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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSCAN30 Gene

protein-coding   GIFtS: 39
GCID: GC18M032833

Zinc Finger And SCAN Domain Containing 30

(Previous names: zinc finger protein 397 opposite strand, ZNF397 opposite...)
(Previous symbol: ZNF397OS)
Microbiology & Infectious Diseases Congress
  Search for ZSCAN30
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 301 2     Zinc Finger Protein 397OS2 3
Zinc Finger Protein 397 Opposite Strand1 2 3     ZNF-WYM2 3
ZNF397OS1 2 3     ZNF9172
ZNF397 Opposite Strand1 2     Zinc Finger And SCAN Domain-Containing Protein 302

External Ids:    HGNC: 335171   Entrez Gene: 1001014672   Ensembl: ENSG000001868147   UniProtKB: Q86W113   

Export aliases for ZSCAN30 gene to outside databases

Previous GC identifer: GC18M029690


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZSCAN30 Gene: 
ZSCAN30 (zinc finger and SCAN domain containing 30) is a protein-coding gene. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZSCAN30
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZSCAN30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12.2

ZSCAN30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN30 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M032833:  view genomic region     (about GC identifiers)

Start:
32,831,023 bp from pter      End:
32,870,196 bp from pter
Size:
39,174 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 30  
Size: 494 amino acids; 56364 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAL26786.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B4E0N0 Q6ZNB3 Q96PN3
Alternative splicing: 2 isoforms:  Q86W11-1   Q86W11-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZSCAN30: NX_Q86W11

Explore proteomics data for ZSCAN30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86W11

  • ZSCAN30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZSCAN30 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001106205.1  NP_001159484.1  

    ENSEMBL proteins: 
     ENSP00000329738   ENSP00000392371   ENSP00000465046   ENSP00000470677   ENSP00000472179  
     ENSP00000470443   ENSP00000468180   ENSP00000467308   ENSP00000372569  

    Human Recombinant Protein Products for ZSCAN30: 
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    Cloud-Clone Corp. Proteins for ZSCAN30 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZSCAN30 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry Q86W11

    ProtoNet protein and cluster: Q86W11

    1 Blocks protein domain: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: ZSC30_HUMAN, Q86W11
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    ZSCAN30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSC30_HUMAN, Q86W11
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZSCAN30 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for ZSCAN30 (ENSP000003297384) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF496ENSP000002947534STRING: ENSP00000294753
    ZNF232ENSP000002500764STRING: ENSP00000250076
    ZSCAN16ENSP000003665274STRING: ENSP00000366527
    ZSCAN9ENSP000002522074STRING: ENSP00000252207
    SUFUENSP000003589184STRING: ENSP00000358918
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0016032viral process ----

    ZSCAN30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSCAN30 (ZSC30)

    Search CenterWatch for drugs/clinical trials and news about ZSCAN30 / ZSC30

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZSCAN30 gene (2 alternative transcripts): 
    NM_001112734.2  NM_001166012.1  

    Unigene Cluster for ZSCAN30:

    Zinc finger and SCAN domain containing 30
    Hs.619840  [show with all ESTs]
    Unigene Representative Sequence: AK128697
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333206(uc002kym.3) ENST00000420878(uc002kyl.3) ENST00000590777
    ENST00000589178 ENST00000588448 ENST00000601405 ENST00000592278 ENST00000592598
    ENST00000592211 ENST00000588832 ENST00000383091(uc002kyn.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZSCAN30 (see all 16):
    hsa-miR-18a hsa-miR-4297 hsa-miR-4272 hsa-miR-324-3p hsa-miR-548e hsa-miR-4294 hsa-miR-548a-3p hsa-miR-513b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN30

    Additional mRNA sequence: 

    AF303374.1 AK001503.1 AK057386.1 AK057518.1 AK128697.1 AK131291.1 AK303447.1 AL832180.1 
    AY234408.1 

    8 DOTS entries:

    DT.95090370  DT.95110056  DT.40299345  DT.75191728  DT.95352035  DT.121090861  DT.91776167  DT.97820354 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN30    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b
    SP1:                    -     -               
    SP2:                    -                     
    SP3:                          -               


    ECgene alternative splicing isoforms for ZSCAN30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSCAN30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGGTAC
    ZSCAN30 Expression
    About this image


    See ZSCAN30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSCAN30

    SOURCE GeneReport for Unigene cluster: Hs.619840
        SABiosciences Custom PCR Arrays for ZSCAN30
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZSCAN30 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zscan305 zinc finger and SCAN domain containing 30   --   18 (12.47 cM) 23970975 


    ENSEMBL Gene Tree for ZSCAN30 (if available)
    TreeFam Gene Tree for ZSCAN30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSCAN30 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF2322  ZNF1742  ZNF32  ZKSCAN42  
    ZNF3962  ZSCAN122  ZNF3942  ZSCAN232  ZSCAN212  ZNF1652  ZSCAN162  ZKSCAN82  
    ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    18/474 SIMAP similar genes for ZSCAN30 using alignment to 7 protein entries:     ZSC30_HUMAN (see all proteins) (see all similar genes):
    LOC100128510    SCAND1    ZNF78L1    FANCA    ZNF213    ZNF22
    ZNF879    DKFZp666C237    ZNF674    ZNF876P    ZNF396    ZKSCAN8
    DKFZp434K202    HZF36    ZNF146    ZNF167    ZNF480    ZNF501

    ZSCAN30 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/511 SNPs in ZSCAN30 are shown (see all 511)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0599144
    ----see VAR_0599142 Q P mis40--------
    rs129585661,2
    C,H--32838902(+) GTATAG/AATTGT 2 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1872595471,2
    --32838925(+) CTCTGC/TAAACT 2 -- int10--------
    rs129581961,2
    H--32838927(+) CTGTAA/TACTAA 2 -- int14Minor allele frequency- T:0.00NS EA 418
    rs129594161,2
    H--32838955(+) TAAATT/AAAAGT 2 -- int14Minor allele frequency- A:0.00NS EA 420
    rs121508071,2
    H--32838989(+) AGGAAG/AAATTT 2 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1419486301,2
    --32839290(+) AGCTGA/GGGCTA 2 -- int10--------
    rs1915862281,2
    --32839384(+) AGTAAA/TCTGCC 2 -- int10--------
    rs759357191,2
    C,F--32839409(+) AAAGCG/ACTGGC 2 -- int13Minor allele frequency- A:0.19CSA WA 121
    rs1838257531,2
    --32839438(+) TGCACA/CCGGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZSCAN30 (32831023 - 32870196 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZSCAN30:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270226CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZSCAN30
    DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSCAN30 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSCAN30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two novel human SCAN domain- containing zinc finger genes ZNF396 and ZNF397. (PubMed id 12801647)1, 2, 3 Wu Y.... Zhao S. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100101467 HGNC: 33517 Ensembl:ENSG00000186814 euGenes: HUgn100101467 ECgene: ZSCAN30
    H-InvDB: ZSCAN30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSCAN30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZSCAN30 gene:
    Search GeneIP for patents involving ZSCAN30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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