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Aliases for ZSCAN25 Gene

Aliases for ZSCAN25 Gene

  • Zinc Finger And SCAN Domain Containing 25 2 3 5
  • Zinc Finger Protein 498 2 3 4
  • ZNF498 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 25 3

External Ids for ZSCAN25 Gene

Previous HGNC Symbols for ZSCAN25 Gene

  • ZNF498

Previous GeneCards Identifiers for ZSCAN25 Gene

  • GC07P099215

Summaries for ZSCAN25 Gene

Entrez Gene Summary for ZSCAN25 Gene

  • This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZSCAN25 Gene

ZSCAN25 (Zinc Finger And SCAN Domain Containing 25) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF449.

UniProtKB/Swiss-Prot for ZSCAN25 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN25 Gene

Genomics for ZSCAN25 Gene

Regulatory Elements for ZSCAN25 Gene

Enhancers for ZSCAN25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G099579 1.5 FANTOM5 Ensembl ENCODE 64.5 -36.2 -36211 1.2 AGO1 ZNF2 RAD21 ZBTB40 ZNF354C ZNF366 ZNF263 ZNF202 ZNF680 ELF4 ZSCAN25 LOC100131859 TRRAP AP4M1 ZNF655 LOC101927550 LOC100419643 ENSG00000242798 STAG3L5P SMURF1
GH07G099464 1.2 ENCODE 62.4 -150.8 -150807 2.0 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D ZSCAN25 ZNF655 LOC100131859 TRRAP LOC101927550 SMURF1 AP4M1 LOC100419643 ENSG00000242798 STAG3L5P
GH07G100356 0.9 dbSUPER 64.3 +740.3 740265 1.6 ZFP64 YY1 ZNF354C FOS ZNF202 ZNF680 ZNF654 ZBTB11 ZNF426 CEBPB PILRA LOC100131859 ZSCAN25 AP4M1 ZNF655 GIGYF1 PCOLCE-AS1 STAG3L5P ENSG00000242798 FAM200A
GH07G100450 1.3 Ensembl ENCODE 44.5 +834.1 834118 1.5 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZSCAN25 ZNF655 GIGYF1 STAG3L5P ENSG00000242798 MEPCE AP4M1 PPP1R35 TSC22D4 NYAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN25 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215680 289 1401 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1

Genomic Location for ZSCAN25 Gene

99,616,611 bp from pter
99,738,530 bp from pter
121,920 bases
Plus strand

Genomic View for ZSCAN25 Gene

Genes around ZSCAN25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN25 Gene

Proteins for ZSCAN25 Gene

  • Protein details for ZSCAN25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and SCAN domain-containing protein 25
    Protein Accession:
    Secondary Accessions:
    • A4D290
    • D6W5T5
    • Q14C82
    • Q14C99
    • Q5EBM9
    • Q6DJZ0
    • Q6N032
    • Q6ZML3

    Protein attributes for ZSCAN25 Gene

    544 amino acids
    Molecular mass:
    61474 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI14574.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI14942.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAD18712.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAL23869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN25 Gene


neXtProt entry for ZSCAN25 Gene

Post-translational modifications for ZSCAN25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN25 Gene

Domains & Families for ZSCAN25 Gene

Gene Families for ZSCAN25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN25: view

Function for ZSCAN25 Gene

Molecular function for ZSCAN25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

Phenotypes for ZSCAN25 Gene

genes like me logo Genes that share phenotypes with ZSCAN25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN25 Gene

Localization for ZSCAN25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN25 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

Pathways & Interactions for ZSCAN25 Gene

SuperPathways for ZSCAN25 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZSCAN25: view

Pathways by source for ZSCAN25 Gene

2 Reactome pathways for ZSCAN25 Gene

Gene Ontology (GO) - Biological Process for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

No data available for SIGNOR curated interactions for ZSCAN25 Gene

Drugs & Compounds for ZSCAN25 Gene

No Compound Related Data Available

Transcripts for ZSCAN25 Gene

Unigene Clusters for ZSCAN25 Gene

Zinc finger and SCAN domain containing 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN25 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6: -
SP7: - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - -

Relevant External Links for ZSCAN25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSCAN25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN25 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSCAN25 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN25 Gene:


SOURCE GeneReport for Unigene cluster for ZSCAN25 Gene:


Evidence on tissue expression from TISSUES for ZSCAN25 Gene

  • Nervous system(4.2)
  • Lung(4.1)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with ZSCAN25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN25 Gene

Orthologs for ZSCAN25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF498 34 35
  • 99.45 (n)
(Canis familiaris)
Mammalia ZSCAN25 34 35
  • 86.58 (n)
(Mus musculus)
Mammalia Zscan25 34 16 35
  • 83.15 (n)
(Rattus norvegicus)
Mammalia Zfp498 34
  • 83.09 (n)
(Bos Taurus)
Mammalia ZSCAN25 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ZSCAN25 35
  • 33 (a)
Species where no ortholog for ZSCAN25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN25 Gene

Gene Tree for ZSCAN25 (if available)
Gene Tree for ZSCAN25 (if available)

Paralogs for ZSCAN25 Gene

Paralogs for ZSCAN25 Gene

(239) SIMAP similar genes for ZSCAN25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZSCAN25: view

Variants for ZSCAN25 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs776746 drug-response 99,672,916(-) TTTCA(A/G)TATCT intron-variant, upstream-variant-2KB, splice-acceptor-variant, utr-variant-5-prime
rs4646450 other 99,668,695(-) tggca(C/T)tgcaa intron-variant, upstream-variant-2KB
rs1000006168 -- 99,642,880(+) TTAAA(C/T)GGATG intron-variant
rs1000093241 -- 99,683,083(+) TTTCA(A/T)ATATC intron-variant
rs1000111953 -- 99,680,238(+) CCCTC(C/T)ATGGC intron-variant, upstream-variant-2KB

Variation tolerance for ZSCAN25 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSCAN25 Gene

Disorders for ZSCAN25 Gene

Relevant External Links for ZSCAN25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZSCAN25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN25 Gene

Publications for ZSCAN25 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  2. Zinc finger proteins: new insights into structural and functional diversity. (PMID: 11179890) Laity J.H. … Wright P.E. (Curr. Opin. Struct. Biol. 2001) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZSCAN25 Gene

Sources for ZSCAN25 Gene

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