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Aliases for ZSWIM8 Gene

Aliases for ZSWIM8 Gene

  • Zinc Finger SWIM-Type Containing 8 2 3 5
  • KIAA0913 2 3 4
  • Zinc Finger SWIM Domain-Containing Protein 8 3
  • 4832404P21Rik 3

External Ids for ZSWIM8 Gene

Previous HGNC Symbols for ZSWIM8 Gene

  • KIAA0913

Previous GeneCards Identifiers for ZSWIM8 Gene

  • GC10P075546
  • GC10P075549
  • GC10P075555

Summaries for ZSWIM8 Gene

GeneCards Summary for ZSWIM8 Gene

ZSWIM8 (Zinc Finger SWIM-Type Containing 8) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.

Additional gene information for ZSWIM8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM8 Gene

Genomics for ZSWIM8 Gene

Regulatory Elements for ZSWIM8 Gene

Enhancers for ZSWIM8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H073809 1.3 ENCODE dbSUPER 34.2 +25.4 25441 3.5 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 SP3 SP5 ECD ZSWIM8 DUSP8P5 NDST2 SEC24C FUT11 ENSG00000272140 GLUD1P3 ENSG00000242288 CAMK2G
GH10H073964 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 17.5 +181.6 181623 6.2 PKNOX1 SIN3A FEZF1 ZNF2 ETS1 GTF3C2 GLIS2 ATF7 FOS SP3 SEC24C GLUD1P3 ENSG00000272140 DUSP8P5 BMS1P4 AP3M1 ENSG00000242288 ECD ZSWIM8 RPL17P50
GH10H073584 1.6 Ensembl ENCODE dbSUPER 24.6 -199.2 -199237 2.9 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 FOS ENSG00000272140 AGAP5 GLUD1P3 SEC24C NUDT13 DUSP8P5 ZSWIM8 BMS1P4 ZSWIM8-AS1 ENSG00000242288
GH10H073250 1.4 ENCODE dbSUPER 27.9 -533.2 -533244 3.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ECD NUDT13 DNAJB12 AP3M1 NDST2 ZSWIM8 SEC24C ENSG00000272140 GLUD1P3 ENSG00000242288
GH10H073624 1.4 ENCODE dbSUPER 27.8 -159.7 -159700 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 NDST2 SEC24C ZSWIM8 NUDT13 AP3M1 ENSG00000272140 GLUD1P3 ECD DUSP8P5 CFAP70
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Promoters for ZSWIM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029860 423 2001 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207

Genomic Locations for ZSWIM8 Gene

Genomic Locations for ZSWIM8 Gene
16,222 bases
Plus strand

Genomic View for ZSWIM8 Gene

Genes around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM8 Gene

Proteins for ZSWIM8 Gene

  • Protein details for ZSWIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger SWIM domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • B2RP37
    • O94987
    • Q17RS8
    • Q2TAB8
    • Q6P439
    • Q8IW81
    • Q8NB34
    • Q9H8F3

    Protein attributes for ZSWIM8 Gene

    1837 amino acids
    Molecular mass:
    197297 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI37250.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI37251.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB14664.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03709.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSWIM8 Gene


neXtProt entry for ZSWIM8 Gene

Post-translational modifications for ZSWIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSWIM8 Gene

Domains & Families for ZSWIM8 Gene

Gene Families for ZSWIM8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZSWIM8 Gene


Suggested Antigen Peptide Sequences for ZSWIM8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSWIM8: view

No data available for UniProtKB/Swiss-Prot for ZSWIM8 Gene

Function for ZSWIM8 Gene

Phenotypes From GWAS Catalog for ZSWIM8 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM8: view

Phenotypes for ZSWIM8 Gene

genes like me logo Genes that share phenotypes with ZSWIM8: view

Animal Model Products

CRISPR Products

miRNA for ZSWIM8 Gene

miRTarBase miRNAs that target ZSWIM8

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM8 Gene

Localization for ZSWIM8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM8 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM8 Gene

Pathways & Interactions for ZSWIM8 Gene

SuperPathways for ZSWIM8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM8 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZSWIM8 Gene

Drugs & Compounds for ZSWIM8 Gene

No Compound Related Data Available

Transcripts for ZSWIM8 Gene

Unigene Clusters for ZSWIM8 Gene

Zinc finger, SWIM-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM8 Gene

No ASD Table

Relevant External Links for ZSWIM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSWIM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSWIM8 Gene

This gene is overexpressed in Brain (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSWIM8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSWIM8 Gene:


SOURCE GeneReport for Unigene cluster for ZSWIM8 Gene:


Evidence on tissue expression from TISSUES for ZSWIM8 Gene

  • Nervous system(4.7)
  • Skin(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ZSWIM8: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM8 Gene

Orthologs for ZSWIM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA0913 34
  • 100 (a)
  • 99.75 (n)
(Canis familiaris)
Mammalia ZSWIM8 33 34
  • 94.18 (n)
(Bos Taurus)
Mammalia ZSWIM8 33 34
  • 93.38 (n)
(Mus musculus)
Mammalia Zswim8 33 16 34
  • 91.24 (n)
(Monodelphis domestica)
Mammalia ZSWIM8 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Zswim8 33
  • 90.81 (n)
(Ornithorhynchus anatinus)
Mammalia ZSWIM8 34
  • 73 (a)
(Gallus gallus)
Aves KIAA0913 33 34
  • 73.81 (n)
(Anolis carolinensis)
Reptilia ZSWIM8 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim8 33
  • 70.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13157 33
(Danio rerio)
Actinopterygii zswim8 33 34
  • 70.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34401 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for ZSWIM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM8 Gene

Gene Tree for ZSWIM8 (if available)
Gene Tree for ZSWIM8 (if available)

Paralogs for ZSWIM8 Gene

Paralogs for ZSWIM8 Gene

genes like me logo Genes that share paralogs with ZSWIM8: view

Variants for ZSWIM8 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000017397 -- 73,798,973(+) TTCCC(A/C)CTTAA intron-variant
rs1000035989 -- 73,793,182(+) CCTTT(A/G)CACTC intron-variant
rs1000108319 -- 73,799,875(+) GCCAC(C/T)GCACT intron-variant
rs1000176467 -- 73,798,184(+) CCAGT(-/G)GTGCC intron-variant, downstream-variant-500B
rs1000419857 -- 73,786,457(+) CTTTG(A/G)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM8 Gene

Variant ID Type Subtype PubMed ID
nsv831912 CNV gain 17160897
nsv825468 CNV gain 20364138
nsv551517 CNV loss 21841781
nsv551516 CNV loss 21841781
nsv1035634 CNV gain 25217958
dgv46n21 CNV loss 19592680

Variation tolerance for ZSWIM8 Gene

Residual Variation Intolerance Score: 0.675% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSWIM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM8 Gene

Disorders for ZSWIM8 Gene

Relevant External Links for ZSWIM8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZSWIM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM8 Gene

Publications for ZSWIM8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ZSWIM8 Gene

Sources for ZSWIM8 Gene

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