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Aliases for ZSCAN21 Gene

Aliases for ZSCAN21 Gene

  • Zinc Finger And SCAN Domain Containing 21 2 3 5
  • Renal Carcinoma Antigen NY-REN-21 3 4
  • Zinc Finger Protein 38 (KOX 25) 2 3
  • Zinc Finger Protein 38 Homolog 3 4
  • Zfp-38 3 4
  • ZNF38 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 21 3
  • Zinc Finger Protein NY-REN-21 Antigen 3
  • Zinc Finger Protein 38 2
  • NY-REN-21 3
  • Zipro1 3
  • ZFP38 4

External Ids for ZSCAN21 Gene

Previous HGNC Symbols for ZSCAN21 Gene

  • ZNF38

Previous GeneCards Identifiers for ZSCAN21 Gene

  • GC07P099486
  • GC07P099647
  • GC07P094282

Summaries for ZSCAN21 Gene

GeneCards Summary for ZSCAN21 Gene

ZSCAN21 (Zinc Finger And SCAN Domain Containing 21) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZSCAN21 Gene

  • Strong transcriptional activator.

Gene Wiki entry for ZSCAN21 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN21 Gene

Genomics for ZSCAN21 Gene

Regulatory Elements for ZSCAN21 Gene

Enhancers for ZSCAN21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100076 1.2 ENCODE 18.8 +30.3 30337 6.7 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D SSRP1 AP4M1 ZSCAN25 ZNF655 ENSG00000242798 SMURF1 MBLAC1 PPP1R35 ZSCAN21 RN7SL416P RN7SL750P
GH07F100049 1.1 ENCODE 16 +0.3 334 2.3 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF263 AP4M1 ZSCAN21 LOC100131859 MIR6875 PIR43713
GH07F100052 1 Ensembl ENCODE 15.9 +3.5 3525 1.6 CTCF ARID4B CEBPG ZIC2 RAD21 YY1 ZNF664 ZNF316 SMC3 ZNF600 ZSCAN21 STAG3 PIR43713 PIR44616 GC07M100077
GH07F100040 1 Ensembl ENCODE 15.7 -8.2 -8207 1.9 BCOR CTCF PKNOX1 ESRRA TAL1 JUN THRB RAD21 ZNF644 CTBP1 AP4M1 ZSCAN21 ZKSCAN1 MCM7 COPS6 MIR106B MIR25 MIR93 PILRA GC07P100039
GH07F100022 0.9 ENCODE 17.3 -26.2 -26235 2.4 ELF3 TBP PKNOX1 MLX ARID4B SIN3A DMAP1 THRB RAD21 RARA ZSCAN21 AP4M1 PVRIG TRIM4 MUC3A ZKSCAN1 GC07P100035
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN21 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158406 133 1401 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Location for ZSCAN21 Gene

Chromosome:
7
Start:
100,049,767 bp from pter
End:
100,065,042 bp from pter
Size:
15,276 bases
Orientation:
Plus strand

Genomic View for ZSCAN21 Gene

Genes around ZSCAN21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN21 Gene

Proteins for ZSCAN21 Gene

  • Protein details for ZSCAN21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5A6-ZSC21_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 21
    Protein Accession:
    Q9Y5A6
    Secondary Accessions:
    • A4D2A6
    • D6W5T9
    • Q9H0B5

    Protein attributes for ZSCAN21 Gene

    Size:
    473 amino acids
    Molecular mass:
    53658 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN21 Gene

Post-translational modifications for ZSCAN21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN21 Gene

No data available for DME Specific Peptides for ZSCAN21 Gene

Domains & Families for ZSCAN21 Gene

Gene Families for ZSCAN21 Gene

Suggested Antigen Peptide Sequences for ZSCAN21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5A6

UniProtKB/Swiss-Prot:

ZSC21_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN21: view

Function for ZSCAN21 Gene

Molecular function for ZSCAN21 Gene

UniProtKB/Swiss-Prot Function:
Strong transcriptional activator.

Gene Ontology (GO) - Molecular Function for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19549071
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19549071
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ZSCAN21: view

Phenotypes for ZSCAN21 Gene

genes like me logo Genes that share phenotypes with ZSCAN21: view

Animal Models for ZSCAN21 Gene

MGI Knock Outs for ZSCAN21:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZSCAN21 Gene

Localization for ZSCAN21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN21 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZSCAN21: view

Pathways & Interactions for ZSCAN21 Gene

SuperPathways for ZSCAN21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 19549071
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IMP --
GO:0016567 protein ubiquitination IMP --
genes like me logo Genes that share ontologies with ZSCAN21: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN21 Gene

Transcripts for ZSCAN21 Gene

Unigene Clusters for ZSCAN21 Gene

Zinc finger and SCAN domain containing 21:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ZSCAN21 Gene

GeneLoc Exon Structure for
ZSCAN21
ECgene alternative splicing isoforms for
ZSCAN21

Expression for ZSCAN21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN21 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN21 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSCAN21 Gene



Protein tissue co-expression partners for ZSCAN21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN21 Gene:

ZSCAN21

SOURCE GeneReport for Unigene cluster for ZSCAN21 Gene:

Hs.632294
genes like me logo Genes that share expression patterns with ZSCAN21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSCAN21 Gene

Orthologs for ZSCAN21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN21 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia ZSCAN21 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN21 34 35
  • 84.99 (n)
rat
(Rattus norvegicus)
Mammalia Zscan21 34
  • 82.56 (n)
mouse
(Mus musculus)
Mammalia Zscan21 34 16 35
  • 81.28 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSCAN21 35
  • 44 (a)
OneToOne
Species where no ortholog for ZSCAN21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN21 Gene

ENSEMBL:
Gene Tree for ZSCAN21 (if available)
TreeFam:
Gene Tree for ZSCAN21 (if available)

Paralogs for ZSCAN21 Gene

(566) SIMAP similar genes for ZSCAN21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZSCAN21: view

Variants for ZSCAN21 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN21 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10281368 -- 100,058,274(+) GACAG(A/G)GGGGG intron-variant
rs10596959 -- 100,054,958(+) CTCTC(-/TT)TTTTT intron-variant
rs10689639 -- 100,065,127(+) CTTTT(-/TT)AGAAA intron-variant, downstream-variant-500B
rs111230268 -- 100,065,424(+) GTCTC(-/A)AAAAA intron-variant, downstream-variant-500B
rs111319211 -- 100,062,762(+) CCCAG(C/T)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN21 Gene

Variant ID Type Subtype PubMed ID
esv2667101 CNV deletion 23128226
esv2734888 CNV deletion 23290073
esv3614288 CNV loss 21293372
esv3614289 CNV loss 21293372
nsv469687 CNV loss 16826518
nsv507405 OTHER sequence alteration 20534489
nsv510966 OTHER complex 20534489

Variation tolerance for ZSCAN21 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Disorders for ZSCAN21 Gene

Relevant External Links for ZSCAN21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN21

No disorders were found for ZSCAN21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN21 Gene

Publications for ZSCAN21 Gene

  1. Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. (PMID: 16540086) Carneiro F.R. … Zanchin N.I. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4 64

Products for ZSCAN21 Gene

Sources for ZSCAN21 Gene

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