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Aliases for ZSCAN4 Gene

Aliases for ZSCAN4 Gene

  • Zinc Finger And SCAN Domain Containing 4 2 3
  • Zinc Finger Protein 494 2 3 4
  • ZNF494 3 4 6
  • Zinc Finger And SCAN Domain-Containing Protein 4 3

External Ids for ZSCAN4 Gene

Previous HGNC Symbols for ZSCAN4 Gene

  • ZNF494

Previous GeneCards Identifiers for ZSCAN4 Gene

  • GC19P062874
  • GC19P062875
  • GC19P058180
  • GC19P054492

Summaries for ZSCAN4 Gene

Entrez Gene Summary for ZSCAN4 Gene

  • The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

GeneCards Summary for ZSCAN4 Gene

ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZSCAN4 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN4 Gene

Genomics for ZSCAN4 Gene

Regulatory Elements for ZSCAN4 Gene

Genomic Location for ZSCAN4 Gene

Start:
57,668,935 bp from pter
End:
57,679,152 bp from pter
Size:
10,218 bases
Orientation:
Plus strand

Genomic View for ZSCAN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN4 Gene

Proteins for ZSCAN4 Gene

  • Protein details for ZSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAM6-ZSCA4_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 4
    Protein Accession:
    Q8NAM6
    Secondary Accessions:
    • Q3MIQ2

    Protein attributes for ZSCAN4 Gene

    Size:
    433 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN4 Gene

Proteomics data for ZSCAN4 Gene at MOPED

Post-translational modifications for ZSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZSCAN4 Gene

Domains for ZSCAN4 Gene

Gene Families for ZSCAN4 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZSCAN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAM6

UniProtKB/Swiss-Prot:

ZSCA4_HUMAN :
  • Q8NAM6
Domain:
  • Contains 1 SCAN box domain.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN4: view

Function for ZSCAN4 Gene

Molecular function for ZSCAN4 Gene

UniProtKB/Swiss-Prot Function:
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

Gene Ontology (GO) - Molecular Function for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN4: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN4 Gene

miRTarBase miRNAs that target ZSCAN4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSCAN4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZSCAN4 Gene

Localization for ZSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN4 Gene COMPARTMENTS Subcellular localization image for ZSCAN4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region ISS --
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with ZSCAN4: view

Pathways for ZSCAN4 Gene

SuperPathways for ZSCAN4 Gene

No Data Available

Interacting Proteins for ZSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010833 telomere maintenance via telomere lengthening ISS --
genes like me logo Genes that share ontologies with ZSCAN4: view

No data available for Pathways by source for ZSCAN4 Gene

Transcripts for ZSCAN4 Gene

mRNA/cDNA for ZSCAN4 Gene

(3) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN4 Gene

Zinc finger and SCAN domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSCAN4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN4 Gene

No ASD Table

Relevant External Links for ZSCAN4 Gene

GeneLoc Exon Structure for
ZSCAN4
ECgene alternative splicing isoforms for
ZSCAN4

Expression for ZSCAN4 Gene

mRNA expression in normal human tissues for ZSCAN4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN4 Gene

This gene is overexpressed in Cervix - Endocervix (6.4) and Bladder (6.2).

SOURCE GeneReport for Unigene cluster for ZSCAN4 Gene Hs.469663

genes like me logo Genes that share expressions with ZSCAN4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ZSCAN4 Gene

Orthologs for ZSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZSCAN4 35
  • 75.18 (n)
  • 60.19 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN4 35
  • 99.46 (n)
  • 98.61 (a)
ZSCAN4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN4 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan4b 36
  • 36 (a)
OneToMany
Zscan4c 36
  • 36 (a)
OneToMany
Zscan4d 36
  • 36 (a)
OneToMany
Zscan4e 36
  • 36 (a)
OneToMany
Zscan4f 36
  • 36 (a)
OneToMany
Species with no ortholog for ZSCAN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN4 Gene

ENSEMBL:
Gene Tree for ZSCAN4 (if available)
TreeFam:
Gene Tree for ZSCAN4 (if available)

Paralogs for ZSCAN4 Gene

Selected SIMAP similar genes for ZSCAN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN4: view

No data available for Paralogs for ZSCAN4 Gene

Variants for ZSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2106945 -- 57,669,420(+) ttttt(G/T)tgtgt intron-variant, upstream-variant-2KB
rs2360526 -- 57,670,056(-) GCATG(C/G)TGGTG intron-variant, upstream-variant-2KB
rs2360527 -- 57,670,041(-) cctgt(A/G)atccc intron-variant, upstream-variant-2KB
rs2360528 -- 57,669,987(-) aggca(A/G)aggct intron-variant, upstream-variant-2KB
rs2360529 -- 57,669,980(-) GGCTA(C/G)AGTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN4 Gene

Variant ID Type Subtype PubMed ID
dgv4028n71 CNV Loss 21882294
nsv912528 CNV Gain 21882294

Relevant External Links for ZSCAN4 Gene

HapMap Linkage Disequilibrium report
ZSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Disorders for ZSCAN4 Gene

No disorders were found for ZSCAN4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZSCAN4 Gene

Publications for ZSCAN4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. (PMID: 24735877) Dan J. … Liu L. (Dev. Cell 2014) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZSCAN4 Gene

Sources for ZSCAN4 Gene

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