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Aliases for ZSWIM2 Gene

Aliases for ZSWIM2 Gene

  • Zinc Finger SWIM-Type Containing 2 2 3 5
  • Zinc Finger SWIM Domain-Containing Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase ZSWIM2 3 4
  • ZZ-Type Zinc Finger-Containing Protein 2 3 4
  • MEKK1-Related Protein X 3 4
  • ZZZ2 3 4
  • MEX 3 4
  • Zinc Finger, SWIM Domain Containing 2 3
  • E3 Ubiquitin-Protein Ligase ZSWIM2 3
  • EC 4

External Ids for ZSWIM2 Gene

Previous GeneCards Identifiers for ZSWIM2 Gene

  • GC02M187895
  • GC02M187894
  • GC02M187517
  • GC02M187400
  • GC02M187693
  • GC02M179552

Summaries for ZSWIM2 Gene

GeneCards Summary for ZSWIM2 Gene

ZSWIM2 (Zinc Finger SWIM-Type Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and protein self-association.

UniProtKB/Swiss-Prot for ZSWIM2 Gene

  • E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.

Additional gene information for ZSWIM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM2 Gene

Genomics for ZSWIM2 Gene

GeneHancer (GH) Regulatory Elements for ZSWIM2 Gene

Promoters and enhancers for ZSWIM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I186848 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 555.1 -0.1 -67 1.4 ZSCAN4 ZNF76 SIN3A BMI1 ZNF335 GLIS2 ZNF143 RCOR1 FOS EGR2 ZSWIM2 FAM171B LINC01473 ENSG00000259915 ITGAV GC02M187006 PIR60867
GH02I187539 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -698.0 -698031 16.2 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TFPI CALCRL ZSWIM2 GAPDHP59 ST13P2 GC02M187465 LOC105373786
GH02I186886 Enhancer 1 Ensembl ENCODE 11.4 -38.3 -38296 1.2 MEIS2 PKNOX1 SMAD1 TEAD4 TAL1 BACH1 CEBPG EBF1 BATF IRF9 ZSWIM2 GC02M187006 PIR60867
GH02I186883 Enhancer 0.8 ENCODE 11.4 -35.9 -35870 3.1 HDAC1 MEIS2 PKNOX1 JUN TEAD4 TAL1 CHAMP1 TCF12 CC2D1A CTBP1 ZSWIM2 FAM171B GC02M187006 PIR60867
GH02I186771 Enhancer 0.7 ENCODE 10.6 +77.1 77075 1.7 ESRRA CLOCK NFIB DDX20 NEUROD1 SIN3A EBF1 FEZF1 ZIC2 CTBP1 ZSWIM2 ENSG00000227227
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSWIM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSWIM2 gene promoter:

Genomic Locations for ZSWIM2 Gene

Genomic Locations for ZSWIM2 Gene
21,729 bases
Minus strand

Genomic View for ZSWIM2 Gene

Genes around ZSWIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM2 Gene

Proteins for ZSWIM2 Gene

  • Protein details for ZSWIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase ZSWIM2
    Protein Accession:
    Secondary Accessions:
    • B3KXV6
    • Q53SI3
    • Q57ZY3

    Protein attributes for ZSWIM2 Gene

    633 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    • Dimer. Interacts with UBE2D1.

    Three dimensional structures from OCA and Proteopedia for ZSWIM2 Gene

neXtProt entry for ZSWIM2 Gene

Post-translational modifications for ZSWIM2 Gene

  • Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).

Other Protein References for ZSWIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM2 Gene

Domains & Families for ZSWIM2 Gene

Gene Families for ZSWIM2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZSWIM2 Gene

Suggested Antigen Peptide Sequences for ZSWIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The SWIM-type zinc finger is reqiered for ubiquitination activity.
  • The SWIM-type zinc finger is reqiered for ubiquitination activity.
genes like me logo Genes that share domains with ZSWIM2: view

Function for ZSWIM2 Gene

Molecular function for ZSWIM2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.

Enzyme Numbers (IUBMB) for ZSWIM2 Gene

Phenotypes From GWAS Catalog for ZSWIM2 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0043621 protein self-association IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM2: view

Phenotypes for ZSWIM2 Gene

GenomeRNAi human phenotypes for ZSWIM2:
genes like me logo Genes that share phenotypes with ZSWIM2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSWIM2 Gene

Localization for ZSWIM2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM2 gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZSWIM2 Gene

Pathways & Interactions for ZSWIM2 Gene

SuperPathways for ZSWIM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006915 apoptotic process IEA --
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA --
genes like me logo Genes that share ontologies with ZSWIM2: view

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM2 Gene

Drugs & Compounds for ZSWIM2 Gene

No Compound Related Data Available

Transcripts for ZSWIM2 Gene

mRNA/cDNA for ZSWIM2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM2 Gene

Zinc finger, SWIM-type containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -

Relevant External Links for ZSWIM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSWIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ZSWIM2 Gene

This gene is overexpressed in Testis (x31.0) and Pituitary (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of ZSWIM2 Gene:


SOURCE GeneReport for Unigene cluster for ZSWIM2 Gene:

genes like me logo Genes that share expression patterns with ZSWIM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM2 Gene

Orthologs for ZSWIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZSWIM2 33 34
  • 98.74 (n)
(Canis familiaris)
Mammalia ZSWIM2 33 34
  • 88.39 (n)
(Bos Taurus)
Mammalia ZSWIM2 33 34
  • 84.12 (n)
(Rattus norvegicus)
Mammalia Zswim2 33
  • 78.17 (n)
(Mus musculus)
Mammalia Zswim2 33 16 34
  • 77.8 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
-- 34
  • 40 (a)
(Monodelphis domestica)
Mammalia ZSWIM2 34
  • 54 (a)
(Anolis carolinensis)
Reptilia ZSWIM2 34
  • 56 (a)
(Danio rerio)
Actinopterygii zgc:165651 33
  • 55.11 (n)
  • 35 (a)
Species where no ortholog for ZSWIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM2 Gene

Gene Tree for ZSWIM2 (if available)
Gene Tree for ZSWIM2 (if available)

Paralogs for ZSWIM2 Gene

No data available for Paralogs for ZSWIM2 Gene

Variants for ZSWIM2 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000003166 -- 186,849,048(-) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000303248 -- 186,830,264(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000353435 -- 186,830,117(-) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000579638 -- 186,850,313(-) A/C upstream_transcript_variant
rs1000729022 -- 186,831,203(-) T/C genic_downstream_transcript_variant, intron_variant

Variation tolerance for ZSWIM2 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSWIM2 Gene

Disorders for ZSWIM2 Gene

Additional Disease Information for ZSWIM2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZSWIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM2 Gene

Publications for ZSWIM2 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. (PMID: 16522193) Nishito Y … Núñez G (The Biochemical journal 2006) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZSWIM2 Gene

Sources for ZSWIM2 Gene

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