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ZWILCH Gene

protein-coding   GIFtS: 52
GCID: GC15P066797

Zwilch Kinetochore Protein

(Previous names: Zwilch, kinetochore associated, homolog (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zwilch Kinetochore Protein1 2     Homolog Of Drosophila Zwilch2
hZwilch2 3     Protein Zwilch Homolog2
Zwilch, Kinetochore Associated, Homolog (Drosophila)1     Zwilch, Kinetochore Associated, Homolog2
KNTC1AP2     

External Ids:    HGNC: 254681   Entrez Gene: 550552   Ensembl: ENSG000001744427   OMIM: 6099845   UniProtKB: Q9H9003   

Export aliases for ZWILCH gene to outside databases

Previous GC identifers: GC15P064585 GC15P043633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZWILCH Gene:
ZWILCH (zwilch kinetochore protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZWILC_HUMAN, Q9H900
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZWILCH gene promoter:
         TBP   FOXF2   Pax-5   TFIID   Meis-1a   HNF-3beta   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZWILCH promoter sequence
   Search Chromatin IP Primers for ZWILCH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZWILCH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

ZWILCH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZWILCH gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P066797:  view genomic region     (about GC identifiers)

Start:
66,797,297 bp from pter      End:
66,842,115 bp from pter
Size:
44,819 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZWILC_HUMAN, Q9H900 (See protein sequence)
Recommended Name: Protein zwilch homolog  
Size: 591 amino acids; 67214 Da
Subunit: Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts directly with KNTC1/ROD.
Component of the NRZ complex composed of ZWILCH, KNTC1/ROD, RINT1, ZW10 and NBAS
Miscellaneous: ZWILCH gene is deleted in a patient suffering from colorectal cancer with chromosomal instability
Sequence caution: Sequence=AK000898; Type=Erroneous termination; Positions=366; Note=Translated as Leu;
Sequence=AK000898; Type=Frameshift; Positions=248; Sequence=BAB55133.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZWILCH:
3IF8 (3D)    
Secondary accessions: B3KVB8 Q6N049 Q8N404 Q96SY7 Q9NWG7
Alternative splicing: 2 isoforms:  Q9H900-1   Q9H900-2   

Explore the universe of human proteins at neXtProt for ZWILCH: NX_Q9H900

Explore proteomics data for ZWILCH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZWILCH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001274750.1  NP_001274751.1  NP_001274752.1  NP_060445.3  

    ENSEMBL proteins: 
     ENSP00000437749   ENSP00000311429   ENSP00000402217   ENSP00000454737   ENSP00000456689  
     ENSP00000455548   ENSP00000455336  
    Reactome Protein details: Q9H900

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    antibodies-online peptides for ZWILCH

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018630 RZZ-complex_zwilch

    Graphical View of Domain Structure for InterPro Entry Q9H900

    ProtoNet protein and cluster: Q9H900

    UniProtKB/Swiss-Prot: ZWILC_HUMAN, Q9H900
    Similarity: Belongs to the ZWILCH family


    Find genes that share domains with ZWILCH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZWILC_HUMAN, Q9H900
    Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
    Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12686595
         
    Find genes that share ontologies with ZWILCH           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZWILCH

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    5 qRT-PCR Assays for microRNAs that regulate ZWILCH:
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    SwitchGear 3'UTR luciferase reporter plasmidZWILCH 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZWILC_HUMAN, Q9H900: Chromosome, centromere, kinetochore
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA12686595
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ZWILCH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZWILCH About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with ZWILCH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for ZWILCH
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZWILCH
    Interactions:

        GeneGlobe Interaction Network for ZWILCH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZWILCH (Q9H9003 ENSP000003114294) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZW10O432643, ENSP000002001354I2D: score=2 STRING: ENSP00000200135
    KNTC1P507483, ENSP000003282364I2D: score=1 STRING: ENSP00000328236
    AURKBENSP000003139504STRING: ENSP00000313950
    BIRC5ENSP000003016334STRING: ENSP00000301633
    BUB1ENSP000003025304STRING: ENSP00000302530
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007093mitotic cell cycle checkpoint IMP15824131

    Find genes that share ontologies with ZWILCH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZWILCH (ZWILC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZWILCH gene (4 alternative transcripts): 
    NM_001287821.1  NM_001287822.1  NM_001287823.1  NM_017975.4  

    Unigene Cluster for ZWILCH:

    Zwilch kinetochore protein
    Hs.21331  [show with all ESTs]
    Unigene Representative Sequence: BX640701
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535141 ENST00000307897(uc002aqb.3 uc010bhv.3) ENST00000446801(uc010bhu.1 uc002aqa.3)
    ENST00000563698 ENST00000565627 ENST00000564309 ENST00000567926 ENST00000564179
    ENST00000565960 ENST00000561583 ENST00000562645 ENST00000567816 ENST00000569489

