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Aliases for ZSWIM7 Gene

Aliases for ZSWIM7 Gene

  • Zinc Finger SWIM-Type Containing 7 2 3 5
  • SWIM Domain-Containing And Srs2-Interacting Protein 1 Homolog 3 4
  • SWIM-Type Zinc Finger Domain-Containing Protein 7 3 4
  • SWS1 3 4
  • SWIM Domain Containing Srs2 Interacting Protein 1 2
  • Zinc Finger SWIM Domain-Containing Protein 7 3

External Ids for ZSWIM7 Gene

Previous GeneCards Identifiers for ZSWIM7 Gene

  • GC17U900830
  • GC17M015820

Summaries for ZSWIM7 Gene

GeneCards Summary for ZSWIM7 Gene

ZSWIM7 (Zinc Finger SWIM-Type Containing 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZSWIM7 Gene

  • Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.

Additional gene information for ZSWIM7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM7 Gene

Genomics for ZSWIM7 Gene

GeneHancer (GH) Regulatory Elements for ZSWIM7 Gene

Promoters and enhancers for ZSWIM7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I015998 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 592 0.0 -31 3.1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZSWIM7 TTC19 MEIS3P1 ENSG00000265519 ZNF286A UPF3AP1 GC17M016015
GH17I016001 Enhancer 0.7 ENCODE dbSUPER 564.9 -1.7 -1705 0.2 ZNF366 ZNF529 ATF7 TRIM24 SETDB1 ZSWIM7 ZNF286A UPF3AP1 TEKT3 TTC19 GC17M016015
GH17I015962 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 71 +34.5 34537 5.8 ELF3 PKNOX1 FOXA2 ZFP64 ARID4B KLF17 ZNF76 SIN3A ZSCAN9 RARA ZSWIM7 ADORA2B TTC19 RNU6-314P NCOR1 CDRT1 PIR48319
GH17I016212 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 41.8 -215.8 -215810 5.9 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A ZFP41 PIGL NCOR1 ZSWIM7 ENSG00000266538 PPIAP53 TVP23C LOC644422 ZNF286A UPF3AP1 MPRIP-AS1
GH17I015980 Enhancer 1.2 Ensembl ENCODE dbSUPER 66.1 +18.0 17983 2.7 HDAC1 NFRKB BATF CHAMP1 TCF12 ZNF121 ETV6 FOS IKZF2 RUNX3 ZSWIM7 ADORA2B TTC19 PIR48319
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSWIM7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSWIM7 gene promoter:

Genomic Locations for ZSWIM7 Gene

Genomic Locations for ZSWIM7 Gene
chr17:15,976,560-15,999,717
(GRCh38/hg38)
Size:
23,158 bases
Orientation:
Minus strand
chr17:15,879,874-15,903,031
(GRCh37/hg19)

Genomic View for ZSWIM7 Gene

Genes around ZSWIM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM7 Gene

Proteins for ZSWIM7 Gene

  • Protein details for ZSWIM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q19AV6-ZSWM7_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 7
    Protein Accession:
    Q19AV6

    Protein attributes for ZSWIM7 Gene

    Size:
    140 amino acids
    Molecular mass:
    15386 Da
    Quaternary structure:
    • Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other.

neXtProt entry for ZSWIM7 Gene

Post-translational modifications for ZSWIM7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZSWIM7 Gene

Domains & Families for ZSWIM7 Gene

Gene Families for ZSWIM7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZSWIM7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM7 Gene

Graphical View of Domain Structure for InterPro Entry

Q19AV6

UniProtKB/Swiss-Prot:

ZSWM7_HUMAN :
  • Belongs to the SWS1 family.
Family:
  • Belongs to the SWS1 family.
genes like me logo Genes that share domains with ZSWIM7: view

Function for ZSWIM7 Gene

Molecular function for ZSWIM7 Gene

UniProtKB/Swiss-Prot Function:
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.

