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Aliases for ZW10 Gene

Aliases for ZW10 Gene

  • Zw10 Kinetochore Protein 2 3 5
  • ZW10 (Drosophila) Homolog, Centromere/Kinetochore Protein 2
  • ZW10, Kinetochore Associated, Homolog (Drosophila) 2
  • ZW10 Homolog, Centromere/Kinetochore Protein 3
  • ZW10, Kinetochore Associated, Homolog 3
  • Zeste White 10 Homolog 3
  • KNTC1AP 3
  • HZW10 3

External Ids for ZW10 Gene

Previous GeneCards Identifiers for ZW10 Gene

  • GC11M115956
  • GC11M115115
  • GC11M113141
  • GC11M113110
  • GC11M113603
  • GC11M109532

Summaries for ZW10 Gene

Entrez Gene Summary for ZW10 Gene

  • This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZW10 Gene

ZW10 (Zw10 Kinetochore Protein) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include centromeric DNA binding.

UniProtKB/Swiss-Prot for ZW10 Gene

  • Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).

Gene Wiki entry for ZW10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZW10 Gene

Genomics for ZW10 Gene

Regulatory Elements for ZW10 Gene

Promoters for ZW10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZW10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZW10 Gene

Chromosome:
11
Start:
113,733,183 bp from pter
End:
113,773,811 bp from pter
Size:
40,629 bases
Orientation:
Minus strand

Genomic View for ZW10 Gene

Genes around ZW10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZW10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZW10 Gene

Proteins for ZW10 Gene

  • Protein details for ZW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43264-ZW10_HUMAN
    Recommended name:
    Centromere/kinetochore protein zw10 homolog
    Protein Accession:
    O43264
    Secondary Accessions:
    • A1A528

    Protein attributes for ZW10 Gene

    Size:
    779 amino acids
    Molecular mass:
    88829 Da
    Quaternary structure:
    • Interacts with NBAS and KNTC1/ROD; the interactions are mutually exclusive and indicative for its association in two different vesicle tethering complexes (PubMed:11590237, PubMed:15824131, PubMed:20462495). Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH (PubMed:12686595, PubMed:20462495). Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex). Interacts directly with RINT1/TIP20L bound to BNIP1/SEC20L (PubMed:15029241, PubMed:15272311, PubMed:20462495, PubMed:19369418). Interacts with C19orf25 and ZWINT (PubMed:15485811, PubMed:15824131., PubMed:16732327).
    Miscellaneous:
    • Overexpression as well as silencing of ZW10 disrupts the morphology of the ER-Golgi intermediate compartment as well as the Golgi apparatus and slows down ER-Golgi transport.

    Alternative splice isoforms for ZW10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZW10 Gene

Proteomics data for ZW10 Gene at MOPED

Post-translational modifications for ZW10 Gene

  • Ubiquitination at Lys 624
  • Modification sites at PhosphoSitePlus

Other Protein References for ZW10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZW10 Gene

Domains & Families for ZW10 Gene

Protein Domains for ZW10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZW10 Gene

Graphical View of Domain Structure for InterPro Entry

O43264

UniProtKB/Swiss-Prot:

ZW10_HUMAN :
  • Belongs to the ZW10 family.
Family:
  • Belongs to the ZW10 family.
genes like me logo Genes that share domains with ZW10: view

No data available for Gene Families for ZW10 Gene

Function for ZW10 Gene

Molecular function for ZW10 Gene

GENATLAS Biochemistry:
zeste-white 10,Drosophila homolog,moving from the centromere/kinetochore at prometaphase to kinetochore microtubule at metaphase and then back to the centromere/kinetochore at anaphase,recruiting dynein and dynactin to the centromere
UniProtKB/Swiss-Prot Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).
genes like me logo Genes that share phenotypes with ZW10: view

Animal Model Products

miRNA for ZW10 Gene

miRTarBase miRNAs that target ZW10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZW10 Gene

Localization for ZW10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZW10 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237). {ECO:0000269 PubMed:11590237, ECO:0000269 PubMed:15029241}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZW10 Gene COMPARTMENTS Subcellular localization image for ZW10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endoplasmic reticulum 5
nucleus 5
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 11682612
genes like me logo Genes that share ontologies with ZW10: view

Pathways & Interactions for ZW10 Gene

genes like me logo Genes that share pathways with ZW10: view

Pathways by source for ZW10 Gene

1 GeneGo (Thomson Reuters) pathway for ZW10 Gene

Gene Ontology (GO) - Biological Process for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle TAS --
GO:0007030 Golgi organization IMP 20163571
GO:0007093 mitotic cell cycle checkpoint IDA 11146660
GO:0007094 mitotic spindle assembly checkpoint IBA --
genes like me logo Genes that share ontologies with ZW10: view

