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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSCAN5B Gene

protein-coding   GIFtS: 37
GCID: GC19M056701

Zinc Finger And SCAN Domain Containing 5B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 5B1 2
ZNF3712
ZNF495B2
Zinc Finger And SCAN Domain-Containing Protein 5B2

External Ids:    HGNC: 342461   Entrez Gene: 3429332   Ensembl: ENSG000001972137   UniProtKB: A6NJL13   

Export aliases for ZSCAN5B gene to outside databases

Previous GC identifers: GC19M061397 GC19M053010


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZSCAN5B Gene: 
ZSCAN5B (zinc finger and SCAN domain containing 5B) is a protein-coding gene. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZSCAN5A.

UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSCAN5B gene promoter:
         SRF   Pbx1a   SRF (504 AA)   HSF1 (long)   NF-kappaB   AREB6   POU2F1a   HSF1short   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZSCAN5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.42

ZSCAN5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN5B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056701:  view genomic region     (about GC identifiers)

Start:
56,700,939 bp from pter      End:
56,709,289 bp from pter
Size:
8,351 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 5B  
Size: 495 amino acids; 55826 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for ZSCAN5B: NX_A6NJL1

Explore proteomics data for ZSCAN5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NJL1

  • ZSCAN5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZSCAN5B Protein Expression
    REFSEQ proteins: NP_001073925.2  
    ENSEMBL proteins: 
     ENSP00000466072   ENSP00000465118   ENSP00000468660   ENSP00000351883  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    ZSCAN5B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry A6NJL1

    ProtoNet protein and cluster: A6NJL1

    UniProtKB/Swiss-Prot: ZSA5B_HUMAN, A6NJL1
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    ZSCAN5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSA5B_HUMAN, A6NJL1
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZSCAN5B for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN5B

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0016032viral process ----

    ZSCAN5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSCAN5B (ZSA5B)

    Search CenterWatch for drugs/clinical trials and news about ZSCAN5B / ZSA5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZSCAN5B gene: 
    NM_001080456.2  

    Unigene Cluster for ZSCAN5B:

    Zinc finger and SCAN domain containing 5B
    Hs.132130  [show with all ESTs]
    Unigene Representative Sequence: NM_001080456
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586855 ENST00000589938 ENST00000587032 ENST00000358992(uc010ygh.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    1 DOTS entry:

    DT.40129144 

    24/47 AceView cDNA sequences (see all 47):

    BU753182 AI699820 BG055866 BI829761 AW614347 BM563481 R27198 BU616538 
    NM_024303 CA310351 AK098700 BC002636 AA961935 BI520206 BQ024588 BP371211 
    BU535566 BE391420 BG334103 BQ428522 BI334413 BI520841 BX366910 BM556563 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSCAN5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACGTGTGC
    ZSCAN5B Expression
    About this image


    See ZSCAN5B Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.132130
        SABiosciences Custom PCR Arrays for ZSCAN5B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZSCAN5B gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zscan5b1 , 5 zinc finger and SCAN domain containing 5B1, 5 58.9(n)1
    47.29(a)1
      7 (3.61 cM)5
    1707341  NM_133204.21  NP_573467.21 
     62222785 


    ENSEMBL Gene Tree for ZSCAN5B (if available)
    TreeFam Gene Tree for ZSCAN5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSCAN5B gene
    ZSCAN5A2  ZSCAN5C2  ZSCAN5D2  
    18/81 SIMAP similar genes for ZSCAN5B using alignment to 3 protein entries:     ZSA5B_HUMAN (see all proteins) (see all similar genes):
    ZSCAN5C    ZSCAN5A    ZSCAN5D    DKFZp434J0650    ZNF585B    ZNF
    ZNF78L1    kr-znf3    zf30    ZKSCAN2    ZNF664    ZFS-5
    ZNF18    ZNF396    ZSCAN10    ZNF32    ZNF625    ZNF844

    ZSCAN5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZSCAN5B
    PGOHUM00000260497


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/229 SNPs in ZSCAN5B are shown (see all 229)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921652901,2
    --56700652(+) GGATAC/TATACC 1 -- ds50010--------
    rs1827449911,2
    --56700666(+) TGCCTA/CGAATA 1 -- ds50010--------
    rs1416445971,2
    --56700777(+) TCACTC/TGCTTG 1 -- ds50010--------
    rs783880691,2
    C,F--56700880(+) CAAACC/ATCCTG 1 -- ds50011Minor allele frequency- A:0.16EA 120
    rs736175601,2
    C,F--56701034(+) AGACAT/AAATCA 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1873543051,2
    --56701108(+) AAGTGC/TTTTAT 1 -- ut310--------
    rs1932933711,2
    --56701139(+) CATTGG/TAGAAA 1 -- ut310--------
    rs2019292421,2
    C--56701205(+) TGGGAA/GGTGGT 2 T syn10--------
    rs1854912431,2
    C--56701233(+) GGTGAC/TGCTTG 2 H R mis10--------
    rs2015111481,2
    --56701255(+) CTGACA/GGAAGG 2 R C mis10--------

    HapMap Linkage Disequilibrium report for ZSCAN5B (56700939 - 56709289 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZSCAN5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663363CNV Deletion23128226
    dgv206n21CNV Loss19592680
    nsv828646CNV Loss20364138
    nsv828647CNV Loss20364138
    nsv912516CNV Gain21882294
    esv5726OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSCAN5B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSCAN5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 342933 HGNC: 34246 AceView: ZNF495 Ensembl:ENSG00000197213 euGenes: HUgn342933
    ECgene: ZSCAN5B H-InvDB: ZSCAN5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSCAN5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZSCAN5B gene:
    Search GeneIP for patents involving ZSCAN5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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