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ZSCAN5A Gene

protein-coding   GIFtS: 45
GCID: GC19M056732

Zinc Finger And SCAN Domain Containing 5A

(Previous names: zinc finger protein 495, zinc finger and SCAN domain containing...)
(Previous symbols: ZNF495, ZSCAN5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And SCAN Domain Containing 5A1 2
Zinc Finger Protein 4951 2 3
ZNF4951 2 3
ZSCAN51 2 3
Zinc Finger And SCAN Domain Containing 51 2
Zinc Finger And SCAN Domain-Containing Protein 5A2

External Ids:    HGNC: 237101   Entrez Gene: 791492   Ensembl: ENSG000001318487   UniProtKB: Q9BUG63   

Export aliases for ZSCAN5A gene to outside databases

Previous GC identifers: GC19M061426 GC19M053042


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSCAN5A Gene:
ZSCAN5A (zinc finger and SCAN domain containing 5A) is a protein-coding gene. Diseases associated with ZSCAN5A include breast and colorectal cancer, and colorectal cancer. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZSCAN5DP.

UniProtKB/Swiss-Prot: ZSA5A_HUMAN, Q9BUG6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZSCAN5A gene promoter:
         AREB6   POU2F1   POU2F1a   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZSCAN5A promoter sequence
   Search Chromatin IP Primers for ZSCAN5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSCAN5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZSCAN5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN5A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056732:  view genomic region     (about GC identifiers)

Start:
56,732,679 bp from pter      End:
56,879,752 bp from pter
Size:
147,074 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZSA5A_HUMAN, Q9BUG6 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 5A  
Size: 496 amino acids; 55865 Da
Secondary accessions: Q49A73 Q53F04 Q8N7B3

Explore the universe of human proteins at neXtProt for ZSCAN5A: NX_Q9BUG6

Explore proteomics data for ZSCAN5A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSCAN5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077279.1  
    ENSEMBL proteins: 
     ENSP00000375593   ENSP00000467238   ENSP00000467631   ENSP00000466445   ENSP00000464936  
     ENSP00000468797   ENSP00000468008   ENSP00000468675   ENSP00000466830   ENSP00000254165  

    ZSCAN5A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZSCAN5A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9BUG6

    ProtoNet protein and cluster: Q9BUG6

    1 Blocks protein domain: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: ZSA5A_HUMAN, Q9BUG6
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    ZSCAN5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSA5A_HUMAN, Q9BUG6
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0046872metal ion binding IEA--
         
    ZSCAN5A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZSCAN5A:
     Increased 8N DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZSCAN5A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZSCAN5A
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZSCAN5A

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZSCAN5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN5A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZSA5A_HUMAN, Q9BUG6: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    ZSCAN5A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSCAN5A
    Interactions:

        Search GeneGlobe Interaction Network for ZSCAN5A

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    ZSCAN5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSCAN5A (ZSA5A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZSCAN5A gene: 
    NM_024303.1  

    Unigene Cluster for ZSCAN5A:

    Zinc finger and SCAN domain containing 5A
    Hs.177688  [show with all ESTs]
    Unigene Representative Sequence: BC043232
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391713(uc002qmq.3 uc002qmr.3 uc002qms.1) ENST00000592355
    ENST00000587340 ENST00000587492 ENST00000593106 ENST00000592101 ENST00000592509
    ENST00000588955 ENST00000588442 ENST00000592679 ENST00000590675 ENST00000586031
    ENST00000591078 ENST00000589279 ENST00000585670 ENST00000587075 ENST00000587614
    ENST00000254165(uc010ygi.2)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZSCAN5A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZSCAN5A
    SwitchGear 3'UTR luciferase reporter plasmidZSCAN5A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZSCAN5A
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZSCAN5A (NM_024303)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN5A
    Primer
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    OriGene qPCR primer pairs and template standards for ZSCAN5A
    OriGene qSTAR qPCR primer pairs in human, mouse for ZSCAN5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZSCAN5A
      QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN5A
      QuantiFast Probe-based Assays in human, mouse, rat ZSCAN5A

    Additional mRNA sequence: 

    AK098700.1 AK223485.1 AK301873.1 AK310500.1 BC002636.1 BC043232.1 

    9 DOTS entries:

    DT.407669  DT.100770533  DT.100770535  DT.92420440  DT.97840260  DT.97774941  DT.210582  DT.121490855 
    DT.121491014 

    Selected AceView cDNA sequences (see all 47):

    CA310351 BM563481 AK098700 BU535566 BU753182 BU616538 BP371211 AA961935 
    BE391420 BI829761 BG055866 R27198 BC002636 NM_024303 BQ024588 AW614347 
    BI520206 AI699820 BI334413 AI768104 AI224867 BE463585 BG721125 BM556563 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN5A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                                      
    SP2:                          -                           
    SP3:                                                      
    SP4:                          -                           
    SP5:        -     -     -     -                           


    ECgene alternative splicing isoforms for ZSCAN5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSCAN5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGGCGTC
    ZSCAN5A Expression
    About this image

    ZSCAN5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSCAN5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.177688
        Custom PCR Arrays for ZSCAN5A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for ZSCAN5A (if available)
    TreeFam Gene Tree for ZSCAN5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSCAN5A gene
    ZSCAN5DP2  ZSCAN5C2  ZSCAN5B2  
    Selected SIMAP similar genes for ZSCAN5A using alignment to 8 protein entries:     ZSA5A_HUMAN (see all proteins) (see all similar genes):
    ZSCAN5C    ZSCAN5B    ZSCAN5D    kr-znf3    ZNF782    ZSCAN23
    DKFZp666M039    ZNF26    ZNF391    ZNF394    LOC100128510    ZNF78L1
    ZNF678    ZSCAN10    ZSCAN30    ZNF112    ZNF28    ZNF286B

    ZSCAN5A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZSCAN5A (see all 333)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356034
    A colorectal cancer sample4--see VAR_0356032 E Q mis40--------
    rs1382715651,2
    --56732315(+) GTCTCA/GGCTGC 1 -- int10--------
    rs1112612991,2
    C,F--56732323(+) TGCTCG/TGGAGG 1 -- int12Minor allele frequency- T:0.12CSA WA 120
    rs1175046171,2
    C,F--56732325(+) CTCGGG/AAGGCT 1 -- int12Minor allele frequency- A:0.10NA EA 240
    rs104156161,2
    C,F,H--56732335(+) TTAGAC/TGGGAG 1 -- int113Minor allele frequency- T:0.25NA WA CSA EA 377
    rs1438662661,2
    --56732336(+) TAGATA/GGGAGG 1 -- int10--------
    rs1854967601,2
    --56732348(+) TTGCTC/TGAGCC 1 -- int10--------
    rs1445810551,2
    C--56732362(+) AAGGTC/TGCGGC 1 -- int10--------
    rs736194321,2
    C,F--56732363(+) AGGTCG/TCGGCT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs126106591,2
    H--56732391(+) tgccaA/Ctgaac 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZSCAN5A (56732679 - 56879752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZSCAN5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719027CNV Deletion23290073
    nsv828646CNV Loss20364138
    nsv828647CNV Loss20364138
    esv7336CNV Loss19470904
    nsv912516CNV Gain21882294
    esv5726OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZSCAN5A
    DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZSCAN5A:    About MalaCards
    breast and colorectal cancer    colorectal cancer


    ZSCAN5A for disorders           About GeneDecksing


    Export disorders for ZSCAN5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSCAN5A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZSCAN5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    3. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79149 HGNC: 23710 AceView: ZNF495 Ensembl:ENSG00000131848 euGenes: HUgn79149
    ECgene: ZSCAN5A H-InvDB: ZSCAN5A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSCAN5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZSCAN5A gene:
    Search GeneIP for patents involving ZSCAN5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZSCAN5A  
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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