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Aliases for ZSWIM7 Gene

Aliases for ZSWIM7 Gene

  • Zinc Finger SWIM-Type Containing 7 2 3
  • SWIM Domain-Containing And Srs2-Interacting Protein 1 Homolog 3 4
  • SWIM-Type Zinc Finger Domain-Containing Protein 7 3 4
  • Zinc Finger, SWIM-Type Containing 7 3 5
  • SWS1 3 4
  • SWIM Domain Containing Srs2 Interacting Protein 1 2

External Ids for ZSWIM7 Gene

Previous GeneCards Identifiers for ZSWIM7 Gene

  • GC17U900830
  • GC17M015820

Summaries for ZSWIM7 Gene

GeneCards Summary for ZSWIM7 Gene

ZSWIM7 (Zinc Finger SWIM-Type Containing 7) is a Protein Coding gene. Diseases associated with ZSWIM7 include Intestinal Benign Neoplasm.

UniProtKB/Swiss-Prot for ZSWIM7 Gene

  • Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM7 Gene

Genomics for ZSWIM7 Gene

Regulatory Elements for ZSWIM7 Gene

Enhancers for ZSWIM7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZSWIM7 on UCSC Golden Path with GeneCards custom track

Promoters for ZSWIM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZSWIM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSWIM7 Gene

15,976,560 bp from pter
15,999,717 bp from pter
23,158 bases
Minus strand

Genomic View for ZSWIM7 Gene

Genes around ZSWIM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM7 Gene

Proteins for ZSWIM7 Gene

  • Protein details for ZSWIM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger SWIM domain-containing protein 7
    Protein Accession:

    Protein attributes for ZSWIM7 Gene

    140 amino acids
    Molecular mass:
    15386 Da
    Quaternary structure:
    • Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other.

neXtProt entry for ZSWIM7 Gene

Proteomics data for ZSWIM7 Gene at MOPED

Post-translational modifications for ZSWIM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSWIM7 Gene

Domains & Families for ZSWIM7 Gene

Gene Families for ZSWIM7 Gene

Protein Domains for ZSWIM7 Gene


Suggested Antigen Peptide Sequences for ZSWIM7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SWS1 family.
  • Contains 1 SWIM-type zinc finger.
  • Belongs to the SWS1 family.
  • Contains 1 SWIM-type zinc finger.
genes like me logo Genes that share domains with ZSWIM7: view

Function for ZSWIM7 Gene

Molecular function for ZSWIM7 Gene

UniProtKB/Swiss-Prot Function:
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.

Phenotypes for ZSWIM7 Gene

GenomeRNAi human phenotypes for ZSWIM7:
genes like me logo Genes that share phenotypes with ZSWIM7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM7 Gene

Localization for ZSWIM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSWIM7 Gene

Subcellular locations from

Jensen Localization Image for ZSWIM7 Gene COMPARTMENTS Subcellular localization image for ZSWIM7 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ZSWIM7 Gene

Pathways & Interactions for ZSWIM7 Gene

SuperPathways for ZSWIM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM7 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZSWIM7 Gene

Drugs & Compounds for ZSWIM7 Gene

No Compound Related Data Available

Transcripts for ZSWIM7 Gene

mRNA/cDNA for ZSWIM7 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM7 Gene

Zinc finger, SWIM-type containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM7 Gene

No ASD Table

Relevant External Links for ZSWIM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSWIM7 Gene

mRNA expression in normal human tissues for ZSWIM7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZSWIM7 Gene

SOURCE GeneReport for Unigene cluster for ZSWIM7 Gene Hs.593985

genes like me logo Genes that share expression patterns with ZSWIM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZSWIM7 Gene

Orthologs for ZSWIM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZSWIM7 35
  • 83.09 (n)
  • 85.51 (a)
  • 81 (a)
(Canis familiaris)
Mammalia ZSWIM7 35
  • 86.37 (n)
  • 87.59 (a)
  • 85 (a)
(Mus musculus)
Mammalia Zswim7 35
  • 81.16 (n)
  • 81.88 (a)
Zswim7 16
Zswim7 36
  • 74 (a)
(Pan troglodytes)
Mammalia ZSWIM7 35
  • 99.52 (n)
  • 99.29 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Zswim7 35
  • 82.14 (n)
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia ZSWIM7 36
  • 70 (a)
(Gallus gallus)
Aves ZSWIM7 35
  • 65.71 (n)
  • 62.14 (a)
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim7 35
  • 63.41 (n)
  • 61.65 (a)
(Danio rerio)
Actinopterygii zswim7 35
  • 58.33 (n)
  • 56.06 (a)
zswim7 36
  • 53 (a)
Species with no ortholog for ZSWIM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM7 Gene

Gene Tree for ZSWIM7 (if available)
Gene Tree for ZSWIM7 (if available)

Paralogs for ZSWIM7 Gene

No data available for Paralogs for ZSWIM7 Gene

Variants for ZSWIM7 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11654 -- 15,977,837(-) GTCTT(C/G)TCAAG utr-variant-3-prime
rs1045599 -- 15,976,596(-) CAACA(A/G)ATAAA utr-variant-3-prime
rs2109632 -- 15,978,414(+) CTGAT(A/G)TGGCA intron-variant
rs2159643 -- 15,978,502(+) CTGAG(C/G)CATGA intron-variant
rs2535614 -- 15,978,426(+) AACCC(C/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM7 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv907706 CNV Gain 21882294
dgv3062n71 CNV Gain 21882294
esv2715706 CNV Deletion 23290073
esv1788130 CNV Deletion 17803354
esv29086 CNV Loss 19812545

Variation tolerance for ZSWIM7 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZSWIM7 Gene

Disorders for ZSWIM7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSWIM7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal benign neoplasm
  • intestinal tumors
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZSWIM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZSWIM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSWIM7 Gene

Publications for ZSWIM7 Gene

  1. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. (PMID: 16710300) Martin V. … Russell P. (EMBO J. 2006) 2 3 4 67
  2. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  3. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. (PMID: 25659377) Godin S.K. … Bernstein K.A. (Genetics 2015) 3
  4. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PMID: 21965664) Liu T. … Huang J. (J. Biol. Chem. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZSWIM7 Gene

Sources for ZSWIM7 Gene