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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZSCAN16 Gene

protein-coding   GIFtS: 44
GCID: GC06P028093

zinc finger and SCAN domain containing 16

(Previous names: zinc finger protein 392, zinc finger protein 435 )
(Previous symbols: ZNF392, ZNF435)
  Search for ZSCAN16
in our new
 Human Malady Compendium 
Biological research products
for ZSCAN16
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 161 2     ZNF4351 2 3
Zinc Finger Protein 3921 2 3     DJ265C24.31
Zinc Finger Protein 4351 2 3     FLJ221911
ZNF3921 2 3     Zinc Finger And SCAN Domain-Containing Protein 162

External Ids:    HGNC: 208131   Entrez Gene: 803452   Ensembl: ENSG000001968127   UniProtKB: Q9H4T23   

Export aliases for ZSCAN16 gene to outside databases

Previous GC identifers: GC06P028201 GC06P027900


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZSCAN16 gene promoter:
         AP-1   NF-YA   ATF-2   NF-YC   CBF-C   NF-YB   c-Jun   CP1A   CP1C   NF-Y   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZSCAN16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.33

ZSCAN16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028093:  view genomic region     (about GC identifiers)

Start:
28,092,338 bp from pter      End:
28,097,860 bp from pter
Size:
5,523 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 16  
Size: 348 amino acids; 40792 Da
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for ZSCAN16:
2COT (3D)    
Secondary accessions: Q9H6K2

Explore the universe of human proteins at neXtProt for ZSCAN16: NX_Q9H4T2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H4T2

  • ZSCAN16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079507.1  
    ENSEMBL proteins: 
     ENSP00000366527  

    Human Recombinant Protein Products: 
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    Novus Biologicals ZSCAN16 Proteins
    Novus Biologicals ZSCAN16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZSCAN16

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    ZSCAN16 for ontologies           About GeneDecksing



    ZSCAN16 Antibody Products: 
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    Uscn ELISAs and CLIAs for ZSCAN16


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZSCAN16 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR003309 Tscrpt_reg_SCAN

    Graphical View of Domain Structure for InterPro Entry Q9H4T2

    ProtoNet protein and cluster: Q9H4T2

    2 Blocks protein families:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2
    Function: May be involved in transcriptional regulation

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZSCAN16
    OriGene shRNA RFP: ZSCAN16
    OriGene siRNA: ZSCAN16
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN16

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZSCAN16 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZSCAN16

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for ZSCAN16 (Q9H4T22, 3 ENSP000003665274) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC25A38Q96DW62, 3, ENSP000002731584MINT-65496 I2D: score=5 STRING: ENSP00000273158
    ZNF446Q9NWS93, ENSP000003365654I2D: score=3 STRING: ENSP00000336565
    ZSCAN30ENSP000003297384STRING: ENSP00000329738
    --Q9H6863, 2MINT-66063 I2D: score=1 
    --Q9H6863, 2MINT-66063 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016032viral reproduction IEA--


    ZSCAN16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZSCAN16
    Search CenterWatch for drugs/clinical trials and news about ZSCAN16 / ZSC16 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZSCAN16 gene: 
    NM_025231.1  

    Unigene Cluster for ZSCAN16:

    Zinc finger and SCAN domain containing 16
    Hs.656641  [show with all ESTs]
    Unigene Representative Sequence: AK025844
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340487(uc011dky.1 uc003nkm.3)

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN16

    Additional cDNA sequence: 

    AK025844.1 AK294017.1 AK309837.1 BC004255.1 

    5 DOTS entries:

    DT.111406  DT.121369150  DT.91746572  DT.121369152  DT.121369145 

    24/42 AceView cDNA sequences (see all 42):

    AA832500 CA306342 BC004255 AI638002 AA994242 AK025844 AI299165 BQ056457 
    CB123283 AW440443 CB158915 AA932097 BX279844 CB118492 AA586903 N79472 
    NM_025231 AI446189 CA453903 BE379209 BM974835 CF137683 AI242121 AV705346 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN16    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                                      -     -               
    SP2:                                                            
    SP3:                          -                                 
    SP4:                                      -                     


    ECgene alternative splicing isoforms for ZSCAN16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZSCAN16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAAGTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZSCAN16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZSCAN16

    SOURCE GeneReport for Unigene cluster: Hs.656641
        SABiosciences Custom PCR Arrays for ZSCAN16
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZSCAN16 (if available)
    TreeFam Gene Tree for ZSCAN16 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZSCAN16 gene
    ZNF4962  ZNF4492  ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  
    ZSCAN302  ZNF2322  ZNF2022  ZNF2632  ZKSCAN42  ZNF1742  ZSCAN252  ZNF3962  
    ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  ZNF1652  ZKSCAN82  ZSCAN312  ZSCAN222  
    ZKSCAN32  ZNF242  ZNF182  
    18/356 SIMAP similar genes for ZSCAN16 using alignment to 1 protein entry:     ZSC16_HUMAN(see all similar genes):
    ZNF    ZNF551    ZNF84    DKFZp686N14223    ZNF3    ZNF850
    ZFP3    ZNF154    ZNF211    ZNF226    ZNF304    ZNF419
    ZNF586    ZNF623    ZNF93    ZFP90    ZNF146    ZNF17

    ZSCAN16 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZSCAN16
    PGOHUM00000243101


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 NCBI SNPs in ZSCAN16 are shown (see all 146    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005075611,2
    C--28090471(+) GGCTTG/TTTCAT 1 -- us2k10--------
    rs1410670141,2
    --28090474(+) TTGTT-/CATA  
            
    TTTTT
    1 -- us2k10--------
    rs764408861,2
    C,F,--28090562(+) CTTTTA/CGTTTA 1 -- us2k12Minor allele frequency- C:0.05NA EA 240
    rs762067841,2
    C,--28090656(+) TTTTAT/CGTCTT 1 -- us2k12Minor allele frequency- C:0.11CSA WA 120
    rs77477721,2
    C,F,H,--28090662(+) GTCTTT/CAGGGG 1 -- us2k1 tfbs314Minor allele frequency- C:0.03NS EA WA 2102
    rs1931204631,2
    --28090674(+) TTGTGC/TTATTC 1 -- us2k10--------
    rs1850860471,2
    --28090773(+) CATAGC/TAGCCA 1 -- us2k10--------
    rs1884022411,2
    --28090821(+) TTCTCC/TACTCA 1 -- us2k10--------
    rs1397929311,2
    --28090848(+) CATGCA/TGGGTA 1 -- us2k10--------
    rs1445281111,2
    --28090892(+) TGAGGC/TGAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZSCAN16 (28092338 - 28097860 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZSCAN16: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZSCAN16
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZSCAN16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZSCAN16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. ZNF435, a novel human SCAN-containing zinc finger protein, inhibits AP-1-mediated transcriptional activation. (PubMed id 17646705)1 Gu X....Mao Y. (2007)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80345 HGNC: 20813 AceView: ZNF435 Ensembl:ENSG00000196812 euGenes: HUgn80345
    ECgene: ZSCAN16 H-InvDB: ZSCAN16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZSCAN16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZSCAN16 gene:
    Search GeneIP for patents involving ZSCAN16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
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    von Willebrand factor
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