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ZSWIM6 Gene

protein-coding   GIFtS: 42
GCID: GC05P060628

Zinc Finger, SWIM-Type Containing 6

  Search for ZSWIM6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, SWIM-Type Containing 61 2
Zinc Finger SWIM Domain-Containing Protein 62
Zinc Finger, SWIM Domain Containing 62
KIAA15773

External Ids:    HGNC: 293161   Entrez Gene: 576882   Ensembl: ENSG000001304497   UniProtKB: Q9HCJ53   

Export aliases for ZSWIM6 gene to outside databases

Previous GC identifers: GC05P060783 GC05P060645 GC05P060663 GC05P057585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSWIM6 Gene:
ZSWIM6 (zinc finger, SWIM-type containing 6) is a protein-coding gene. An important paralog of this gene is ZSWIM4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZSWIM6 gene promoter:
         TBP   POU3F1   LCR-F1   Meis-1b   MEF-2A   E2F   E2F-1   Meis-1a   RSRFC4   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZSWIM6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSWIM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12.1

ZSWIM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSWIM6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P060628:  view genomic region     (about GC identifiers)

Start:
60,628,100 bp from pter      End:
60,841,999 bp from pter
Size:
213,900 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZSWM6_HUMAN, Q9HCJ5 (See protein sequence)
Recommended Name: Zinc finger SWIM domain-containing protein 6  
Size: 1215 amino acids; 133470 Da

Explore the universe of human proteins at neXtProt for ZSWIM6: NX_Q9HCJ5

Explore proteomics data for ZSWIM6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSWIM6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065979.1  
    ENSEMBL proteins: 
     ENSP00000252744  

    ZSWIM6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZSWIM: Zinc fingers, SWIM-type

    1 InterPro protein domain:
     IPR007527 Znf_SWIM

    Graphical View of Domain Structure for InterPro Entry Q9HCJ5

    ProtoNet protein and cluster: Q9HCJ5

    UniProtKB/Swiss-Prot: ZSWM6_HUMAN, Q9HCJ5
    Similarity: Contains 1 SWIM-type zinc finger


    Find genes that share domains with ZSWIM6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZSWIM6           About GenesLikeMe


    Animal Models:
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    hsa-mir-502-3p (MIRT037981), hsa-mir-18a-5p (MIRT050654), hsa-mir-324-3p (MIRT042841), hsa-mir-374b-5p (MIRT016083)

    Block miRNA regulation of human, mouse, rat ZSWIM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZSWIM6 (see all 129):
    hsa-miR-605 hsa-miR-3074-3p hsa-miR-208b hsa-miR-4273 hsa-miR-3612 hsa-miR-509-3-5p hsa-miR-519e hsa-miR-548y
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSWIM6
    Interactions:

        Search GeneGlobe Interaction Network for ZSWIM6

    1 Interacting protein for ZSWIM6 (Q9HCJ53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048812neuron projection morphogenesis IEA--
    GO:2001222regulation of neuron migration IEA--

    Find genes that share ontologies with ZSWIM6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSWIM6 (ZSWM6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZSWIM6 gene: 
    NM_020928.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252744(uc003jsr.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZSWIM6 (see all 129):
    hsa-miR-605 hsa-miR-3074-3p hsa-miR-208b hsa-miR-4273 hsa-miR-3612 hsa-miR-509-3-5p hsa-miR-519e hsa-miR-548y
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZSWIM6
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      QuantiTect SYBR Green Assays in human, mouse, rat ZSWIM6
      QuantiFast Probe-based Assays in human, mouse, rat ZSWIM6

    Selected AceView cDNA sequences (see all 108):

    AA252801 BE219697 AB046797 AA434440 AI692595 BU617053 AI569864 CD676963 
    AI093990 AW338114 AA736573 BM970818 AA769432 AW955618 T71919 BM971699 
    CA944901 BQ016316 BF060709 AA830446 AA434212 AA740254 AA758470 CB242299 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSWIM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTGAAAG
    ZSWIM6 Expression
    About this image


    ZSWIM6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    ZSWIM6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSWIM6 Protein Expression
        Custom PCR Arrays for ZSWIM6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSWIM6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZSWIM6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zswim61 , 5 zinc finger, SWIM domain containing 65
    zinc finger SWIM-type containing 61
    93.16(n)1
    98.22(a)1
      13 (59.39 cM)5
    672631  NM_145456.21  NP_663431.21 
     1077246185 
    chicken
    (Gallus gallus)
    Aves ZSWIM61 zinc finger, SWIM-type containing 6 88.65(n)
    96.18(a)
      770670  XM_001234009.3  XP_001234010.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZSWIM66
    zinc finger, SWIM-type containing 6
    85(a)
    1 ↔ 1
    2(8617723-8721584)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ083517.12   -- 88.65(n)    BJ083517.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283812 Danio rerio cDNA clone IMAGE6798981, partial cds 84.32(n)    BC058044.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ebax-16
    Protein PQN-55 (pqn-55) mRNA, complete cds
    14(a)
    1 → many
    IV(10286955-10293008) WBGene00004140


    ENSEMBL Gene Tree for ZSWIM6 (if available)
    TreeFam Gene Tree for ZSWIM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSWIM6 gene
    ZSWIM42  ZSWIM52  ZSWIM82  
    2 SIMAP similar genes for ZSWIM6 using alignment to 1 protein entry:     ZSWM6_HUMAN:
    ZSWIM5    ZSWIM4

    Find genes that share paralogs with ZSWIM6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZSWIM6 (see all 3320)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868688611,2
    --60626126(+) CCTAGA/GCATGG 1 -- us2k10--------
    rs1913574551,2
    --60626334(+) CCGAAA/GCGCGC 1 -- us2k10--------
    rs1834971611,2
    --60626471(+) CAGTAA/GAAACA 1 -- us2k10--------
    rs1120454571,2
    C,F--60626506(+) GTCTCC/GGACGC 1 -- us2k12Minor allele frequency- G:0.16CSA WA 120
    rs1491070501,2
    --60626532(+) GGCTTA/GGAAGC 1 -- us2k10--------
    rs1891046681,2
    --60626539(+) AAGCAA/GATTTG 1 -- us2k10--------
    rs1431447031,2
    --60626587(+) TCCAGC/GTTCAG 1 -- us2k10--------
    rs1148935401,2
    F--60626596(+) AGAGAG/CGGACT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1932792011,2
    --60626635(+) CACCAA/GCGAGC 1 -- us2k10--------
    rs1160019881,2
    F--60626694(+) CGAGGG/AGACTG 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for ZSWIM6 (60628100 - 60841999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZSWIM6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730245CNV Deletion23290073
    nsv522826CNV Loss19592680
    nsv823090CNV Loss20364138
    nsv823089CNV Gain20364138
    esv22368CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSWIM6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZSWIM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis. (PubMed id 16427614)1, 3 Kai N....Yuasa S. (Brain Res. 2006)
    3. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    5. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (Mol. Psychiatry 2012)
    6. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
    9. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57688 HGNC: 29316 AceView: ZSWIM6.1 Ensembl:ENSG00000130449 euGenes: HUgn57688
    ECgene: ZSWIM6 H-InvDB: ZSWIM6

    (According to HUGE)
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    HUGE: KIAA1577

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSWIM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZSWIM6 gene:
    Search GeneIP for patents involving ZSWIM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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