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ZSCAN5B Gene

protein-coding   GIFtS: 37
GCID: GC19M056701

Zinc Finger And SCAN Domain Containing 5B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And SCAN Domain Containing 5B1 2
ZNF3712
ZNF495B2
Zinc Finger And SCAN Domain-Containing Protein 5B2

External Ids:    HGNC: 342461   Entrez Gene: 3429332   Ensembl: ENSG000001972137   UniProtKB: A6NJL13   

Export aliases for ZSCAN5B gene to outside databases

Previous GC identifers: GC19M061397 GC19M053010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSCAN5B Gene:
ZSCAN5B (zinc finger and SCAN domain containing 5B) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZSCAN5A.

UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZSCAN5B gene promoter:
         SRF   Pbx1a   SRF (504 AA)   HSF1 (long)   NF-kappaB   AREB6   POU2F1a   HSF1short   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZSCAN5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSCAN5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.42

ZSCAN5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN5B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056701:  view genomic region     (about GC identifiers)

Start:
56,700,939 bp from pter      End:
56,709,289 bp from pter
Size:
8,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 5B  
Size: 495 amino acids; 55826 Da

Explore the universe of human proteins at neXtProt for ZSCAN5B: NX_A6NJL1

Explore proteomics data for ZSCAN5B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSCAN5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073925.2  
    ENSEMBL proteins: 
     ENSP00000466072   ENSP00000465118   ENSP00000468660   ENSP00000351883  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry A6NJL1

    ProtoNet protein and cluster: A6NJL1

    UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with ZSCAN5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSA5B_HUMAN, A6NJL1
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZSCAN5B           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZSA5B_HUMAN, A6NJL1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    Find genes that share ontologies with ZSCAN5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSCAN5B
    Interactions:

        Search GeneGlobe Interaction Network for ZSCAN5B

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ZSCAN5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSCAN5B (ZSA5B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZSCAN5B gene: 
    NM_001080456.2  

    Unigene Cluster for ZSCAN5B:

    Zinc finger and SCAN domain containing 5B
    Hs.132130  [show with all ESTs]
    Unigene Representative Sequence: NM_001080456
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586855 ENST00000589938 ENST00000587032 ENST00000358992(uc010ygh.2)

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      QuantiFast Probe-based Assays in human, mouse, rat ZSCAN5B

    1 DOTS entry:

    DT.40129144 

    Selected AceView cDNA sequences (see all 47):

    BP371211 BU535566 BU616538 BG055866 AK098700 BI829761 NM_024303 BU753182 
    AW614347 CA310351 BE391420 BC002636 BM563481 BI520206 R27198 AI699820 
    BQ024588 AA961935 BX366909 AI224867 AI041519 BI560465 BG721125 AI201290 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSCAN5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACGTGTGC
    ZSCAN5B Expression
    About this image

    ZSCAN5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSCAN5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132130
        Custom PCR Arrays for ZSCAN5B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZSCAN5B gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zscan5b1 , 5 zinc finger and SCAN domain containing 5B1, 5 58.94(n)1
    47.54(a)1
      7 (3.61 cM)5
    1707341  NM_133204.21  NP_573467.21 
     62222785 


    ENSEMBL Gene Tree for ZSCAN5B (if available)
    TreeFam Gene Tree for ZSCAN5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSCAN5B gene
    ZSCAN5A2  ZSCAN5DP2  ZSCAN5C2  
    Selected SIMAP similar genes for ZSCAN5B using alignment to 3 protein entries:     ZSA5B_HUMAN (see all proteins) (see all similar genes):
    ZSCAN5C    ZSCAN5A    ZSCAN5D    DKFZp434J0650    ZNF585B    ZNF
    ZNF78L1    kr-znf3    zf30    ZKSCAN2    ZNF664    ZFS-5
    ZNF18    ZNF396    ZSCAN10    ZNF32    ZNF625    ZNF844

    Find genes that share paralogs with ZSCAN5B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZSCAN5B
    PGOHUM00000260497


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZSCAN5B (see all 229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921652901,2
    --56700652(+) GGATAC/TATACC 1 -- ds50010--------
    rs1827449911,2
    --56700666(+) TGCCTA/CGAATA 1 -- ds50010--------
    rs1416445971,2
    --56700777(+) TCACTC/TGCTTG 1 -- ds50010--------
    rs783880691,2
    C,F--56700880(+) CAAACC/ATCCTG 1 -- ds50011Minor allele frequency- A:0.16EA 120
    rs736175601,2
    C,F--56701034(+) AGACAT/AAATCA 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1873543051,2
    --56701108(+) AAGTGC/TTTTAT 1 -- ut310--------
    rs1932933711,2
    --56701139(+) CATTGG/TAGAAA 1 -- ut310--------
    rs2019292421,2
    C--56701205(+) TGGGAA/GGTGGT 2 T syn10--------
    rs1854912431,2
    C--56701233(+) GGTGAC/TGCTTG 2 H R mis10--------
    rs2015111481,2
    --56701255(+) CTGACA/GGAAGG 2 R C mis10--------

    HapMap Linkage Disequilibrium report for ZSCAN5B (56700939 - 56709289 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZSCAN5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663363CNV Deletion23128226
    dgv206n21CNV Loss19592680
    nsv828646CNV Loss20364138
    nsv828647CNV Loss20364138
    nsv912516CNV Gain21882294
    esv5726OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSCAN5B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZSCAN5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342933 HGNC: 34246 AceView: ZNF495 Ensembl:ENSG00000197213 euGenes: HUgn342933
    ECgene: ZSCAN5B H-InvDB: ZSCAN5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSCAN5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZSCAN5B gene:
    Search GeneIP for patents involving ZSCAN5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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