Phenotypes From GWAS Catalog for ZSWIM7 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21965664
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM7: view

Phenotypes for ZSWIM7 Gene

genes like me logo Genes that share phenotypes with ZSWIM7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM7 Gene

Localization for ZSWIM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSWIM7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM7 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSWIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0097196 Shu complex IDA 21965664
genes like me logo Genes that share ontologies with ZSWIM7: view

Pathways & Interactions for ZSWIM7 Gene

SuperPathways for ZSWIM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21965664
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0050821 protein stabilization IMP 21965664
genes like me logo Genes that share ontologies with ZSWIM7: view

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM7 Gene

Drugs & Compounds for ZSWIM7 Gene

No Compound Related Data Available

Transcripts for ZSWIM7 Gene

mRNA/cDNA for ZSWIM7 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM7 Gene

Zinc finger, SWIM-type containing 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM7 Gene

No ASD Table

Relevant External Links for ZSWIM7 Gene

GeneLoc Exon Structure for
ZSWIM7
ECgene alternative splicing isoforms for
ZSWIM7

Expression for ZSWIM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSWIM7 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZSWIM7 Gene:

ZSWIM7

SOURCE GeneReport for Unigene cluster for ZSWIM7 Gene:

Hs.593985
genes like me logo Genes that share expression patterns with ZSWIM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM7 Gene

Orthologs for ZSWIM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM7 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia ZSWIM7 33 34
  • 86.37 (n)
cow
(Bos Taurus)
Mammalia ZSWIM7 33 34
  • 83.09 (n)
rat
(Rattus norvegicus)
Mammalia Zswim7 33
  • 82.14 (n)
mouse
(Mus musculus)
Mammalia Zswim7 33 16 34
  • 81.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZSWIM7 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZSWIM7 33 34
  • 65.71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim7 33
  • 63.41 (n)
zebrafish
(Danio rerio)
Actinopterygii zswim7 33 34
  • 58.33 (n)
Species where no ortholog for ZSWIM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM7 Gene

ENSEMBL:
Gene Tree for ZSWIM7 (if available)
TreeFam:
Gene Tree for ZSWIM7 (if available)

Paralogs for ZSWIM7 Gene

No data available for Paralogs for ZSWIM7 Gene

Variants for ZSWIM7 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs149555498 uncertain-significance, Mitochondrial complex III deficiency, not specified 15,999,776(-) G/A upstream_transcript_variant
rs199843558 uncertain-significance, Mitochondrial complex III deficiency 15,999,659(-) C/A/T 5_prime_UTR_variant
rs200004394 benign, uncertain-significance, not specified, Mitochondrial complex III deficiency 15,999,509(-) G/C intron_variant
rs368411974 uncertain-significance, Mitochondrial complex III deficiency 15,999,766(-) C/A/T upstream_transcript_variant
rs537063695 uncertain-significance, likely-benign, Mitochondrial complex III deficiency, not specified 15,999,994(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM7 Gene

Variant ID Type Subtype PubMed ID
dgv3107n100 CNV gain 25217958
dgv3108n100 CNV gain 25217958
esv1788130 CNV deletion 17803354
esv2715702 CNV deletion 23290073
esv29086 CNV loss 19812545
esv3572431 CNV gain 25503493
esv3640092 CNV loss 21293372
esv3892973 CNV gain 25118596

Variation tolerance for ZSWIM7 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM7 Gene

Human Gene Mutation Database (HGMD)
ZSWIM7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM7 Gene

Disorders for ZSWIM7 Gene

Additional Disease Information for ZSWIM7

No disorders were found for ZSWIM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM7 Gene

Publications for ZSWIM7 Gene

  1. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. (PMID: 16710300) Martín V … Russell P (The EMBO journal 2006) 2 3 4 58
  2. hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PMID: 21965664) Liu T … Huang J (The Journal of biological chemistry 2011) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung YJ … Rao DC (American journal of hypertension 2015) 3 58
  5. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. (PMID: 25659377) Godin SK … Bernstein KA (Genetics 2015) 3 58

Products for ZSWIM7 Gene

Sources for ZSWIM7 Gene

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