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ZW10 Gene

protein-coding   GIFtS: 63
GCID: GC11M113603

Zw10 Kinetochore Protein

(Previous names: ZW10 (Drosophila) homolog, centromere/kinetochore protein,...)
  See ZW10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zw10 Kinetochore Protein1 2     Centromere/Kinetochore Protein Zw10 Homolog2
ZW10 (Drosophila) Homolog, Centromere/Kinetochore Protein1     Zeste White 10 Homolog2
ZW10, Kinetochore Associated, Homolog (Drosophila)1     ZW10 Homolog, Centromere/Kinetochore Protein2
HZW102     ZW10, Kinetochore Associated, Homolog2
KNTC1AP2     

External Ids:    HGNC: 131941   Entrez Gene: 91832   Ensembl: ENSG000000868277   OMIM: 6039545   UniProtKB: O432643   

Export aliases for ZW10 gene to outside databases

Previous GC identifers: GC11M115956 GC11M115115 GC11M113637 GC11M113141 GC11M113110 GC11M109532


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZW10 Gene:
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation
during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from
prematurely exiting mitosis. (provided by RefSeq, Aug 2011)

GeneCards Summary for ZW10 Gene:
ZW10 (zw10 kinetochore protein) is a protein-coding gene. Diseases associated with ZW10 include roberts syndrome. GO annotations related to this gene include centromeric DNA binding.

UniProtKB/Swiss-Prot: ZW10_HUMAN, O43264
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in
regulation of membrane traffic between the Golgi and the endoplasmic reticulum

Gene Wiki entry for ZW10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZW10 gene promoter:
         USF1   Lmo2   CUTL1   Evi-1   HNF-1A   GATA-2   POU2F1   USF-1   HNF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZW10 promoter sequence
   Search Chromatin IP Primers for ZW10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZW10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23

ZW10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZW10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M113603:  view genomic region     (about GC identifiers)

Start:
113,603,909 bp from pter      End:
113,644,533 bp from pter
Size:
40,625 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZW10_HUMAN, O43264 (See protein sequence)
Recommended Name: Centromere/kinetochore protein zw10 homolog  
Size: 779 amino acids; 88829 Da
Subunit: Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B through direct
interaction with RINT1/TIP20L bound to BNIP1/SEC20L. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and
ZWILCH. Interacts with C19orf25, KNTC1, and ZWINT
Developmental stage: No significant variation in expression during cell cycle
Miscellaneous: Overexpression as well as silencing of ZW10 disrupts the morphology of the ER-Golgi intermediate
compartment as well as the Golgi apparatus and slows down ER-Golgi transport

Explore the universe of human proteins at neXtProt for ZW10: NX_O43264

Explore proteomics data for ZW10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys624
  • Modification sites at PhosphoSitePlus

  • See ZW10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004715.1  
    ENSEMBL proteins: 
     ENSP00000200135   ENSP00000440879   ENSP00000439197  
    Reactome Protein details: O43264

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009361 RZZ-complex_Zw10

    Graphical View of Domain Structure for InterPro Entry O43264

    ProtoNet protein and cluster: O43264

    1 Blocks protein domain: IPB009361 Centromerekinetochore Zw10

    UniProtKB/Swiss-Prot: ZW10_HUMAN, O43264
    Similarity: Belongs to the ZW10 family


    Find genes that share domains with ZW10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZW10_HUMAN, O43264
    Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
    Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in
    regulation of membrane traffic between the Golgi and the endoplasmic reticulum

         Genatlas biochemistry entry for ZW10:
    zeste-white 10,Drosophila homolog,moving from the centromere/kinetochore at prometaphase to kinetochore
    microtubule at metaphase and then back to the centromere/kinetochore at anaphase,recruiting dynein and dynactin
    to the centromere

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11146660
    GO:0019237centromeric DNA binding TAS9700164
         
    Find genes that share ontologies with ZW10           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZW10:
     Increased cell death in breast  Small cells  Upregulation of Wnt/beta-caten 

    Animal Models:
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    hsa-mir-222-3p (MIRT046629), hsa-mir-18a-3p (MIRT040820)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZW10_HUMAN, O43264: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome,
    centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell
    cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the
    kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly
    at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and
    telophase, accumulates at the spindle midzone
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    cytosol4
    nucleus4
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region ----
    GO:0000776kinetochore IDA11682612
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IDA11146660
    GO:0005634nucleus IDA15485811

    Find genes that share ontologies with ZW10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZW10 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation


    Find genes that share SuperPaths with ZW10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ZW10
        Cell cycle Spindle assembly and chromosome separation

    3 Reactome Pathways for ZW10
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZW10
    Interactions:

        GeneGlobe Interaction Network for ZW10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZW10 (O432641, 3 ENSP000002001354) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZWINTO952291, 3, ENSP000003630554EBI-1001217,EBI-1001132 I2D: score=2 STRING: ENSP00000363055
    RINT1Q6NUQ13, ENSP000002577004I2D: score=3 STRING: ENSP00000257700
    DCTN2Q135613, ENSP000004089104I2D: score=2 STRING: ENSP00000408910
    KNTC1P507483, ENSP000003282364I2D: score=2 STRING: ENSP00000328236
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=2 STRING: ENSP00000356278
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IDA11146660
    GO:0000132establishment of mitotic spindle orientation IMP19468067
    GO:0000278mitotic cell cycle TAS--
    GO:0006461protein complex assembly IDA11146660
    GO:0006888ER to Golgi vesicle-mediated transport IMP15029241

    Find genes that share ontologies with ZW10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZW10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZW10 gene: 
    NM_004724.3  

