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Aliases for ZSWIM4 Gene

Aliases for ZSWIM4 Gene

  • Zinc Finger SWIM-Type Containing 4 2 3
  • Zinc Finger, SWIM-Type Containing 4 5

External Ids for ZSWIM4 Gene

Previous GeneCards Identifiers for ZSWIM4 Gene

  • GC19P013906
  • GC19P013477

Summaries for ZSWIM4 Gene

GeneCards Summary for ZSWIM4 Gene

ZSWIM4 (Zinc Finger SWIM-Type Containing 4) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM4 Gene

Genomics for ZSWIM4 Gene

Regulatory Elements for ZSWIM4 Gene

Promoters for ZSWIM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZSWIM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSWIM4 Gene

Chromosome:
19
Start:
13,795,434 bp from pter
End:
13,832,254 bp from pter
Size:
36,821 bases
Orientation:
Plus strand

Genomic View for ZSWIM4 Gene

Genes around ZSWIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM4 Gene

Proteins for ZSWIM4 Gene

  • Protein details for ZSWIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7M6-ZSWM4_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 4
    Protein Accession:
    Q9H7M6

    Protein attributes for ZSWIM4 Gene

    Size:
    989 amino acids
    Molecular mass:
    110138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15742.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZSWIM4 Gene

Proteomics data for ZSWIM4 Gene at MOPED

Post-translational modifications for ZSWIM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSWIM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM4 Gene

Domains & Families for ZSWIM4 Gene

Gene Families for ZSWIM4 Gene

Protein Domains for ZSWIM4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7M6

UniProtKB/Swiss-Prot:

ZSWM4_HUMAN :
  • Contains 1 SWIM-type zinc finger.
Similarity:
  • Contains 1 SWIM-type zinc finger.
genes like me logo Genes that share domains with ZSWIM4: view

Function for ZSWIM4 Gene

genes like me logo Genes that share phenotypes with ZSWIM4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM4 Gene

Localization for ZSWIM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSWIM4 Gene COMPARTMENTS Subcellular localization image for ZSWIM4 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM4 Gene

Pathways & Interactions for ZSWIM4 Gene

SuperPathways for ZSWIM4 Gene

No Data Available

Interacting Proteins for ZSWIM4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000254323%0d%0a9606.ENSP00000262982%0d%0a
Selected Interacting proteins: ENSP00000254323 Q9H7M6-ZSWM4_HUMAN for ZSWIM4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ZSWIM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM4 Gene

Drugs & Compounds for ZSWIM4 Gene

No Compound Related Data Available

Transcripts for ZSWIM4 Gene

Unigene Clusters for ZSWIM4 Gene

Zinc finger, SWIM-type containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - - -
SP3: -

Relevant External Links for ZSWIM4 Gene

GeneLoc Exon Structure for
ZSWIM4
ECgene alternative splicing isoforms for
ZSWIM4

Expression for ZSWIM4 Gene

mRNA expression in normal human tissues for ZSWIM4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSWIM4 Gene

This gene is overexpressed in Minor Salivary Gland (x4.6) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for ZSWIM4 Gene

This gene is overexpressed in Serum (36.0) and Heart (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSWIM4 Gene



SOURCE GeneReport for Unigene cluster for ZSWIM4 Gene Hs.466015

genes like me logo Genes that share expression patterns with ZSWIM4: view

Protein tissue co-expression partners for ZSWIM4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZSWIM4 Gene

Orthologs for ZSWIM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM4 36
  • 99 (a)
OneToOne
ZSWIM4 35
  • 99.49 (n)
  • 99.49 (a)
cow
(Bos Taurus)
Mammalia ZSWIM4 35
  • 90.17 (n)
  • 95.96 (a)
ZSWIM4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSWIM4 36
  • 86 (a)
OneToOne
ZSWIM4 35
  • 91 (n)
  • 96.56 (a)
mouse
(Mus musculus)
Mammalia Zswim4 36
  • 83 (a)
OneToOne
Zswim4 16
Zswim4 35
  • 84.66 (n)
  • 93.16 (a)
oppossum
(Monodelphis domestica)
Mammalia ZSWIM4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZSWIM4 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zswim4 35
  • 84.03 (n)
  • 91.71 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 68 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZSWIM4 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2486 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.523 35
zswim4 35
  • 74.97 (n)
  • 79.96 (a)
zebrafish
(Danio rerio)
Actinopterygii zswim5 36
  • 59 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ebax-1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for ZSWIM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZSWIM4 Gene

ENSEMBL:
Gene Tree for ZSWIM4 (if available)
TreeFam:
Gene Tree for ZSWIM4 (if available)

Paralogs for ZSWIM4 Gene

Paralogs for ZSWIM4 Gene

(2) SIMAP similar genes for ZSWIM4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZSWIM4: view

Variants for ZSWIM4 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs237698 -- 13,822,570(+) aggca(C/T)ggtgg intron-variant
rs168288 -- 13,825,038(+) GCttt(G/T)ctttt intron-variant
rs1056882 -- 13,831,890(+) CTTAC(A/T)CTGTT utr-variant-3-prime
rs1056883 -- 13,831,981(+) CCCCC(A/C)CCTTG utr-variant-3-prime
rs1056884 -- 13,832,046(+) CCCTT(C/T)TTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM4 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897
nsv911097 CNV Loss 21882294
nsv911098 CNV Loss 21882294
dgv3738n71 CNV Loss 21882294
esv2665506 CNV Deletion 23128226

Variation tolerance for ZSWIM4 Gene

Residual Variation Intolerance Score: 7.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSWIM4 Gene

HapMap Linkage Disequilibrium report
ZSWIM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM4 Gene

Disorders for ZSWIM4 Gene

Relevant External Links for ZSWIM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSWIM4

No disorders were found for ZSWIM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM4 Gene

Publications for ZSWIM4 Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4 67
  2. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZSWIM4 Gene

Sources for ZSWIM4 Gene

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