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Aliases for ZSWIM6 Gene

Aliases for ZSWIM6 Gene

  • Zinc Finger, SWIM-Type Containing 6 2 3
  • Zinc Finger SWIM Domain-Containing Protein 6 3
  • Zinc Finger, SWIM Domain Containing 6 3
  • KIAA1577 4
  • AFND 3

External Ids for ZSWIM6 Gene

Previous GeneCards Identifiers for ZSWIM6 Gene

  • GC05P060783
  • GC05P060645
  • GC05P060663
  • GC05P060628
  • GC05P057585

Summaries for ZSWIM6 Gene

GeneCards Summary for ZSWIM6 Gene

ZSWIM6 (Zinc Finger, SWIM-Type Containing 6) is a Protein Coding gene. Diseases associated with ZSWIM6 include acromelic frontonasal dysostosis. An important paralog of this gene is ZSWIM8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM6 Gene

Genomics for ZSWIM6 Gene

Regulatory Elements for ZSWIM6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZSWIM6 Gene

61,332,273 bp from pter
61,546,172 bp from pter
213,900 bases
Plus strand

Genomic View for ZSWIM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSWIM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM6 Gene

Proteins for ZSWIM6 Gene

  • Protein details for ZSWIM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger SWIM domain-containing protein 6
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ZSWIM6 Gene

    1215 amino acids
    Molecular mass:
    133470 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSWIM6 Gene

Proteomics data for ZSWIM6 Gene at MOPED

Post-translational modifications for ZSWIM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSWIM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM6 Gene

Domains for ZSWIM6 Gene

Gene Families for ZSWIM6 Gene

Protein Domains for ZSWIM6 Gene


Suggested Antigen Peptide Sequences for ZSWIM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SWIM-type zinc finger.
  • Contains 1 SWIM-type zinc finger.
genes like me logo Genes that share domains with ZSWIM6: view

Function for ZSWIM6 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM6: view

Animal Model Products

miRNA for ZSWIM6 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSWIM6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZSWIM6 Gene

Localization for ZSWIM6 Gene

Subcellular locations from

Jensen Localization Image for ZSWIM6 Gene COMPARTMENTS Subcellular localization image for ZSWIM6 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM6 Gene

Pathways for ZSWIM6 Gene

SuperPathways for ZSWIM6 Gene

No Data Available

Interacting Proteins for ZSWIM6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000252744 Q9HCJ5-ZSWM6_HUMAN for ZSWIM6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ZSWIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048812 neuron projection morphogenesis IEA --
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with ZSWIM6: view

No data available for Pathways by source for ZSWIM6 Gene

Transcripts for ZSWIM6 Gene

mRNA/cDNA for ZSWIM6 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM6 Gene

Zinc finger, SWIM-type containing 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSWIM6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM6 Gene

No ASD Table

Relevant External Links for ZSWIM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSWIM6 Gene

mRNA expression in normal human tissues for ZSWIM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZSWIM6 Gene

This gene is overexpressed in Liver, secretome (66.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZSWIM6 Gene

SOURCE GeneReport for Unigene cluster for ZSWIM6 Gene Hs.744939

genes like me logo Genes that share expressions with ZSWIM6: view

Expression partners for ZSWIM6 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSWIM6 Gene

Orthologs for ZSWIM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZSWIM6 35
  • 95.79 (n)
  • 98.89 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ZSWIM6 35
  • 95.04 (n)
  • 98.12 (a)
  • 98 (a)
(Mus musculus)
Mammalia Zswim6 35
  • 93.16 (n)
  • 98.22 (a)
Zswim6 16
Zswim6 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Zswim6 35
  • 93 (n)
  • 98.03 (a)
(Monodelphis domestica)
Mammalia ZSWIM6 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia ZSWIM6 36
  • 75 (a)
(Pan troglodytes)
Mammalia ZSWIM6 36
  • 98 (a)
(Gallus gallus)
Aves ZSWIM6 35
  • 88.65 (n)
  • 96.18 (a)
-- 36
  • 94 (a)
-- 36
  • 94 (a)
(Anolis carolinensis)
Reptilia ZSWIM6 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim6 35
  • 84.75 (n)
  • 96.36 (a)
(Danio rerio)
Actinopterygii Dr.28381 35
zswim6 35
  • 75.42 (n)
  • 86.47 (a)
zswim6 36
  • 82 (a)
(Caenorhabditis elegans)
Secernentea ebax-1 36
  • 14 (a)
Species with no ortholog for ZSWIM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZSWIM6 Gene

Gene Tree for ZSWIM6 (if available)
Gene Tree for ZSWIM6 (if available)

Paralogs for ZSWIM6 Gene

Paralogs for ZSWIM6 Gene

(2) SIMAP similar genes for ZSWIM6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSWIM6: view

Variants for ZSWIM6 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1045352 -- 61,537,253(+) TTCTT(A/C)ATGGG intron-variant
rs1058429 -- 61,375,725(-) TTGCT(C/T)GCACC intron-variant
rs1080390 -- 61,447,170(-) cagga(A/G)agcag intron-variant
rs1111429 -- 61,451,025(-) GTTCA(G/T)GACAT intron-variant
rs1348716 -- 61,451,158(+) CTCCT(A/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM6 Gene

Variant ID Type Subtype PubMed ID
nsv823089 CNV Gain 20364138
esv22368 CNV Gain+Loss 19812545
esv2730245 CNV Deletion 23290073
nsv522826 CNV Loss 19592680
nsv823090 CNV Loss 20364138

Relevant External Links for ZSWIM6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM6 Gene

Disorders for ZSWIM6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZSWIM6 Gene in MalaCards »

(1) Disease for ZSWIM6 Gene


  • Acromelic frontonasal dysostosis (AFND) [MIM:603671]: A rare variant form of frontonasal dysplasia, an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism, broadening of the nasal root, median facial cleft affecting the nose and/or upper lip and palate, unilateral or bilateral clefting of the alae nasi, lack of formation of the nasal tip, anterior cranium bifidum occultum, a V-shaped or widows peak frontal hairline. AFND is characterized by the association of frontonasal malformations with various combinations of polydactyly, tibial hypoplasia, epibulbar dermoid, encephalocoele, corpus callosum agenesis and Dandy-Walker malformation. {ECO:0000269 PubMed:25105228}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZSWIM6: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZSWIM6 Gene

Publications for ZSWIM6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Exome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis. (PMID: 25105228) Smith J.D. … Cunningham M.L. (Am. J. Hum. Genet. 2014) 3 4
  3. Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis. (PMID: 16427614) Kai N. … Yuasa S. (Brain Res. 2006) 2 3
  4. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. (PMID: 22688191) Bergen S.E. … Sullivan P.F. (Mol. Psychiatry 2012) 3
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3

Products for ZSWIM6 Gene

Sources for ZSWIM6 Gene

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