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ZSCAN16 Gene

protein-coding   GIFtS: 46
GCID: GC06P028093

Zinc Finger And SCAN Domain Containing 16

(Previous names: zinc finger protein 392, zinc finger protein 435)
(Previous symbols: ZNF392, ZNF435)
  See ZSCAN16-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And SCAN Domain Containing 161 2     ZNF4351 2 3
Zinc Finger Protein 3921 2 3     dJ265C24.32
Zinc Finger Protein 4351 2 3     Zinc Finger And SCAN Domain-Containing Protein 162
ZNF3921 2 3     

External Ids:    HGNC: 208131   Entrez Gene: 803452   Ensembl: ENSG000001968127   UniProtKB: Q9H4T23   

Export aliases for ZSCAN16 gene to outside databases

Previous GC identifers: GC06P028201 GC06P027900


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZSCAN16 Gene:
ZSCAN16 (zinc finger and SCAN domain containing 16) is a protein-coding gene. Diseases associated with ZSCAN16 include breast and colorectal cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZSCAN16 gene promoter:
         AP-1   NF-YA   ATF-2   NF-YC   CBF-C   NF-YB   c-Jun   CP1A   CP1C   NF-Y   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZSCAN16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZSCAN16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.33

ZSCAN16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028093:  view genomic region     (about GC identifiers)

Start:
28,092,338 bp from pter      End:
28,097,860 bp from pter
Size:
5,523 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2 (See protein sequence)
Recommended Name: Zinc finger and SCAN domain-containing protein 16  
Size: 348 amino acids; 40792 Da
1 PDB 3D structure from and Proteopedia for ZSCAN16:
2COT (3D)    
Secondary accessions: Q9H6K2

Explore the universe of human proteins at neXtProt for ZSCAN16: NX_Q9H4T2

Explore proteomics data for ZSCAN16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZSCAN16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079507.1  
    ENSEMBL proteins: 
     ENSP00000366527  

    ZSCAN16 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZSCAN16

     
    Search eBioscience for Proteins for ZSCAN16 

    ZSCAN16 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ZSCAN16

    ZSCAN16 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H4T2

    ProtoNet protein and cluster: Q9H4T2

    2 Blocks protein domains:
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZSC16_HUMAN, Q9H4T2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with ZSCAN16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZSC16_HUMAN, Q9H4T2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZSCAN16           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZSCAN16
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    miRNA
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    miRTarBase miRNAs that target ZSCAN16:
    hsa-mir-26b-5p (MIRT028787)

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    Search for qRT-PCR Assays for microRNAs that regulate ZSCAN16
    SwitchGear 3'UTR luciferase reporter plasmidZSCAN16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZSCAN16

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZSCAN16

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZSC16_HUMAN, Q9H4T2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZSCAN16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZSCAN16
    Interactions:

        Search GeneGlobe Interaction Network for ZSCAN16

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ZSCAN16 (Q9H4T22, 3 ENSP000003665274) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC25A38Q96DW62, 3, ENSP000002731584MINT-65496 I2D: score=5 STRING: ENSP00000273158
    ZNF446Q9NWS93, ENSP000003365654I2D: score=3 STRING: ENSP00000336565
    ZSCAN30ENSP000003297384STRING: ENSP00000329738
    --Q9H6863, 2MINT-66063 I2D: score=1 
    --Q9H6863, 2MINT-66063 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with ZSCAN16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZSCAN16 (ZSC16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZSCAN16 gene: 
    NM_025231.1  

    Unigene Cluster for ZSCAN16:

    Zinc finger and SCAN domain containing 16
    Hs.656641  [show with all ESTs]
    Unigene Representative Sequence: AK025844
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340487(uc011dky.1 uc003nkm.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZSCAN16
      QuantiFast Probe-based Assays in human, mouse, rat ZSCAN16

    Additional mRNA sequence: 

    AK025844.1 AK294017.1 AK309837.1 BC004255.1 

    5 DOTS entries:

    DT.111406  DT.121369150  DT.91746572  DT.121369152  DT.121369145 

    Selected AceView cDNA sequences (see all 42):

    NM_025231 CB118492 AI299165 AW440443 CA306342 AA586903 AA932097 AA832500 
    CB158915 BC004255 CB123283 BX279844 N79472 AA994242 AK025844 BQ056457 
    AI638002 CF137683 AI446189 AI432672 AI242121 BM460682 AW303298 AV705346 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN16    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                                      -     -               
    SP2:                                                            
    SP3:                          -                                 
    SP4:                                      -                     


    ECgene alternative splicing isoforms for ZSCAN16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZSCAN16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGTTGG
    ZSCAN16 Expression
    About this image

    ZSCAN16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZSCAN16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656641
        Custom PCR Arrays for ZSCAN16
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZSCAN16 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZSCAN161 zinc finger and SCAN domain containing 16 84.1(n)
    82.47(a)
      102153717  XM_005640130.1  XP_005640187.1 


    ENSEMBL Gene Tree for ZSCAN16 (if available)
    TreeFam Gene Tree for ZSCAN16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZSCAN16 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  ZNF2322  ZSCAN302  
    ZNF1742  ZNF32  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  
    ZNF1652  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    Selected SIMAP similar genes for ZSCAN16 using alignment to 1 protein entry:     ZSC16_HUMAN(see all similar genes):
    ZNF    ZNF551    ZNF84    DKFZp686N14223    ZNF135    ZNF3
    ZNF850    ZFP3    ZNF154    ZNF211    ZNF226    ZNF304
    ZNF419    ZNF586    ZNF623    ZNF93    ZFP90    ZNF146

    Find genes that share paralogs with ZSCAN16           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZSCAN16
    PGOHUM00000243101


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for ZSCAN16    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356044
    A colorectal cancer sample4--see VAR_0356042 R Q mis40--------

    HapMap Linkage Disequilibrium report for ZSCAN16 (28092338 - 28097860 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZSCAN16: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZSCAN16
    DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZSCAN16:    
    About MalaCards
    breast and colorectal cancer


    Find genes that share disorders with ZSCAN16           About GenesLikeMe


    Export disorders for ZSCAN16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZSCAN16 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZSCAN16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. ZNF435, a novel human SCAN-containing zinc finger protein, inhibits AP-1-mediated transcriptional activation. (PubMed id 17646705)1 Gu X....Mao Y. (Mol. Cells 2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80345 HGNC: 20813 AceView: ZNF435 Ensembl:ENSG00000196812 euGenes: HUgn80345
    ECgene: ZSCAN16 H-InvDB: ZSCAN16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZSCAN16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZSCAN16 gene:
    Search GeneIP for patents involving ZSCAN16

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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