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Aliases for ZWILCH Gene

Aliases for ZWILCH Gene

  • Zwilch Kinetochore Protein 2 3
  • HZwilch 3 4
  • Zwilch, Kinetochore Associated, Homolog (Drosophila) 2
  • Zwilch, Kinetochore Associated, Homolog 3
  • Homolog Of Drosophila Zwilch 3
  • Protein Zwilch Homolog 3
  • KNTC1AP 3

External Ids for ZWILCH Gene

Previous GeneCards Identifiers for ZWILCH Gene

  • GC15P064585
  • GC15P066797
  • GC15P043633

Summaries for ZWILCH Gene

GeneCards Summary for ZWILCH Gene

ZWILCH (Zwilch Kinetochore Protein) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for ZWILCH Gene

  • Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZWILCH Gene

Genomics for ZWILCH Gene

Regulatory Elements for ZWILCH Gene

Genomic Location for ZWILCH Gene

66,504,959 bp from pter
66,550,128 bp from pter
45,170 bases
Plus strand

Genomic View for ZWILCH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZWILCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZWILCH Gene

Proteins for ZWILCH Gene

  • Protein details for ZWILCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein zwilch homolog
    Protein Accession:
    Secondary Accessions:
    • B3KVB8
    • Q6N049
    • Q8N404
    • Q96SY7
    • Q9NWG7

    Protein attributes for ZWILCH Gene

    591 amino acids
    Molecular mass:
    67214 Da
    Quaternary structure:
    • Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts directly with KNTC1/ROD. Component of the NRZ complex composed of ZWILCH, KNTC1/ROD, RINT1, ZW10 and NBAS.
    • ZWILCH gene is deleted in a patient suffering from colorectal cancer with chromosomal instability
    • Sequence=AK000898; Type=Erroneous termination; Positions=366; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=AK000898; Type=Frameshift; Positions=248; Evidence={ECO:0000305}; Sequence=BAB55133.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZWILCH Gene

    Alternative splice isoforms for ZWILCH Gene


neXtProt entry for ZWILCH Gene

Proteomics data for ZWILCH Gene at MOPED

Post-translational modifications for ZWILCH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZWILCH Gene

Domains for ZWILCH Gene

Protein Domains for ZWILCH Gene


Suggested Antigen Peptide Sequences for ZWILCH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H900
  • Belongs to the ZWILCH family.
genes like me logo Genes that share domains with ZWILCH: view

No data available for Gene Families for ZWILCH Gene

Function for ZWILCH Gene

Molecular function for ZWILCH Gene

UniProtKB/Swiss-Prot Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.

Gene Ontology (GO) - Molecular Function for ZWILCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12686595
genes like me logo Genes that share ontologies with ZWILCH: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZWILCH Gene

Localization for ZWILCH Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZWILCH Gene

Chromosome, centromere, kinetochore.

Subcellular locations from

Jensen Localization Image for ZWILCH Gene COMPARTMENTS Subcellular localization image for ZWILCH gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZWILCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 12686595
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZWILCH: view

Pathways for ZWILCH Gene

genes like me logo Genes that share pathways with ZWILCH: view

Pathways by source for ZWILCH Gene

Gene Ontology (GO) - Biological Process for ZWILCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007093 mitotic cell cycle checkpoint IMP 15824131
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ZWILCH: view

Transcripts for ZWILCH Gene

Unigene Clusters for ZWILCH Gene

Zwilch kinetochore protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZWILCH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZWILCH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -

Relevant External Links for ZWILCH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZWILCH Gene

mRNA expression in normal human tissues for ZWILCH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZWILCH Gene

This gene is overexpressed in Testis (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZWILCH Gene

SOURCE GeneReport for Unigene cluster for ZWILCH Gene Hs.21331

genes like me logo Genes that share expressions with ZWILCH: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZWILCH Gene

Orthologs for ZWILCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZWILCH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZWILCH 35
  • 99.49 (n)
  • 99.49 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ZWILCH 35
  • 88.96 (n)
  • 85.06 (a)
  • 85 (a)
(Canis familiaris)
Mammalia ZWILCH 35
  • 89.49 (n)
  • 87.78 (a)
  • 88 (a)
(Mus musculus)
Mammalia Zwilch 35
  • 83.98 (n)
  • 80.98 (a)
Zwilch 16
Zwilch 36
  • 80 (a)
(Monodelphis domestica)
Mammalia ZWILCH 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia ZWILCH 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Zwilch 35
  • 82.96 (n)
  • 81.85 (a)
(Gallus gallus)
Aves ZWILCH 35
  • 65.53 (n)
  • 56.16 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia ZWILCH 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17630 35
zwilch 35
  • 61.33 (n)
  • 52.98 (a)
(Danio rerio)
Actinopterygii zwilch 35
  • 54.79 (n)
  • 45.64 (a)
zwilch 36
  • 43 (a)
Species with no ortholog for ZWILCH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZWILCH Gene

Gene Tree for ZWILCH (if available)
Gene Tree for ZWILCH (if available)

Paralogs for ZWILCH Gene

No data available for Paralogs for ZWILCH Gene

Variants for ZWILCH Gene

Sequence variations from dbSNP and Humsavar for ZWILCH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4238406 -- 66,513,970(+) TTGCT(C/T)GATAC intron-variant
rs4332695 -- 66,511,723(+) TGATT(C/G)TTCTG intron-variant
rs4340280 -- 66,537,726(+) AAGCA(C/T)TTTAA intron-variant
rs4346161 -- 66,541,049(+) gaggc(A/G)ggtgg intron-variant
rs4392012 -- 66,535,402(+) cgggc(A/G)cggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZWILCH Gene

Variant ID Type Subtype PubMed ID
esv1595826 CNV Insertion 17803354
esv2674741 CNV Deletion 23128226

Relevant External Links for ZWILCH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZWILCH Gene

Disorders for ZWILCH Gene

Relevant External Links for ZWILCH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZWILCH: view

No data available for UniProtKB/Swiss-Prot for ZWILCH Gene

Publications for ZWILCH Gene

  1. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PMID: 12686595) Williams B.C. … Goldberg M.L. (Mol. Biol. Cell 2003) 2 3 4 23
  2. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. (PMID: 20462495) Civril F. … Musacchio A. (Structure 2010) 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PMID: 15824131) Kops G.J.P.L. … Cleveland D.W. (J. Cell Biol. 2005) 3 4
  5. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PMID: 19008095) Brendle A. … FAPrsti A. (Eur. J. Cancer 2009) 3 48

Products for ZWILCH Gene

Sources for ZWILCH Gene

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