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Aliases for ZW10 Gene

Aliases for ZW10 Gene

  • Zw10 Kinetochore Protein 2 3
  • ZW10 (Drosophila) Homolog, Centromere/Kinetochore Protein 2
  • ZW10, Kinetochore Associated, Homolog (Drosophila) 2
  • ZW10 Homolog, Centromere/Kinetochore Protein 3
  • Centromere/Kinetochore Protein Zw10 Homolog 3
  • ZW10, Kinetochore Associated, Homolog 3
  • Zeste White 10 Homolog 3
  • KNTC1AP 3
  • HZW10 3

External Ids for ZW10 Gene

Previous GeneCards Identifiers for ZW10 Gene

  • GC11M115956
  • GC11M115115
  • GC11M113141
  • GC11M113110
  • GC11M113603
  • GC11M109532

Summaries for ZW10 Gene

Entrez Gene Summary for ZW10 Gene

  • This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZW10 Gene

ZW10 (Zw10 Kinetochore Protein) is a Protein Coding gene. Diseases associated with ZW10 include roberts syndrome. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include centromeric DNA binding.

UniProtKB/Swiss-Prot for ZW10 Gene

  • Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum.

Gene Wiki entry for ZW10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZW10 Gene

Genomics for ZW10 Gene

Regulatory Elements for ZW10 Gene

Genomic Location for ZW10 Gene

Start:
113,733,183 bp from pter
End:
113,773,811 bp from pter
Size:
40,629 bases
Orientation:
Minus strand

Genomic View for ZW10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZW10 Gene

Proteins for ZW10 Gene

  • Protein details for ZW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43264-ZW10_HUMAN
    Recommended name:
    Centromere/kinetochore protein zw10 homolog
    Protein Accession:
    O43264
    Secondary Accessions:
    • A1A528

    Protein attributes for ZW10 Gene

    Size:
    779 amino acids
    Molecular mass:
    88829 Da
    Quaternary structure:
    • Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B through direct interaction with RINT1/TIP20L bound to BNIP1/SEC20L. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts with C19orf25, KNTC1, and ZWINT.
    Miscellaneous:
    • Overexpression as well as silencing of ZW10 disrupts the morphology of the ER-Golgi intermediate compartment as well as the Golgi apparatus and slows down ER-Golgi transport

    Alternative splice isoforms for ZW10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZW10 Gene

Proteomics data for ZW10 Gene at MOPED

Post-translational modifications for ZW10 Gene

  • Ubiquitination at Lys624
  • Modification sites at PhosphoSitePlus

Other Protein References for ZW10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZW10 Gene

Domains for ZW10 Gene

Protein Domains for ZW10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZW10 Gene

Graphical View of Domain Structure for InterPro Entry

O43264

UniProtKB/Swiss-Prot:

ZW10_HUMAN :
  • O43264
Family:
  • Belongs to the ZW10 family.
genes like me logo Genes that share domains with ZW10: view

No data available for Gene Families for ZW10 Gene

Function for ZW10 Gene

Molecular function for ZW10 Gene

GENATLAS Biochemistry: zeste-white 10,Drosophila homolog,moving from the centromere/kinetochore at prometaphase to kinetochore microtubule at metaphase and then back to the centromere/kinetochore at anaphase,recruiting dynein and dynactin to the centromere
UniProtKB/Swiss-Prot Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum.

Gene Ontology (GO) - Molecular Function for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11146660
GO:0019237 centromeric DNA binding TAS 9700164
genes like me logo Genes that share ontologies with ZW10: view
genes like me logo Genes that share phenotypes with ZW10: view

Animal Model Products

CRISPR Products

miRNA for ZW10 Gene

miRTarBase miRNAs that target ZW10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZW10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZW10 Gene

Localization for ZW10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZW10 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZW10 Gene COMPARTMENTS Subcellular localization image for ZW10 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
cytosol 4
nucleus 4
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region --
GO:0000776 kinetochore IDA 11682612
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IDA 11146660
GO:0005634 nucleus IDA 15485811
genes like me logo Genes that share ontologies with ZW10: view

Pathways for ZW10 Gene

genes like me logo Genes that share pathways with ZW10: view

Pathways by source for ZW10 Gene

Gene Ontology (GO) - Biological Process for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 11146660
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle TAS --
GO:0006461 protein complex assembly IDA 11146660
GO:0006888 ER to Golgi vesicle-mediated transport IMP 15029241
genes like me logo Genes that share ontologies with ZW10: view

