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Aliases for ZWILCH Gene

Aliases for ZWILCH Gene

  • Zwilch Kinetochore Protein 2 3 5
  • HZwilch 3 4
  • Zwilch, Kinetochore Associated, Homolog (Drosophila) 2
  • Zwilch, Kinetochore Associated, Homolog 3
  • Homolog Of Drosophila Zwilch 3
  • KNTC1AP 3

External Ids for ZWILCH Gene

Previous GeneCards Identifiers for ZWILCH Gene

  • GC15P064585
  • GC15P066797
  • GC15P043633

Summaries for ZWILCH Gene

GeneCards Summary for ZWILCH Gene

ZWILCH (Zwilch Kinetochore Protein) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for ZWILCH Gene

  • Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZWILCH Gene

Genomics for ZWILCH Gene

Regulatory Elements for ZWILCH Gene

Enhancers for ZWILCH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZWILCH on UCSC Golden Path with GeneCards custom track

Promoters for ZWILCH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZWILCH on UCSC Golden Path with GeneCards custom track

Genomic Location for ZWILCH Gene

Chromosome:
15
Start:
66,504,959 bp from pter
End:
66,550,128 bp from pter
Size:
45,170 bases
Orientation:
Plus strand

Genomic View for ZWILCH Gene

Genes around ZWILCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZWILCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZWILCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZWILCH Gene

Proteins for ZWILCH Gene

  • Protein details for ZWILCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H900-ZWILC_HUMAN
    Recommended name:
    Protein zwilch homolog
    Protein Accession:
    Q9H900
    Secondary Accessions:
    • B3KVB8
    • Q6N049
    • Q8N404
    • Q96SY7
    • Q9NWG7

    Protein attributes for ZWILCH Gene

    Size:
    591 amino acids
    Molecular mass:
    67214 Da
    Quaternary structure:
    • Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH; in the complex interacts directly with KNTC1/ROD.
    Miscellaneous:
    • ZWILCH gene is deleted in a patient suffering from colorectal cancer with chromosomal instability.
    SequenceCaution:
    • Sequence=AK000898; Type=Erroneous termination; Positions=366; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=AK000898; Type=Frameshift; Positions=248; Evidence={ECO:0000305}; Sequence=BAB55133.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZWILCH Gene

    Alternative splice isoforms for ZWILCH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZWILCH Gene

Proteomics data for ZWILCH Gene at MOPED

Post-translational modifications for ZWILCH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZWILCH Gene

Domains & Families for ZWILCH Gene

Protein Domains for ZWILCH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZWILCH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H900

UniProtKB/Swiss-Prot:

ZWILC_HUMAN :
  • Belongs to the ZWILCH family.
Family:
  • Belongs to the ZWILCH family.
genes like me logo Genes that share domains with ZWILCH: view

No data available for Gene Families for ZWILCH Gene

Function for ZWILCH Gene

Molecular function for ZWILCH Gene

UniProtKB/Swiss-Prot Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
genes like me logo Genes that share phenotypes with ZWILCH: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZWILCH Gene

Localization for ZWILCH Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZWILCH Gene

Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZWILCH Gene COMPARTMENTS Subcellular localization image for ZWILCH gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZWILCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
genes like me logo Genes that share ontologies with ZWILCH: view

Pathways & Interactions for ZWILCH Gene

genes like me logo Genes that share pathways with ZWILCH: view

Pathways by source for ZWILCH Gene

Gene Ontology (GO) - Biological Process for ZWILCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ZWILCH: view

No data available for SIGNOR curated interactions for ZWILCH Gene

Drugs & Compounds for ZWILCH Gene

No Compound Related Data Available

Transcripts for ZWILCH Gene

Unigene Clusters for ZWILCH Gene

Zwilch kinetochore protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZWILCH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for ZWILCH Gene

GeneLoc Exon Structure for
ZWILCH
ECgene alternative splicing isoforms for
ZWILCH

Expression for ZWILCH Gene

mRNA expression in normal human tissues for ZWILCH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZWILCH Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for ZWILCH Gene

This gene is overexpressed in Bone (59.1) and Breast (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZWILCH Gene



SOURCE GeneReport for Unigene cluster for ZWILCH Gene Hs.21331

genes like me logo Genes that share expression patterns with ZWILCH: view

Protein tissue co-expression partners for ZWILCH Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZWILCH Gene

Orthologs for ZWILCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZWILCH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZWILCH 35
  • 88.96 (n)
  • 85.06 (a)
ZWILCH 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZWILCH 35
  • 89.49 (n)
  • 87.78 (a)
ZWILCH 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zwilch 35
  • 83.98 (n)
  • 80.98 (a)
Zwilch 16
Zwilch 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZWILCH 35
  • 99.49 (n)
  • 99.49 (a)
ZWILCH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zwilch 35
  • 82.96 (n)
  • 81.85 (a)
oppossum
(Monodelphis domestica)
Mammalia ZWILCH 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZWILCH 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZWILCH 35
  • 65.53 (n)
  • 56.16 (a)
ZWILCH 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZWILCH 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17630 35
zwilch 35
  • 61.33 (n)
  • 52.98 (a)
zebrafish
(Danio rerio)
Actinopterygii zwilch 35
  • 54.79 (n)
  • 45.64 (a)
zwilch 36
  • 43 (a)
OneToOne
Species with no ortholog for ZWILCH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZWILCH Gene

ENSEMBL:
Gene Tree for ZWILCH (if available)
TreeFam:
Gene Tree for ZWILCH (if available)

Paralogs for ZWILCH Gene

No data available for Paralogs for ZWILCH Gene

Variants for ZWILCH Gene

Sequence variations from dbSNP and Humsavar for ZWILCH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11071896 - 66,528,912(+) TTCGG(A/G)GTGAT reference, missense
rs6494578 -- 66,522,970(+) ggggc(A/G)tgcca intron-variant
rs6494579 -- 66,523,845(+) AACTT(C/G)TTCAG intron-variant
rs6494580 -- 66,528,836(+) TGAAG(C/G)TTGCT intron-variant
rs12385959 -- 66,512,878(+) gcaag(A/C)tccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZWILCH Gene

Variant ID Type Subtype PubMed ID
esv1595826 CNV Insertion 17803354
esv2674741 CNV Deletion 23128226

Variation tolerance for ZWILCH Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZWILCH Gene

Disorders for ZWILCH Gene

Relevant External Links for ZWILCH

Genetic Association Database (GAD)
ZWILCH
Human Genome Epidemiology (HuGE) Navigator
ZWILCH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZWILCH

No disorders were found for ZWILCH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZWILCH Gene

Publications for ZWILCH Gene

  1. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PMID: 12686595) Williams B.C. … Goldberg M.L. (Mol. Biol. Cell 2003) 2 3 4 23 67
  2. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. (PMID: 20462495) Civril F. … Musacchio A. (Structure 2010) 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for ZWILCH Gene

Sources for ZWILCH Gene

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