Gene

Publications for ZWINT Gene

  1. HZwint-1, a novel human kinetochore component that interacts with HZW10. (PMID: 10806105) Starr D.A. … Goldberg M.L. (J. Cell Sci. 2000) 2 3 4 22 64
  2. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PMID: 16732327) Lin Y.-T. … Lee W.-H. (Oncogene 2006) 3 4 22 64
  3. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. (PMID: 15094189) Musio A. … Vezzoni P. (Gene 2004) 3 4 22 64
  4. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. (PMID: 15485811) Wang H. … Yao X. (J. Biol. Chem. 2004) 3 4 22 64
  5. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PMID: 19008095) Brendle A. … FAPrsti A. (Eur. J. Cancer 2009) 3 46 64

Products for ZWINT Gene

Sources for ZWINT Gene

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