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Aliases for ZSCAN31 Gene

Aliases for ZSCAN31 Gene

  • Zinc Finger And SCAN Domain Containing 31 2 3 5
  • Zinc Finger Protein 323 2 3 4
  • ZNF310P 3 4
  • ZNF323 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 31 3
  • Zinc Finger Protein 310 Pseudogene 2
  • ZNF20-Lp 3

External Ids for ZSCAN31 Gene

Previous HGNC Symbols for ZSCAN31 Gene

  • ZNF310P
  • ZNF323

Previous GeneCards Identifiers for ZSCAN31 Gene

  • GC06M028296
  • GC06M028325

Summaries for ZSCAN31 Gene

Entrez Gene Summary for ZSCAN31 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for ZSCAN31 Gene

ZSCAN31 (Zinc Finger And SCAN Domain Containing 31) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN12.

UniProtKB/Swiss-Prot for ZSCAN31 Gene

  • May function as a transcription factor. May be involved in the development of multiple embryonic organs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN31 Gene

Genomics for ZSCAN31 Gene

Regulatory Elements for ZSCAN31 Gene

Enhancers for ZSCAN31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F028211 1.4 Ensembl ENCODE 21.8 +143.7 143737 2.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF143 ZKSCAN8 ZKSCAN3 ZNF603P ZKSCAN4 ZSCAN9 ZSCAN31 NKAPL ZNF311 ZSCAN23 PGBD1
GH06F028382 1.4 Ensembl ENCODE 17.4 -27.1 -27129 1.9 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZKSCAN3 ZNF603P ZKSCAN8 ZSCAN23 ZSCAN31 ZNF311 ZNF192P1 NKAPL ZKSCAN4 ZSCAN16
GH06F028266 1.1 ENCODE 20.8 +88.8 88786 2.4 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZKSCAN8 ZKSCAN3 ZSCAN31 ZNF603P ZNF311 ZSCAN23 ZNF165 ZSCAN12 ZNF391 LOC102724889
GH06F028398 1.2 ENCODE 14.8 -43.0 -43048 2.5 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF603P ZKSCAN3 ZKSCAN8 ZSCAN23 ZSCAN31 ZNF311 ZNF192P1 ZKSCAN4 COX11P1 OR2E1P
GH06F028334 1.2 ENCODE 14.2 +20.0 19970 4.0 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZKSCAN4 ZKSCAN8 ZNF603P ZSCAN23 ZSCAN31 ZKSCAN3 NKAPL TRIM27 OR2B7P ZNF391
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN31 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214530 271 801 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ZNF143

Genomic Location for ZSCAN31 Gene

Chromosome:
6
Start:
28,312,837 bp from pter
End:
28,356,271 bp from pter
Size:
43,435 bases
Orientation:
Minus strand

Genomic View for ZSCAN31 Gene

Genes around ZSCAN31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN31 Gene

Proteins for ZSCAN31 Gene

  • Protein details for ZSCAN31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW9-ZSC31_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 31
    Protein Accession:
    Q96LW9
    Secondary Accessions:
    • Q6P178
    • Q8WWS5

    Protein attributes for ZSCAN31 Gene

    Size:
    406 amino acids
    Molecular mass:
    47293 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN31 Gene

Post-translational modifications for ZSCAN31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN31 Gene

Domains & Families for ZSCAN31 Gene

Gene Families for ZSCAN31 Gene

Suggested Antigen Peptide Sequences for ZSCAN31 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LW9

UniProtKB/Swiss-Prot:

ZSC31_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN31: view

Function for ZSCAN31 Gene

Molecular function for ZSCAN31 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. May be involved in the development of multiple embryonic organs.

Gene Ontology (GO) - Molecular Function for ZSCAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN31: view
genes like me logo Genes that share phenotypes with ZSCAN31: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN31 Gene

Localization for ZSCAN31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN31 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZSCAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZSCAN31: view

Pathways & Interactions for ZSCAN31 Gene

SuperPathways for ZSCAN31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN31: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN31 Gene

Transcripts for ZSCAN31 Gene

Unigene Clusters for ZSCAN31 Gene

Zinc finger and SCAN domain containing 31:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN31 Gene

No ASD Table

Relevant External Links for ZSCAN31 Gene

GeneLoc Exon Structure for
ZSCAN31
ECgene alternative splicing isoforms for
ZSCAN31

Expression for ZSCAN31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSCAN31 Gene

This gene is overexpressed in Skin (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSCAN31 Gene



Protein tissue co-expression partners for ZSCAN31 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN31 Gene:

ZSCAN31

SOURCE GeneReport for Unigene cluster for ZSCAN31 Gene:

Hs.656413

mRNA Expression by UniProt/SwissProt for ZSCAN31 Gene:

Q96LW9-ZSC31_HUMAN
Tissue specificity: Expressed at high levels in the lung, liver, and kidney, while weakly expressed in intestine, brain, muscle, cholecyst, heart, and pancreas.
genes like me logo Genes that share expression patterns with ZSCAN31: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZSCAN31 Gene

Orthologs for ZSCAN31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF323 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia ZNF323 34 35
  • 86.54 (n)
dog
(Canis familiaris)
Mammalia ZSCAN31 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 30 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 35
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZSCAN31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN31 Gene

ENSEMBL:
Gene Tree for ZSCAN31 (if available)
TreeFam:
Gene Tree for ZSCAN31 (if available)

Paralogs for ZSCAN31 Gene

Pseudogenes.org Pseudogenes for ZSCAN31 Gene

genes like me logo Genes that share paralogs with ZSCAN31: view

Variants for ZSCAN31 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10484542 -- 28,341,976(-) AAATA(C/T)GTTTT intron-variant
rs10591593 -- 28,347,766(+) TGGGC(-/CAAT)GTGTG intron-variant
rs10599228 -- 28,349,199(+) ATATA(-/TA)GGTGT intron-variant, upstream-variant-2KB
rs10611941 -- 28,338,089(+) AAAAA(-/C)AAAAA intron-variant, upstream-variant-2KB
rs111403132 -- 28,348,924(+) TGTCT(-/CA)TATAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN31 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897
esv3416573 CNV insertion 20981092
esv3349303 CNV insertion 20981092
esv3309931 CNV mobile element insertion 20981092
esv3307746 CNV mobile element insertion 20981092

Variation tolerance for ZSCAN31 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN31 Gene

Disorders for ZSCAN31 Gene

Relevant External Links for ZSCAN31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN31

No disorders were found for ZSCAN31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN31 Gene

Publications for ZSCAN31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. A novel human SCAN/(Cys)2(His)2 zinc-finger transcription factor ZNF323 in early human embryonic development. (PMID: 12147252) Pi H. … Liu M. (Biochem. Biophys. Res. Commun. 2002) 3 4 64
  4. Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function. (PMID: 25759474) Luo X.J. … Yao Y.G. (Schizophr Bull 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZSCAN31 Gene

Sources for ZSCAN31 Gene

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