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ZSCAN23 Gene

protein-coding   GIFtS: 39
GCID: GC06M028399

Zinc Finger And SCAN Domain Containing 23

(Previous names: zinc finger protein 453, zinc finger protein 390)
(Previous symbols: ZNF453, ZNF390)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And SCAN Domain Containing 231 2     ZNF4531 2 3
Zinc Finger Protein 3901 2 3     dJ29K1.32
Zinc Finger Protein 4531 2 3     dJ29K1.3.12
ZNF3901 2 3     Zinc Finger And SCAN Domain-Containing Protein 232

External Ids:    HGNC: 211931   Entrez Gene: 2226962   Ensembl: ENSG000001879877   UniProtKB: Q3MJ623   

Export aliases for ZSCAN23 gene to outside databases

Previous GC identifers: GC06M028513 GC06U901203 GC06M028206


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSCAN23 Gene:
ZSCAN23 (zinc finger and SCAN domain containing 23) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZSCAN23 gene promoter:
         Pax-5   POU3F1   FOXD1   Nkx2-5   CUTL1   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZSCAN23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSCAN23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.33

ZSCAN23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN23 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M028399:  view genomic region     (about GC identifiers)

Start:
28,399,707 bp from pter      End:
28,411,279 bp from pter
Size:
11,573 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 23  
Size: 389 amino acids; 44955 Da
Sequence caution: Sequence=CAC44641.1; Type=Erroneous gene model prediction;
Secondary accessions: Q96KV9

Explore the universe of human proteins at neXtProt for ZSCAN23: NX_Q3MJ62

Explore proteomics data for ZSCAN23 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSCAN23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012458.1  
    ENSEMBL proteins: 
     ENSP00000435430   ENSP00000289788  

    ZSCAN23 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q3MJ62

    ProtoNet protein and cluster: Q3MJ62

    2 Blocks protein domains:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    ZSCAN23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSC23_HUMAN, Q3MJ62
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    ZSCAN23 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZSCAN23
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    miRTarBase miRNAs that target ZSCAN23:
    hsa-mir-335-5p (MIRT017469)

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    7 qRT-PCR Assays for microRNAs that regulate ZSCAN23:
    hsa-miR-561 hsa-miR-518a-5p hsa-miR-16-1* hsa-miR-378* hsa-miR-3148 hsa-miR-570 hsa-miR-4267
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZSC23_HUMAN, Q3MJ62: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZSCAN23 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSCAN23
    Interactions:

        Search GeneGlobe Interaction Network for ZSCAN23

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    ZSCAN23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSCAN23 (ZSC23)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZSCAN23 gene: 
    NM_001012455.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481983(uc003nlh.2 uc010jrf.1) ENST00000289788(uc011dli.2 uc003nli.4)
    ENST00000486481
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ZSCAN23:
    hsa-miR-561 hsa-miR-518a-5p hsa-miR-16-1* hsa-miR-378* hsa-miR-3148 hsa-miR-570 hsa-miR-4267
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZSCAN23
    Predesigned siRNA for gene silencing in human, mouse, rat ZSCAN23
    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN23
      QuantiFast Probe-based Assays in human, mouse, rat ZSCAN23

    10 AceView cDNA sequences:

    AL833347 BX283350 BX484226 AK092117 CA394737 AX747363 BP872840 BF698315 
    BE969777 BG820514 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN23    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
    SP1:                              
    SP2:        -           -         


    ECgene alternative splicing isoforms for ZSCAN23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSCAN23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAATATA
    ZSCAN23 Expression
    About this image

    ZSCAN23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSCAN23 Protein Expression
        Custom PCR Arrays for ZSCAN23
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZSCAN23 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZSCAN231 zinc finger and SCAN domain containing 23 83.65(n)
    79.89(a)
      100685292  XM_005640137.1  XP_005640194.1 


    ENSEMBL Gene Tree for ZSCAN23 (if available)
    TreeFam Gene Tree for ZSCAN23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSCAN23 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  ZNF2322  ZSCAN302  
    ZNF1742  ZNF32  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZNF1652  
    ZSCAN162  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    Selected SIMAP similar genes for ZSCAN23 using alignment to 2 protein entries:     ZSC23_HUMAN (see all proteins) (see all similar genes):
    ZNF551    ZNF391    ZNF585B    ZNF619    DKFZp666C237    ZNF211
    ZNF34    ZNF420    ZNF485    ZNF514    ZNF772    ZNF135
    ZNF260    ZNF530    ZNF621    HZF36    ZIM3    ZNF202

    ZSCAN23 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZSCAN23
    PGOHUM00000258049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZSCAN23 (see all 236)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs173939391,2
    C,F,H--28399962(+) TATCTT/AAAATG 1 -- ds500112Minor allele frequency- A:0.07NA NS EA WA 924
    rs615409481,2
    C,F--28400077(+) GAGTCT/AACTAT 1 -- ds50013Minor allele frequency- A:0.04WA NA 240
    rs20234931,2
    C,F,A,H--28400162(+) ATACTC/TTTCAG 1 -- ds500114Minor allele frequency- N:0.01MN EA NA WA CSA 768
    rs1825520771,2
    --28400173(+) GAAATA/GTAAGT 1 -- ds50010--------
    rs77659891,2
    C,F,A,H--28400295(+) ACTTCT/CCCATT 1 -- ds500113Minor allele frequency- C:0.16NS EA NA WA CSA 787
    rs1869423801,2
    --28400335(+) GTTGCC/TCACGC 1 -- ds50010--------
    rs168941061,2
    C,F,H--28400339(+) CCCACA/GCCTTG 1 -- ds500130Minor allele frequency- N:0.00NA EA NS WA CSA 2977
    rs28593661,2
    C,F,H--28400437(+) TAACAT/GTTTAA 1 -- ut314Minor allele frequency- G:0.01NS EA 404
    rs77663561,2
    C,F,H--28400538(+) TCTGTT/CATGAT 1 -- ut3122Minor allele frequency- C:0.12NS EA NA CSA WA 2640
    rs1832149911,2
    --28400955(+) TTGAGC/TAACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZSCAN23 (28399707 - 28411279 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZSCAN23: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZSCAN23
    DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSCAN23 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZSCAN23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222696 HGNC: 21193 AceView: ZNF390 Ensembl:ENSG00000187987 euGenes: HUgn222696
    ECgene: ZSCAN23 H-InvDB: ZSCAN23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSCAN23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZSCAN23 gene:
    Search GeneIP for patents involving ZSCAN23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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