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Aliases for ZSCAN18 Gene

Aliases for ZSCAN18 Gene

  • Zinc Finger And SCAN Domain Containing 18 2 3 5
  • Zinc Finger Protein 447 2 3 4
  • ZNF447 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 18 3

External Ids for ZSCAN18 Gene

Previous HGNC Symbols for ZSCAN18 Gene

  • ZNF447

Previous GeneCards Identifiers for ZSCAN18 Gene

  • GC19M063289
  • GC19M058595
  • GC19M054906

Summaries for ZSCAN18 Gene

GeneCards Summary for ZSCAN18 Gene

ZSCAN18 (Zinc Finger And SCAN Domain Containing 18) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF274.

UniProtKB/Swiss-Prot for ZSCAN18 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN18 Gene

Genomics for ZSCAN18 Gene

Regulatory Elements for ZSCAN18 Gene

Enhancers for ZSCAN18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H058325 1.2 ENCODE 54 -208.4 -208438 3 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 ZNF134 ZNF606 ZNF549 ZNF446 ZNF17 ZNF135 ZNF417 ZNF324B TRIM28 LOC100128398
GH19H058571 1.4 ENCODE dbSUPER 43 -455.7 -455680 4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 TRIM28 ZSCAN18 ZNF446 LOC100128398 ZNF135 ZNF134 ZNF132 ZNF418 ENSG00000268201 LOC105372482
GH19H058379 1.2 ENCODE 50.1 -262.7 -262653 2 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 ZNF610 LOC100128398 ZNF329 ZNF606 ZSCAN18 ZNF135 TRIM28 ZNF446 ZNF132 ZNF549 ZNF417
GH19H058517 2 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -401.3 -401276 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZNF324B ZNF446 TRIM28 ZNF134 ZNF549 ZNF417 ZNF606 ZNF135 MZF1 ZNF274
GH19H058181 1.1 ENCODE 30.2 -64.8 -64804 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF773 ZNF550 ZNF543 ZNF256 LOC105372483
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN18 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSCAN18 Gene

Chromosome:
19
Start:
58,083,834 bp from pter
End:
58,118,433 bp from pter
Size:
34,600 bases
Orientation:
Minus strand

Genomic View for ZSCAN18 Gene

Genes around ZSCAN18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN18 Gene

Proteins for ZSCAN18 Gene

  • Protein details for ZSCAN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBC5-ZSC18_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 18
    Protein Accession:
    Q8TBC5
    Secondary Accessions:
    • B4DG23
    • E9PBI0
    • Q9BRK7
    • Q9H9A0

    Protein attributes for ZSCAN18 Gene

    Size:
    510 amino acids
    Molecular mass:
    54804 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN18 Gene

Post-translational modifications for ZSCAN18 Gene

  • Ubiquitination at Lys217 and Lys244
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ZSCAN18

No data available for DME Specific Peptides for ZSCAN18 Gene

Domains & Families for ZSCAN18 Gene

Gene Families for ZSCAN18 Gene

Suggested Antigen Peptide Sequences for ZSCAN18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBC5

UniProtKB/Swiss-Prot:

ZSC18_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN18: view

Function for ZSCAN18 Gene

Molecular function for ZSCAN18 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN18: view
genes like me logo Genes that share phenotypes with ZSCAN18: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN18 Gene

miRTarBase miRNAs that target ZSCAN18

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN18 Gene

Localization for ZSCAN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN18 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZSCAN18: view

Pathways & Interactions for ZSCAN18 Gene

SuperPathways for ZSCAN18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZSCAN18: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN18 Gene

Drugs & Compounds for ZSCAN18 Gene

No Compound Related Data Available

Transcripts for ZSCAN18 Gene

Unigene Clusters for ZSCAN18 Gene

Zinc finger and SCAN domain containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:
SP4: -
SP5: - -

Relevant External Links for ZSCAN18 Gene

GeneLoc Exon Structure for
ZSCAN18
ECgene alternative splicing isoforms for
ZSCAN18

Expression for ZSCAN18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSCAN18 Gene

This gene is overexpressed in Stomach (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSCAN18 Gene



Protein tissue co-expression partners for ZSCAN18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN18 Gene:

ZSCAN18

SOURCE GeneReport for Unigene cluster for ZSCAN18 Gene:

Hs.235390

Evidence on tissue expression from TISSUES for ZSCAN18 Gene

  • Nervous system(5)
  • Muscle(4.3)
  • Spleen(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZSCAN18: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN18 Gene

Orthologs for ZSCAN18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN18 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia ZSCAN18 33 34
  • 72.6 (n)
rat
(Rattus norvegicus)
Mammalia Zscan18 33
  • 67.83 (n)
mouse
(Mus musculus)
Mammalia Zscan18 33 16 34
  • 67.14 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
OneToMany
Species where no ortholog for ZSCAN18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN18 Gene

ENSEMBL:
Gene Tree for ZSCAN18 (if available)
TreeFam:
Gene Tree for ZSCAN18 (if available)

Paralogs for ZSCAN18 Gene

Variants for ZSCAN18 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000049058 -- 58,105,744(+) GGAGG(C/T)TGAAG intron-variant
rs1000158585 -- 58,088,238(+) GGGCA(A/G)CTAAA intron-variant
rs1000202331 -- 58,112,861(+) CAGGG(C/G)AATCA intron-variant
rs1000313220 -- 58,091,212(+) GCAGT(A/G)AGCCG intron-variant
rs1000324608 -- 58,118,028(+) CGTTA(C/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN18 Gene

Variant ID Type Subtype PubMed ID
esv1409673 CNV deletion 17803354
esv2189581 CNV deletion 18987734
esv2719099 CNV deletion 23290073
esv3556692 CNV deletion 23714750
esv3644925 CNV loss 21293372
esv3893260 CNV gain 25118596
esv6433 CNV loss 19470904
nsv1066059 CNV gain 25217958
nsv1134818 CNV deletion 24896259
nsv1146008 CNV deletion 26484159
nsv458836 CNV gain 19166990
nsv580403 CNV gain 21841781
nsv833885 CNV loss 17160897
nsv833886 CNV gain 17160897
nsv956610 CNV deletion 24416366

Variation tolerance for ZSCAN18 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN18 Gene

Disorders for ZSCAN18 Gene

Relevant External Links for ZSCAN18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN18

No disorders were found for ZSCAN18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN18 Gene

Publications for ZSCAN18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. (PMID: 24948044) Vedeld HM … Lind GE (International journal of cancer 2015) 3 60

Products for ZSCAN18 Gene

Sources for ZSCAN18 Gene

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