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Aliases for ZSWIM1 Gene

Aliases for ZSWIM1 Gene

  • Zinc Finger SWIM-Type Containing 1 2 3 5
  • C20orf162 3 4
  • Zinc Finger SWIM Domain-Containing Protein 1 3
  • Zinc Finger, SWIM Domain Containing 1 3
  • Chromosome 20 Open Reading Frame 162 2

External Ids for ZSWIM1 Gene

Previous HGNC Symbols for ZSWIM1 Gene

  • C20orf162

Previous GeneCards Identifiers for ZSWIM1 Gene

  • GC20P045195
  • GC20P043943
  • GC20P044509
  • GC20P041251

Summaries for ZSWIM1 Gene

GeneCards Summary for ZSWIM1 Gene

ZSWIM1 (Zinc Finger SWIM-Type Containing 1) is a Protein Coding gene. An important paralog of this gene is ZSWIM3.

Additional gene information for ZSWIM1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM1 Gene

Genomics for ZSWIM1 Gene

GeneHancer (GH) Regulatory Elements for ZSWIM1 Gene

Promoters and enhancers for ZSWIM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045880 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.5 +0.3 330 1.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZSWIM1 NCOA5 TP53RK PCIF1 CD40 ZNF335 WFDC3 SLC35C2 SPATA25 RPS2P7
GH20I045334 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.2 -538.9 -538862 14.4 CLOCK MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 SDC4 NCOA5 PCIF1 ZNF335 ZSWIM1 CD40 SPATA25 ENSG00000271984 SNX21 DBNDD2
GH20I044909 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 19.4 -970.2 -970197 2.9 HDGF CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 PABPC1L YWHAB ENSG00000271984 ZSWIM1 SPATA25 TOMM34 STK4 STK4-AS1 DBNDD2 PIR52220
GH20I045362 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20 -517.5 -517489 1.9 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SYS1 SYS1-DBNDD2 NCOA5 ZNF335 TP53TG5 PCIF1 ZSWIM1 CD40 ENSG00000271984 NDUFB4P10
GH20I045933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +55.4 55388 6.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCIF1 SNX21 NCOA5 TP53RK SPATA25 ZNF335 PLTP SLC35C2 WFDC3 ENSG00000271984
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSWIM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSWIM1 gene promoter:

Genomic Locations for ZSWIM1 Gene

Genomic Locations for ZSWIM1 Gene
chr20:45,880,942-45,885,266
(GRCh38/hg38)
Size:
4,325 bases
Orientation:
Plus strand
chr20:44,509,848-44,513,905
(GRCh37/hg19)

Genomic View for ZSWIM1 Gene

Genes around ZSWIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM1 Gene

Proteins for ZSWIM1 Gene

  • Protein details for ZSWIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR11-ZSWM1_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 1
    Protein Accession:
    Q9BR11
    Secondary Accessions:
    • Q5JZH2
    • Q9BR12
    • Q9BV30

    Protein attributes for ZSWIM1 Gene

    Size:
    485 amino acids
    Molecular mass:
    55071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSWIM1 Gene

Post-translational modifications for ZSWIM1 Gene

No Post-translational modifications

Other Protein References for ZSWIM1 Gene

No data available for DME Specific Peptides for ZSWIM1 Gene

Domains & Families for ZSWIM1 Gene

Gene Families for ZSWIM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZSWIM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSWIM1: view

No data available for UniProtKB/Swiss-Prot for ZSWIM1 Gene

Function for ZSWIM1 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM1: view
genes like me logo Genes that share phenotypes with ZSWIM1: view

Animal Models for ZSWIM1 Gene

MGI Knock Outs for ZSWIM1:

miRNA for ZSWIM1 Gene

miRTarBase miRNAs that target ZSWIM1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZSWIM1 Gene

Localization for ZSWIM1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM1 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSWIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSWIM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZSWIM1 Gene

Pathways & Interactions for ZSWIM1 Gene

SuperPathways for ZSWIM1 Gene

No Data Available

Interacting Proteins for ZSWIM1 Gene

Selected Interacting proteins: Q9BR11-ZSWM1_HUMAN for ZSWIM1 Gene via IID

Symbol External ID(s) Details
ELAVL1
MAPK14

Gene Ontology (GO) - Biological Process for ZSWIM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM1 Gene

Drugs & Compounds for ZSWIM1 Gene

No Compound Related Data Available

Transcripts for ZSWIM1 Gene

mRNA/cDNA for ZSWIM1 Gene

Unigene Clusters for ZSWIM1 Gene

Zinc finger, SWIM-type containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for ZSWIM1 Gene

GeneLoc Exon Structure for
ZSWIM1
ECgene alternative splicing isoforms for
ZSWIM1

Expression for ZSWIM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSWIM1 Gene:

ZSWIM1

SOURCE GeneReport for Unigene cluster for ZSWIM1 Gene:

Hs.517075

Evidence on tissue expression from TISSUES for ZSWIM1 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZSWIM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM1 Gene

Orthologs for ZSWIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM1 33
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia ZSWIM1 33 34
  • 89.91 (n)
cow
(Bos Taurus)
Mammalia ZSWIM1 33 34
  • 85.38 (n)
rat
(Rattus norvegicus)
Mammalia Zswim1 33
  • 85.05 (n)
mouse
(Mus musculus)
Mammalia Zswim1 33 16 34
  • 84.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSWIM1 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZSWIM1 33
  • 57.03 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim1 33
  • 51.55 (n)
Species where no ortholog for ZSWIM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSWIM1 Gene

ENSEMBL:
Gene Tree for ZSWIM1 (if available)
TreeFam:
Gene Tree for ZSWIM1 (if available)

Paralogs for ZSWIM1 Gene

Paralogs for ZSWIM1 Gene

(1) SIMAP similar genes for ZSWIM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSWIM1: view

Variants for ZSWIM1 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000736491 -- 45,879,469(+) G/A upstream_transcript_variant
rs1001055911 -- 45,883,324(+) C/G coding_sequence_variant, synonymous_variant
rs1001719583 -- 45,881,587(+) A/G intron_variant
rs1002793135 -- 45,880,083(+) G/A upstream_transcript_variant
rs1003195188 -- 45,881,265(+) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM1 Gene

Variant ID Type Subtype PubMed ID
nsv517296 CNV loss 19592680
nsv833990 CNV loss 17160897

Variation tolerance for ZSWIM1 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM1 Gene

Disorders for ZSWIM1 Gene

Additional Disease Information for ZSWIM1

No disorders were found for ZSWIM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM1 Gene

Publications for ZSWIM1 Gene

  1. ZSWIM1: a novel biomarker in T helper cell differentiation. (PMID: 24508175) Ko KK … Hogarth PM (Immunology letters 2014) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZSWIM1 Gene

Sources for ZSWIM1 Gene

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