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Aliases for ZSCAN4 Gene

Aliases for ZSCAN4 Gene

  • Zinc Finger And SCAN Domain Containing 4 2 3 5
  • Zinc Finger Protein 494 2 3 4
  • ZNF494 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 4 3

External Ids for ZSCAN4 Gene

Previous HGNC Symbols for ZSCAN4 Gene

  • ZNF494

Previous GeneCards Identifiers for ZSCAN4 Gene

  • GC19P062874
  • GC19P062875
  • GC19P058180
  • GC19P054492
  • GC19P057668

Summaries for ZSCAN4 Gene

Entrez Gene Summary for ZSCAN4 Gene

  • The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

GeneCards Summary for ZSCAN4 Gene

ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. Diseases associated with ZSCAN4 include Facioscapulohumeral Muscular Dystrophy 1. Among its related pathways are Preimplantation Embryo. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZSCAN4 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

Additional gene information for ZSCAN4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN4 Gene

Genomics for ZSCAN4 Gene

Regulatory Elements for ZSCAN4 Gene

Enhancers for ZSCAN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H058517 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +868.2 868205 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZNF324B ZNF446 TRIM28 ZNF134 ZNF549 ZNF417 ZNF606 ZNF135 MZF1 ZNF274
GH19H058325 1.2 ENCODE 10.3 +675.4 675367 3 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 ZNF134 ZNF606 ZNF549 ZNF446 ZNF17 ZNF135 ZNF417 ZNF324B TRIM28 LOC100128398
GH19H057681 1.1 ENCODE 10.6 +30.6 30643 1 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF416 ZNF143 ZNF207 SP3 ZHX2 ZNF17 ZNF549 ZNF304 ZNF134 ZNF773 ZNF446 ZNF211 ZNF135 ZNF544 ZNF551
GH19H058181 1.1 ENCODE 10.3 +531.7 531733 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF773 ZNF550 ZNF543 ZNF256 LOC105372483
GH19H057769 1 ENCODE 9.9 +118.7 118720 2 PKNOX1 ATF1 SIN3A YY1 ETS1 ZNF766 CBX5 ELK1 ZNF207 ZNF143 ZNF814 ZNF776 ZNF586 ZNF671 ZNF417 ZNF154 ZNF256 RPL19P19 ZSCAN4 ZNF419
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSCAN4 Gene

Chromosome:
19
Start:
57,651,504 bp from pter
End:
57,679,152 bp from pter
Size:
27,649 bases
Orientation:
Plus strand

Genomic View for ZSCAN4 Gene

Genes around ZSCAN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN4 Gene

Proteins for ZSCAN4 Gene

  • Protein details for ZSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAM6-ZSCA4_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 4
    Protein Accession:
    Q8NAM6
    Secondary Accessions:
    • Q3MIQ2

    Protein attributes for ZSCAN4 Gene

    Size:
    433 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN4 Gene

Post-translational modifications for ZSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN4 Gene

No data available for DME Specific Peptides for ZSCAN4 Gene

Domains & Families for ZSCAN4 Gene

Gene Families for ZSCAN4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN4 Gene

Suggested Antigen Peptide Sequences for ZSCAN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSCAN4: view

No data available for UniProtKB/Swiss-Prot for ZSCAN4 Gene

Function for ZSCAN4 Gene

Molecular function for ZSCAN4 Gene

UniProtKB/Swiss-Prot Function:
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

Gene Ontology (GO) - Molecular Function for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN4: view
genes like me logo Genes that share phenotypes with ZSCAN4: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN4 Gene

miRTarBase miRNAs that target ZSCAN4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZSCAN4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN4 Gene

Localization for ZSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region ISS 20336070
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZSCAN4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZSCAN4 Gene

Pathways & Interactions for ZSCAN4 Gene

SuperPathways for ZSCAN4 Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with ZSCAN4: view

Pathways by source for ZSCAN4 Gene

1 BioSystems pathway for ZSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010833 telomere maintenance via telomere lengthening ISS 20336070
GO:0045950 negative regulation of mitotic recombination ISS 20336070
genes like me logo Genes that share ontologies with ZSCAN4: view

No data available for SIGNOR curated interactions for ZSCAN4 Gene

Drugs & Compounds for ZSCAN4 Gene

No Compound Related Data Available

Transcripts for ZSCAN4 Gene

mRNA/cDNA for ZSCAN4 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN4 Gene

Zinc finger and SCAN domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZSCAN4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN4 Gene

No ASD Table

Relevant External Links for ZSCAN4 Gene

GeneLoc Exon Structure for
ZSCAN4
ECgene alternative splicing isoforms for
ZSCAN4

Expression for ZSCAN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN4 Gene

This gene is overexpressed in Cervix - Endocervix (x6.4) and Bladder (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN4 Gene:

ZSCAN4

SOURCE GeneReport for Unigene cluster for ZSCAN4 Gene:

Hs.469663

Evidence on tissue expression from TISSUES for ZSCAN4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZSCAN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN4 Gene

Orthologs for ZSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN4 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia ZSCAN4 33
  • 75.18 (n)
-- 34
  • 56 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZSCAN4 34
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan4b 34
  • 36 (a)
OneToMany
Zscan4c 34
  • 36 (a)
OneToMany
Zscan4d 34
  • 36 (a)
OneToMany
Zscan4e 34
  • 36 (a)
OneToMany
Zscan4f 34
  • 36 (a)
OneToMany
Species where no ortholog for ZSCAN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN4 Gene

ENSEMBL:
Gene Tree for ZSCAN4 (if available)
TreeFam:
Gene Tree for ZSCAN4 (if available)

Paralogs for ZSCAN4 Gene

(9) SIMAP similar genes for ZSCAN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN4: view

No data available for Paralogs for ZSCAN4 Gene

Variants for ZSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000170822 -- 57,664,202(+) GAGGA(A/C)GGGAG intron-variant, downstream-variant-500B
rs1000342500 -- 57,657,954(+) TGCAT(G/T)TTCAG intron-variant, upstream-variant-2KB
rs1000360902 -- 57,679,160(+) ATGTT(C/G)ATATC downstream-variant-500B
rs1000576195 -- 57,667,913(+) TTGTT(C/T)GTTTT intron-variant, upstream-variant-2KB
rs1000587331 -- 57,650,612(+) GATGG(A/G)GTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN4 Gene

Variant ID Type Subtype PubMed ID
nsv580402 CNV gain 21841781

Variation tolerance for ZSCAN4 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Disorders for ZSCAN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSCAN4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZSCAN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN4
genes like me logo Genes that share disorders with ZSCAN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN4 Gene

Publications for ZSCAN4 Gene

  1. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. (PMID: 24735877) Dan J … Liu L (Developmental cell 2014) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos. (PMID: 27699651) Ishiguro KI … Ko MS (In vitro cellular & developmental biology. Animal 2017) 3 60
  5. Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis. (PMID: 27699653) Ishiguro KI … Ko MS (In vitro cellular & developmental biology. Animal 2017) 3 60

Products for ZSCAN4 Gene

Sources for ZSCAN4 Gene

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