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ZSCAN26 Gene

protein-coding   GIFtS: 38
GCID: GC06P028235

Zinc Finger And SCAN Domain Containing 26

(Previous name: zinc finger protein 187)
(Previous symbol: ZNF187)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And SCAN Domain Containing 261 2
Zinc Finger Protein 1871 2 3
ZNF1871 2 3
SRE-ZBP2
Zinc Finger And SCAN Domain-Containing Protein 262
Protein SRE-ZBP3

External Ids:    HGNC: 129781   Entrez Gene: 77412   Ensembl: ENSG000001970627   UniProtKB: Q166703   

Export aliases for ZSCAN26 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSCAN26 Gene:
ZSCAN26 (zinc finger and SCAN domain containing 26) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and nucleic acid binding.

UniProtKB/Swiss-Prot: ZSC26_HUMAN, Q16670
Function: May be involved in transcriptional regulation (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZSCAN26
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZSCAN26 promoter sequence
   Search Chromatin IP Primers for ZSCAN26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSCAN26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.31

ZSCAN26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN26 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028235:  view genomic region     (about GC identifiers)

Start:
28,234,788 bp from pter      End:
28,245,981 bp from pter
Size:
11,194 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZSC26_HUMAN, Q16670 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 26  
Size: 478 amino acids; 55254 Da
Sequence caution: Sequence=CAD97775.1; Type=Frameshift; Positions=155, 353;
Secondary accessions: Q5JPG4 Q7Z3Q6 Q96A17
Alternative splicing: 2 isoforms:  Q16670-1   Q16670-2   

Explore the universe of human proteins at neXtProt for ZSCAN26: NX_Q16670

Explore proteomics data for ZSCAN26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSCAN26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001018854.2  NP_001104509.1  NP_001274350.1  NP_001274351.1  NP_689949.3  

    ZSCAN26 Human Recombinant Protein Products:

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    Novus Biologicals ZSCAN26 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ZSCAN26 

     
    antibodies-online proteins for ZSCAN26 (2 products) 

     
    antibodies-online peptides for ZSCAN26

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    antibodies-online antibodies for ZSCAN26 (28 products) 

    ZSCAN26 Assay Products:

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    Search eBioscience for ELISAs for ZSCAN26 
    antibodies-online kits for ZSCAN26 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q16670

    ProtoNet protein and cluster: Q16670

    2 Blocks protein domains:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZSC26_HUMAN, Q16670
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with ZSCAN26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSC26_HUMAN, Q16670
    Function: May be involved in transcriptional regulation (Probable)
    Induction: By serum stimulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1569959
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZSCAN26           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZSCAN26

    miRNA
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    Block miRNA regulation of human, mouse, rat ZSCAN26 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZSC26_HUMAN, Q16670: Nucleus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1569959

    Find genes that share ontologies with ZSCAN26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSCAN26
    Interactions:

        Search GeneGlobe Interaction Network for ZSCAN26

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS1569959

    Find genes that share ontologies with ZSCAN26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSCAN26 (ZSC26)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZSCAN26 gene (6 alternative transcripts): 
    NM_007151.1  NM_001023560.3  NM_001111039.2  NM_001287421.1  NM_001287422.1  NM_152736.5  

    Unigene Cluster for ZSCAN26:

    Zinc finger and SCAN domain containing 26
    Hs.157883  [show with all ESTs]
    Unigene Representative Sequence: AL832741
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423234 ENST00000421553(uc011dlc.2 uc011dld.2 uc003nkw.4 uc011dle.2 uc011dlg.2)
    ENST00000316606(uc003nku.4 uc011dlf.2)
    miRNA
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    Inhib. RNA
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    GenScript Custom all cDNA clones Services for ZSCAN26
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZSCAN26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN26
    Primer
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    OriGene qPCR primer pairs and template standards for ZSCAN26
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ZSCAN26
      QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN26
      QuantiFast Probe-based Assays in human, mouse, rat ZSCAN26

    Additional mRNA sequence: 

