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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSCAN18 Gene

protein-coding   GIFtS: 45
GCID: GC19M058595

zinc finger and SCAN domain containing 18

(Previous name: zinc finger protein 447 )
(Previous symbol: ZNF447)
  Search for ZSCAN18
in our new
 Human Malady Compendium 
Biological research products
for ZSCAN18
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 181 2
Zinc Finger Protein 4471 2 3
ZNF4471 2 3
FLJ128951
Zinc Finger And SCAN Domain-Containing Protein 182

External Ids:    HGNC: 210371   Entrez Gene: 659822   Ensembl: ENSG000001214137   UniProtKB: Q8TBC53   

Export aliases for ZSCAN18 gene to outside databases

Previous GC identifers: GC19M063289 GC19M054906


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZSC18_HUMAN, Q8TBC5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSCAN18 gene promoter:
         AML1a   Pax-6   FOXJ2 (long isoform)   FOXO4   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZSCAN18 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZSCAN18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZSCAN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN18 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058595:  view genomic region     (about GC identifiers)

Start:
58,595,209 bp from pter      End:
58,629,793 bp from pter
Size:
34,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZSC18_HUMAN, Q8TBC5 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 18  
Size: 510 amino acids; 54804 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B4DG23 Q9BRK7 Q9H9A0
Alternative splicing: 3 isoforms:  Q8TBC5-1   Q8TBC5-2   Q8TBC5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZSCAN18: NX_Q8TBC5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TBC5

  • ZSCAN18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001139014.1  NP_001139015.1  NP_001139016.1  NP_076415.3  

    ENSEMBL proteins: 
     ENSP00000412253   ENSP00000240727   ENSP00000392653  

    Human Recombinant Protein Products: 
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    Novus Biologicals ZSCAN18 Proteins
    Novus Biologicals ZSCAN18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZSCAN18

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    ZSCAN18 for ontologies           About GeneDecksing



    ZSCAN18 Antibody Products: 
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    Uscn ELISAs and CLIAs for ZSCAN18


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZSCAN18 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry Q8TBC5

    ProtoNet protein and cluster: Q8TBC5

    1 Blocks protein family: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: ZSC18_HUMAN, Q8TBC5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 2 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZSC18_HUMAN, Q8TBC5
    Function: May be involved in transcriptional regulation

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZSCAN18:
    hsa-miR-3910 hsa-miR-3140-3p hsa-miR-124 hsa-miR-506 hsa-miR-1305 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidZSCAN18 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZSCAN18
    OriGene shRNA RFP: ZSCAN18
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN18 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN18

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZSCAN18 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZSCAN18:
     Actin fiber cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN18

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZSCAN18 (Q8TBC53 ENSP000004122534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXD4P090163, ENSP000003025484I2D: score=1 STRING: ENSP00000302548
    LIG4ENSP000003493934STRING: ENSP00000349393
    SAFB2ENSP000002525424STRING: ENSP00000252542
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016032viral reproduction IEA--


    ZSCAN18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSCAN18
    Search CenterWatch for drugs/clinical trials and news about ZSCAN18 / ZSC18 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZSCAN18 gene (4 alternative transcripts): 
    NM_001145542.1  NM_001145543.1  NM_001145544.1  NM_023926.4  

    Unigene Cluster for ZSCAN18:

    Zinc finger and SCAN domain containing 18
    Hs.235390  [show with all ESTs]
    Unigene Representative Sequence: NM_023926
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433686(uc002qrj.3 uc010yht.1 uc002qrk.1 uc002qrm.2)
    ENST00000240727(uc002qrh.2 uc002qri.2 uc002qrl.2) ENST00000421612(uc010yhs.1)


    miRNA
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    OriGene 3'-UTR Clone (see all 4): ZSCAN18
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZSCAN18:
    hsa-miR-3910 hsa-miR-3140-3p hsa-miR-124 hsa-miR-506 hsa-miR-1305 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidZSCAN18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZSCAN18
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN18

