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Aliases for ZUFSP Gene

Aliases for ZUFSP Gene

  • Zinc Finger With UFM1 Specific Peptidase Domain 2 3 5
  • C6orf113 3 4
  • Zinc Finger With UFM1-Specific Peptidase Domain Protein 3
  • Chromosome 6 Open Reading Frame 113 2
  • DJ412I7.3 3

External Ids for ZUFSP Gene

Previous HGNC Symbols for ZUFSP Gene

  • C6orf113

Previous GeneCards Identifiers for ZUFSP Gene

  • GC06M117064
  • GC06M116956
  • GC06M114536

Summaries for ZUFSP Gene

GeneCards Summary for ZUFSP Gene

ZUFSP (Zinc Finger With UFM1 Specific Peptidase Domain) is a Protein Coding gene. Diseases associated with ZUFSP include Neuronal Ceroid Lipofuscinosis.

Additional gene information for ZUFSP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZUFSP Gene

Genomics for ZUFSP Gene

Regulatory Elements for ZUFSP Gene

Enhancers for ZUFSP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H116665 1.3 FANTOM5 ENCODE 13.2 +1.3 1309 3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZUFSP CALHM5 KPNA5 RWDD1 DSE GC06P116597
GH06H116276 1.4 ENCODE dbSUPER 10.1 +389.4 389384 5 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CALHM6 TSPYL4 CALHM4 TSPYL1 TRAPPC3L KRT18P22 CBX3P9 ENSG00000244158 ENSG00000234117 ZUFSP
GH06H116384 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +279.4 279354 9 PKNOX1 BATF ZNF366 FOS ATF7 ETV6 RUNX3 CREM IKZF2 YY2 DSE CALHM6 CALHM4 CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
GH06H116446 1.3 FANTOM5 Ensembl ENCODE 2.7 +221.5 221545 2 PKNOX1 NFIA CEBPB CEBPG RAD21 PRDM6 ZBTB48 POLR2A ZSCAN5C SMC3 CALHM6 CALHM4 ENSG00000234117 DSE ZUFSP CBX3P9 PIR34878
GH06H116461 1.3 FANTOM5 Ensembl ENCODE 2.6 +205.2 205156 4 MXI1 BACH1 MAX BMI1 E2F1 CTBP1 ZNF316 POLR2A SCRT2 RUNX3 CALHM6 DSE ENSG00000234117 TRAPPC3L RWDD1 TSPYL1 ZUFSP ENSG00000244158
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZUFSP on UCSC Golden Path with GeneCards custom track

Promoters for ZUFSP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201700 610 2000 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for ZUFSP Gene

Chromosome:
6
Start:
116,635,618 bp from pter
End:
116,668,810 bp from pter
Size:
33,193 bases
Orientation:
Minus strand

Genomic View for ZUFSP Gene

Genes around ZUFSP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZUFSP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZUFSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZUFSP Gene

Proteins for ZUFSP Gene

  • Protein details for ZUFSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AP4-ZUFSP_HUMAN
    Recommended name:
    Zinc finger with UFM1-specific peptidase domain protein
    Protein Accession:
    Q96AP4
    Secondary Accessions:
    • Q5TD92
    • Q6PJH7
    • Q96NV6

    Protein attributes for ZUFSP Gene

    Size:
    578 amino acids
    Molecular mass:
    65959 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20499.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZUFSP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZUFSP Gene

Post-translational modifications for ZUFSP Gene

  • Ubiquitination at Lys262, Lys276, Lys301, isoforms=356, isoforms=2525, and isoforms=2534
  • Modification sites at PhosphoSitePlus

Other Protein References for ZUFSP Gene

No data available for DME Specific Peptides for ZUFSP Gene

Domains & Families for ZUFSP Gene

Gene Families for ZUFSP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZUFSP Gene

Suggested Antigen Peptide Sequences for ZUFSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZUFSP: view

