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Aliases for ZSCAN18 Gene

Aliases for ZSCAN18 Gene

  • Zinc Finger And SCAN Domain Containing 18 2 3
  • Zinc Finger Protein 447 2 3 4
  • ZNF447 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 18 3

External Ids for ZSCAN18 Gene

Previous Symbols for ZSCAN18 Gene

  • ZNF447

Summaries for ZSCAN18 Gene

GeneCards Summary for ZSCAN18 Gene

ZSCAN18 (Zinc Finger And SCAN Domain Containing 18) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZSCAN1.

UniProtKB/Swiss-Prot for ZSCAN18 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN18 Gene

Genomics for ZSCAN18 Gene

Genomic Location for ZSCAN18 Gene

Start:
58,083,837 bp from pter
End:
58,118,427 bp from pter
Size:
34,591 bases
Orientation:
Minus strand

Genomic View for ZSCAN18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSCAN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN18 Gene

Regulatory Elements for ZSCAN18 Gene

Proteins for ZSCAN18 Gene

  • Protein details for ZSCAN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBC5-ZSC18_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 18
    Protein Accession:
    Q8TBC5
    Secondary Accessions:
    • B4DG23
    • E9PBI0
    • Q9BRK7
    • Q9H9A0

    Protein attributes for ZSCAN18 Gene

    Size:
    510 amino acids
    Molecular mass:
    54804 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN18 Gene

Proteomics data for ZSCAN18 Gene at MOPED

Post-translational modifications for ZSCAN18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys217, Lys240, and Lys244

No data available for DME Specific Peptides for ZSCAN18 Gene

Domains for ZSCAN18 Gene

Gene Families for ZSCAN18 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZSC18_HUMAN
Domain:
  • Contains 1 SCAN box domain.:
    • Q8TBC5
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8TBC5
Similarity:
  • Contains 2 C2H2-type zinc fingers.:
    • Q8TBC5
genes like me logo Genes that share domains with ZSCAN18: view

Function for ZSCAN18 Gene

Molecular function for ZSCAN18 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN18: view

Phenotypes for ZSCAN18 Gene

GenomeRNAi human phenotypes for ZSCAN18:
genes like me logo Genes that share phenotypes with ZSCAN18: view

miRNA for ZSCAN18 Gene

miRTarBase miRNAs that target ZSCAN18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZSCAN18 Gene

Localization for ZSCAN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN18 Gene COMPARTMENTS Subcellular localization image for ZSCAN18 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZSCAN18: view

Pathways for ZSCAN18 Gene

SuperPathways for ZSCAN18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZSCAN18: view

No data available for Pathways by source for ZSCAN18 Gene

Transcripts for ZSCAN18 Gene

Unigene Clusters for ZSCAN18 Gene

Zinc finger and SCAN domain containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:
SP4: -
SP5: - -

Relevant External Links for ZSCAN18 Gene

GeneLoc Exon Structure for
ZSCAN18
ECgene alternative splicing isoforms for
ZSCAN18

Expression for ZSCAN18 Gene

mRNA expression in normal human tissues for ZSCAN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZSCAN18 Gene

SOURCE GeneReport for Unigene cluster for ZSCAN18 Gene Hs.235390

genes like me logo Genes that share expressions with ZSCAN18: view

Orthologs for ZSCAN18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN18 36
  • 99.48 (n)
  • 99.61 (a)
ZSCAN18 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN18 36
  • 72.6 (n)
  • 61.44 (a)
ZSCAN18 37
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan18 36
  • 67.14 (n)
  • 59.19 (a)
Zscan18 16
Zscan18 37
  • 27 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 22 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zscan18 36
  • 67.83 (n)
  • 60.25 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 25 (a)
OneToMany
Species with no ortholog for ZSCAN18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN18 Gene

ENSEMBL:
Gene Tree for ZSCAN18 (if available)
TreeFam:
Gene Tree for ZSCAN18 (if available)

Paralogs for ZSCAN18 Gene

Paralogs for ZSCAN18 Gene

genes like me logo Genes that share paralogs with ZSCAN18: view

Variants for ZSCAN18 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10878 -- 58,084,309(+) AAACA(G/T)GAGGA utr-variant-3-prime
rs167182 -- 58,104,382(-) gtttt(G/T)ttttt intron-variant
rs186101 -- 58,083,462(+) agcct(C/T)ctgag downstream-variant-500B
rs188415 -- 58,104,946(-) actac(C/G)tggca intron-variant
rs211579 -- 58,103,903(-) ATTCA(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN18 Gene

Variant ID Type Subtype PubMed ID
nsv833885 CNV Loss 17160897
nsv912533 CNV Loss 21882294
nsv458836 CNV Gain 19166990
nsv912535 CNV Loss 21882294
nsv912536 CNV Gain 21882294
esv2189581 CNV Deletion 18987734
esv6433 CNV Loss 19470904
esv2719099 CNV Deletion 23290073
esv1409673 CNV Deletion 17803354
nsv833886 CNV Gain 17160897

Relevant External Links for ZSCAN18 Gene

HapMap Linkage Disequilibrium report
ZSCAN18

Disorders for ZSCAN18 Gene

No disorders were found for ZSCAN18 Gene.

No data available for UniProtKB/Swiss-Prot for ZSCAN18 Gene

Publications for ZSCAN18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ZSCAN18 Gene

Sources for ZSCAN18 Gene

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