Transcripts for ZW10 Gene

mRNA/cDNA for ZW10 Gene

Unigene Clusters for ZW10 Gene

Zw10 kinetochore protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZW10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZW10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZW10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - -
SP3:

Relevant External Links for ZW10 Gene

GeneLoc Exon Structure for
ZW10
ECgene alternative splicing isoforms for
ZW10

Expression for ZW10 Gene

mRNA expression in normal human tissues for ZW10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZW10 Gene

SOURCE GeneReport for Unigene cluster for ZW10 Gene Hs.503886

mRNA Expression by UniProt/SwissProt for ZW10 Gene

O43264-ZW10_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with ZW10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZW10 Gene

Orthologs for ZW10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZW10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZW10 35
  • 99.74 (n)
  • 100 (a)
ZW10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZW10 35
  • 89.09 (n)
  • 90.89 (a)
ZW10 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZW10 35
  • 91.06 (n)
  • 92.43 (a)
ZW10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zw10 35
  • 84.94 (n)
  • 86.14 (a)
Zw10 16
Zw10 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZW10 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zw10 35
  • 84.68 (n)
  • 85.59 (a)
chicken
(Gallus gallus)
Aves ZW10 35
  • 70.17 (n)
  • 70.79 (a)
lizard
(Anolis carolinensis)
Reptilia ZW10 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14398 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.350 35
zw10 35
  • 68 (n)
  • 70.75 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc55782 35
zw10 35
  • 60.97 (n)
  • 60.63 (a)
zw10 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mit(1)15 36
  • 22 (a)
OneToOne
mit(1)15 37
  • 22 (a)
worm
(Caenorhabditis elegans)
Secernentea czw-1 35
  • 41.94 (n)
  • 23.72 (a)
czw-1 36
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATZW10 35
  • 39.98 (n)
  • 24.57 (a)
rice
(Oryza sativa)
Liliopsida Os11g0545700 35
  • 42.11 (n)
  • 26.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1167 36
  • 33 (a)
OneToOne
Species with no ortholog for ZW10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZW10 Gene

ENSEMBL:
Gene Tree for ZW10 (if available)
TreeFam:
Gene Tree for ZW10 (if available)

Paralogs for ZW10 Gene

No data available for Paralogs for ZW10 Gene

Variants for ZW10 Gene

Sequence variations from dbSNP and Humsavar for ZW10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs906847 -- 113,761,569(-) gtgcc(A/G)tggct intron-variant
rs1000559 -- 113,774,495(-) CACCA(C/T)CCATA upstream-variant-2KB
rs1112642 -- 113,742,930(-) TGGCC(C/G)AATCA intron-variant
rs1467057 -- 113,774,828(+) TTCCA(C/G)AATAT upstream-variant-2KB
rs1713683 -- 113,746,797(+) agtcc(A/C)ggatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZW10 Gene

Variant ID Type Subtype PubMed ID
nsv820035 CNV Loss 19587683

Relevant External Links for ZW10 Gene

HapMap Linkage Disequilibrium report
ZW10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZW10 Gene

Disorders for ZW10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZW10 Gene including...

Search for ZW10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZW10 Gene

Relevant External Links for ZW10

Genetic Association Database (GAD)
ZW10
genes like me logo Genes that share disorders with ZW10: view

No data available for UniProtKB/Swiss-Prot for ZW10 Gene

Publications for ZW10 Gene

  1. Conservation of the centromere/kinetochore protein ZW10. (PMID: 9298984) Starr D.A. … Goldberg M.L. (J. Cell Biol. 1997) 2 3 4 23
  2. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. (PMID: 11590237) Scaeerou F. … Goldberg M.L. (J. Cell Sci. 2001) 3 4 23
  3. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. (PMID: 12686595) Williams B.C. … Goldberg M.L. (Mol. Biol. Cell 2003) 3 4 23
  4. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H. … Tagaya M. (EMBO J. 2004) 3 4 23
  5. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. (PMID: 15094189) Musio A. … Vezzoni P. (Gene 2004) 3 4 23

Products for ZW10 Gene

Sources for ZW10 Gene

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