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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZSWIM4 Gene

protein-coding GIFtS: 41
GCID: GC19P013906

zinc finger, SWIM-type containing 4

Search for ZSWIM4
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger, SWIM-Type Containing 4¹ ²
FLJ12221¹
Zinc Finger SWIM Domain-Containing Protein 4²
Zinc Finger, SWIM Domain Containing 4²

External Ids:	HGNC: 25704¹	Entrez Gene: 65249²	Ensembl: ENSG00000132003⁷	UniProtKB: Q9H7M6³

Export aliases for ZSWIM4 gene to outside databases

Previous GC identifers: GC19P013767 GC19P013477

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZSWIM4 gene promoter:
SRF USF1 Egr-1 SRF (504 AA) Pax-2 Lmo2 USF2 USF-1:USF-2 USF-1 Sox9
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZSWIM4 promoter sequence

Search SABiosciences Chromatin IP Primers for ZSWIM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSWIM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.13 Ensembl cytogenetic band: 19p13.13 HGNC cytogenetic band: 19p13.13

ZSWIM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSWIM4 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P013906: view genomic region (about GC identifiers)

Start:	13,906,274 bp from pter	End:	13,943,044 bp from pter
Size:	36,771 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZSWM4_HUMAN, Q9H7M6 (See protein sequence)

Recommended Name: Zinc finger SWIM domain-containing protein 4

Size: 989 amino acids; 110138 Da

Sequence caution: Sequence=BAB15742.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for ZSWIM4: NX_Q9H7M6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H7M6

ZSWIM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_075560.2

ENSEMBL proteins:

ENSP00000254323 ENSP00000468285 ENSP00000465180 ENSP00000405278

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZSWIM4 for domains About GeneDecksing

1 InterPro domain/family:

IPR007527 Znf_SWIM

Graphical View of Domain Structure for InterPro Entry Q9H7M6

ProtoNet protein and cluster: Q9H7M6

1 Blocks protein family: IPB007527 SWIM Zn-finger

UniProtKB/Swiss-Prot: ZSWM4_HUMAN, Q9H7M6

Similarity: Contains 1 SWIM-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

ZSWIM4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZSWIM4

2 Interacting proteins for ZSWIM4 (Q9H7M6³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EWSR1	Q01844³	I2D: score=1
SSBP3	Q9BWW4³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ZSWIM4
Search CenterWatch for drugs/clinical trials and news about ZSWIM4 / ZSWM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZSWIM4 gene:

NM_023072.2

Unigene Cluster for ZSWIM4:

Zinc finger, SWIM-type containing 4

Hs.466015 [show with all ESTs]

Unigene Representative Sequence: AK024452

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000254323(uc002mxh.1 uc010xng.1) ENST00000590508 ENST00000592227

ENST00000440752

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Additional cDNA sequence:

AK022283.1 AK024452.1 AK299057.1

6 DOTS entries:

DT.95365698 DT.95126799 DT.95156453 DT.102825690 DT.91907233 DT.91864797

24/49 AceView cDNA sequences (see all 49):

BQ892080 BG763782 AU121845 BG828408 CK906063 BG698291 BM127152 AK022283

BM701403 BU429287 BG764264 CD367924 BM674307 BG765226 AI540686 AI368746

BQ212723 AA310926 BM127422 CK906064 AI521434 BG256498 AK024452 BU684945

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM4 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14a	·	14b
SP1:													-				-
SP2:																					-		-		-		-
SP3:																	-

ECgene alternative splicing isoforms for ZSWIM4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZSWIM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTTTCCT

About this image

ZSWIM4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZSWIM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZSWIM4

SOURCE GeneReport for Unigene cluster: Hs.466015

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM4 gene from 2/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ZSWIM4⁶	--	72(a)	1 ↔ 1	2(29078684-29117860)
African clawed frog (Xenopus laevis)	Amphibia	Xl.2486²	Xenopus laevis transcribed sequences	77.45(n)		BU912361.1

ENSEMBL Gene Tree for ZSWIM4 (if available)
TreeFam Gene Tree for ZSWIM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZSWIM4 gene

ZSWIM5² ZSWIM8² ZSWIM6²

2 SIMAP similar genes for ZSWIM4 using alignment to 4 protein entries: ZSWM4_HUMAN (see all proteins):

ZSWIM5 ZSWIM6

ZSWIM4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190862628^1,2		--	13904310(+)	`GCTCAC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs182748763^1,2		--	13904443(+)	`TGGGTA/GCCTGT`	1	--	us2k¹		0	--	--	--	--
rs59238884^1,2	C	--	13904535(+)	`AAAAAA/-GAAAT`	1	--	us2k¹		1		NA	2
rs111602145^1,2		--	13904681(+)	`CCATAA/CTGGAC`	1	--	us2k¹		1		CSA	1
rs60646979^1,2	C	--	13904830(+)	`TTTTT-/TCTGCT`	1	--	us2k¹		0	--	--	--	--
rs78743336^1,2	C	--	13904842(+)	`TTTTTC/TTCTGC`	1	--	us2k¹		1		NA	2
rs138474802^1,2		--	13904957(+)	`GCACAA/GATGGG`	1	--	us2k¹		0	--	--	--	--
rs188120804^1,2		--	13904999(+)	`AGAGGC/GAGAGA`	1	--	us2k¹		0	--	--	--	--
rs191384566^1,2		--	13905022(+)	`AACTAC/TCAAAG`	1	--	us2k¹		0	--	--	--	--
rs142773568^1,2		--	13905055(+)	`TTCAAA/GACCAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZSWIM4 (13906274 - 13943044 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZSWIM4
1 CNV: 5088

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZSWIM4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZSWIM4)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)^{1, 2} Hattori A.... Ohara O. (2000)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 65249	HGNC: 25704	AceView: ZSWIM4	Ensembl:ENSG00000132003	euGenes: HUgn65249
ECgene: ZSWIM4	H-InvDB: ZSWIM4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZSWIM4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZSWIM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZSWIM4 gene:
Search GeneIP for patents involving ZSWIM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZSWIM4 gene at Home site.

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ZSWIM4 Gene

zinc finger, SWIM-type containing 4

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ZSWIM4 Gene

zinc finger, SWIM-type containing 4

Aliasesfor ZSWIM4 gene

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Genomic Viewsfor ZSWIM4 gene

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Specialized Databases showing ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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for ZSWIM4 gene

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