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Aliases for ZSCAN21 Gene

Aliases for ZSCAN21 Gene

  • Zinc Finger And SCAN Domain Containing 21 2 3
  • ZNF38 3 4 6
  • Renal Carcinoma Antigen NY-REN-21 3 4
  • Zinc Finger Protein 38 (KOX 25) 2 3
  • Zinc Finger Protein 38 Homolog 3 4
  • Zfp-38 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 21 3
  • Zinc Finger Protein NY-REN-21 Antigen 3
  • Zinc Finger Protein 38 2
  • NY-REN-21 3
  • Zipro1 3
  • KOX25 6
  • ZFP38 4

External Ids for ZSCAN21 Gene

Previous Symbols for ZSCAN21 Gene

  • ZNF38

Summaries for ZSCAN21 Gene

GeneCards Summary for ZSCAN21 Gene

ZSCAN21 (Zinc Finger And SCAN Domain Containing 21) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZSCAN21 Gene

  • Strong transcriptional activator.

Gene Wiki entry for ZSCAN21 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN21 Gene

Genomics for ZSCAN21 Gene

Genomic Location for ZSCAN21 Gene

Start:
100,049,767 bp from pter
End:
100,065,040 bp from pter
Size:
15,274 bases
Orientation:
Plus strand

Genomic View for ZSCAN21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSCAN21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN21 Gene

Regulatory Elements for ZSCAN21 Gene

Proteins for ZSCAN21 Gene

  • Protein details for ZSCAN21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5A6-ZSC21_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 21
    Protein Accession:
    Q9Y5A6
    Secondary Accessions:
    • A4D2A6
    • D6W5T9
    • Q9H0B5

    Protein attributes for ZSCAN21 Gene

    Size:
    473 amino acids
    Molecular mass:
    53658 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN21 Gene

Proteomics data for ZSCAN21 Gene at MOPED

Post-translational modifications for ZSCAN21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN21 Gene

No data available for DME Specific Peptides for ZSCAN21 Gene

Domains for ZSCAN21 Gene

Gene Families for ZSCAN21 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZSCAN21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5A6

UniProtKB/Swiss-Prot:

ZSC21_HUMAN
Domain:
  • Contains 1 SCAN box domain.:
    • Q9Y5A6
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9Y5A6
Similarity:
  • Contains 7 C2H2-type zinc fingers.:
    • Q9Y5A6
genes like me logo Genes that share domains with ZSCAN21: view

Function for ZSCAN21 Gene

Molecular function for ZSCAN21 Gene

UniProtKB/Swiss-Prot Function: Strong transcriptional activator.

Gene Ontology (GO) - Molecular Function for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19549071
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 19549071
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 19549071
genes like me logo Genes that share ontologies with ZSCAN21: view

Phenotypes for ZSCAN21 Gene

MGI mutant phenotypes for ZSCAN21:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZSCAN21: view

Animal Models for ZSCAN21 Gene

MGI Knock Outs for ZSCAN21:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZSCAN21 Gene

Localization for ZSCAN21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Gene Ontology (GO) - Cellular Components for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN21: view

No data available for Subcellular locations from COMPARTMENTS for ZSCAN21 Gene

Pathways for ZSCAN21 Gene

SuperPathways for ZSCAN21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IMP 19549071
GO:0045893 positive regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 19549071
genes like me logo Genes that share ontologies with ZSCAN21: view

No data available for Pathways by source for ZSCAN21 Gene

Transcripts for ZSCAN21 Gene

Unigene Clusters for ZSCAN21 Gene

Zinc finger and SCAN domain containing 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ZSCAN21 Gene

GeneLoc Exon Structure for
ZSCAN21
ECgene alternative splicing isoforms for
ZSCAN21

Expression for ZSCAN21 Gene

mRNA expression in normal human tissues for ZSCAN21 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZSCAN21 Gene

SOURCE GeneReport for Unigene cluster for ZSCAN21 Gene Hs.632294

genes like me logo Genes that share expressions with ZSCAN21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSCAN21 Gene

Orthologs for ZSCAN21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN21 35
  • 99.86 (n)
  • 99.79 (a)
ZSCAN21 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN21 35
  • 84.99 (n)
  • 85.06 (a)
ZSCAN21 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN21 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan21 35
  • 81.28 (n)
  • 81.94 (a)
Zscan21 16
Zscan21 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZSCAN21 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zscan21 35
  • 82.56 (n)
  • 83.22 (a)
Species with no ortholog for ZSCAN21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN21 Gene

ENSEMBL:
Gene Tree for ZSCAN21 (if available)
TreeFam:
Gene Tree for ZSCAN21 (if available)

Paralogs for ZSCAN21 Gene

Selected SIMAP similar genes for ZSCAN21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZSCAN21: view

Variants for ZSCAN21 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN21 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4421299 -- 100,062,525(+) gggag(A/G)cagag intron-variant
rs4729571 -- 100,050,644(+) actga(A/G)ccgag intron-variant, upstream-variant-2KB
rs4729572 -- 100,052,443(+) aaaaa(A/T)ttaaa intron-variant
rs7776586 -- 100,054,781(+) ttgca(A/G)tgagc intron-variant
rs7780686 -- 100,055,299(+) ttgct(C/G)tgtca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN21 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489
nsv507405 CNV Insertion 20534489
esv2667101 CNV Deletion 23128226

Relevant External Links for ZSCAN21 Gene

HapMap Linkage Disequilibrium report
ZSCAN21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Disorders for ZSCAN21 Gene

No disorders were found for ZSCAN21 Gene.

No data available for UniProtKB/Swiss-Prot for ZSCAN21 Gene

Publications for ZSCAN21 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. (PMID: 16540086) Carneiro F.R. … Zanchin N.I. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3
  5. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4

Products for ZSCAN21 Gene

Sources for ZSCAN21 Gene

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