Aliases for ZSWIM8 Gene
Aliases for ZSWIM8 Gene
External Ids for ZSWIM8 Gene
- HGNC: 23528
- Entrez Gene: 23053
- Ensembl: ENSG00000214655
- UniProtKB: A7E2V4
Previous HGNC Symbols for ZSWIM8 Gene
- KIAA0913
Previous GeneCards Identifiers for ZSWIM8 Gene
- GC10P075546
- GC10P075549
- GC10P075555
Summaries for ZSWIM8 Gene
GeneCards Summary for ZSWIM8 Gene
ZSWIM8 (Zinc Finger SWIM-Type Containing 8) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM8 Gene
Genomics for ZSWIM8 Gene
Regulatory Elements for ZSWIM8 Gene
Enhancers for ZSWIM8 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZSWIM8 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ZSWIM8 Gene
- Chromosome:
- 10
- Start:
- 73,785,577 bp from pter
- End:
- 73,801,798 bp from pter
- Size:
- 16,222 bases
- Orientation:
- Plus strand
Genomic View for ZSWIM8 Gene
Genes around ZSWIM8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q22.2 by Ensembl
- 10q22.2 by Entrez Gene
- 10q22.2 by HGNC
ZSWIM8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZSWIM8 Gene
Proteins for ZSWIM8 Gene
-
Protein details for ZSWIM8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A7E2V4-ZSWM8_HUMAN
- Recommended name:
- Zinc finger SWIM domain-containing protein 8
- Protein Accession:
- A7E2V4
- B2RP37
- O94987
- Q17RS8
- Q2TAB8
- Q6P439
- Q8IW81
- Q8NB34
- Q9H8F3
Protein attributes for ZSWIM8 Gene
- Size:
- 1837 amino acids
- Molecular mass:
- 197297 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI37250.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI37251.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB14664.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03709.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for ZSWIM8 Gene
Post-translational modifications for ZSWIM8 Gene
Other Protein References for ZSWIM8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZSWIM8
- Invitrogen Antibodies for ZSWIM8
- Search GeneTex for Antibodies for ZSWIM8
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZSWIM8
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZSWIM8
- Origene Custom Protein Services for ZSWIM8
- Novus Biologicals proteins for ZSWIM8
- Search GeneTex for Proteins for ZSWIM8
No data available for DME Specific Peptides for ZSWIM8 Gene
Domains & Families for ZSWIM8 Gene
Gene Families for ZSWIM8 Gene
Suggested Antigen Peptide Sequences for ZSWIM8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZSWIM8 Gene
Function for ZSWIM8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZSWIM8 Gene
- GenomeRNAi human phenotypes for ZSWIM8:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZSWIM8
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZSWIM8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZSWIM8 gene
- Search ViGene Biosciences for ZSWIM8
CRISPR Products
-
OriGene CRISPR knockouts for ZSWIM8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZSWIM8
- GenScript: Design CRISPR guide RNA sequences for ZSWIM8
miRNA for ZSWIM8 Gene
- miRTarBase miRNAs that target ZSWIM8
miRNA Products
- Search ViGene Biosciences for ZSWIM8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZSWIM8
- Browse OriGene Inhibitory RNA Products For ZSWIM8
-
ViGene Biosciences ready-to-package AAV shRNAs for ZSWIM8 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZSWIM8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZSWIM8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZSWIM8
-
ViGene Biosciences adenoviral particle packaged cDNA for ZSWIM8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZSWIM8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZSWIM8 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM8 Gene
Localization for ZSWIM8 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytosol | 2 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM8 Gene
Pathways & Interactions for ZSWIM8 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ZSWIM8 Gene
Transcripts for ZSWIM8 Gene
mRNA/cDNA for ZSWIM8 Gene
- (9) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (213) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZSWIM8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZSWIM8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZSWIM8
- GenScript: Design CRISPR guide RNA sequences for ZSWIM8
miRNA Products
- Search ViGene Biosciences for ZSWIM8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZSWIM8
- Browse OriGene Inhibitory RNA Products For ZSWIM8
-
ViGene Biosciences ready-to-package AAV shRNAs for ZSWIM8 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZSWIM8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZSWIM8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for ZSWIM8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
This gene is overexpressed in Brain (53.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSWIM8 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZSWIM8 Gene:
ZSWIM8SOURCE GeneReport for Unigene cluster for ZSWIM8 Gene:
Hs.65135Evidence on tissue expression from TISSUES for ZSWIM8 Gene
- Nervous system(4.7)
- Skin(4.4)
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for ZSWIM8
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM8 Gene
Orthologs for ZSWIM8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KIAA0913 35 |
|
OneToOne | |
| ZSWIM8 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | ZSWIM8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ZSWIM8 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Zswim8 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZSWIM8 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zswim8 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZSWIM8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KIAA0913 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZSWIM8 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zswim8 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13157 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zswim8 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG34401 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for ZSWIM8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZSWIM8 Gene
(1) SIMAP similar genes for ZSWIM8 Gene using alignment to 10 proteins:
Variants for ZSWIM8 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017397 | -- | 73,798,973(+) | TTCCC(A/C)CTTAA | intron-variant | |
| rs1000035989 | -- | 73,793,182(+) | CCTTT(A/G)CACTC | intron-variant | |
| rs1000108319 | -- | 73,799,875(+) | GCCAC(C/T)GCACT | intron-variant | |
| rs1000176467 | -- | 73,798,184(+) | CCAGT(-/G)GTGCC | intron-variant, downstream-variant-500B | |
| rs1000419857 | -- | 73,786,457(+) | CTTTG(A/G)CTTGG | intron-variant |
Residual Variation Intolerance Score:
0.675% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.66;
31.79% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZSWIM8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZSWIM8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM8 Gene
Disorders for ZSWIM8 Gene
Relevant External Links for ZSWIM8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZSWIM8
No disorders were found for ZSWIM8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM8 Gene
Publications for ZSWIM8 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
Products for ZSWIM8 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZSWIM8
- Origene Custom Protein Services for ZSWIM8
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZSWIM8
- Browse OriGene Inhibitory RNA Products For ZSWIM8
- OriGene qPCR primer pairs for ZSWIM8
- OriGene CRISPR knockouts for ZSWIM8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZSWIM8
- GenScript: Next-day shipping cDNA ORF clone for ZSWIM8 in any vector
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- GenScript Custom Assay Services for ZSWIM8
- GenScript Custom overexpressing Cell Line Services for ZSWIM8
- GenScript: Design CRISPR guide RNA sequences for ZSWIM8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
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- Novus Biologicals Antibodies for ZSWIM8
- Novus Biologicals proteins for ZSWIM8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for ZSWIM8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for ZSWIM8
- Search GeneTex for Proteins for ZSWIM8
- ViGene Biosciences adenoviral particle packaged cDNA for ZSWIM8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ZSWIM8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZSWIM8 gene
- Search ViGene Biosciences for ZSWIM8
- Santa Cruz Biotechnology (SCBT) Antibodies for ZSWIM8
- Search Santa Cruz Biotechnology (SCBT) for ZSWIM8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZSWIM8
- Horizon Cell Lines for ZSWIM8
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZSWIM8
- VectorBuilder custom plasmid, inducible vectors for ZSWIM8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZSWIM8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZSWIM8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer