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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSCAN5A Gene

protein-coding   GIFtS: 45
GCID: GC19M056732

Zinc Finger And SCAN Domain Containing 5A

(Previous names: zinc finger protein 495, zinc finger and SCAN domain containing...)
(Previous symbols: ZNF495, ZSCAN5)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 5A1 2
Zinc Finger Protein 4951 2 3
ZNF4951 2 3
ZSCAN51 2 3
Zinc Finger And SCAN Domain Containing 51 2
Zinc Finger And SCAN Domain-Containing Protein 5A2

External Ids:    HGNC: 237101   Entrez Gene: 791492   Ensembl: ENSG000001318487   UniProtKB: Q9BUG63   

Export aliases for ZSCAN5A gene to outside databases

Previous GC identifers: GC19M061426 GC19M053042


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZSCAN5A Gene: 
ZSCAN5A (zinc finger and SCAN domain containing 5A) is a protein-coding gene. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZSCAN5C.

UniProtKB/Swiss-Prot: ZSA5A_HUMAN, Q9BUG6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSCAN5A gene promoter:
         AREB6   POU2F1   POU2F1a   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZSCAN5A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZSCAN5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZSCAN5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN5A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056732:  view genomic region     (about GC identifiers)

Start:
56,732,679 bp from pter      End:
56,879,752 bp from pter
Size:
147,074 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZSA5A_HUMAN, Q9BUG6 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 5A  
Size: 496 amino acids; 55865 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q49A73 Q53F04 Q8N7B3

Explore the universe of human proteins at neXtProt for ZSCAN5A: NX_Q9BUG6

Explore proteomics data for ZSCAN5A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUG6

  • ZSCAN5A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZSCAN5A Protein Expression
    REFSEQ proteins: NP_077279.1  
    ENSEMBL proteins: 
     ENSP00000375593   ENSP00000467238   ENSP00000467631   ENSP00000466445   ENSP00000464936  
     ENSP00000468797   ENSP00000468008   ENSP00000468675   ENSP00000466830   ENSP00000254165  

    Human Recombinant Protein Products for ZSCAN5A: 
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    Novus Biologicals ZSCAN5A Protein
    Novus Biologicals ZSCAN5A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZSCAN5A 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    ZSCAN5A for ontologies           About GeneDecksing



    ZSCAN5A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry Q9BUG6

    ProtoNet protein and cluster: Q9BUG6

    1 Blocks protein domain: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: ZSA5A_HUMAN, Q9BUG6
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    ZSCAN5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSA5A_HUMAN, Q9BUG6
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0008270zinc ion binding ----
         
    ZSCAN5A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZSCAN5A:
     Increased 8N DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZSCAN5A 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN5A

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0016032viral process ----

    ZSCAN5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSCAN5A (ZSA5A)

    Search CenterWatch for drugs/clinical trials and news about ZSCAN5A / ZSA5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZSCAN5A gene: 
    NM_024303.1  

    Unigene Cluster for ZSCAN5A:

    Zinc finger and SCAN domain containing 5A
    Hs.177688  [show with all ESTs]
    Unigene Representative Sequence: BC043232
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391713(uc002qmq.3 uc002qmr.3 uc002qms.1) ENST00000592355
    ENST00000587340 ENST00000587492 ENST00000593106 ENST00000592101 ENST00000592509
    ENST00000588955 ENST00000588442 ENST00000592679 ENST00000590675 ENST00000586031
    ENST00000591078 ENST00000589279 ENST00000585670 ENST00000587075 ENST00000587614
    ENST00000254165(uc010ygi.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZSCAN5A
    SwitchGear 3'UTR luciferase reporter plasmidZSCAN5A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZSCAN5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZSCAN5A
    Clone
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    OriGene clones in human, mouse for ZSCAN5A (see all 4)
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    GenScript: all cDNA clones in your preferred vector: ZSCAN5A (NM_024303)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZSCAN5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN5A
    Sirion Biotech Customized lentivirus for stable overexpression of ZSCAN5A 
                         Customized lentivirus expression plasmids for stable overexpression of ZSCAN5A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZSCAN5A
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZSCAN5A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN5A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN5A

