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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSCAN23 Gene

protein-coding   GIFtS: 39
GCID: GC06M028399

Zinc Finger And SCAN Domain Containing 23

(Previous names: zinc finger protein 453, zinc finger protein 390)
(Previous symbols: ZNF453, ZNF390)
Microbiology & Infectious Diseases Congress
  Search for ZSCAN23
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 231 2     ZNF4531 2 3
Zinc Finger Protein 3901 2 3     dJ29K1.32
Zinc Finger Protein 4531 2 3     dJ29K1.3.12
ZNF3901 2 3     Zinc Finger And SCAN Domain-Containing Protein 232

External Ids:    HGNC: 211931   Entrez Gene: 2226962   Ensembl: ENSG000001879877   UniProtKB: Q3MJ623   

Export aliases for ZSCAN23 gene to outside databases

Previous GC identifers: GC06M028513 GC06U901203 GC06M028206


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZSCAN23 Gene: 
ZSCAN23 (zinc finger and SCAN domain containing 23) is a protein-coding gene. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSCAN23 gene promoter:
         Pax-5   POU3F1   FOXD1   Nkx2-5   CUTL1   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZSCAN23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.33

ZSCAN23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN23 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M028399:  view genomic region     (about GC identifiers)

Start:
28,399,707 bp from pter      End:
28,411,279 bp from pter
Size:
11,573 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 23  
Size: 389 amino acids; 44955 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=CAC44641.1; Type=Erroneous gene model prediction;
Secondary accessions: Q96KV9

Explore the universe of human proteins at neXtProt for ZSCAN23: NX_Q3MJ62

Explore proteomics data for ZSCAN23 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3MJ62

  • ZSCAN23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZSCAN23 Protein Expression
    REFSEQ proteins: NP_001012458.1  
    ENSEMBL proteins: 
     ENSP00000435430   ENSP00000289788  

    Human Recombinant Protein Products for ZSCAN23: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZSCAN23 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry Q3MJ62

    ProtoNet protein and cluster: Q3MJ62

    2 Blocks protein domains:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    ZSCAN23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSC23_HUMAN, Q3MJ62
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZSCAN23 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN23

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0016032viral process ----

    ZSCAN23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSCAN23 (ZSC23)

    Search CenterWatch for drugs/clinical trials and news about ZSCAN23 / ZSC23

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZSCAN23 gene: 
    NM_001012455.1  

    Unigene Cluster for ZSCAN23:

    Zinc finger and SCAN domain containing 23
    Hs.721841  [show with all ESTs]
    Unigene Representative Sequence: NM_001012455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481983(uc003nlh.2 uc010jrf.1) ENST00000289788(uc011dli.2 uc003nli.4)
    ENST00000486481
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZSCAN23:
    hsa-miR-561 hsa-miR-518a-5p hsa-miR-16-1* hsa-miR-378* hsa-miR-3148 hsa-miR-570 hsa-miR-4267
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN23
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN23

    Additional mRNA sequence: 

    AK092117.1 AK309235.1 AL833347.1 BC101557.1 BC101559.1 BC143560.1 

    4 DOTS entries:

    DT.100010150  DT.92013254  DT.121344039  DT.91789137 

    10 AceView cDNA sequences:

    AL833347 AX747363 BP872840 BX484226 BX283350 CA394737 AK092117 BF698315 
    BE969777 BG820514 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN23    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
    SP1:                              
    SP2:        -           -         


    ECgene alternative splicing isoforms for ZSCAN23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSCAN23 expression in normal human tissues (normalized intensities)      ZSCAN23 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAATATA
    ZSCAN23 Expression
    About this image


    ZSCAN23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See ZSCAN23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSCAN23

    SOURCE GeneReport for Unigene cluster: Hs.721841
        SABiosciences Custom PCR Arrays for ZSCAN23
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZSCAN23 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZSCAN236
    zinc finger and SCAN domain containing 23
    76(a)
    1 ↔ 1
    35(25544732-25556464)


    ENSEMBL Gene Tree for ZSCAN23 (if available)
    TreeFam Gene Tree for ZSCAN23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSCAN23 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF2322  ZSCAN302  ZNF1742  ZNF32  
    ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZNF1652  ZSCAN162  ZKSCAN82  
    ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    18/428 SIMAP similar genes for ZSCAN23 using alignment to 2 protein entries:     ZSC23_HUMAN (see all proteins) (see all similar genes):
    ZNF551    ZNF391    ZNF585B    ZNF619    DKFZp666C237    ZNF211
    ZNF34    ZNF420    ZNF485    ZNF514    ZNF772    ZNF135
    ZNF260    ZNF530    ZNF621    HZF36    ZIM3    ZNF202

    ZSCAN23 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZSCAN23
    PGOHUM00000258049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/236 SNPs in ZSCAN23 are shown (see all 236)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs173939391,2
    C,F,H--28399962(+) TATCTT/AAAATG 1 -- ds500112Minor allele frequency- A:0.07NA NS EA WA 924
    rs615409481,2
    C,F--28400077(+) GAGTCT/AACTAT 1 -- ds50013Minor allele frequency- A:0.04WA NA 240
    rs20234931,2
    C,F,A,H--28400162(+) ATACTC/TTTCAG 1 -- ds500114Minor allele frequency- N:0.01MN EA NA WA CSA 768
    rs1825520771,2
    --28400173(+) GAAATA/GTAAGT 1 -- ds50010--------
    rs77659891,2
    C,F,A,H--28400295(+) ACTTCT/CCCATT 1 -- ds500113Minor allele frequency- C:0.16NS EA NA WA CSA 787
    rs1869423801,2
    --28400335(+) GTTGCC/TCACGC 1 -- ds50010--------
    rs168941061,2
    C,F,H--28400339(+) CCCACA/GCCTTG 1 -- ds500130Minor allele frequency- N:0.00NA EA NS WA CSA 2977
    rs28593661,2
    C,F,H--28400437(+) TAACAT/GTTTAA 1 -- ut314Minor allele frequency- G:0.01NS EA 404
    rs77663561,2
    C,F,H--28400538(+) TCTGTT/CATGAT 1 -- ut3122Minor allele frequency- C:0.12NS EA NA CSA WA 2640
    rs1832149911,2
    --28400955(+) TTGAGC/TAACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZSCAN23 (28399707 - 28411279 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZSCAN23: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZSCAN23
    DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSCAN23 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSCAN23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222696 HGNC: 21193 AceView: ZNF390 Ensembl:ENSG00000187987 euGenes: HUgn222696
    ECgene: ZSCAN23 H-InvDB: ZSCAN23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSCAN23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZSCAN23 gene:
    Search GeneIP for patents involving ZSCAN23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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