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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSWIM6 Gene

protein-coding   GIFtS: 41
GCID: GC05P060628

zinc finger, SWIM-type containing 6
  Search for ZSWIM6
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZSWIM6    

Aliases
for ZSWIM6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger, SWIM-Type Containing 61 2
KIAA15771 3
Zinc Finger SWIM Domain-Containing Protein 62
Zinc Finger, SWIM Domain Containing 62

External Ids:    HGNC: 293161   Entrez Gene: 576882   Ensembl: ENSG000001304497   UniProtKB: Q9HCJ53   

Export aliases for ZSWIM6 gene to outside databases

Previous GC identifers: GC05P060783 GC05P060645 GC05P060663 GC05P057585


Summaries
for ZSWIM6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ZSWIM6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSWIM6 gene promoter:
         TBP   POU3F1   LCR-F1   Meis-1b   MEF-2A   E2F   E2F-1   Meis-1a   RSRFC4   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZSWIM6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSWIM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12.1

ZSWIM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSWIM6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P060628:  view genomic region     (about GC identifiers)

Start:
 60,628,100 bp from pter      End:
 60,841,999 bp from pter
Size:
 213,900 bases      Orientation:
 plus strand

Proteins
for ZSWIM6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZSWM6_HUMAN, Q9HCJ5 (See protein sequence)
Recommended Name: Zinc finger SWIM domain-containing protein 6  
Size: 1215 amino acids; 133470 Da

Explore the universe of human proteins at neXtProt for ZSWIM6: NX_Q9HCJ5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HCJ5

    • ZSWIM6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065979.1  
    ENSEMBL proteins: 
     ENSP00000252744  

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    Protein Domains /
    Families
    for ZSWIM6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZSWIM6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007527 Znf_SWIM

    Graphical View of Domain Structure for InterPro Entry Q9HCJ5

    ProtoNet protein and cluster: Q9HCJ5

    UniProtKB/Swiss-Prot: ZSWM6_HUMAN, Q9HCJ5
    Similarity: Contains 1 SWIM-type zinc finger


    Function
    for ZSWIM6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    hsa-miR-605 hsa-miR-3074-3p hsa-miR-208b hsa-miR-4273 hsa-miR-3612 hsa-miR-509-3-5p hsa-miR-519e hsa-miR-548y
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--


    ZSWIM6 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZSWIM6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSWIM6

    1 Interacting protein for ZSWIM6 (Q9HCJ53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048812neuron projection morphogenesis IEA--
    GO:2001222regulation of neuron migration IEA--


    ZSWIM6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZSWIM6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSWIM6
    Search CenterWatch for drugs/clinical trials and news about ZSWIM6 / ZSWM6 

    Transcripts
    for ZSWIM6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZSWIM6 gene: 
    NM_020928.1  

    Unigene Cluster for ZSWIM6:

    Zinc finger, SWIM-type containing 6
    Hs.650537  [show with all ESTs]
    Unigene Representative Sequence: NM_020928
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252744(uc003jsr.3)

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    hsa-miR-605 hsa-miR-3074-3p hsa-miR-208b hsa-miR-4273 hsa-miR-3612 hsa-miR-509-3-5p hsa-miR-519e hsa-miR-548y
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSWIM6

    Additional cDNA sequence: 

    AB046797.1 BC039438.1 

    2 DOTS entries:

    DT.214020  DT.100663586 

    24/108 AceView cDNA sequences (see all 108):

    CA944901 BQ026095 AI692595 BU617053 AI093990 AA758470 CB243796 AA830446 
    BF060709 AA736573 AB046797 BM979222 AA740254 CB242299 AI248571 BM971699 
    AA383339 BF439730 AI636391 CD679534 BQ016316 BE219697 BM970818 AW955618 

    GeneLoc Exon Structure


    Expression
    for ZSWIM6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSWIM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTTGAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZSWIM6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZSWIM6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSWIM6

    SOURCE GeneReport for Unigene cluster: Hs.650537
        SABiosciences Custom PCR Arrays for ZSWIM6
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSWIM6

    Orthologs
    for ZSWIM6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZSWIM6 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zswim61 , 5 zinc finger, SWIM domain containing 65
    zinc finger SWIM-type containing 61    		 92.93(n)1
    97.59(a)1    		   13 (59.39 cM)5
    672631  NM_145456.21  NP_663431.21 
     1077246185 
    chicken
    (Gallus gallus)    		 Aves ZSWIM61 zinc finger, SWIM-type containing 6 87.9(n)
    95.16(a)    		   770670  XM_001234009.2  XP_001234010.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ZSWIM66
    		 --
    		 85(a)
    		 1 ↔ 1
    		 2(8617723-8721584)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ083517.12   -- 88.65(n)    BJ083517.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.283812 Danio rerio cDNA clone IMAGE6798981, partial cds 84.32(n)    BC058044.1 


    ENSEMBL Gene Tree for ZSWIM6 (if available)
    TreeFam Gene Tree for ZSWIM6 (if available) 

    Paralogs
    for ZSWIM6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSWIM6 gene
    ZSWIM42  ZSWIM52  ZSWIM82  
    2 SIMAP similar genes for ZSWIM6 using alignment to 1 protein entry:     ZSWM6_HUMAN:
    ZSWIM5    ZSWIM4

    ZSWIM6 for paralogs           About GeneDecksing



    Genomic Variants
    for ZSWIM6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2626 NCBI SNPs in ZSWIM6 are shown (see all 2626)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1868688611,2
    		--60626126(+) CCTAGA/GCATGG 1 -- us2k10--------
    rs1913574551,2
    		--60626334(+) CCGAAA/GCGCGC 1 -- us2k10--------
    rs1834971611,2
    		--60626471(+) CAGTAA/GAAACA 1 -- us2k10--------
    rs1120454571,2
    		--60626506(+) GTCTCC/GGACGC 1 -- us2k12Minor allele frequency- G:0.16CSA WA 120
    rs1491070501,2
    		--60626532(+) GGCTTA/GGAAGC 1 -- us2k10--------
    rs1891046681,2
    		--60626539(+) AAGCAA/GATTTG 1 -- us2k10--------
    rs1431447031,2
    		--60626587(+) TCCAGC/GTTCAG 1 -- us2k10--------
    rs1148935401,2
    		F,--60626596(+) AGAGAG/CGGACT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1932792011,2
    		--60626635(+) CACCAA/GCGAGC 1 -- us2k10--------
    rs1160019881,2
    		F,--60626694(+) CGAGGG/AGACTG 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for ZSWIM6 (60628100 - 60841999 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZSWIM6
         1 CNV: 69073

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    Disorders / Diseases
    for ZSWIM6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ZSWIM6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSWIM6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSWIM6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis. (PubMed id 16427614)1, 3 Kai N....Yuasa S. (2006)
    3. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
    4. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    7. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

    External Searches for ZSWIM6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZSWIM6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57688 HGNC: 29316 AceView: ZSWIM6.1 Ensembl:ENSG00000130449 euGenes: HUgn57688
    ECgene: ZSWIM6 H-InvDB: ZSWIM6

    Other Databases showing ZSWIM6 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1577

    Specialized Databases showing ZSWIM6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSWIM6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZSWIM6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZSWIM6 gene:
    Search GeneIP for patents involving ZSWIM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZSWIM6 gene

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    About This Section

     
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