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ZSWIM4 Gene

protein-coding   GIFtS: 40
GCID: GC19P013906

Zinc Finger, SWIM-Type Containing 4

  Search for ZSWIM4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, SWIM-Type Containing 41 2
Zinc Finger SWIM Domain-Containing Protein 42
Zinc Finger, SWIM Domain Containing 42

External Ids:    HGNC: 257041   Entrez Gene: 652492   Ensembl: ENSG000001320037   UniProtKB: Q9H7M63   

Export aliases for ZSWIM4 gene to outside databases

Previous GC identifers: GC19P013767 GC19P013477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSWIM4 Gene:
ZSWIM4 (zinc finger, SWIM-type containing 4) is a protein-coding gene. An important paralog of this gene is ZSWIM5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZSWIM4 gene promoter:
         SRF   USF1   Egr-1   SRF (504 AA)   Pax-2   Lmo2   USF2   USF-1:USF-2   USF-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZSWIM4 promoter sequence
   Search Chromatin IP Primers for ZSWIM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSWIM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.13   Ensembl cytogenetic band:  19p13.13   HGNC cytogenetic band: 19p13.13

ZSWIM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSWIM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013906:  view genomic region     (about GC identifiers)

Start:
13,906,274 bp from pter      End:
13,943,044 bp from pter
Size:
36,771 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZSWM4_HUMAN, Q9H7M6 (See protein sequence)
Recommended Name: Zinc finger SWIM domain-containing protein 4  
Size: 989 amino acids; 110138 Da
Sequence caution: Sequence=BAB15742.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for ZSWIM4: NX_Q9H7M6

Explore proteomics data for ZSWIM4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSWIM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075560.2  
    ENSEMBL proteins: 
     ENSP00000254323   ENSP00000468285   ENSP00000465180   ENSP00000405278  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZSWIM: Zinc fingers, SWIM-type

    1 InterPro protein domain:
     IPR007527 Znf_SWIM

    Graphical View of Domain Structure for InterPro Entry Q9H7M6

    ProtoNet protein and cluster: Q9H7M6

    1 Blocks protein domain: IPB007527 SWIM Zn-finger

    UniProtKB/Swiss-Prot: ZSWM4_HUMAN, Q9H7M6
    Similarity: Contains 1 SWIM-type zinc finger


    ZSWIM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ZSWIM4 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZSWIM4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSWIM4
    Interactions:

        Search GeneGlobe Interaction Network for ZSWIM4

    2 Interacting proteins for ZSWIM4 (Q9H7M63) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443I2D: score=1 
    SSBP3Q9BWW43I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSWIM4 (ZSWM4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZSWIM4 gene: 
    NM_023072.2  

    Unigene Cluster for ZSWIM4:

    Zinc finger, SWIM-type containing 4
    Hs.466015  [show with all ESTs]
    Unigene Representative Sequence: AK024452
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254323(uc002mxh.1 uc010xng.1) ENST00000590508 ENST00000592227
    ENST00000440752
    miRNA
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    hsa-miR-194* hsa-miR-219-1-3p hsa-miR-300 hsa-let-7d hsa-miR-429 hsa-let-7g hsa-let-7a hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidZSWIM4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK022283.1 AK024452.1 AK299057.1 

    6 DOTS entries:

    DT.95365698  DT.95126799  DT.95156453  DT.102825690  DT.91907233  DT.91864797 

    Selected AceView cDNA sequences (see all 49):

    BG828408 CK906063 AK022283 BM127152 BG763782 AU121845 BU429287 BG698291 
    BM701403 BG764264 BQ892080 CD367924 BQ212723 AA310926 BG256498 BM674307 
    BG765226 AI540686 AI521434 CK906064 BU684945 AI368746 AK024452 BM127422 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                      -           -                                                               
    SP2:                                                              -     -     -     -                                 
    SP3:                                                  -                                                               


    ECgene alternative splicing isoforms for ZSWIM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSWIM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTTTCCT
    ZSWIM4 Expression
    About this image

    ZSWIM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSWIM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466015
        Custom PCR Arrays for ZSWIM4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZSWIM4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zswim41 , 5 zinc finger, SWIM domain containing 45
    zinc finger SWIM-type containing 41
    84.66(n)1
    93.16(a)1
      8 (40.59 cM)5
    2121681  NM_172503.31  NP_766091.21 
     842109425 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    68(a)
    many ↔ many
    JH375158.1(11400-28058)
    lizard
    (Anolis carolinensis)
    Reptilia ZSWIM46
    zinc finger, SWIM-type containing 4
    73(a)
    1 ↔ 1
    2(29078476-29122324)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24862 Xenopus laevis transcribed sequences 77.45(n)    BU912361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zswim56
    zinc finger, SWIM-type containing 5
    59(a)
    many ↔ many
    2(27639236-27692112) ENSDARG00000055900
    worm
    (Caenorhabditis elegans)
    Secernentea ebax-16
    Protein PQN-55 (pqn-55) mRNA, complete cds
    12(a)
    1 → many
    IV(10286955-10293008) WBGene00004140


    ENSEMBL Gene Tree for ZSWIM4 (if available)
    TreeFam Gene Tree for ZSWIM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSWIM4 gene
    ZSWIM52  ZSWIM82  ZSWIM62  
    2 SIMAP similar genes for ZSWIM4 using alignment to 4 protein entries:     ZSWM4_HUMAN (see all proteins):
    ZSWIM5    ZSWIM6

    ZSWIM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZSWIM4 (see all 1027)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908626281,2
    --13904310(+) GCTCAC/TGCCTG 1 -- us2k10--------
    rs1827487631,2
    C--13904443(+) TGGGTA/GCCTGT 1 -- us2k10--------
    rs1116021451,2
    C,F--13904681(+) CCATAA/CTGGAC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs606469791,2
    C--13904830(+) TTTTT-/TCTGCT 1 -- us2k10--------
    rs787433361,2
    C--13904842(+) TTTTTC/TTCTGC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1384748021,2
    --13904957(+) GCACAA/GATGGG 1 -- us2k10--------
    rs1881208041,2
    --13904999(+) AGAGGC/GAGAGA 1 -- us2k10--------
    rs1913845661,2
    --13905022(+) AACTAC/TCAAAG 1 -- us2k10--------
    rs1427735681,2
    C--13905055(+) TTCAAA/GACCAG 1 -- us2k10--------
    rs1473749041,2
    --13905115(+) CCGGGC/TGTGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZSWIM4 (13906274 - 13943044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZSWIM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665506CNV Deletion23128226
    nsv911097CNV Loss21882294
    nsv833757CNV Loss17160897
    dgv3738n71CNV Loss21882294
    nsv911098CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSWIM4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZSWIM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    2. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    3. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65249 HGNC: 25704 AceView: ZSWIM4 Ensembl:ENSG00000132003 euGenes: HUgn65249
    ECgene: ZSWIM4 H-InvDB: ZSWIM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSWIM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZSWIM4 gene:
    Search GeneIP for patents involving ZSWIM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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