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Aliases for ZSCAN30 Gene

Aliases for ZSCAN30 Gene

  • Zinc Finger And SCAN Domain Containing 30 2 3 5
  • Zinc Finger Protein 397 Opposite Strand 2 3 4
  • Zinc Finger Protein 397OS 3 4
  • ZNF397 Opposite Strand 2 3
  • ZNF397OS 3 4
  • ZNF-WYM 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 30 3
  • ZNF917 3

External Ids for ZSCAN30 Gene

Previous HGNC Symbols for ZSCAN30 Gene

  • ZNF397OS

Previous GeneCards Identifiers for ZSCAN30 Gene

  • GC18M032833
  • GC18M029690

Summaries for ZSCAN30 Gene

GeneCards Summary for ZSCAN30 Gene

ZSCAN30 (Zinc Finger And SCAN Domain Containing 30) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF397.

UniProtKB/Swiss-Prot for ZSCAN30 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN30 Gene

Genomics for ZSCAN30 Gene

Regulatory Elements for ZSCAN30 Gene

Enhancers for ZSCAN30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H035495 1.4 ENCODE dbSUPER 40.6 -206.8 -206787 3.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 ZC3H11A MEF2D ZNF397 ENSG00000268573 ELP2 ZSCAN30 RPRD1A C18orf21 ZNF271P ZNF396 INO80C ENSG00000267140
GH18H035266 0.6 ENCODE 11.9 +22.5 22538 1.8 L3MBTL2 CEBPB MAX ELF1 GABPA ETS1 POLR2A ZBTB33 MGA ZSCAN30 ZNF24 ENSG00000274184 ENSG00000279989
GH18H035289 1.2 ENCODE 5.2 0.0 -36 2.3 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF397 ENSG00000268573 C18orf21 ZNF24 ZSCAN30 ZNF271P PIR53427 GC18M035301
GH18H035109 1 ENCODE 5.3 +179.4 179440 2.5 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 ZSCAN30 MAPRE2 ENSG00000280096 ENSG00000274400
GH18H035230 1.2 Ensembl ENCODE 4.3 +59.1 59081 0.4 ATF1 FOXA2 RB1 ARID4B BMI1 BRCA1 RAD21 CHAMP1 RFX5 SCRT2 ZNF396 ZSCAN30 PIR47170 ZNF397
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN30 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102191 159 1801 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Locations for ZSCAN30 Gene

Genomic Locations for ZSCAN30 Gene
chr18:35,251,058-35,290,259
(GRCh38/hg38)
Size:
39,202 bases
Orientation:
Minus strand
chr18:32,831,023-32,870,196
(GRCh37/hg19)

Genomic View for ZSCAN30 Gene

Genes around ZSCAN30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN30 Gene

Proteins for ZSCAN30 Gene

  • Protein details for ZSCAN30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W11-ZSC30_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 30
    Protein Accession:
    Q86W11
    Secondary Accessions:
    • B4E0N0
    • Q6ZNB3
    • Q96PN3

    Protein attributes for ZSCAN30 Gene

    Size:
    494 amino acids
    Molecular mass:
    56364 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL26786.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN30 Gene

Post-translational modifications for ZSCAN30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN30 Gene

Domains & Families for ZSCAN30 Gene

Gene Families for ZSCAN30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN30 Gene

Suggested Antigen Peptide Sequences for ZSCAN30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W11

UniProtKB/Swiss-Prot:

ZSC30_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN30: view

Function for ZSCAN30 Gene

Molecular function for ZSCAN30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN30: view

Phenotypes for ZSCAN30 Gene

genes like me logo Genes that share phenotypes with ZSCAN30: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN30 Gene

Localization for ZSCAN30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN30 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN30: view

Pathways & Interactions for ZSCAN30 Gene

SuperPathways for ZSCAN30 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN30: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN30 Gene

Drugs & Compounds for ZSCAN30 Gene

No Compound Related Data Available

Transcripts for ZSCAN30 Gene

mRNA/cDNA for ZSCAN30 Gene

(14) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN30 Gene

Zinc finger and SCAN domain containing 30:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN30 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b
SP1: - -
SP2: -
SP3: -

Relevant External Links for ZSCAN30 Gene

GeneLoc Exon Structure for
ZSCAN30
ECgene alternative splicing isoforms for
ZSCAN30

Expression for ZSCAN30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN30 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN30 Gene

This gene is overexpressed in Adipocyte (39.0) and Spinal cord (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN30 Gene



Protein tissue co-expression partners for ZSCAN30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN30 Gene:

ZSCAN30

SOURCE GeneReport for Unigene cluster for ZSCAN30 Gene:

Hs.619840
genes like me logo Genes that share expression patterns with ZSCAN30: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN30 Gene

Orthologs for ZSCAN30 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN30 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ZSCAN30 33 34
  • 84.93 (n)
cow
(Bos Taurus)
Mammalia ZSCAN30 33
  • 83.2 (n)
mouse
(Mus musculus)
Mammalia Zscan30 33 16 34
  • 74.69 (n)
rat
(Rattus norvegicus)
Mammalia Zscan30 33
  • 73.4 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSCAN30 34
  • 56 (a)
OneToOne
Species where no ortholog for ZSCAN30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN30 Gene

ENSEMBL:
Gene Tree for ZSCAN30 (if available)
TreeFam:
Gene Tree for ZSCAN30 (if available)

Paralogs for ZSCAN30 Gene

(474) SIMAP similar genes for ZSCAN30 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZSCAN30 Gene

genes like me logo Genes that share paralogs with ZSCAN30: view

Variants for ZSCAN30 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN30 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000012357 -- 35,267,157(+) CCCGT(C/G)TCAAA intron-variant
rs1000014415 -- 35,251,456(+) GACAC(-/AAAG)AGGCC intron-variant, utr-variant-3-prime
rs1000157606 -- 35,291,902(+) TCAAT(C/G)TCAAA intron-variant, upstream-variant-2KB
rs1000209521 -- 35,292,223(+) GCCAA(A/G)GCAGG intron-variant, upstream-variant-2KB
rs1000326648 -- 35,285,061(+) AGCAT(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN30 Gene

Variant ID Type Subtype PubMed ID
esv3642197 CNV gain 21293372
nsv1059793 CNV gain 25217958
esv3390534 CNV insertion 20981092
esv3305949 CNV mobile element insertion 20981092

Variation tolerance for ZSCAN30 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN30 Gene

Disorders for ZSCAN30 Gene

Relevant External Links for ZSCAN30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN30

No disorders were found for ZSCAN30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN30 Gene

Publications for ZSCAN30 Gene

  1. Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397. (PMID: 12801647) Wu Y … Zhao S (Gene 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ZSCAN30 Gene

Sources for ZSCAN30 Gene

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