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Aliases for ZSWIM7 Gene

Aliases for ZSWIM7 Gene

  • Zinc Finger, SWIM-Type Containing 7 2 3
  • SWS1 3 4 6
  • SWIM Domain-Containing And Srs2-Interacting Protein 1 Homolog 3 4
  • SWIM-Type Zinc Finger Domain-Containing Protein 7 3 4
  • SWIM Domain Containing Srs2 Interacting Protein 1 2
  • Zinc Finger SWIM Domain-Containing Protein 7 3

External Ids for ZSWIM7 Gene

Previous GeneCards Identifiers for ZSWIM7 Gene

  • GC17U900830
  • GC17M015820

Summaries for ZSWIM7 Gene

GeneCards Summary for ZSWIM7 Gene

ZSWIM7 (Zinc Finger, SWIM-Type Containing 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZSWIM7 Gene

  • Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM7 Gene

Genomics for ZSWIM7 Gene

Regulatory Elements for ZSWIM7 Gene

Genomic Location for ZSWIM7 Gene

Start:
15,976,560 bp from pter
End:
15,999,717 bp from pter
Size:
23,158 bases
Orientation:
Minus strand

Genomic View for ZSWIM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSWIM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM7 Gene

Proteins for ZSWIM7 Gene

  • Protein details for ZSWIM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q19AV6-ZSWM7_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 7
    Protein Accession:
    Q19AV6
    Secondary Accessions:

    Protein attributes for ZSWIM7 Gene

    Size:
    140 amino acids
    Molecular mass:
    15386 Da
    Quaternary structure:
    • Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other.

neXtProt entry for ZSWIM7 Gene

Proteomics data for ZSWIM7 Gene at MOPED

Post-translational modifications for ZSWIM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSWIM7 Gene

Domains for ZSWIM7 Gene

Gene Families for ZSWIM7 Gene

HGNC:
  • ZSWIM :Zinc fingers, SWIM-type

Protein Domains for ZSWIM7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM7 Gene

Graphical View of Domain Structure for InterPro Entry

Q19AV6

UniProtKB/Swiss-Prot:

ZSWM7_HUMAN :
  • Q19AV6
Family:
  • Belongs to the SWS1 family.
Similarity:
  • Contains 1 SWIM-type zinc finger.
genes like me logo Genes that share domains with ZSWIM7: view

Function for ZSWIM7 Gene

Molecular function for ZSWIM7 Gene

UniProtKB/Swiss-Prot Function: Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.

Gene Ontology (GO) - Molecular Function for ZSWIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21965664
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM7: view

miRNA for ZSWIM7 Gene

miRTarBase miRNAs that target ZSWIM7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZSWIM7 Gene

Localization for ZSWIM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSWIM7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSWIM7 Gene COMPARTMENTS Subcellular localization image for ZSWIM7 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZSWIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0097196 Shu complex IDA 21965664
genes like me logo Genes that share ontologies with ZSWIM7: view

Pathways for ZSWIM7 Gene

SuperPathways for ZSWIM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21965664
GO:0050821 protein stabilization IMP 21965664
genes like me logo Genes that share ontologies with ZSWIM7: view

No data available for Pathways by source for ZSWIM7 Gene

Transcripts for ZSWIM7 Gene

mRNA/cDNA for ZSWIM7 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM7 Gene

Zinc finger, SWIM-type containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM7 Gene

No ASD Table

Relevant External Links for ZSWIM7 Gene

GeneLoc Exon Structure for
ZSWIM7
ECgene alternative splicing isoforms for
ZSWIM7

Expression for ZSWIM7 Gene

mRNA expression in normal human tissues for ZSWIM7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZSWIM7 Gene

SOURCE GeneReport for Unigene cluster for ZSWIM7 Gene Hs.593985

genes like me logo Genes that share expressions with ZSWIM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSWIM7 Gene

Orthologs for ZSWIM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM7 35
  • 99.52 (n)
  • 99.29 (a)
ZSWIM7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSWIM7 35
  • 83.09 (n)
  • 85.51 (a)
ZSWIM7 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSWIM7 35
  • 86.37 (n)
  • 87.59 (a)
ZSWIM7 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zswim7 35
  • 81.16 (n)
  • 81.88 (a)
Zswim7 16
Zswim7 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZSWIM7 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zswim7 35
  • 82.14 (n)
  • 85 (a)
chicken
(Gallus gallus)
Aves ZSWIM7 35
  • 65.71 (n)
  • 62.14 (a)
ZSWIM7 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim7 35
  • 63.41 (n)
  • 61.65 (a)
zebrafish
(Danio rerio)
Actinopterygii zswim7 35
  • 58.33 (n)
  • 56.06 (a)
zswim7 36
  • 53 (a)
OneToOne
Species with no ortholog for ZSWIM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM7 Gene

ENSEMBL:
Gene Tree for ZSWIM7 (if available)
TreeFam:
Gene Tree for ZSWIM7 (if available)

Paralogs for ZSWIM7 Gene

No data available for Paralogs for ZSWIM7 Gene

Variants for ZSWIM7 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11654 -- 15,977,837(-) GTCTT(C/G)TCAAG utr-variant-3-prime
rs1045599 -- 15,976,596(-) CAACA(A/G)ATAAA utr-variant-3-prime
rs2109632 -- 15,978,414(+) CTGAT(A/G)TGGCA intron-variant
rs2159643 -- 15,978,502(+) CTGAG(C/G)CATGA intron-variant
rs2286795 -- 15,980,495(+) GAAAA(C/T)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM7 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv907706 CNV Gain 21882294
dgv3062n71 CNV Gain 21882294
esv2715706 CNV Deletion 23290073
esv1788130 CNV Deletion 17803354
esv29086 CNV Loss 19812545

Relevant External Links for ZSWIM7 Gene

HapMap Linkage Disequilibrium report
ZSWIM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM7 Gene

Disorders for ZSWIM7 Gene

No disorders were found for ZSWIM7 Gene.

No data available for UniProtKB/Swiss-Prot for ZSWIM7 Gene

Publications for ZSWIM7 Gene

  1. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. (PMID: 16710300) Martin V. … Russell P. (EMBO J. 2006) 2 3 4
  2. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PMID: 21965664) Liu T. … Huang J. (J. Biol. Chem. 2011) 3 4
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZSWIM7 Gene

Sources for ZSWIM7 Gene

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