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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZSCAN23 Gene

protein-coding GIFtS: 40
GCID: GC06M028399

zinc finger and SCAN domain containing 23

(Previous names: zinc finger protein 453, zinc finger protein 390 )
(Previous symbols: ZNF453, ZNF390)

Search for ZSCAN23
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 23¹ ²		ZNF453¹ ² ³
Zinc Finger Protein 390¹ ² ³		DJ29K1.3.1¹
Zinc Finger Protein 453¹ ² ³		DJ29K1.3¹
ZNF390¹ ² ³		Zinc Finger And SCAN Domain-Containing Protein 23²

External Ids:	HGNC: 21193¹	Entrez Gene: 222696²	Ensembl: ENSG00000187987⁷	UniProtKB: Q3MJ62³

Export aliases for ZSCAN23 gene to outside databases

Previous GC identifers: GC06M028513 GC06U901203 GC06M028206

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZSCAN23 gene promoter:
Pax-5 POU3F1 FOXD1 Nkx2-5 CUTL1 C/EBPalpha FOXJ2 (long isoform) FOXJ2 En-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZSCAN23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.33

ZSCAN23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN23 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M028399: view genomic region (about GC identifiers)

Start:	28,399,707 bp from pter	End:	28,411,279 bp from pter
Size:	11,573 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62 (See protein sequence)

Recommended Name: Zinc finger and SCAN domain-containing protein 23

Size: 389 amino acids; 44955 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=CAC44641.1; Type=Erroneous gene model prediction;

Secondary accessions: Q96KV9

Explore the universe of human proteins at neXtProt for ZSCAN23: NX_Q3MJ62

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3MJ62

ZSCAN23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001012458.1

ENSEMBL proteins:

ENSP00000435430 ENSP00000289788

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	Uscn Proteins for ZSCAN23

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZSCAN23 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZSCAN23 for domains About GeneDecksing

5 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR008916 Retrov_capsid_C

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

IPR003309 Tscrpt_reg_SCAN

Graphical View of Domain Structure for InterPro Entry Q3MJ62

ProtoNet protein and cluster: Q3MJ62

2 Blocks protein families:

IPB003309 Transcriptional regulator SCAN

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

Similarity: Contains 1 SCAN box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZSC23_HUMAN, Q3MJ62

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZSCAN23 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZSCAN23

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0016032	viral reproduction	IEA	--

ZSCAN23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZSCAN23
Search CenterWatch for drugs/clinical trials and news about ZSCAN23 / ZSC23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZSCAN23 gene:

NM_001012455.1

Unigene Cluster for ZSCAN23:

Zinc finger and SCAN domain containing 23

Hs.721841 [show with all ESTs]

Unigene Representative Sequence: NM_001012455

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000481983(uc003nlh.2 uc010jrf.1) ENST00000289788(uc011dli.2 uc003nli.4)

ENST00000486481

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZSCAN23:
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Additional cDNA sequence:

AK092117.1 AK309235.1 AL833347.1 BC101557.1 BC101559.1 BC143560.1

4 DOTS entries:

DT.100010150 DT.92013254 DT.121344039 DT.91789137

10 AceView cDNA sequences:

AL833347 AK092117 CA394737 BX283350 AX747363 BX484226 BP872840 BF698315

BE969777 BG820514

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN23 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4
SP1:
SP2:			-				-

ECgene alternative splicing isoforms for ZSCAN23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZSCAN23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAATATA

About this image

ZSCAN23 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZSCAN23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZSCAN23

SOURCE GeneReport for Unigene cluster: Hs.721841

SABiosciences Custom PCR Arrays for ZSCAN23

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZSCAN23 (if available)
TreeFam Gene Tree for ZSCAN23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZSCAN23 gene

ZNF496² ZNF449² ZNF446² ZSCAN9² ZKSCAN1² ZNF397² ZNF500² ZNF213²

ZSCAN30² ZNF232² ZNF202² ZNF263² ZNF174² ZSCAN25² ZKSCAN4² ZNF396²

ZSCAN12² ZNF394² ZSCAN21² ZNF165² ZSCAN16² ZKSCAN8² ZSCAN31² ZSCAN22²

ZKSCAN3² ZNF24² ZNF18²

18/424 SIMAP similar genes for ZSCAN23 using alignment to 2 protein entries: ZSC23_HUMAN (see all proteins) (see all similar genes):

ZNF551 ZNF391 ZNF585B ZNF619 DKFZp666C237 ZNF211

ZNF34 ZNF420 ZNF485 ZNF514 ZNF772 ZNF260

ZNF530 ZNF621 ZNF135 HZF36 ZIM3 ZNF202

ZSCAN23 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZSCAN23
PGOHUM00000258049

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17393939^1,2	C,F,H,	--	28399962(+)	`TATCTT/AAAATG`	1	--	ds500¹		12		NA NS EA WA	924
rs61540948^1,2	C,	--	28400077(+)	`GAGTCT/AACTAT`	1	--	ds500¹		3		WA NA	240
rs2023493^1,2	C,F,A,H,	--	28400162(+)	`ATACTC/TTTCAG`	1	--	ds500¹		14		MN EA NA WA CSA	768
rs182552077^1,2		--	28400173(+)	`GAAATA/GTAAGT`	1	--	ds500¹		0	--	--	--	--
rs7765989^1,2	C,F,A,H,	--	28400295(+)	`ACTTCT/CCCATT`	1	--	ds500¹		13		NS EA NA WA CSA	787
rs186942380^1,2		--	28400335(+)	`GTTGCC/TCACGC`	1	--	ds500¹		0	--	--	--	--
rs16894106^1,2	C,F,H,	--	28400339(+)	`CCCACA/GCCTTG`	1	--	ds500¹		30		NA EA NS WA CSA	2977
rs2859366^1,2	C,F,H,	--	28400437(+)	`TAACAT/GTTTAA`	1	--	ut3¹		4		NS EA	404
rs7766356^1,2	C,F,H,	--	28400538(+)	`TCTGTT/CATGAT`	1	--	ut3¹		22		NS EA NA CSA WA	2640
rs183214991^1,2		--	28400955(+)	`TTGAGC/TAACTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZSCAN23 (28399707 - 28411279 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZSCAN23: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZSCAN23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZSCAN23)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 222696	HGNC: 21193	AceView: ZNF390	Ensembl:ENSG00000187987	euGenes: HUgn222696
ECgene: ZSCAN23	H-InvDB: ZSCAN23

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZSCAN23	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZSCAN23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZSCAN23 gene:
Search GeneIP for patents involving ZSCAN23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZSCAN23 gene at Home site.

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ZSCAN23 Gene

zinc finger and SCAN domain containing 23

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ZSCAN23 Gene

zinc finger and SCAN domain containing 23

Aliasesfor ZSCAN23 gene

Summariesfor ZSCAN23 gene

Genomic Viewsfor ZSCAN23 gene

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Protein Domains /Familiesfor ZSCAN23 gene

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