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Aliases for ZSWIM2 Gene

Aliases for ZSWIM2 Gene

  • Zinc Finger SWIM-Type Containing 2 2 3
  • Zinc Finger SWIM Domain-Containing Protein 2 3 4
  • ZZ-Type Zinc Finger-Containing Protein 2 3 4
  • Zinc Finger, SWIM-Type Containing 2 3 5
  • MEKK1-Related Protein X 3 4
  • ZZZ2 3 4
  • MEX 3 4
  • Zinc Finger, SWIM Domain Containing 2 3
  • EC 6.3.2.- 4

External Ids for ZSWIM2 Gene

Previous GeneCards Identifiers for ZSWIM2 Gene

  • GC02M187895
  • GC02M187894
  • GC02M187517
  • GC02M187400
  • GC02M187693
  • GC02M179552

Summaries for ZSWIM2 Gene

GeneCards Summary for ZSWIM2 Gene

ZSWIM2 (Zinc Finger SWIM-Type Containing 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity and protein self-association.

UniProtKB/Swiss-Prot for ZSWIM2 Gene

  • E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM2 Gene

Genomics for ZSWIM2 Gene

Regulatory Elements for ZSWIM2 Gene

Enhancers for ZSWIM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZSWIM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSWIM2 Gene

186,827,480 bp from pter
186,849,208 bp from pter
21,729 bases
Minus strand

Genomic View for ZSWIM2 Gene

Genes around ZSWIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM2 Gene

Proteins for ZSWIM2 Gene

  • Protein details for ZSWIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase ZSWIM2
    Protein Accession:
    Secondary Accessions:
    • B3KXV6
    • Q53SI3
    • Q57ZY3

    Protein attributes for ZSWIM2 Gene

    633 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    • Dimer. Interacts with UBE2D1.

    Three dimensional structures from OCA and Proteopedia for ZSWIM2 Gene

neXtProt entry for ZSWIM2 Gene

Proteomics data for ZSWIM2 Gene at MOPED

Post-translational modifications for ZSWIM2 Gene

  • Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSWIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM2 Gene

Domains & Families for ZSWIM2 Gene

Gene Families for ZSWIM2 Gene

Protein Domains for ZSWIM2 Gene

Suggested Antigen Peptide Sequences for ZSWIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The SWIM-type zinc finger is reqiered for ubiquitination activity.
  • Contains 2 RING-type zinc fingers.
  • The SWIM-type zinc finger is reqiered for ubiquitination activity.
  • Contains 2 RING-type zinc fingers.
  • Contains 1 SWIM-type zinc finger.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with ZSWIM2: view

Function for ZSWIM2 Gene

Molecular function for ZSWIM2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity).

Enzyme Numbers (IUBMB) for ZSWIM2 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0016874 ligase activity IEA --
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with ZSWIM2: view

Phenotypes for ZSWIM2 Gene

GenomeRNAi human phenotypes for ZSWIM2:
genes like me logo Genes that share phenotypes with ZSWIM2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSWIM2 Gene

Localization for ZSWIM2 Gene

Subcellular locations from

Jensen Localization Image for ZSWIM2 Gene COMPARTMENTS Subcellular localization image for ZSWIM2 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM2 Gene

Pathways & Interactions for ZSWIM2 Gene

SuperPathways for ZSWIM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZSWIM2 Gene

Drugs & Compounds for ZSWIM2 Gene

No Compound Related Data Available

Transcripts for ZSWIM2 Gene

mRNA/cDNA for ZSWIM2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM2 Gene

Zinc finger, SWIM-type containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -

Relevant External Links for ZSWIM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSWIM2 Gene

mRNA expression in normal human tissues for ZSWIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ZSWIM2 Gene

This gene is overexpressed in Testis (x31.0) and Pituitary (x5.5).

SOURCE GeneReport for Unigene cluster for ZSWIM2 Gene Hs.375054

genes like me logo Genes that share expression patterns with ZSWIM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZSWIM2 Gene

Orthologs for ZSWIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZSWIM2 35
  • 84.12 (n)
  • 76.74 (a)
  • 77 (a)
(Canis familiaris)
Mammalia ZSWIM2 35
  • 88.39 (n)
  • 86.45 (a)
  • 76 (a)
(Mus musculus)
Mammalia Zswim2 35
  • 77.8 (n)
  • 68.68 (a)
Zswim2 16
Zswim2 36
  • 68 (a)
(Pan troglodytes)
Mammalia ZSWIM2 35
  • 98.74 (n)
  • 98.26 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Zswim2 35
  • 78.17 (n)
  • 70.91 (a)
(Monodelphis domestica)
Mammalia ZSWIM2 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
-- 36
  • 60 (a)
(Anolis carolinensis)
Reptilia ZSWIM2 36
  • 56 (a)
(Danio rerio)
Actinopterygii zgc:165651 35
  • 55.11 (n)
  • 46.46 (a)
  • 35 (a)
Species with no ortholog for ZSWIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM2 Gene

Gene Tree for ZSWIM2 (if available)
Gene Tree for ZSWIM2 (if available)

Paralogs for ZSWIM2 Gene

No data available for Paralogs for ZSWIM2 Gene

Variants for ZSWIM2 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1901342 -- 186,846,094(+) CAAGT(C/G)TTCAT intron-variant
rs3100021 -- 186,848,669(+) AATGC(A/C)AACCA intron-variant
rs3100024 -- 186,840,109(+) ATCGC(A/G)GTTCC intron-variant
rs3100036 -- 186,842,637(+) agcag(A/G)gctcc intron-variant
rs3100041 -- 186,847,078(+) caatg(C/T)tcact intron-variant

Variation tolerance for ZSWIM2 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZSWIM2 Gene

Disorders for ZSWIM2 Gene

Relevant External Links for ZSWIM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZSWIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM2 Gene

Publications for ZSWIM2 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3

Products for ZSWIM2 Gene

Sources for ZSWIM2 Gene