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Aliases for ZSCAN4 Gene

Aliases for ZSCAN4 Gene

  • Zinc Finger And SCAN Domain Containing 4 2 3 5
  • Zinc Finger Protein 494 2 3 4
  • ZNF494 3 4

External Ids for ZSCAN4 Gene

Previous HGNC Symbols for ZSCAN4 Gene

  • ZNF494

Previous GeneCards Identifiers for ZSCAN4 Gene

  • GC19P062874
  • GC19P062875
  • GC19P058180
  • GC19P054492
  • GC19P057668

Summaries for ZSCAN4 Gene

Entrez Gene Summary for ZSCAN4 Gene

  • The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

GeneCards Summary for ZSCAN4 Gene

ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZSCAN4 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN4 Gene

Genomics for ZSCAN4 Gene

Regulatory Elements for ZSCAN4 Gene

Genomic Location for ZSCAN4 Gene

Chromosome:
19
Start:
57,651,504 bp from pter
End:
57,679,152 bp from pter
Size:
27,649 bases
Orientation:
Plus strand

Genomic View for ZSCAN4 Gene

Genes around ZSCAN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN4 Gene

Proteins for ZSCAN4 Gene

  • Protein details for ZSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAM6-ZSCA4_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 4
    Protein Accession:
    Q8NAM6
    Secondary Accessions:
    • Q3MIQ2

    Protein attributes for ZSCAN4 Gene

    Size:
    433 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN4 Gene

Proteomics data for ZSCAN4 Gene at MOPED

Post-translational modifications for ZSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZSCAN4 Gene

Domains & Families for ZSCAN4 Gene

Gene Families for ZSCAN4 Gene

Suggested Antigen Peptide Sequences for ZSCAN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAM6

UniProtKB/Swiss-Prot:

ZSCA4_HUMAN :
  • Contains 1 SCAN box domain.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN4: view

Function for ZSCAN4 Gene

Molecular function for ZSCAN4 Gene

UniProtKB/Swiss-Prot Function:
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
genes like me logo Genes that share phenotypes with ZSCAN4: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN4 Gene

miRTarBase miRNAs that target ZSCAN4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN4 Gene

Localization for ZSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN4 Gene COMPARTMENTS Subcellular localization image for ZSCAN4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZSCAN4 Gene

Pathways & Interactions for ZSCAN4 Gene

SuperPathways for ZSCAN4 Gene

No Data Available

Interacting Proteins for ZSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZSCAN4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN4 Gene

Drugs & Compounds for ZSCAN4 Gene

No Compound Related Data Available

Transcripts for ZSCAN4 Gene

mRNA/cDNA for ZSCAN4 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN4 Gene

Zinc finger and SCAN domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN4 Gene

No ASD Table

Relevant External Links for ZSCAN4 Gene

GeneLoc Exon Structure for
ZSCAN4
ECgene alternative splicing isoforms for
ZSCAN4

Expression for ZSCAN4 Gene

mRNA expression in normal human tissues for ZSCAN4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN4 Gene

This gene is overexpressed in Cervix - Endocervix (x6.4) and Bladder (x6.2).

SOURCE GeneReport for Unigene cluster for ZSCAN4 Gene Hs.469663

genes like me logo Genes that share expression patterns with ZSCAN4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZSCAN4 Gene

Orthologs for ZSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN4 35
  • 99.46 (n)
  • 98.61 (a)
ZSCAN4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN4 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
ZSCAN4 35
  • 75.18 (n)
  • 60.19 (a)
mouse
(Mus musculus)
Mammalia Zscan4b 36
  • 36 (a)
OneToMany
Zscan4c 36
  • 36 (a)
OneToMany
Zscan4d 36
  • 36 (a)
OneToMany
Zscan4e 36
  • 36 (a)
OneToMany
Zscan4f 36
  • 36 (a)
OneToMany
Species with no ortholog for ZSCAN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN4 Gene

ENSEMBL:
Gene Tree for ZSCAN4 (if available)
TreeFam:
Gene Tree for ZSCAN4 (if available)

Paralogs for ZSCAN4 Gene

(9) SIMAP similar genes for ZSCAN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN4: view

No data available for Paralogs for ZSCAN4 Gene

Variants for ZSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11668570 - 57,678,762(+) CTCAT(A/C/G)AGAGA reference, missense
rs2360528 -- 57,669,987(-) aggca(A/G)aggct intron-variant
rs2360529 -- 57,669,980(-) GGCTA(C/G)AGTGA intron-variant
rs2360530 -- 57,669,785(-) CGCCC(C/T)ACTGA intron-variant
rs2360531 -- 57,669,590(-) aatta(C/G)ccagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN4 Gene

Variant ID Type Subtype PubMed ID
dgv4028n71 CNV Loss 21882294
nsv912528 CNV Gain 21882294

Variation tolerance for ZSCAN4 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN4 Gene

HapMap Linkage Disequilibrium report
ZSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Disorders for ZSCAN4 Gene

Relevant External Links for ZSCAN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN4

No disorders were found for ZSCAN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN4 Gene

Publications for ZSCAN4 Gene

  1. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. (PMID: 24735877) Dan J. … Liu L. (Dev. Cell 2014) 2 3 67
  2. Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status. (PMID: 24840609) Lee K. … Gollahon L.S. (Cancer Biol. Ther. 2014) 3
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. Zscan4 regulates telomere elongation and genomic stability in ES cells. (PMID: 20336070) Zalzman M. … Ko M.S. (Nature 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZSCAN4 Gene

Sources for ZSCAN4 Gene

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