ZSWIM2 Gene
protein-coding GIFtS: 44
GCID: GC02M187693
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zinc finger, SWIM-type containing 2
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Aliases
for ZSWIM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, SWIM-Type Containing 21 2 | | ZZ-Type Zinc Finger-Containing Protein 22 3 | | ZZZ21 2 3 | | MGC338901 | | Zinc Finger SWIM Domain-Containing Protein 22 3 | | E3 Ubiquitin-Protein Ligase ZSWIM22 | | MEX2 3 | | Zinc Finger, SWIM Domain Containing 22 | | MEKK1-Related Protein X2 3 | | EC 6.3.2.-3 |
Export aliases for ZSWIM2 gene to outside databasesPrevious GC identifers: GC02M187895 GC02M187894 GC02M187517 GC02M187400 GC02M179552 |
Summaries
for ZSWIM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZSWM2_HUMAN, Q8NEG5Function: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions inconjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity)
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Genomic Views
for ZSWIM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZSWIM2 gene promoter:
STAT5B Nkx3-1 Nkx3-1 v4 MEF-2 Nkx3-1 v1 Nkx3-1 v2 HEN1 MEF-2A Nkx3-1 v3 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZSWIM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSWIM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32.2ZSWIM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M187693: view genomic region
(about GC identifiers)
Start:
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187,692,207 bp from pter |
End:
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187,713,935 bp from pter |
Size:
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21,729 bases |
Orientation:
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minus strand |
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Proteins
for ZSWIM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZSWM2_HUMAN, Q8NEG5 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase ZSWIM2 Size: 633 amino acids; 72732 Da
Subunit: Dimer (By similarity). Interacts with UBE2D1 (By similarity)
1 PDB 3D structure from  and Proteopedia  for ZSWIM2:2DIP (3D)
Secondary accessions: B3KXV6 Q53SI3 Q57ZY3Explore the universe of human proteins at neXtProt for ZSWIM2: NX_Q8NEG5
Post-translational modifications:
Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEG5
ZSWIM2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872327.2
ENSEMBL proteins: ENSP00000295131 ENSP00000400595
Human Recombinant Protein Products:
ZSWIM2 Antibody Products:
Assay Products for ZSWIM2: |
Protein
Domains /
Families
for ZSWIM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZSWIM2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NEG5ProtoNet protein and cluster: Q8NEG5 2 Blocks protein families: IPB000433 Zn-finger IPB001841 Zn-finger
UniProtKB/Swiss-Prot: ZSWM2_HUMAN, Q8NEG5Domain: The SWIM-type zinc finger is reqiered for ubiquitination activity (By similarity)Similarity: Contains 2 RING-type zinc fingersSimilarity: Contains 1 SWIM-type zinc fingerSimilarity: Contains 1 ZZ-type zinc finger |
Function
for ZSWIM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZSWM2_HUMAN, Q8NEG5Function: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions inconjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity)Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZSWIM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZSWIM2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSWIM2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSWIM2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZSWIM2 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZSWIM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSWIM2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZSWIM2 (Q8NEG52, 3 ENSP000002951314) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000209 | protein polyubiquitination |
IEA | -- | | GO:0006915 | apoptotic process |
IEA | -- | | GO:0042981 | regulation of apoptotic process |
IEA | -- |
ZSWIM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZSWIM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZSWIM2
Search CenterWatch for drugs/clinical trials and news about ZSWIM2 / ZSWM2
|
Transcripts
for ZSWIM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZSWIM2 gene: NM_182521.2 Unigene Cluster for ZSWIM2: Zinc finger, SWIM-type containing 2 Hs.375054 [show with all ESTs]Unigene Representative Sequence: NM_1825212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000295131(uc002upu.1) ENST00000419862
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZSWIM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZSWIM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZSWIM2 (NM_182521) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZSWIM2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSWIM2 |
Additional cDNA sequence: AK128006.1 BC031094.1 1 DOTS entry: DT.101979115 6 AceView cDNA sequences: NM_182521 BU852709 BC031094 AK128006 BM807593 BI562507
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
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| SP1: | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZSWIM2
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Expression
for ZSWIM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZSWIM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATATTCA
About this image
See ZSWIM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZSWIM2
SOURCE GeneReport for Unigene cluster: Hs.375054
SABiosciences Custom PCR Arrays for ZSWIM2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZSWIM2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZSWIM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSWIM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSWIM2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSWIM2 |
Orthologs
for ZSWIM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZSWIM2 gene from 3/15 species (see all 15) About this table
ENSEMBL Gene Tree for ZSWIM2 (if available)
TreeFam Gene Tree for ZSWIM2 (if available) |
Paralogs
for ZSWIM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZSWIM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZSWIM2 (187692207 - 187713935 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZSWIM2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZSWIM2 |
|
Disorders
/ Diseases
for ZSWIM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZSWIM2 for disorders About GeneDecksing
3  diseases for ZSWIM2: About MalaCardsfanconi's anemia conjunctivitis anemia
Human Genome Epidemiology (HuGE) Navigator: ZSWIM2 (3 documents)
Export disorders for ZSWIM2 gene to outside databases
|
Publications
for ZSWIM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZSWIM2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZSWIM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. (PubMed id 16522193)1 Nishito Y....Nunez G. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for ZSWIM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZSWIM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZSWIM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZSWIM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZSWIM2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZSWIM2 gene:
Search GeneIP for patents involving ZSWIM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZSWIM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZSWIM2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZSWIM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSWIM2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZSWIM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSWIM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSWIM2 |
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 | | | ZSWIM2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSWIM2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZSWIM2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSWIM2 |
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