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Aliases for ZSCAN22 Gene

Aliases for ZSCAN22 Gene

  • Zinc Finger And SCAN Domain Containing 22 2 3 5
  • Zinc Finger Protein 50 2 3 4
  • Krueppel-Related Zinc Finger Protein 2 3 4
  • GLI-Kruppel Family Member HKR2 2 3
  • ZNF50 3 4
  • HKR2 3 4
  • Oncogene HKR2 2
  • Protein HKR2 4

External Ids for ZSCAN22 Gene

Previous HGNC Symbols for ZSCAN22 Gene

  • ZNF50
  • HKR2

Previous GeneCards Identifiers for ZSCAN22 Gene

  • GC19P063531
  • GC19P058838
  • GC19P055147

Summaries for ZSCAN22 Gene

GeneCards Summary for ZSCAN22 Gene

ZSCAN22 (Zinc Finger And SCAN Domain Containing 22) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZSCAN22 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN22 Gene

Genomics for ZSCAN22 Gene

Regulatory Elements for ZSCAN22 Gene

Promoters for ZSCAN22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSCAN22 Gene

Chromosome:
19
Start:
58,327,019 bp from pter
End:
58,342,349 bp from pter
Size:
15,331 bases
Orientation:
Plus strand

Genomic View for ZSCAN22 Gene

Genes around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN22 Gene

Proteins for ZSCAN22 Gene

  • Protein details for ZSCAN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10073-ZSC22_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 22
    Protein Accession:
    P10073
    Secondary Accessions:
    • Q15922
    • Q7Z3L8

    Protein attributes for ZSCAN22 Gene

    Size:
    491 amino acids
    Molecular mass:
    54561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN22 Gene

Proteomics data for ZSCAN22 Gene at MOPED

Post-translational modifications for ZSCAN22 Gene

  • Ubiquitination at Lys 133
  • Modification sites at PhosphoSitePlus

Other Protein References for ZSCAN22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZSCAN22 Gene

Domains & Families for ZSCAN22 Gene

Gene Families for ZSCAN22 Gene

Suggested Antigen Peptide Sequences for ZSCAN22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10073

UniProtKB/Swiss-Prot:

ZSC22_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN22: view

Function for ZSCAN22 Gene

Molecular function for ZSCAN22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN22: view
genes like me logo Genes that share phenotypes with ZSCAN22: view

Animal Model Products

CRISPR Products

Targeted motifs for ZSCAN22 Gene
HOMER Transcription Factor Regulatory Elements motif ZSCAN22
  • Consensus sequence: SMCAGTCWGAKGGAGGAGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZSCAN22 Gene

Localization for ZSCAN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN22 Gene COMPARTMENTS Subcellular localization image for ZSCAN22 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ZSCAN22 Gene

Pathways & Interactions for ZSCAN22 Gene

SuperPathways for ZSCAN22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN22 Gene

Drugs & Compounds for ZSCAN22 Gene

No Compound Related Data Available

Transcripts for ZSCAN22 Gene

Unigene Clusters for ZSCAN22 Gene

Zinc finger and SCAN domain containing 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:
SP3:

Relevant External Links for ZSCAN22 Gene

GeneLoc Exon Structure for
ZSCAN22
ECgene alternative splicing isoforms for
ZSCAN22

Expression for ZSCAN22 Gene

mRNA expression in normal human tissues for ZSCAN22 Gene

SOURCE GeneReport for Unigene cluster for ZSCAN22 Gene Hs.388162

genes like me logo Genes that share expression patterns with ZSCAN22: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZSCAN22 Gene

Orthologs for ZSCAN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN22 36
  • 99 (a)
OneToOne
ZSCAN22 35
  • 98.98 (n)
  • 98.98 (a)
dog
(Canis familiaris)
Mammalia ZSCAN22 35
  • 84.46 (n)
  • 82.62 (a)
ZSCAN22 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan22 16
Zscan22 36
  • 74 (a)
OneToOne
Zscan22 35
  • 78.8 (n)
  • 75.05 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZSCAN22 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102553294 35
  • 77.87 (n)
  • 72.95 (a)
chicken
(Gallus gallus)
Aves ZFP92 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for ZSCAN22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN22 Gene

ENSEMBL:
Gene Tree for ZSCAN22 (if available)
TreeFam:
Gene Tree for ZSCAN22 (if available)

Paralogs for ZSCAN22 Gene

(462) SIMAP similar genes for ZSCAN22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN22: view

Variants for ZSCAN22 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN22 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1268538 -- 58,341,997(+) TTGCT(C/T)AGTCT utr-variant-3-prime
rs4801262 -- 58,336,750(+) gagGC(C/G)ATGGA intron-variant
rs4801263 -- 58,336,879(+) GGCAG(A/G)ACTGA intron-variant
rs10423596 -- 58,335,780(+) TACCA(C/G)ATGTC intron-variant
rs12977231 -- 58,329,697(+) ataat(G/T)gttct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN22 Gene

Variant ID Type Subtype PubMed ID
nsv833886 CNV Gain 17160897
nsv912537 CNV Loss 21882294
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897

Variation tolerance for ZSCAN22 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN22 Gene

HapMap Linkage Disequilibrium report
ZSCAN22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Disorders for ZSCAN22 Gene

Relevant External Links for ZSCAN22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN22

No disorders were found for ZSCAN22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN22 Gene

Publications for ZSCAN22 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3 4 67
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert J.M. … Vogelstein B. (Mol. Cell. Biol. 1988) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. ZifBASE: a database of zinc finger proteins and associated resources. (PMID: 19737425) Jayakanthan M. … Sundar D. (BMC Genomics 2009) 23

Products for ZSCAN22 Gene

Sources for ZSCAN22 Gene

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