    Unigene Cluster for ZW10:

    Zw10 kinetochore protein
    Hs.503886  [show with all ESTs]
    Unigene Representative Sequence: NM_004724
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200135(uc001poe.3 uc009yyv.3) ENST00000535142 ENST00000538209

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZW10

    Additional mRNA sequence: 

    AK303871.1 AK312925.1 U54996.1 

    4 DOTS entries:

    DT.113113  DT.101964515  DT.100716209  DT.113114 

    Selected AceView cDNA sequences (see all 88):

    NM_004724 BM833775 BX281452 CA428822 BG500200 BU621771 BX951579 BM459539 
    BQ226793 BQ776903 AA251899 AL528376 AU132193 AU127878 AW235646 CB132664 
    AA599145 AU130114 CR622121 BX281124 AL559459 CB118509 CB147896 CD514451 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZW10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                                                                        
    SP2:                    -     -     -                                                                                       
    SP3:                                                                                                                        


    ECgene alternative splicing isoforms for ZW10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZW10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTTCCAG
    ZW10 Expression
    About this image


    ZW10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ZW10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZW10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503886

    UniProtKB/Swiss-Prot: ZW10_HUMAN, O43264
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZW10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZW10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zw101 , 5 ZW10 homolog (Drosophila), centromere/kinetochore protein5
    zw10 kinetochore protein1
    84.94(n)1
    86.14(a)1
      9 (26.58 cM)5
    269511  NM_012039.21  NP_036169.11 
     490555815 
    chicken
    (Gallus gallus)
    Aves ZW101 ZW10, kinetochore associated, homolog (Drosophila) 70.17(n)
    70.79(a)
      395275  NM_204583.1  NP_989914.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZW106
    zw10 kinetochore protein
    58(a)
    1 ↔ 1
    GL343354.1(288636-338143)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143982 Xenopus laevis transcribed sequence with weak similarity more 75.36(n)    48049540 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557822 similar to ZW10 homolog, centromere/kinetochore protein more 73.81(n)   393110  BC044489.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mit(1)153 chromosome segregation 22(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea czw-11 czw-1 41.94(n)
    23.72(a)
      177587  NM_068926.4  NP_501327.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATZW101 ATZW10 39.98(n)
    24.57(a)
      817851  NM_128850.2  NP_565757.2 
    rice
    (Oryza sativa)
    Liliopsida Os11g05457001 Os11g0545700 42.11(n)
    26.33(a)
      4350690  NM_001074592.1  NP_001068060.1 


    ENSEMBL Gene Tree for ZW10 (if available)
    TreeFam Gene Tree for ZW10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZW10 (see all 862)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003317431,2
    C--113603456(+) AACCT-/TAACA 
            
    TAATA
    1 -- ds50010--------
    rs1428530901,2
    --113603464(+) CATAAC/TATATT 1 -- ds50010--------
    rs1887893901,2
    --113603557(+) TAAAGA/GCCAGA 1 -- ds50010--------
    rs1142632131,2
    F--113603616(+) GACCTT/CTGCCA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1808547811,2
    --113603688(+) TAATTG/TAAATA 1 -- ds50010--------
    rs116054831,2
    C,F,H--113603779(+) ATGAAT/CGAAGA 1 -- ds50018Minor allele frequency- C:0.09NS NA 900
    rs1862589851,2
    --113603811(+) GTGACA/GGTCAT 1 -- ds50010--------
    rs1380334371,2
    --113603822(+) ATACCG/TCAATA 1 -- ds50010--------
    rs1908244671,2
    --113603838(+) GATGGC/TATAGA 1 -- ds50010--------
    rs1838729721,2
    --113603956(+) TCTCCC/TTAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZW10 (113603909 - 113644533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZW10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820035CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZW10
    DNA2.0 Custom Variant and Variant Library Synthesis for ZW10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603954    OMIM disorders: --

    1 disease for ZW10:    
    About MalaCards
    roberts syndrome

    1 disease from the University of Copenhagen DISEASES database for ZW10:
    Roberts syndrome

    Find genes that share disorders with ZW10           About GenesLikeMe

    Genetic Association Database (GAD): ZW10

    Export disorders for ZW10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZW10 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with ZW10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation of the centromere/kinetochore protein ZW10. (PubMed id 9298984)1, 2, 3, 9 Starr D.A....Goldberg M.L. (J. Cell Biol. 1997)
    2. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PubMed id 16732327)1, 2, 9 Lin Y.-T.... Lee W.-H. (Oncogene 2006)
    3. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2, 9 Hirose H.... Tagaya M. (EMBO J. 2004)
    4. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. (PubMed id 15485811)1, 2, 9 Wang H.... Yao X. (J. Biol. Chem. 2004)
    5. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. (PubMed id 15094189)1, 2, 9 Musio A....Vezzoni P. (Gene 2004)
    6. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. (PubMed id 11590237)1, 2, 9 Scaeerou F....Goldberg M.L. (J. Cell Sci. 2001)
    7. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PubMed id 12686595)1, 2, 9 Williams B.C....Goldberg M.L. (Mol. Biol. Cell 2003)
    8. ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PubMed id 15824131)1, 2 Kops G.J.P.L.... Cleveland D.W. (J. Cell Biol. 2005)
    9. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2 Nakajima K.... Tagaya M. (EMBO J. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9183 HGNC: 13194 AceView: ZW10 Ensembl:ENSG00000086827 euGenes: HUgn9183
    ECgene: ZW10 H-InvDB: ZW10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZW10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZW10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZW10 gene:
    Search GeneIP for patents involving ZW10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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