    Additional mRNA sequence: 

    AK098700.1 AK223485.1 AK301873.1 AK310500.1 BC002636.1 BC043232.1 

    9 DOTS entries:

    DT.407669  DT.100770533  DT.100770535  DT.92420440  DT.97840260  DT.97774941  DT.210582  DT.121490855 
    DT.121491014 

    24/47 AceView cDNA sequences (see all 47):

    BI520206 R27198 BM563481 BU535566 NM_024303 BQ024588 AK098700 BU753182 
    BP371211 BE391420 BI829761 AA961935 AW614347 CA310351 BC002636 BU616538 
    BG055866 AI699820 BI334413 BE463585 AI768104 AI201290 AI224867 BI520841 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN5A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                                      
    SP2:                          -                           
    SP3:                                                      
    SP4:                          -                           
    SP5:        -     -     -     -                           


    ECgene alternative splicing isoforms for ZSCAN5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSCAN5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGGCGTC
    ZSCAN5A Expression
    About this image


    See ZSCAN5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSCAN5A

    SOURCE GeneReport for Unigene cluster: Hs.177688
        SABiosciences Custom PCR Arrays for ZSCAN5A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZSCAN5A (if available)
    TreeFam Gene Tree for ZSCAN5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSCAN5A gene
    ZSCAN5C2  ZSCAN5B2  ZSCAN5D2  
    18/190 SIMAP similar genes for ZSCAN5A using alignment to 8 protein entries:     ZSA5A_HUMAN (see all proteins) (see all similar genes):
    ZSCAN5C    ZSCAN5B    ZSCAN5D    kr-znf3    ZNF782    ZSCAN23
    DKFZp666M039    ZNF26    ZNF391    ZNF394    LOC100128510    ZNF78L1
    ZNF678    ZSCAN10    ZSCAN30    ZNF112    ZNF135    ZNF28

    ZSCAN5A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 SNPs in ZSCAN5A are shown (see all 333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356034
    A colorectal cancer sample4--see VAR_0356032 E Q mis40--------
    rs1382715651,2
    --56732315(+) GTCTCA/GGCTGC 1 -- int10--------
    rs1112612991,2
    C,F--56732323(+) TGCTCG/TGGAGG 1 -- int12Minor allele frequency- T:0.12CSA WA 120
    rs1175046171,2
    C,F--56732325(+) CTCGGG/AAGGCT 1 -- int12Minor allele frequency- A:0.10NA EA 240
    rs104156161,2
    C,F,H--56732335(+) TTAGAC/TGGGAG 1 -- int113Minor allele frequency- T:0.25NA WA CSA EA 377
    rs1438662661,2
    --56732336(+) TAGATA/GGGAGG 1 -- int10--------
    rs1854967601,2
    --56732348(+) TTGCTC/TGAGCC 1 -- int10--------
    rs1445810551,2
    C--56732362(+) AAGGTC/TGCGGC 1 -- int10--------
    rs736194321,2
    C,F--56732363(+) AGGTCG/TCGGCT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs126106591,2
    H--56732391(+) tgccaA/Ctgaac 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZSCAN5A (56732679 - 56879752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZSCAN5A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719027CNV Deletion23290073
    nsv828646CNV Loss20364138
    nsv828647CNV Loss20364138
    esv7336CNV Loss19470904
    nsv912516CNV Gain21882294
    esv5726OTHER Inversion19470904

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSCAN5A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSCAN5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79149 HGNC: 23710 AceView: ZNF495 Ensembl:ENSG00000131848 euGenes: HUgn79149
    ECgene: ZSCAN5A H-InvDB: ZSCAN5A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSCAN5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZSCAN5A gene:
    Search GeneIP for patents involving ZSCAN5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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