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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSWIM5 Gene

protein-coding   GIFtS: 41
GCID: GC01M045482

zinc finger, SWIM-type containing 5
  Search for ZSWIM5
in
MalaCards
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 Human Malady Compendium 
Biological research products
for ZSWIM5    

Aliases
for ZSWIM5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger, SWIM-Type Containing 51 2
KIAA15111 3
Zinc Finger SWIM Domain-Containing Protein 52
Zinc Finger, SWIM Domain Containing 52

External Ids:    HGNC: 292991   Entrez Gene: 576432   Ensembl: ENSG000001624157   UniProtKB: Q9P2173   

Export aliases for ZSWIM5 gene to outside databases

Previous GC identifers: GC01M044895 GC01M045151 GC01M045254 GC01M043594


Summaries
for ZSWIM5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for ZSWIM5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSWIM5 gene promoter:
         USF1   Pax-5   RREB-1   USF2   USF-1:USF-2   E4BP4   HNF-1A   N-Myc   USF-1   HNF-1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSWIM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

ZSWIM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSWIM5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045482:  view genomic region     (about GC identifiers)

Start:
 45,482,071 bp from pter      End:
 45,771,881 bp from pter
Size:
 289,811 bases      Orientation:
 minus strand

Proteins
for ZSWIM5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZSWM5_HUMAN, Q9P217 (See protein sequence)
Recommended Name: Zinc finger SWIM domain-containing protein 5  
Size: 1185 amino acids; 130634 Da
Sequence caution: Sequence=BAA96035.1; Type=Erroneous initiation;
Secondary accessions: Q5SXQ9

Explore the universe of human proteins at neXtProt for ZSWIM5: NX_Q9P217

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P217

    • ZSWIM5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065934.1  
    ENSEMBL proteins: 
     ENSP00000352614  

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    Protein Domains /
    Families
    for ZSWIM5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZSWIM5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007527 Znf_SWIM

    Graphical View of Domain Structure for InterPro Entry Q9P217

    ProtoNet protein and cluster: Q9P217

    1 Blocks protein family: IPB007527 SWIM Zn-finger

    UniProtKB/Swiss-Prot: ZSWM5_HUMAN, Q9P217
    Similarity: Contains 1 SWIM-type zinc finger


    Function
    for ZSWIM5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--


    ZSWIM5 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZSWIM5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSWIM5

    Drugs & Compounds
    for ZSWIM5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZSWIM5
    Search CenterWatch for drugs/clinical trials and news about ZSWIM5 / ZSWM5 

    Transcripts
    for ZSWIM5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ZSWIM5 gene: 
    NM_020883.1  

    Unigene Cluster for ZSWIM5:

    Zinc finger, SWIM-type containing 5
    Hs.656613  [show with all ESTs]
    Unigene Representative Sequence: NM_020883
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359600(uc001cnd.2) ENST00000464588

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    hsa-miR-640 hsa-miR-193a-3p hsa-miR-376b hsa-miR-30d hsa-miR-3138 hsa-miR-4267 hsa-miR-30a hsa-miR-192*
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB040944.1 BC013836.1 

    1 DOTS entry:

    DT.106459 

    22 AceView cDNA sequences:

    Z39929 BC013836 BM665606 BM729303 Z43863 AI479419 AB040944 AA676667 
    BQ448086 CB048825 BU150426 AW079608 AI811841 AA776824 AA206184 BG057008 
    BM711793 BQ424913 BX282875 CB048824 W22749 BQ356077 

    GeneLoc Exon Structure


    Expression
    for ZSWIM5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSWIM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATCACATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZSWIM5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ZSWIM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSWIM5

    SOURCE GeneReport for Unigene cluster: Hs.656613
        SABiosciences Custom PCR Arrays for ZSWIM5
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    In Situ
    Assay Products:     
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    Orthologs
    for ZSWIM5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZSWIM5 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZSWIM51 zinc finger, SWIM-type containing 5 77.92(n)
    87.06(a)    		   424591  XM_422431.3  XP_422431.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ZSWIM56
    		 --
    		 89(a)
    		 1 ↔ 1
    		 4(110550598-110596932)
    zebrafish
    (Danio rerio)    		 Actinopterygii zswim51 zinc finger, SWIM-type containing 5 74.37(n)
    84.47(a)    		   100149522  NM_001144819.1  NP_001138291.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0100621 AGAP010062-PA 57.43(n)
    57.59(a)    		   1279493  XM_319218.4  XP_319218.4 


    ENSEMBL Gene Tree for ZSWIM5 (if available)
    TreeFam Gene Tree for ZSWIM5 (if available) 

    Paralogs
    for ZSWIM5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSWIM5 gene
    ZSWIM42  ZSWIM82  ZSWIM62  
    2 SIMAP similar genes for ZSWIM5 using alignment to 1 protein entry:     ZSWM5_HUMAN:
    ZSWIM6    ZSWIM4

    ZSWIM5 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZSWIM5
    PGOHUM00000236931 PGOHUM00000236970 PGOHUM00000245695


    Genomic Variants
    for ZSWIM5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2805 NCBI SNPs in ZSWIM5 are shown (see all 2805)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs726844061,2
    		C,F,--45481853(+) CCACCC/TTTCCT 1 -- int12Minor allele frequency- T:0.07NA EA 240
    rs1910577241,2
    		--45481938(+) TTCTTG/TATCTG 1 -- int10--------
    rs1475357671,2
    		--45481970(+) AGACCA/GCTAGG 1 -- int10--------
    rs1829727451,2
    		--45482005(+) CAGCTA/CCCTGG 1 -- int10--------
    rs1875555981,2
    		--45482043(+) GATGGA/GTTTCA 1 -- int10--------
    rs1926722361,2
    		--45482061(+) AGAGAA/TCACAA 1 -- int10--------
    rs1832325301,2
    		--45482088(+) AATGAC/TCTTTT 1 -- ut310--------
    rs789207991,2
    		F,--45482122(+) GAAAAG/CCACTG 1 -- ut311Minor allele frequency- C:0.06WA 118
    rs1462354121,2
    		C,--45482187(+) CTCTC-/TTTTTT 1 -- ut310--------
    rs1875521481,2
    		--45482440(+) ACACTC/GGTTCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZSWIM5 (45482071 - 45732071 bp, first 250kb of ZSWIM5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZSWIM5
         1 CNV: 63666

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    Disorders / Diseases
    for ZSWIM5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZSWIM5 for disorders           About MalaCards

    ZSWIM5 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ZSWIM5 (1 document)

    Export disorders for ZSWIM5 gene to outside databases

    Publications
    for ZSWIM5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSWIM5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSWIM5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for ZSWIM5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZSWIM5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57643 HGNC: 29299 AceView: ZSWIM5 Ensembl:ENSG00000162415 euGenes: HUgn57643
    ECgene: ZSWIM5 H-InvDB: ZSWIM5

    Other Databases showing ZSWIM5 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1511

    Specialized Databases showing ZSWIM5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSWIM5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZSWIM5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZSWIM5 gene:
    Search GeneIP for patents involving ZSWIM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZSWIM5 gene

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    About This Section

     
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