No data available for SIGNOR curated interactions for ZW10 Gene

Drugs & Compounds for ZW10 Gene

No Compound Related Data Available

Transcripts for ZW10 Gene

mRNA/cDNA for ZW10 Gene

Unigene Clusters for ZW10 Gene

Zw10 kinetochore protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZW10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - -
SP3:

Relevant External Links for ZW10 Gene

GeneLoc Exon Structure for
ZW10
ECgene alternative splicing isoforms for
ZW10

Expression for ZW10 Gene

mRNA expression in normal human tissues for ZW10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZW10 Gene

This gene is overexpressed in Bone (50.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZW10 Gene



SOURCE GeneReport for Unigene cluster for ZW10 Gene Hs.503886

mRNA Expression by UniProt/SwissProt for ZW10 Gene

O43264-ZW10_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZW10: view

Protein tissue co-expression partners for ZW10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZW10 Gene

Orthologs for ZW10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZW10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZW10 35
  • 99.74 (n)
  • 100 (a)
ZW10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZW10 36
  • 91 (a)
OneToOne
ZW10 35
  • 89.09 (n)
  • 90.89 (a)
dog
(Canis familiaris)
Mammalia ZW10 35
  • 91.06 (n)
  • 92.43 (a)
ZW10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zw10 36
  • 86 (a)
OneToOne
Zw10 16
Zw10 35
  • 84.94 (n)
  • 86.14 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ZW10 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zw10 35
  • 84.68 (n)
  • 85.59 (a)
chicken
(Gallus gallus)
Aves ZW10 35
  • 70.17 (n)
  • 70.79 (a)
lizard
(Anolis carolinensis)
Reptilia ZW10 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14398 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.350 35
zw10 35
  • 68 (n)
  • 70.75 (a)
zebrafish
(Danio rerio)
Actinopterygii zw10 36
  • 60 (a)
OneToOne
zgc55782 35
zw10 35
  • 60.97 (n)
  • 60.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta mit(1)15 36
  • 22 (a)
OneToOne
mit(1)15 37
  • 22 (a)
worm
(Caenorhabditis elegans)
Secernentea czw-1 35
  • 41.94 (n)
  • 23.72 (a)
czw-1 36
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATZW10 35
  • 39.98 (n)
  • 24.57 (a)
rice
(Oryza sativa)
Liliopsida Os11g0545700 35
  • 42.11 (n)
  • 26.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1167 36
  • 33 (a)
OneToOne
Species with no ortholog for ZW10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZW10 Gene

ENSEMBL:
Gene Tree for ZW10 (if available)
TreeFam:
Gene Tree for ZW10 (if available)

Paralogs for ZW10 Gene

No data available for Paralogs for ZW10 Gene

Variants for ZW10 Gene

Sequence variations from dbSNP and Humsavar for ZW10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2271796 - 113,768,842(+) CTCTC(C/T)ATCCT reference, missense
rs1000559 -- 113,774,495(-) CACCA(C/T)CCATA upstream-variant-2KB
rs1112642 -- 113,742,930(-) TGGCC(C/G)AATCA intron-variant
rs1713683 -- 113,746,797(+) agtcc(A/C)ggatg intron-variant
rs1713684 -- 113,746,829(+) aatgc(A/C)ataga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZW10 Gene

Variant ID Type Subtype PubMed ID
nsv820035 CNV Loss 19587683

Variation tolerance for ZW10 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZW10 Gene

HapMap Linkage Disequilibrium report
ZW10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZW10 Gene

Disorders for ZW10 Gene

Relevant External Links for ZW10

Genetic Association Database (GAD)
ZW10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZW10

No disorders were found for ZW10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZW10 Gene

Publications for ZW10 Gene

  1. Conservation of the centromere/kinetochore protein ZW10. (PMID: 9298984) Starr D.A. … Goldberg M.L. (J. Cell Biol. 1997) 2 3 4 23 67
  2. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. (PMID: 20462495) Civril F. … Musacchio A. (Structure 2010) 3 23
  3. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. (PMID: 19229290) Sivaram M.V. … Doxsey S.J. (EMBO J. 2009) 3 23
  4. Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. (PMID: 18268100) Famulski J.K. … Chan G. (J. Cell Biol. 2008) 3 23
  5. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PMID: 16732327) Lin Y.-T. … Lee W.-H. (Oncogene 2006) 3 23

Products for ZW10 Gene

Sources for ZW10 Gene

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