Free for academic non-profit institutions. Other users need a Commercial license

ZSWIM8 Gene(Protein Coding)

Zinc Finger SWIM-Type Containing 8

GCID:
GC10P073785
GIFtS:
41
Genes Participants
UDN Logo

Aliases for ZSWIM8 Gene

Aliases for ZSWIM8 Gene

  • Zinc Finger SWIM-Type Containing 8 2 3
  • KIAA0913 2 3 4
  • Zinc Finger, SWIM-Type Containing 8 3 5
  • 4832404P21Rik 3

External Ids for ZSWIM8 Gene

Previous HGNC Symbols for ZSWIM8 Gene

  • KIAA0913

Previous GeneCards Identifiers for ZSWIM8 Gene

  • GC10P075546
  • GC10P075549
  • GC10P075555

Summaries for ZSWIM8 Gene

GeneCards Summary for ZSWIM8 Gene

ZSWIM8 (Zinc Finger SWIM-Type Containing 8) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM8 Gene

Genomics for ZSWIM8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZSWIM8 Gene

Enhancers for ZSWIM8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Promoters for ZSWIM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSWIM8 Gene

Chromosome:
10
Start:
73,785,577 bp from pter
End:
73,801,798 bp from pter
Size:
16,222 bases
Orientation:
Plus strand

Genomic View for ZSWIM8 Gene

Genes around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZSWIM8 Gene

Proteins for ZSWIM8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZSWIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7E2V4-ZSWM8_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 8
    Protein Accession:
    A7E2V4
    Secondary Accessions:
    • B2RP37
    • O94987
    • Q17RS8
    • Q2TAB8
    • Q6P439
    • Q8IW81
    • Q8NB34
    • Q9H8F3

    Protein attributes for ZSWIM8 Gene

    Size:
    1837 amino acids
    Molecular mass:
    197297 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI37250.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI37251.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB14664.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03709.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSWIM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSWIM8 Gene

Proteomics data for ZSWIM8 Gene at MOPED

Protein Expression for ZSWIM8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZSWIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSWIM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM8 Gene

Domains & Families for ZSWIM8 Gene

Gene Families for ZSWIM8 Gene

HGNC:

Protein Domains for ZSWIM8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A7E2V4

UniProtKB/Swiss-Prot:

ZSWM8_HUMAN :
  • Contains 1 SWIM-type zinc finger.
Similarity:
  • Contains 1 SWIM-type zinc finger.
genes like me logo Genes that share domains with ZSWIM8: view

Function for ZSWIM8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for ZSWIM8 Gene

GenomeRNAi human phenotypes for ZSWIM8:
genes like me logo Genes that share phenotypes with ZSWIM8: view

Animal Model Products

CRISPR Products

miRNA for ZSWIM8 Gene

miRTarBase miRNAs that target ZSWIM8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM8 Gene

Localization for ZSWIM8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSWIM8 Gene COMPARTMENTS Subcellular localization image for ZSWIM8 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM8 Gene

Pathways & Interactions for ZSWIM8 Gene

SuperPathways for ZSWIM8 Gene

PathCards logoMore details on SuperPathways for ZSWIM8
No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM8 Gene

Drugs & Compounds for ZSWIM8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZSWIM8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZSWIM8 Gene

(12) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(213) Selected AceView cDNA sequences:
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM8 Gene

Zinc finger, SWIM-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM8 Gene

No ASD Table

Relevant External Links for ZSWIM8 Gene

GeneLoc Exon Structure for
ZSWIM8
ECgene alternative splicing isoforms for
ZSWIM8

Expression for ZSWIM8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ZSWIM8 Gene

mRNA expression in normal human tissues for ZSWIM8 Gene
mRNA expression by BioGPS for ZSWIM8 GenemRNA expression by GTEx for ZSWIM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSWIM8 Gene

This gene is overexpressed in Brain (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZSWIM8 Gene



SOURCE GeneReport for Unigene cluster for ZSWIM8 Gene Hs.65135

genes like me logo Genes that share expression patterns with ZSWIM8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZSWIM8 Gene

Orthologs for ZSWIM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ZSWIM8 35
  • 93.38 (n)
  • 98.58 (a)
ZSWIM8 36
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZSWIM8 35
  • 94.18 (n)
  • 98.75 (a)
ZSWIM8 36
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Zswim8 35
  • 91.24 (n)
  • 97.49 (a)
Zswim8 16
Zswim8 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ZSWIM8 35
  • 99.75 (n)
  • 99.95 (a)
KIAA0913 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Zswim8 35
  • 90.81 (n)
  • 97.15 (a)
oppossum
(Monodelphis domestica)
 Mammalia ZSWIM8 36
  • 91 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ZSWIM8 36
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KIAA0913 35
  • 73.81 (n)
  • 82.45 (a)
KIAA0913 36
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZSWIM8 36
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia zswim8 35
  • 70.94 (n)
  • 80.84 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.13157 35
zebrafish
(Danio rerio)
 Actinopterygii zswim8 35
  • 70.27 (n)
  • 77.52 (a)
zswim8 36
  • 72 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG34401 36
  • 40 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 43 (a)
 OneToOne
Species with no ortholog for ZSWIM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM8 Gene

ENSEMBL:
Gene Tree for ZSWIM8 (if available)
TreeFam:
Gene Tree for ZSWIM8 (if available)

Paralogs for ZSWIM8 Gene

Paralogs for ZSWIM8 Gene

(1) SIMAP similar genes for ZSWIM8 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZSWIM8: view

Variants for ZSWIM8 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3036236 -- 73,786,960(+) TTTTT(-/T)GAGAC intron-variant
rs3740290 -- 73,795,786(+) AACCC(C/T)GTCTC intron-variant
rs3740291 -- 73,795,920(+) ttcac(A/G)ccact intron-variant
rs3829128 -- 73,789,588(-) AGAAG(A/C/G/T)GGGGG intron-variant
rs3911887 -- 73,788,268(+) CGGAG(A/G)CAAGA intron-variant

Variation tolerance for ZSWIM8 Gene

Residual Variation Intolerance Score: 0.675% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZSWIM8 Gene

Disorders for ZSWIM8 Gene

Relevant External Links for ZSWIM8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSWIM8

No disorders were found for ZSWIM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM8 Gene

Publications for ZSWIM8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for ZSWIM8 Gene

Sources for ZSWIM8 Gene

Content