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Aliases for ZSWIM2 Gene

Aliases for ZSWIM2 Gene

  • Zinc Finger, SWIM-Type Containing 2 2 3
  • Zinc Finger SWIM Domain-Containing Protein 2 3 4
  • ZZ-Type Zinc Finger-Containing Protein 2 3 4
  • MEKK1-Related Protein X 3 4
  • ZZZ2 3 4
  • MEX 3 4
  • Zinc Finger, SWIM Domain Containing 2 3
  • E3 Ubiquitin-Protein Ligase ZSWIM2 3
  • EC 6.3.2.- 4

External Ids for ZSWIM2 Gene

Previous GeneCards Identifiers for ZSWIM2 Gene

  • GC02M187895
  • GC02M187894
  • GC02M187517
  • GC02M187400
  • GC02M187693
  • GC02M179552

Summaries for ZSWIM2 Gene

GeneCards Summary for ZSWIM2 Gene

ZSWIM2 (Zinc Finger, SWIM-Type Containing 2) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and protein self-association.

UniProtKB/Swiss-Prot for ZSWIM2 Gene

  • E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM2 Gene

Genomics for ZSWIM2 Gene

Regulatory Elements for ZSWIM2 Gene

Genomic Location for ZSWIM2 Gene

Start:
186,827,480 bp from pter
End:
186,849,208 bp from pter
Size:
21,729 bases
Orientation:
Minus strand

Genomic View for ZSWIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSWIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM2 Gene

Proteins for ZSWIM2 Gene

  • Protein details for ZSWIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEG5-ZSWM2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZSWIM2
    Protein Accession:
    Q8NEG5
    Secondary Accessions:
    • B3KXV6
    • Q53SI3
    • Q57ZY3

    Protein attributes for ZSWIM2 Gene

    Size:
    633 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    • Dimer. Interacts with UBE2D1.

    Three dimensional structures from OCA and Proteopedia for ZSWIM2 Gene

neXtProt entry for ZSWIM2 Gene

Proteomics data for ZSWIM2 Gene at MOPED

Post-translational modifications for ZSWIM2 Gene

  • Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSWIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM2 Gene

Domains for ZSWIM2 Gene

Gene Families for ZSWIM2 Gene

HGNC:
  • ZSWIM :Zinc fingers, SWIM-type
  • ZZZ :Zinc fingers, ZZ-type

Protein Domains for ZSWIM2 Gene

Suggested Antigen Peptide Sequences for ZSWIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEG5

UniProtKB/Swiss-Prot:

ZSWM2_HUMAN :
  • Q8NEG5
Domain:
  • The SWIM-type zinc finger is reqiered for ubiquitination activity.
Similarity:
  • Contains 2 RING-type zinc fingers.
  • Contains 1 SWIM-type zinc finger.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with ZSWIM2: view

Function for ZSWIM2 Gene

Molecular function for ZSWIM2 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity).

Enzyme Numbers (IUBMB) for ZSWIM2 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with ZSWIM2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSWIM2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZSWIM2 Gene

Localization for ZSWIM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSWIM2 Gene COMPARTMENTS Subcellular localization image for ZSWIM2 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM2 Gene

Pathways for ZSWIM2 Gene

SuperPathways for ZSWIM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006915 apoptotic process IEA --
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA --
genes like me logo Genes that share ontologies with ZSWIM2: view

No data available for Pathways by source for ZSWIM2 Gene

Transcripts for ZSWIM2 Gene

mRNA/cDNA for ZSWIM2 Gene

(6) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM2 Gene

Zinc finger, SWIM-type containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSWIM2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZSWIM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for ZSWIM2 Gene

GeneLoc Exon Structure for
ZSWIM2
ECgene alternative splicing isoforms for
ZSWIM2

Expression for ZSWIM2 Gene

mRNA expression in normal human tissues for ZSWIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ZSWIM2 Gene

This gene is overexpressed in Testis (31.0) and Pituitary (5.5).

SOURCE GeneReport for Unigene cluster for ZSWIM2 Gene Hs.375054

genes like me logo Genes that share expressions with ZSWIM2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ZSWIM2 Gene

Orthologs for ZSWIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM2 35
  • 98.74 (n)
  • 98.26 (a)
ZSWIM2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSWIM2 35
  • 84.12 (n)
  • 76.74 (a)
ZSWIM2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSWIM2 35
  • 88.39 (n)
  • 86.45 (a)
ZSWIM2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zswim2 35
  • 77.8 (n)
  • 68.68 (a)
Zswim2 16
Zswim2 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZSWIM2 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zswim2 35
  • 78.17 (n)
  • 70.91 (a)
lizard
(Anolis carolinensis)
Reptilia ZSWIM2 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:165651 35
  • 55.11 (n)
  • 46.46 (a)
ZSWIM2 36
  • 35 (a)
OneToOne
Species with no ortholog for ZSWIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM2 Gene

ENSEMBL:
Gene Tree for ZSWIM2 (if available)
TreeFam:
Gene Tree for ZSWIM2 (if available)

Paralogs for ZSWIM2 Gene

No data available for Paralogs for ZSWIM2 Gene

Variants for ZSWIM2 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1349518 -- 186,844,441(+) AATAC(A/G/T)TAAAT intron-variant
rs1451556 -- 186,849,535(+) TTCAT(C/T)ATCTT upstream-variant-2KB
rs1451557 -- 186,850,343(+) TGGCA(C/G)CTTTC upstream-variant-2KB
rs1451558 -- 186,850,731(+) ATATA(C/T)ATGTG upstream-variant-2KB
rs1901342 -- 186,846,094(+) CAAGT(C/G)TTCAT intron-variant

Relevant External Links for ZSWIM2 Gene

HapMap Linkage Disequilibrium report
ZSWIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSWIM2 Gene

Disorders for ZSWIM2 Gene

Relevant External Links for ZSWIM2

Genetic Association Database (GAD)
ZSWIM2
Human Genome Epidemiology (HuGE) Navigator
ZSWIM2
genes like me logo Genes that share disorders with ZSWIM2: view

No data available for UniProtKB/Swiss-Prot for ZSWIM2 Gene

Publications for ZSWIM2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ZSWIM2 Gene

Sources for ZSWIM2 Gene

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