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Aliases for ZSCAN18 Gene

Aliases for ZSCAN18 Gene

  • Zinc Finger And SCAN Domain Containing 18 2 3 5
  • Zinc Finger Protein 447 2 3 4
  • ZNF447 3 4

External Ids for ZSCAN18 Gene

Previous HGNC Symbols for ZSCAN18 Gene

  • ZNF447

Previous GeneCards Identifiers for ZSCAN18 Gene

  • GC19M063289
  • GC19M058595
  • GC19M054906

Summaries for ZSCAN18 Gene

GeneCards Summary for ZSCAN18 Gene

ZSCAN18 (Zinc Finger And SCAN Domain Containing 18) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF274.

UniProtKB/Swiss-Prot for ZSCAN18 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN18 Gene

Genomics for ZSCAN18 Gene

Regulatory Elements for ZSCAN18 Gene

Genomic Location for ZSCAN18 Gene

Chromosome:
19
Start:
58,083,834 bp from pter
End:
58,118,433 bp from pter
Size:
34,600 bases
Orientation:
Minus strand

Genomic View for ZSCAN18 Gene

Genes around ZSCAN18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN18 Gene

Proteins for ZSCAN18 Gene

  • Protein details for ZSCAN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBC5-ZSC18_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 18
    Protein Accession:
    Q8TBC5
    Secondary Accessions:
    • B4DG23
    • E9PBI0
    • Q9BRK7
    • Q9H9A0

    Protein attributes for ZSCAN18 Gene

    Size:
    510 amino acids
    Molecular mass:
    54804 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN18 Gene

Proteomics data for ZSCAN18 Gene at MOPED

Post-translational modifications for ZSCAN18 Gene

  • Ubiquitination at Lys 217 and Lys 244
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZSCAN18 Gene

Domains & Families for ZSCAN18 Gene

Gene Families for ZSCAN18 Gene

Suggested Antigen Peptide Sequences for ZSCAN18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBC5

UniProtKB/Swiss-Prot:

ZSC18_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN18: view

Function for ZSCAN18 Gene

Molecular function for ZSCAN18 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZSCAN18: view
genes like me logo Genes that share phenotypes with ZSCAN18: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN18 Gene

miRTarBase miRNAs that target ZSCAN18

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN18 Gene

Localization for ZSCAN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN18 Gene COMPARTMENTS Subcellular localization image for ZSCAN18 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZSCAN18 Gene

Pathways & Interactions for ZSCAN18 Gene

SuperPathways for ZSCAN18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN18: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN18 Gene

Drugs & Compounds for ZSCAN18 Gene

No Compound Related Data Available

Transcripts for ZSCAN18 Gene

Unigene Clusters for ZSCAN18 Gene

Zinc finger and SCAN domain containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:
SP4: -
SP5: - -

Relevant External Links for ZSCAN18 Gene

GeneLoc Exon Structure for
ZSCAN18
ECgene alternative splicing isoforms for
ZSCAN18

Expression for ZSCAN18 Gene

mRNA expression in normal human tissues for ZSCAN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSCAN18 Gene

This gene is overexpressed in Stomach (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZSCAN18 Gene



SOURCE GeneReport for Unigene cluster for ZSCAN18 Gene Hs.235390

genes like me logo Genes that share expression patterns with ZSCAN18: view

Protein tissue co-expression partners for ZSCAN18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSCAN18 Gene

Orthologs for ZSCAN18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN18 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZSCAN18 35
  • 72.6 (n)
  • 61.44 (a)
ZSCAN18 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan18 35
  • 67.14 (n)
  • 59.19 (a)
Zscan18 16
Zscan18 36
  • 27 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN18 35
  • 99.48 (n)
  • 99.61 (a)
ZSCAN18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zscan18 35
  • 67.83 (n)
  • 60.25 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
Species with no ortholog for ZSCAN18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN18 Gene

ENSEMBL:
Gene Tree for ZSCAN18 (if available)
TreeFam:
Gene Tree for ZSCAN18 (if available)

Paralogs for ZSCAN18 Gene

Paralogs for ZSCAN18 Gene

genes like me logo Genes that share paralogs with ZSCAN18: view

Variants for ZSCAN18 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2258557 - 58,085,082(+) TCTGC(C/T)CGTCC reference, missense
rs10878 -- 58,084,309(+) AAACA(G/T)GAGGA utr-variant-3-prime
rs295346 -- 58,104,913(-) ttctt(C/T)acatt intron-variant
rs295347 -- 58,104,889(-) actgt(A/C)gcgac intron-variant
rs295350 -- 58,085,558(+) GCCCC(A/G)CGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN18 Gene

Variant ID Type Subtype PubMed ID
nsv833885 CNV Loss 17160897
nsv912533 CNV Loss 21882294
nsv458836 CNV Gain 19166990
nsv912535 CNV Loss 21882294
nsv912536 CNV Gain 21882294
esv2189581 CNV Deletion 18987734
esv6433 CNV Loss 19470904
esv2719099 CNV Deletion 23290073
esv1409673 CNV Deletion 17803354
nsv833886 CNV Gain 17160897

Variation tolerance for ZSCAN18 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN18 Gene

HapMap Linkage Disequilibrium report
ZSCAN18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN18 Gene

Disorders for ZSCAN18 Gene

Relevant External Links for ZSCAN18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN18

No disorders were found for ZSCAN18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN18 Gene

Publications for ZSCAN18 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. (PMID: 24948044) Vedeld H.M. … Lind G.E. (Int. J. Cancer 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ZSCAN18 Gene

Sources for ZSCAN18 Gene

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