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ZWILCH:
    hsa-miR-520d-5p hsa-miR-9* hsa-miR-524-5p hsa-miR-3662 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidZWILCH 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZWILCH
      QuantiFast Probe-based Assays in human, mouse, rat ZWILCH

    Additional mRNA sequence: 

    AK000898.1 AK023175.1 AK027468.1 AK122787.1 AK291048.1 BC036900.1 BC090041.1 BX640701.1 
    NR_003105.1 

    18 DOTS entries:

    DT.455879  DT.99996024  DT.91899221  DT.99935446  DT.95188278  DT.95188274  DT.121047817  DT.100786062 
    DT.101955258  DT.95188276  DT.121047839  DT.86840698  DT.100786066  DT.95188273  DT.100786063  DT.102839852 
    DT.121048184  DT.95245315 

    Selected AceView cDNA sequences (see all 219):

    AI611659 BQ775697 AI830427 BM464249 AI242215 AU131445 AI654343 AW514941 
    BX951253 AW630247 AI633218 NM_017975 AA445994 AL704017 AI910860 BU182407 
    AK023175 AW513401 AA834986 BP341170 BP337483 AK027468 CA425426 AI218680 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZWILCH    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:              -                                             
    SP2:                                                            
    SP3:                                                            


    ECgene alternative splicing isoforms for ZWILCH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZWILCH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTTTATT
    ZWILCH Expression
    About this image


    ZWILCH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    ZWILCH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZWILCH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21331
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZWILCH gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zwilch1 , 5 Zwilch, kinetochore associated, homolog (Drosophila)5
    zwilch kinetochore protein1
    83.98(n)1
    80.98(a)1
      9 (34.52 cM)5
    680141  NM_026507.41  NP_080783.31 
     641371445 
    chicken
    (Gallus gallus)
    Aves ZWILCH1 Zwilch, kinetochore associated, homolog (Drosophila) 65.53(n)
    56.16(a)
      415552  XM_004943911.1  XP_004943968.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZWILCH6
    zwilch kinetochore protein
    45(a)
    1 ↔ 1
    GL343467.1(148078-173578)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.176302 Transcribed sequences 71.17(n)    142026572 
    zebrafish
    (Danio rerio)
    Actinopterygii zwilch1 Zwilch, kinetochore associated, homolog (Drosophila) 54.79(n)
    45.64(a)
      336439  NM_001199735.1  NP_001186664.1 


    ENSEMBL Gene Tree for ZWILCH (if available)
    TreeFam Gene Tree for ZWILCH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZWILCH (see all 961)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs620118831,2
    C,F--66799218(+) TGAGAC/TGGAGT 2 -- int14Minor allele frequency- T:0.25NA 8
    rs1835975401,2
    --66799220(+) AGATGC/GAGTCT 2 -- int10--------
    rs1409361811,2
    --66799221(+) GATGGA/GGTCTC 2 -- int10--------
    rs1421072271,2
    C--66799251(+) GTGCAA/GTGGTG 2 -- int10--------
    rs1513039141,2
    C--66799312(+) GCCTCA/TGCCTC 2 -- int10--------
    rs1405353351,2
    C--66799319(+) CCTCCC/TGAGTA 2 -- int10--------
    rs1895403981,2
    --66799332(+) TGGGAC/TTACAG 2 -- int10--------
    rs1818204071,2
    --66799393(+) AAGAGA/GTTTCA 2 -- int10--------
    rs1848511131,2
    --66799418(+) ATGGTC/GTCAAT 2 -- int10--------
    rs2004371461,2
    --66799539(+) CACTG-/TTTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZWILCH (66797297 - 66842115 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZWILCH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674741CNV Deletion23128226
    esv1595826CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZWILCH
    DNA2.0 Custom Variant and Variant Library Synthesis for ZWILCH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609984    OMIM disorders: --


    Find genes that share disorders with ZWILCH           About GenesLikeMe

    Genetic Association Database (GAD): ZWILCH
    Human Genome Epidemiology (HuGE) Navigator: ZWILCH (2 documents)

    Export disorders for ZWILCH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZWILCH gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ZWILCH)
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    1. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PubMed id 12686595)1, 2, 3, 9 Williams B.C....Goldberg M.L. (Mol. Biol. Cell 2003)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PubMed id 19008095)1, 4 Brendle A....FAPrsti A. (Eur. J. Cancer 2009)
    4. ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PubMed id 15824131)1, 2 Kops G.J.P.L.... Cleveland D.W. (J. Cell Biol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. (PubMed id 20462495)2, 9 Civril F.... Musacchio A. (Structure 2010)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55055 HGNC: 25468 AceView: FLJ10036 Ensembl:ENSG00000174442 euGenes: HUgn55055
    ECgene: ZWILCH H-InvDB: ZWILCH

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZWILCH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZWILCH gene:
    Search GeneIP for patents involving ZWILCH

    GeneCards and IP:
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