    Additional cDNA sequence: 

    AK022957.1 AK096238.1 AK126140.1 AK225548.1 AK294376.1 AK296417.1 AL049448.1 AY279352.1 
    AY280799.1 BC006205.2 BC017411.1 BC022846.2 NR_027135.1 

    18 DOTS entries:

    DT.441381  DT.75168482  DT.91775293  DT.95273940  DT.121438228  DT.100040961  DT.95273948  DT.100673715 
    DT.101982345  DT.97825276  DT.100770717  DT.91775286  DT.121438337  DT.40251004  DT.121438223  DT.121438268 
    DT.121438349  DT.121608457 

    24/253 AceView cDNA sequences (see all 253):

    BM693257 AI421781 CA388826 AU280805 BC006205 AI368950 AA702289 BG056286 
    AU130221 BM741427 BM744373 AI740634 AI375002 AA927548 AI378413 AI654974 
    AI085602 AI042204 BF940478 AL049448 CA390826 BM709577 CA412630 BQ024996 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN18    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                    -                                                               
    SP5:              -     -                                                               


    ECgene alternative splicing isoforms for ZSCAN18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSCAN18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTAAAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZSCAN18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSCAN18

    SOURCE GeneReport for Unigene cluster: Hs.235390
        SABiosciences Custom PCR Arrays for ZSCAN18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZSCAN18 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 20)
    --
    43(a)
    38(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    GL343434.1(394467-394832)
    GL343733.1(38386-38731)


    ENSEMBL Gene Tree for ZSCAN18 (if available)
    TreeFam Gene Tree for ZSCAN18 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSCAN18 gene
    ZNF2742  ZNF2152  ZSCAN12  ZNF4832  
    18/51 SIMAP similar genes for ZSCAN18 using alignment to 9 protein entries:     ZSC18_HUMAN (see all proteins) (see all similar genes):
    FLJ00320    ZSCAN1    ZNF396    ZSCAN31    ZNF394    ZSCAN20
    ZSCAN30    ZNF202    ZNF165    ZNF444    ZNF483    LOC100128510
    ZNF24    ZNF397    ZKSCAN5    ZNF434    ZSCAN23    ZNF213

    ZSCAN18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/802 NCBI SNPs in ZSCAN18 are shown (see all 802    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008884391,2
    C,other58600018(+) CCTAAG/AGCCCA 4 -- int11Minor allele frequency- A:0.00EU 779
    rs1839041931,2
    --58594792(+) ACCTCC/TGCCTC 4 -- int10--------
    rs1418403261,2
    --58594852(+) CAGGCA/GCGCAT 4 -- int10--------
    rs1506267031,2
    --58594906(+) TTTCAC/GCATGT 4 -- int10--------
    rs1889438961,2
    --58595096(+) TCTGTA/GTCTAC 4 -- int10--------
    rs1400184731,2
    --58595112(+) GCAGTC/TAAGTT 4 -- int10--------
    rs1914916611,2
    --58595304(+) AATGTC/TTTACA 4 -- ut310--------
    rs286395251,2
    C,F,--58595364(+) CAGTAT/GTTGCC 4 -- ut31 ese33Minor allele frequency- G:0.09WA CSA 122
    rs1837324401,2
    --58595410(+) GCTTCA/GTTGCT 4 -- ut310--------
    rs1151671221,2
    F,--58595497(+) GCCTTA/TGGCTG 4 -- ut311Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for ZSCAN18 (58595209 - 58629793 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for ZSCAN18
         1 CNV: 5118
         5 Indels: 45809 61732 40296 40295 26361

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSCAN18 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSCAN18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65982 HGNC: 21037 AceView: FLJ12895 Ensembl:ENSG00000121413 euGenes: HUgn65982
    ECgene: ZSCAN18 H-InvDB: ZSCAN18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSCAN18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZSCAN18 gene:
    Search GeneIP for patents involving ZSCAN18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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