ZSCAN5B Gene
protein-coding GIFtS: 35
GCID: GC19M056701
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|
zinc finger and SCAN domain containing 5B
| |
Aliases
for ZSCAN5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And SCAN Domain Containing 5B1 2 | | ZNF3711 2 | | ZNF495B1 2 | | Zinc Finger And SCAN Domain-Containing Protein 5B2 |
Export aliases for ZSCAN5B gene to outside databasesPrevious GC identifers: GC19M061397 GC19M053010 |
Summaries
for ZSCAN5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1Function: May be involved in transcriptional regulation (By similarity)
|
Genomic Views
for ZSCAN5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZSCAN5B gene promoter:
SRF Pbx1a SRF (504 AA) HSF1 (long) NF-kappaB AREB6 POU2F1a HSF1short NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZSCAN5B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN5B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.42ZSCAN5B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M056701: view genomic region
(about GC identifiers)
Start:
|
56,700,949 bp from pter |
End:
|
56,709,289 bp from pter |
Size:
|
8,341 bases |
Orientation:
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minus strand |
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Proteins
for ZSCAN5B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1 (See
protein sequence)Recommended Name: Zinc finger and SCAN domain-containing protein 5B Size: 495 amino acids; 55826 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for ZSCAN5B: NX_A6NJL1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NJL1
ZSCAN5B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073925.2
ENSEMBL proteins: ENSP00000466072 ENSP00000465118 ENSP00000468660 ENSP00000351883
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZSCAN5B for ontologies About GeneDecksing
ZSCAN5B Antibody Products:
Assay Products for ZSCAN5B: |
Protein
Domains /
Families
for ZSCAN5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZSCAN5B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NJL1ProtoNet protein and cluster: A6NJL1 UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1Similarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 SCAN box domain |
Function
for ZSCAN5B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1Function: May be involved in transcriptional regulation (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN5B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZSCAN5B for ontologies About GeneDecksing
|
Pathways & Interactions
for ZSCAN5B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN5B
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZSCAN5B for ontologies About GeneDecksing
|
Drugs & Compounds
for ZSCAN5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZSCAN5B
Search CenterWatch for drugs/clinical trials and news about ZSCAN5B / ZSA5B
|
Transcripts
for ZSCAN5B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZSCAN5B gene: NM_001080456.2 Unigene Cluster for ZSCAN5B: Zinc finger and SCAN domain containing 5B Hs.132130 [show with all ESTs]Unigene Representative Sequence: NM_0010804564 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586855 ENST00000589938 ENST00000587032 ENST00000358992(uc010ygh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN5B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZSCAN5B (NM_001080456) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZSCAN5B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN5B |
1 DOTS entry: DT.40129144 24/47 AceView cDNA sequences (see all 47): CA310351 BU753182 BI520206 R27198 BU616538 BP371211 BU535566 BG055866 AA961935 BC002636 BI829761 BM563481 AW614347 AK098700 BQ024588 NM_024303 BE391420 AI699820 BI334413 BQ428522 BX366909 AI201290 BI560465 AI224867
GeneLoc Exon Structure
|
Expression
for ZSCAN5B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZSCAN5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACGTGTGC
About this image
See ZSCAN5B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.132130
SABiosciences Custom PCR Arrays for ZSCAN5B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZSCAN5B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZSCAN5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN5B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5B |
Orthologs
for ZSCAN5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZSCAN5B gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
BX324198.26 |
-- |
18(a) |
1 → many |
7(19676949-19685583) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cf26Kr6 |
Kruppel |
18(a)15(a) |
possible ortholog1 ↔ many |
2L(4876890-4883341) 2R(21114134-21118917) |
ENSEMBL Gene Tree for ZSCAN5B (if available)
TreeFam Gene Tree for ZSCAN5B (if available) |
Paralogs
for ZSCAN5B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZSCAN5B gene
- ZSCAN5A2 ZSCAN5C2
18/75 SIMAP similar genes for ZSCAN5B using alignment to 3 protein entries: ZSA5B_HUMAN (see all proteins)
(see all similar genes):ZSCAN5C ZSCAN5A ZSCAN5D DKFZp434J0650 ZNF585B ZNF
ZNF78L1 kr-znf3 zf30 ZNF664 ZFS-5 ZNF18
ZNF396 ZSCAN10 ZNF32 ZNF625 ZNF844 DKFZp434G1930
ZSCAN5B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZSCAN5B
PGOHUM00000260497
|
Genomic Variants
for ZSCAN5B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZSCAN5B (56700949 - 56709289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZSCAN5B
1 Inversion: 59752 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZSCAN5B |
|
Disorders
/ Diseases
for ZSCAN5B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZSCAN5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZSCAN5B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZSCAN5B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for ZSCAN5B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZSCAN5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZSCAN5B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZSCAN5B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZSCAN5B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZSCAN5B gene:
Search GeneIP for patents involving ZSCAN5B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZSCAN5B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | ZSCAN5B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5B |
|  |  |  | | | | Search ThermoFisher Antibodies for ZSCAN5B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN5B |
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