ZSCAN4 Gene
protein-coding GIFtS: 44
GCID: GC19P058180
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zinc finger and SCAN domain containing 4(Previous name: zinc finger protein 494 )
(Previous symbol: ZNF494)
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Aliases
for ZSCAN4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And SCAN Domain Containing 41 2 | | ZNF4941 2 3 5 | | Zinc Finger Protein 4941 2 3 | | FLJ351051 | | Zinc Finger And SCAN Domain-Containing Protein 42 |
Export aliases for ZSCAN4 gene to outside databasesPrevious GC identifers: GC19P062874 GC19P062875 GC19P054492 |
Summaries
for ZSCAN4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZSCAN4:
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouseembryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many celldivisions in culture (Zalzman et al., 2010 (PubMed 20336070)).(supplied by OMIM, May 2010)
UniProtKB/Swiss-Prot: ZSCA4_HUMAN, Q8NAM6Function: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Bindstelomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as anactivator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated EScells (By similarity)
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Genomic Views
for ZSCAN4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZSCAN4 gene promoter:
SRF Elk-1 FOXF2 SRF (504 AA) POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 FOXC1 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZSCAN4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZSCAN4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P058180: view genomic region
(about GC identifiers)
Start:
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58,180,303 bp from pter |
End:
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58,190,520 bp from pter |
Size:
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10,218 bases |
Orientation:
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plus strand |
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Proteins
for ZSCAN4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZSCA4_HUMAN, Q8NAM6 (See
protein sequence)Recommended Name: Zinc finger and SCAN domain-containing protein 4 Size: 433 amino acids; 48957 Da
Subcellular location: Nucleus (By similarity). Chromosome, telomere (By similarity)
Secondary accessions: Q3MIQ2Explore the universe of human proteins at neXtProt for ZSCAN4: NX_Q8NAM6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NAM6
ZSCAN4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689890.1
ENSEMBL proteins: ENSP00000321963
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000784 | nuclear chromosome, telomeric region |
ISS | -- |
ZSCAN4 for ontologies About GeneDecksing
ZSCAN4 Antibody Products:
Assay Products for ZSCAN4: |
Protein
Domains /
Families
for ZSCAN4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZSCAN4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NAM6ProtoNet protein and cluster: Q8NAM6 1 Blocks protein family: IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZSCA4_HUMAN, Q8NAM6Similarity: Contains 4 C2H2-type zinc fingersSimilarity: Contains 1 SCAN box domain |
Function
for ZSCAN4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZSCA4_HUMAN, Q8NAM6Function: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Bindstelomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as anactivator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated EScells (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZSCAN4 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZSCAN4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN4
2 Interacting proteins for ZSCAN4 (Q8NAM62, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0010833 | telomere maintenance via telomere lengthening |
ISS | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZSCAN4 for ontologies About GeneDecksing
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Drugs & Compounds
for ZSCAN4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZSCAN4
Search CenterWatch for drugs/clinical trials and news about ZSCAN4 / ZSCA4
|
Transcripts
for ZSCAN4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZSCAN4 gene: NM_152677.2 Unigene Cluster for ZSCAN4: Zinc finger and SCAN domain containing 4 Hs.469663 [show with all ESTs]Unigene Representative Sequence: NM_1526771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000318203(uc002qpu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZSCAN4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZSCAN4 (NM_152677) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZSCAN4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN4 |
Additional cDNA sequence: AK092424.1 BC101738.1 BC101740.1 1 DOTS entry: DT.75129322 6 AceView cDNA sequences: AI138628 AX747538 AK092424 NM_152677 BX118882 BG572132
GeneLoc Exon Structure
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Expression
for ZSCAN4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZSCAN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTTGTCA
About this image
See ZSCAN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZSCAN4
SOURCE GeneReport for Unigene cluster: Hs.469663
SABiosciences Custom PCR Arrays for ZSCAN4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZSCAN4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZSCAN4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN4 |
Orthologs
for ZSCAN4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for ZSCAN4 gene from 3/12 species (see all 12) About this table
Species with no ortholog for ZSCAN4
ENSEMBL Gene Tree for ZSCAN4 (if available)
TreeFam Gene Tree for ZSCAN4 (if available) |
Paralogs
for ZSCAN4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZSCAN4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZSCAN4 (58180303 - 58190520 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZSCAN4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZSCAN4 |
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Disorders
/ Diseases
for ZSCAN4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZSCAN4 for disorders About MalaCards
ZSCAN4 for disorders About GeneDecksing
OMIM gene information: 613419
OMIM disorders: --
Export disorders for ZSCAN4 gene to outside databases
|
Publications
for ZSCAN4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZSCAN4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZSCAN4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Zscan4 regulates telomere elongation and genomic stab ility in ES cells. (PubMed id 20336070)1 Zalzman M....Ko M.S. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZSCAN4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZSCAN4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZSCAN4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZSCAN4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZSCAN4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZSCAN4 gene:
Search GeneIP for patents involving ZSCAN4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZSCAN4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ZSCAN4 | | OriGene Custom Protein Services for ZSCAN4 | | | OriGene Custom Immunoassay Development | | |
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 | | | ZSCAN4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN4 |
|  |  |  | | | | ThermoFisher Antibodies for ZSCAN4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN4 |
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