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Aliases for ZSCAN21 Gene

Aliases for ZSCAN21 Gene

  • Zinc Finger And SCAN Domain Containing 21 2 3
  • Renal Carcinoma Antigen NY-REN-21 3 4
  • Zinc Finger Protein 38 (KOX 25) 2 3
  • Zinc Finger Protein 38 Homolog 3 4
  • Zfp-38 3 4
  • ZNF38 3 4
  • Zinc Finger Protein NY-REN-21 Antigen 3
  • Zinc Finger Protein 38 2
  • NY-REN-21 3
  • Zipro1 3
  • ZFP38 4

External Ids for ZSCAN21 Gene

Previous HGNC Symbols for ZSCAN21 Gene

  • ZNF38

Previous GeneCards Identifiers for ZSCAN21 Gene

  • GC07P099486
  • GC07P099647
  • GC07P094282

Summaries for ZSCAN21 Gene

GeneCards Summary for ZSCAN21 Gene

ZSCAN21 (Zinc Finger And SCAN Domain Containing 21) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZSCAN21 Gene

  • Strong transcriptional activator.

Gene Wiki entry for ZSCAN21 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN21 Gene

Genomics for ZSCAN21 Gene

Regulatory Elements for ZSCAN21 Gene

Genomic Location for ZSCAN21 Gene

Chromosome:
7
Start:
100,049,767 bp from pter
End:
100,065,042 bp from pter
Size:
15,276 bases
Orientation:
Plus strand

Genomic View for ZSCAN21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSCAN21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN21 Gene

Proteins for ZSCAN21 Gene

  • Protein details for ZSCAN21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5A6-ZSC21_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 21
    Protein Accession:
    Q9Y5A6
    Secondary Accessions:
    • A4D2A6
    • D6W5T9
    • Q9H0B5

    Protein attributes for ZSCAN21 Gene

    Size:
    473 amino acids
    Molecular mass:
    53658 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN21 Gene

Proteomics data for ZSCAN21 Gene at MOPED

Post-translational modifications for ZSCAN21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN21 Gene

Antibody Products

No data available for DME Specific Peptides for ZSCAN21 Gene

Domains & Families for ZSCAN21 Gene

Gene Families for ZSCAN21 Gene

Suggested Antigen Peptide Sequences for ZSCAN21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5A6

UniProtKB/Swiss-Prot:

ZSC21_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN21: view

Function for ZSCAN21 Gene

Molecular function for ZSCAN21 Gene

UniProtKB/Swiss-Prot Function:
Strong transcriptional activator.

Gene Ontology (GO) - Molecular Function for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19549071
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19549071
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
genes like me logo Genes that share ontologies with ZSCAN21: view

Phenotypes for ZSCAN21 Gene

MGI mutant phenotypes for ZSCAN21:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZSCAN21:
genes like me logo Genes that share phenotypes with ZSCAN21: view

Animal Models for ZSCAN21 Gene

MGI Knock Outs for ZSCAN21:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSCAN21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZSCAN21 Gene

Localization for ZSCAN21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN21 Gene COMPARTMENTS Subcellular localization image for ZSCAN21 gene
Compartment Confidence
endoplasmic reticulum 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZSCAN21: view

Pathways & Interactions for ZSCAN21 Gene

SuperPathways for ZSCAN21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IMP 19549071
GO:0006366 transcription from RNA polymerase II promoter IDA 19549071
GO:0045893 positive regulation of transcription, DNA-templated --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 19549071
genes like me logo Genes that share ontologies with ZSCAN21: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN21 Gene

Drugs & Compounds for ZSCAN21 Gene

No Compound Related Data Available

Transcripts for ZSCAN21 Gene

Unigene Clusters for ZSCAN21 Gene

Zinc finger and SCAN domain containing 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZSCAN21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ZSCAN21 Gene

GeneLoc Exon Structure for
ZSCAN21
ECgene alternative splicing isoforms for
ZSCAN21

Expression for ZSCAN21 Gene

mRNA expression in normal human tissues for ZSCAN21 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN21 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZSCAN21 Gene



SOURCE GeneReport for Unigene cluster for ZSCAN21 Gene Hs.632294

genes like me logo Genes that share expression patterns with ZSCAN21: view

Protein tissue co-expression partners for ZSCAN21 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSCAN21 Gene

Orthologs for ZSCAN21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZSCAN21 35
  • 84.99 (n)
  • 85.06 (a)
ZSCAN21 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan21 35
  • 81.28 (n)
  • 81.94 (a)
Zscan21 16
Zscan21 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN21 35
  • 99.86 (n)
  • 99.79 (a)
ZSCAN21 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zscan21 35
  • 82.56 (n)
  • 83.22 (a)
dog
(Canis familiaris)
Mammalia ZSCAN21 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZSCAN21 36
  • 44 (a)
OneToOne
Species with no ortholog for ZSCAN21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN21 Gene

ENSEMBL:
Gene Tree for ZSCAN21 (if available)
TreeFam:
Gene Tree for ZSCAN21 (if available)

Paralogs for ZSCAN21 Gene

(566) SIMAP similar genes for ZSCAN21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZSCAN21: view

Variants for ZSCAN21 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN21 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4421299 -- 100,062,525(+) gggag(A/G)cagag intron-variant
rs4729571 -- 100,050,644(+) actga(A/G)ccgag intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs4729572 -- 100,052,443(+) aaaaa(A/T)ttaaa intron-variant
rs7776586 -- 100,054,781(+) ttgca(A/G)tgagc intron-variant
rs7780686 -- 100,055,299(+) ttgct(C/G)tgtca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN21 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489
nsv507405 CNV Insertion 20534489
esv2667101 CNV Deletion 23128226

Variation tolerance for ZSCAN21 Gene

Residual Variation Intolerance Score: 34.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN21 Gene

HapMap Linkage Disequilibrium report
ZSCAN21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Disorders for ZSCAN21 Gene

Relevant External Links for ZSCAN21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN21
genes like me logo Genes that share disorders with ZSCAN21: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN21 Gene

Publications for ZSCAN21 Gene

  1. Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. (PMID: 16540086) Carneiro F.R. … Zanchin N.I. (Biochem. Biophys. Res. Commun. 2006) 23 67
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 67
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for ZSCAN21 Gene

Sources for ZSCAN21 Gene

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