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Aliases for ZSCAN25 Gene

Aliases for ZSCAN25 Gene

  • Zinc Finger And SCAN Domain Containing 25 2 3 5
  • Zinc Finger Protein 498 2 3 4
  • ZNF498 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 25 3

External Ids for ZSCAN25 Gene

Previous HGNC Symbols for ZSCAN25 Gene

  • ZNF498

Previous GeneCards Identifiers for ZSCAN25 Gene

  • GC07P099215

Summaries for ZSCAN25 Gene

Entrez Gene Summary for ZSCAN25 Gene

  • This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZSCAN25 Gene

ZSCAN25 (Zinc Finger And SCAN Domain Containing 25) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot for ZSCAN25 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN25 Gene

Genomics for ZSCAN25 Gene

Regulatory Elements for ZSCAN25 Gene

Enhancers for ZSCAN25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100356 1.2 Ensembl ENCODE 110 +741.3 741328 2.7 ZFP64 RAD21 ZNF354C FOS EGR2 ZNF202 ZNF680 ZNF654 ZBTB11 ZEB2 ZSCAN25 GIGYF1 PILRA LOC100131859 ZNF655 STAG3L5P AP4M1 ENSG00000242798 PPP1R35 PCOLCE-AS1
GH07F099579 1.4 FANTOM5 Ensembl ENCODE 88 -36.3 -36310 1.4 ZNF2 RAD21 ZBTB40 ZNF354C ZNF366 ZNF202 ZNF263 ZNF680 REST ZNF518A ZSCAN25 TRRAP LOC100131859 ZNF655 ENSG00000242798 STAG3L5P AP4M1 LOC101927550 LOC100419643 PPP1R35
GH07F100475 1.1 ENCODE 76.8 +861.1 861144 4.4 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZSCAN25 PILRA GIGYF1 ZNF655 STAG3L5P AP4M1 PPP1R35 PCOLCE EPHB4 ENSG00000242798
GH07F099464 0.2 ENCODE 73.2 -150.8 -150807 2.0 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZSCAN25 ZNF655 LOC100131859 TRRAP LOC101927550 LOC100419643 SMURF1 AP4M1 ENSG00000242798 STAG3L5P
GH07F100514 1 Ensembl ENCODE 66.5 +899.2 899218 2.3 TBL1XR1 SIN3A ZEB1 ZNF121 CBX5 SCRT2 FOS ZNF202 ZNF263 ZNF680 ZSCAN25 GIGYF1 STAG3L5P AP4M1 ENSG00000242798 ZNF655 PPP1R35 PCOLCE-AS1 FBXO24 PCOLCE
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZSCAN25 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068019 289 1401 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5

Genomic Location for ZSCAN25 Gene

Chromosome:
7
Start:
99,616,611 bp from pter
End:
99,738,530 bp from pter
Size:
121,920 bases
Orientation:
Plus strand

Genomic View for ZSCAN25 Gene

Genes around ZSCAN25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN25 Gene

Proteins for ZSCAN25 Gene

  • Protein details for ZSCAN25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSZ9-ZSC25_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 25
    Protein Accession:
    Q6NSZ9
    Secondary Accessions:
    • A4D290
    • D6W5T5
    • Q14C82
    • Q14C99
    • Q5EBM9
    • Q6DJZ0
    • Q6N032
    • Q6ZML3

    Protein attributes for ZSCAN25 Gene

    Size:
    544 amino acids
    Molecular mass:
    61474 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI14574.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI14942.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAD18712.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAL23869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN25 Gene

Post-translational modifications for ZSCAN25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN25 Gene

Domains & Families for ZSCAN25 Gene

Gene Families for ZSCAN25 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NSZ9

UniProtKB/Swiss-Prot:

ZSC25_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN25: view

Function for ZSCAN25 Gene

Molecular function for ZSCAN25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

Phenotypes for ZSCAN25 Gene

genes like me logo Genes that share phenotypes with ZSCAN25: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN25 Gene

Localization for ZSCAN25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN25 Gene

Gene Ontology (GO) - Cellular Components for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZSCAN25: view

No data available for Subcellular locations from COMPARTMENTS for ZSCAN25 Gene

Pathways & Interactions for ZSCAN25 Gene

SuperPathways for ZSCAN25 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZSCAN25: view

Pathways by source for ZSCAN25 Gene

2 Reactome pathways for ZSCAN25 Gene

Gene Ontology (GO) - Biological Process for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

No data available for SIGNOR curated interactions for ZSCAN25 Gene

Transcripts for ZSCAN25 Gene

Unigene Clusters for ZSCAN25 Gene

Zinc finger and SCAN domain containing 25:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN25 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6: -
SP7: - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - -

Relevant External Links for ZSCAN25 Gene

GeneLoc Exon Structure for
ZSCAN25
ECgene alternative splicing isoforms for
ZSCAN25

Expression for ZSCAN25 Gene

mRNA expression in normal human tissues for ZSCAN25 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSCAN25 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZSCAN25 Gene:

ZSCAN25

SOURCE GeneReport for Unigene cluster for ZSCAN25 Gene:

Hs.446297
genes like me logo Genes that share expression patterns with ZSCAN25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZSCAN25 Gene

Orthologs for ZSCAN25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF498 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ZSCAN25 34 35
  • 86.58 (n)
mouse
(Mus musculus)
Mammalia Zscan25 34 16 35
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Zfp498 34
  • 83.09 (n)
cow
(Bos Taurus)
Mammalia ZSCAN25 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZSCAN25 35
  • 33 (a)
OneToOne
Species where no ortholog for ZSCAN25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN25 Gene

ENSEMBL:
Gene Tree for ZSCAN25 (if available)
TreeFam:
Gene Tree for ZSCAN25 (if available)

Paralogs for ZSCAN25 Gene

Paralogs for ZSCAN25 Gene

(239) SIMAP similar genes for ZSCAN25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZSCAN25: view

Variants for ZSCAN25 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs776746 drug-response 99,672,916(-) TTTCA(A/G)TATCT intron-variant, upstream-variant-2KB, splice-acceptor-variant, utr-variant-5-prime
rs4646450 other 99,668,695(-) tggca(C/T)tgcaa intron-variant, upstream-variant-2KB
rs1002856 -- 99,623,845(+) GGAGG(A/C)TGCTG intron-variant
rs1003009 -- 99,626,336(-) GACCC(A/G)GAGTC intron-variant
rs1003010 -- 99,626,116(-) TACAA(C/T)CCAGA intron-variant

Variation tolerance for ZSCAN25 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSCAN25 Gene

Disorders for ZSCAN25 Gene

Relevant External Links for ZSCAN25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN25

No disorders were found for ZSCAN25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN25 Gene

Publications for ZSCAN25 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  2. Zinc finger proteins: new insights into structural and functional diversity. (PMID: 11179890) Laity J.H. … Wright P.E. (Curr. Opin. Struct. Biol. 2001) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZSCAN25 Gene

Sources for ZSCAN25 Gene

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