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Aliases for ZSCAN22 Gene

Aliases for ZSCAN22 Gene

  • Zinc Finger And SCAN Domain Containing 22 2 3 5
  • Zinc Finger Protein 50 2 3 4
  • Krueppel-Related Zinc Finger Protein 2 3 4
  • GLI-Kruppel Family Member HKR2 2 3
  • ZNF50 3 4
  • HKR2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 22 3
  • Oncogene HKR2 2
  • Protein HKR2 4

External Ids for ZSCAN22 Gene

Previous HGNC Symbols for ZSCAN22 Gene

  • ZNF50
  • HKR2

Previous GeneCards Identifiers for ZSCAN22 Gene

  • GC19P063531
  • GC19P058838
  • GC19P055147

Summaries for ZSCAN22 Gene

GeneCards Summary for ZSCAN22 Gene

ZSCAN22 (Zinc Finger And SCAN Domain Containing 22) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is LOC344065.

UniProtKB/Swiss-Prot for ZSCAN22 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN22 Gene

Genomics for ZSCAN22 Gene

Regulatory Elements for ZSCAN22 Gene

Enhancers for ZSCAN22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057583 0.5 ENCODE 21.1 -743.0 -743047 1.4 TBP CBX3 ZNF76 ARID4B RAD21 ZBTB40 ZEB1 ETS1 GLIS2 ZNF416 ZNF549 ZNF17 ZIK1 LOC100128398 ZNF324B MZF1 ZSCAN22 ZNF606 ZNF544 ZNF551
GH19F057476 1 ENCODE 16.2 -849.5 -849542 1.5 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 VN1R1 ZNF773 ZNF417 ZNF606 ZSCAN22 ZNF550 ZNF324B ZNF587 ZNF837 ZNF17
GH19F057798 0.9 Ensembl ENCODE 12.6 -527.6 -527619 2.4 CTCF ZNF202 JUND POLR2A SCRT2 ZBTB33 PRDM1 RAD21 CHAMP1 ZNF587 TRIM28 ENSG00000269867 ZNF324B ZNF814 ZNF264 ZNF417 ZNF550 ZNF543 ZNF548
GH19F057801 1.4 FANTOM5 Ensembl ENCODE 12.6 -523.1 -523086 5.3 HDAC1 CTCF KLF1 SAP130 SIN3A ZNF644 ZBTB40 ZSCAN9 ZNF766 POLR2A ENSG00000269867 ZNF587 TRIM28 ZNF324B ZNF814 ZNF264 ZNF417 ZNF550 ZNF543 ZNF548
GH19F058325 0.2 ENCODE 10.7 -0.1 -149 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF134 ZNF17 ZNF549 ZNF606 ZNF773 ZNF256 ZNF417 ZNF551 ZNF548 ZNF211
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001420263 -119 2201 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZSCAN22 Gene

Chromosome:
19
Start:
58,327,019 bp from pter
End:
58,342,349 bp from pter
Size:
15,331 bases
Orientation:
Plus strand

Genomic View for ZSCAN22 Gene

Genes around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN22 Gene

Proteins for ZSCAN22 Gene

  • Protein details for ZSCAN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10073-ZSC22_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 22
    Protein Accession:
    P10073
    Secondary Accessions:
    • Q15922
    • Q7Z3L8

    Protein attributes for ZSCAN22 Gene

    Size:
    491 amino acids
    Molecular mass:
    54561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN22 Gene

Post-translational modifications for ZSCAN22 Gene

  • Ubiquitination at Lys 133
  • Modification sites at PhosphoSitePlus

Other Protein References for ZSCAN22 Gene

No data available for DME Specific Peptides for ZSCAN22 Gene

Domains & Families for ZSCAN22 Gene

Gene Families for ZSCAN22 Gene

Suggested Antigen Peptide Sequences for ZSCAN22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10073

UniProtKB/Swiss-Prot:

ZSC22_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN22: view

Function for ZSCAN22 Gene

Molecular function for ZSCAN22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN22: view
genes like me logo Genes that share phenotypes with ZSCAN22: view

Animal Model Products

Targeted motifs for ZSCAN22 Gene
HOMER Transcription Factor Regulatory Elements motif ZSCAN22
  • Consensus sequence: SMCAGTCWGAKGGAGGAGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZSCAN22 Gene

Localization for ZSCAN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN22 Gene COMPARTMENTS Subcellular localization image for ZSCAN22 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZSCAN22: view

Pathways & Interactions for ZSCAN22 Gene

SuperPathways for ZSCAN22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZSCAN22: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN22 Gene

Transcripts for ZSCAN22 Gene

Unigene Clusters for ZSCAN22 Gene

Zinc finger and SCAN domain containing 22:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:
SP3:

Relevant External Links for ZSCAN22 Gene

GeneLoc Exon Structure for
ZSCAN22
ECgene alternative splicing isoforms for
ZSCAN22

Expression for ZSCAN22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN22 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN22 Gene:

ZSCAN22

SOURCE GeneReport for Unigene cluster for ZSCAN22 Gene:

Hs.388162
genes like me logo Genes that share expression patterns with ZSCAN22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZSCAN22 Gene

Orthologs for ZSCAN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN22 34 35
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia ZSCAN22 34 35
  • 84.46 (n)
mouse
(Mus musculus)
Mammalia Zscan22 34 16 35
  • 78.8 (n)
rat
(Rattus norvegicus)
Mammalia LOC102553294 34
  • 77.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZSCAN22 35
  • 38 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 35
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
Species where no ortholog for ZSCAN22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN22 Gene

ENSEMBL:
Gene Tree for ZSCAN22 (if available)
TreeFam:
Gene Tree for ZSCAN22 (if available)

Paralogs for ZSCAN22 Gene

(462) SIMAP similar genes for ZSCAN22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN22: view

Variants for ZSCAN22 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN22 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10413401 -- 58,331,215(+) ATGCA(C/T)ttttt intron-variant
rs10422004 -- 58,332,068(+) gggtt(G/T)ctcca intron-variant
rs10422889 -- 58,327,282(+) GCcgg(A/T)cacac intron-variant, upstream-variant-2KB
rs10423596 -- 58,335,780(+) TACCA(C/G)ATGTC intron-variant
rs111430315 -- 58,333,755(+) AGGAG(A/G)ATTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN22 Gene

Variant ID Type Subtype PubMed ID
nsv1058109 CNV gain 25217958
nsv515731 CNV gain+loss 19592680
nsv833886 CNV gain 17160897
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZSCAN22 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Disorders for ZSCAN22 Gene

Relevant External Links for ZSCAN22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN22

No disorders were found for ZSCAN22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN22 Gene

Publications for ZSCAN22 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3 4 64
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert J.M. … Vogelstein B. (Mol. Cell. Biol. 1988) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for ZSCAN22 Gene

Sources for ZSCAN22 Gene

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