    AJ420533.1 AK095948.1 AK293524.1 AK295393.1 AK297613.1 AK301081.1 AK315645.1 AL832741.1 
    BC013951.2 BC013962.2 BX537535.1 Z11773.1 

    13 DOTS entries:

    DT.454031  DT.101963689  DT.95161024  DT.121355848  DT.92424451  DT.95083166  DT.100809609  DT.121355843 
    DT.121355863  DT.40300090  DT.86852593  DT.92424452  DT.97836894 

    Selected AceView cDNA sequences (see all 119):

    AI351281 NM_152736 AL832741 BC013951 BP378899 AI625387 AA283002 CR618009 
    BF055437 BF508298 BQ880207 CR616851 AA595897 AA150907 BQ130116 BF036871 
    AA551413 BG179100 BM561404 AA234111 BC013962 AI376047 BX279682 AI215451 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN26 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d · 8e · 8f ·
    SP1:                                -     -                       -                       -                                                                     
    SP2:                                -     -                 -     -     -     -     -     -                                                                     
    SP3:                                -     -                                               -                                                                     
    SP4:                                -     -                                               -                                                                     
    SP5:                                      -                 -     -     -     -     -     -                                                                     

    ExUns: 8g
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ZSCAN26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSCAN26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZSCAN26 Expression
    About this image


    ZSCAN26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Rib
     
     Brain (Nervous System)
             Cerebral Cortex
    ZSCAN26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSCAN26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.157883
        Custom PCR Arrays for ZSCAN26
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZSCAN26 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zscan261 , 5 zinc finger protein 1875
    zinc finger and SCAN domain containing 261
    78.57(n)1
    70.24(a)1
      13 (7.80 cM)5
    4327311  NM_001013786.21  NP_001013808.21 
     214445345 


    ENSEMBL Gene Tree for ZSCAN26 (if available)
    TreeFam Gene Tree for ZSCAN26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSCAN26 gene
    Selected SIMAP similar genes for ZSCAN26 using alignment to 1 protein entry:     ZSC26_HUMAN(see all similar genes):
    ZNF818P    LOC100128510    SCAND1    kr-znf3    ZNF78L1    ZFS-4
    ZNF566    ZSCAN18    ZFP41    DKFZp434K202    DKFZp666C237    HZF36
    DKFZp434J0650    DKFZp762K012    ZNF    ZNF323    ZNF514    zf30

    Find genes that share paralogs with ZSCAN26           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZSCAN26 (see all 238)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842125551,2
    --28153289(+) TTGAAC/TATCGT 2 -- us2k10--------
    rs122158411,2
    C,F,H--28153311(+) TGGCAG/AAAACA 2 -- us2k15Minor allele frequency- A:0.01NS EA 536
    rs1888133271,2
    --28153783(+) AAGAAA/TATTGA 2 -- us2k10--------
    rs1145102511,2
    C,F--28153798(+) TAATTA/GGTAAC 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1918930091,2
    --28153801(+) TTAGTA/GACACA 2 -- us2k10--------
    rs1844116711,2
    --28153828(+) TGGCCA/TTATGA 2 -- us2k10--------
    rs1884080601,2
    --28153829(+) GGCCTA/TATGAA 2 -- us2k10--------
    rs1465744671,2
    C--28153854(+) ACATAC/TTTAAT 2 -- us2k10--------
    rs1918203001,2
    --28153863(+) ATTTTC/TACTTT 2 -- us2k10--------
    rs1842207941,2
    --28154115(+) TGTTTC/TAGGTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZSCAN26 (28234788 - 28245981 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZSCAN26: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZSCAN26
    DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSCAN26 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZSCAN26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. (PubMed id 1569959)1, 2, 3 Attar R.M. and Gilman M.Z. (Mol. Cell. Biol. 1992)
    2. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    3. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. (PubMed id 19416867)1 Kim Y.C....Wang S.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7741 HGNC: 12978 AceView: ZNF187 Ensembl:ENSG00000197062 euGenes: HUgn7741
    ECgene: ZSCAN26 H-InvDB: ZSCAN26

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSCAN26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZSCAN26 gene:
    Search GeneIP for patents involving ZSCAN26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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