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Aliases for ZSCAN22 Gene

Aliases for ZSCAN22 Gene

  • Zinc Finger And SCAN Domain Containing 22 2 3 5
  • Zinc Finger Protein 50 2 3 4
  • Krueppel-Related Zinc Finger Protein 2 3 4
  • GLI-Kruppel Family Member HKR2 2 3
  • ZNF50 3 4
  • HKR2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 22 3
  • Oncogene HKR2 2
  • Protein HKR2 4

External Ids for ZSCAN22 Gene

Previous HGNC Symbols for ZSCAN22 Gene

  • ZNF50
  • HKR2

Previous GeneCards Identifiers for ZSCAN22 Gene

  • GC19P063531
  • GC19P058838
  • GC19P055147

Summaries for ZSCAN22 Gene

GeneCards Summary for ZSCAN22 Gene

ZSCAN22 (Zinc Finger And SCAN Domain Containing 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZSCAN22 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN22 Gene

Genomics for ZSCAN22 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN22 Gene

Promoters and enhancers for ZSCAN22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 590.5 -0.1 -148 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.6 +192.7 192689 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZSCAN22 ZNF549 ZNF274
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.4 -143.8 -143783 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058361 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.9 +35.4 35386 2.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B LOC105372483 ENSG00000268230 RNA5SP473 ZNF497 ZNF548 ZNF417 ZNF134 TRIM28 ZSCAN22 ZNF274
GH19I058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23 +230.1 230094 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 MZF1 LOC100128398 ERVK3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN22 gene promoter:

Genomic Locations for ZSCAN22 Gene

Genomic Locations for ZSCAN22 Gene
15,331 bases
Plus strand

Genomic View for ZSCAN22 Gene

Genes around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN22 Gene

Proteins for ZSCAN22 Gene

  • Protein details for ZSCAN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and SCAN domain-containing protein 22
    Protein Accession:
    Secondary Accessions:
    • Q15922
    • Q7Z3L8

    Protein attributes for ZSCAN22 Gene

    491 amino acids
    Molecular mass:
    54561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN22 Gene

Post-translational modifications for ZSCAN22 Gene

Other Protein References for ZSCAN22 Gene

No data available for DME Specific Peptides for ZSCAN22 Gene

Domains & Families for ZSCAN22 Gene

Gene Families for ZSCAN22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN22 Gene

Suggested Antigen Peptide Sequences for ZSCAN22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN22: view

Function for ZSCAN22 Gene

Molecular function for ZSCAN22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN22: view
genes like me logo Genes that share phenotypes with ZSCAN22: view

Animal Model Products

miRNA for ZSCAN22 Gene

miRTarBase miRNAs that target ZSCAN22
Targeted motifs for ZSCAN22 Gene
HOMER Transcription Factor Regulatory Elements motif ZSCAN22
  • Consensus sequence: SMCAGTCWGAKGGAGGAGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZSCAN22 Gene

Localization for ZSCAN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN22 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN22: view

Pathways & Interactions for ZSCAN22 Gene

SuperPathways for ZSCAN22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZSCAN22: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN22 Gene

Drugs & Compounds for ZSCAN22 Gene

No Compound Related Data Available

Transcripts for ZSCAN22 Gene

Unigene Clusters for ZSCAN22 Gene

Zinc finger and SCAN domain containing 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -

Relevant External Links for ZSCAN22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSCAN22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN22 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN22 Gene:


SOURCE GeneReport for Unigene cluster for ZSCAN22 Gene:

genes like me logo Genes that share expression patterns with ZSCAN22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN22 Gene

Orthologs for ZSCAN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZSCAN22 33 34
  • 98.98 (n)
(Canis familiaris)
Mammalia ZSCAN22 33 34
  • 84.46 (n)
(Mus musculus)
Mammalia Zscan22 33 16 34
  • 78.8 (n)
(Rattus norvegicus)
Mammalia LOC102553294 33
  • 77.87 (n)
(Ornithorhynchus anatinus)
Mammalia ZSCAN22 34
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 35 (a)
(Gallus gallus)
Aves ZFP92 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
Species where no ortholog for ZSCAN22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN22 Gene

Gene Tree for ZSCAN22 (if available)
Gene Tree for ZSCAN22 (if available)

Paralogs for ZSCAN22 Gene

(462) SIMAP similar genes for ZSCAN22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN22: view

Variants for ZSCAN22 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN22 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000381162 -- 58,337,363(+) C/G/T intron_variant
rs1000409987 -- 58,330,498(+) T/A intron_variant
rs1000698980 -- 58,334,933(+) A/T 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant
rs1000958073 -- 58,341,124(+) A/G 3_prime_UTR_variant
rs1001178283 -- 58,338,663(+) C/T coding_sequence_variant, missense_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN22 Gene

Variant ID Type Subtype PubMed ID
nsv1058109 CNV gain 25217958
nsv515731 CNV gain+loss 19592680
nsv833886 CNV gain 17160897
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZSCAN22 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Disorders for ZSCAN22 Gene

Additional Disease Information for ZSCAN22

No disorders were found for ZSCAN22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN22 Gene

Publications for ZSCAN22 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 4 58
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert JM … Vogelstein B (Molecular and cellular biology 1988) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for ZSCAN22 Gene

Sources for ZSCAN22 Gene

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