No data available for UniProtKB/Swiss-Prot for ZUFSP Gene

Function for ZUFSP Gene

Phenotypes From GWAS Catalog for ZUFSP Gene

Gene Ontology (GO) - Molecular Function for ZUFSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZUFSP: view
genes like me logo Genes that share phenotypes with ZUFSP: view

Animal Model Products

CRISPR Products

miRNA for ZUFSP Gene

miRTarBase miRNAs that target ZUFSP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZUFSP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZUFSP Gene

Localization for ZUFSP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZUFSP gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZUFSP Gene

Pathways & Interactions for ZUFSP Gene

SuperPathways for ZUFSP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZUFSP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZUFSP Gene

Drugs & Compounds for ZUFSP Gene

No Compound Related Data Available

Transcripts for ZUFSP Gene

Unigene Clusters for ZUFSP Gene

Zinc finger with UFM1-specific peptidase domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZUFSP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZUFSP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for ZUFSP Gene

GeneLoc Exon Structure for
ZUFSP
ECgene alternative splicing isoforms for
ZUFSP

Expression for ZUFSP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZUFSP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZUFSP Gene

This gene is overexpressed in Fetal Brain (42.2), Platelet (17.1), and Brain (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZUFSP Gene



Protein tissue co-expression partners for ZUFSP Gene

NURSA nuclear receptor signaling pathways regulating expression of ZUFSP Gene:

ZUFSP

SOURCE GeneReport for Unigene cluster for ZUFSP Gene:

Hs.29857

Evidence on tissue expression from TISSUES for ZUFSP Gene

  • Liver(4.6)
  • Heart(4.2)
  • Intestine(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZUFSP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZUFSP Gene

Orthologs for ZUFSP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZUFSP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZUFSP 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ZUFSP 33 34
  • 90.24 (n)
cow
(Bos Taurus)
Mammalia ZUFSP 33 34
  • 90.08 (n)
mouse
(Mus musculus)
Mammalia Zufsp 33 16 34
  • 86.56 (n)
rat
(Rattus norvegicus)
Mammalia Zufsp 33
  • 83.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZUFSP 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZUFSP 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZUFSP 33 34
  • 71.78 (n)
lizard
(Anolis carolinensis)
Reptilia ZUFSP 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zufsp 33
  • 60.81 (n)
Str.3949 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19781 33
zebrafish
(Danio rerio)
Actinopterygii zufsp 33 34
  • 54.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009608 33
  • 44.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug105 33
  • 46.97 (n)
Species where no ortholog for ZUFSP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZUFSP Gene

ENSEMBL:
Gene Tree for ZUFSP (if available)
TreeFam:
Gene Tree for ZUFSP (if available)

Paralogs for ZUFSP Gene

No data available for Paralogs for ZUFSP Gene

Variants for ZUFSP Gene

Sequence variations from dbSNP and Humsavar for ZUFSP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000004685 -- 116,636,011(+) AAAAA(C/T)TGCAA intron-variant
rs1000006489 -- 116,638,972(+) TCGGG(A/C)CACTC intron-variant
rs1000106954 -- 116,643,467(+) ACAGC(A/C)TGGTA intron-variant
rs1000138104 -- 116,643,318(+) TCTTC(A/T)CAGAA intron-variant
rs1000202045 -- 116,657,930(+) TACTA(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZUFSP Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv5448 CNV insertion 18451855
nsv830783 CNV gain 17160897

Variation tolerance for ZUFSP Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.94; 83.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZUFSP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZUFSP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZUFSP Gene

Disorders for ZUFSP Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZUFSP Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuronal ceroid lipofuscinosis
  • neuronal ceroid-lipofuscinoses
- elite association - COSMIC cancer census association via MalaCards
Search ZUFSP in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZUFSP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZUFSP
genes like me logo Genes that share disorders with ZUFSP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZUFSP Gene

Publications for ZUFSP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 60

Products for ZUFSP Gene

Sources for ZUFSP Gene

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