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Aliases for ZSCAN12 Gene

Aliases for ZSCAN12 Gene

  • Zinc Finger And SCAN Domain Containing 12 2 3 5
  • Zinc Finger Protein 305 2 3 4
  • Zinc Finger Protein 96 2 3 4
  • ZNF305 3 4
  • ZNF96 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 12 3
  • DJ29K1.2 3
  • KIAA0426 4
  • ZNF29K1 3
  • ZFP96 3

External Ids for ZSCAN12 Gene

Previous HGNC Symbols for ZSCAN12 Gene

  • ZNF305
  • ZNF96

Previous GeneCards Identifiers for ZSCAN12 Gene

  • GC06M028456
  • GC06M028152

Summaries for ZSCAN12 Gene

GeneCards Summary for ZSCAN12 Gene

ZSCAN12 (Zinc Finger And SCAN Domain Containing 12) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZSCAN12 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN12 Gene

Genomics for ZSCAN12 Gene

Regulatory Elements for ZSCAN12 Gene

Enhancers for ZSCAN12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H027494 1.4 Ensembl ENCODE 149.6 +904.1 904119 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF302 ZNF143 ZSCAN12 ZKSCAN8 ZKSCAN3 ZNF322 ZSCAN9 ZSCAN23 ZNF391 ZKSCAN4 ZNF204P PGBD1
GH06H028802 1.6 Ensembl ENCODE dbSUPER 76.7 -403.3 -403289 1.1 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF302 SP3 REST ZSCAN12 ZKSCAN3 ZKSCAN8 ZSCAN23 ZKSCAN4 ZSCAN9 PGBD1 TRIM27 ZNF311 ZNF192P1
GH06H027650 1.4 Ensembl ENCODE 65 +748.7 748716 1.1 HDGF FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 ZNF2 SLC30A9 ZNF143 ZKSCAN8 ZSCAN12 ZKSCAN3 ZKSCAN4 ZSCAN9 ZNF322 ZNF391 GUSBP2 ZSCAN23 LOC102724851
GH06H028211 1.4 Ensembl ENCODE 60.8 +187.2 187233 2.2 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZKSCAN8 ZKSCAN3 ZNF603P ZSCAN12 ZSCAN9 ZKSCAN4 ZSCAN23 ZSCAN31 NKAPL ZNF311
GH06H027547 1.3 Ensembl ENCODE 64.8 +851.5 851528 2.1 HDGF ARNT ARID4B FEZF1 ZNF2 FOS SP3 REST ZNF592 MIER3 ZSCAN12 ZKSCAN8 ZSCAN9 ZNF322 ZKSCAN3 ZSCAN23 ABT1 ZNF391 ZSCAN26 ZKSCAN4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN12 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195225 167 2000 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 GLIS1

Genomic Locations for ZSCAN12 Gene

Genomic Locations for ZSCAN12 Gene
chr6:28,378,821-28,399,767
(GRCh38/hg38)
Size:
20,947 bases
Orientation:
Minus strand
chr6:28,346,598-28,367,544
(GRCh37/hg19)

Genomic View for ZSCAN12 Gene

Genes around ZSCAN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN12 Gene

Proteins for ZSCAN12 Gene

  • Protein details for ZSCAN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43309-ZSC12_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 12
    Protein Accession:
    O43309
    Secondary Accessions:
    • O43724

    Protein attributes for ZSCAN12 Gene

    Size:
    604 amino acids
    Molecular mass:
    70222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24856.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZSCAN12 Gene

Post-translational modifications for ZSCAN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN12 Gene

No data available for DME Specific Peptides for ZSCAN12 Gene

Domains & Families for ZSCAN12 Gene

Gene Families for ZSCAN12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZSCAN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43309

UniProtKB/Swiss-Prot:

ZSC12_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN12: view

Function for ZSCAN12 Gene

Molecular function for ZSCAN12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN12 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Phenotypes for ZSCAN12 Gene

GenomeRNAi human phenotypes for ZSCAN12:
genes like me logo Genes that share phenotypes with ZSCAN12: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN12 Gene

Localization for ZSCAN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN12 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Pathways & Interactions for ZSCAN12 Gene

SuperPathways for ZSCAN12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN12 Gene

Drugs & Compounds for ZSCAN12 Gene

No Compound Related Data Available

Transcripts for ZSCAN12 Gene

Unigene Clusters for ZSCAN12 Gene

Zinc finger and SCAN domain containing 12:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:

Relevant External Links for ZSCAN12 Gene

GeneLoc Exon Structure for
ZSCAN12
ECgene alternative splicing isoforms for
ZSCAN12

Expression for ZSCAN12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN12 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN12 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN12 Gene



Protein tissue co-expression partners for ZSCAN12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN12 Gene:

ZSCAN12

SOURCE GeneReport for Unigene cluster for ZSCAN12 Gene:

Hs.134816

Evidence on tissue expression from TISSUES for ZSCAN12 Gene

  • Nervous system(4.2)
  • Skin(4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ZSCAN12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN12 Gene

Orthologs for ZSCAN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN12 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia ZSCAN12 33 34
  • 88.74 (n)
dog
(Canis familiaris)
Mammalia ZSCAN12 33 34
  • 84.55 (n)
rat
(Rattus norvegicus)
Mammalia Zscan12 33
  • 79.16 (n)
mouse
(Mus musculus)
Mammalia Zscan12 33 16 34
  • 78.25 (n)
Species where no ortholog for ZSCAN12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN12 Gene

ENSEMBL:
Gene Tree for ZSCAN12 (if available)
TreeFam:
Gene Tree for ZSCAN12 (if available)

Paralogs for ZSCAN12 Gene

(441) SIMAP similar genes for ZSCAN12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZSCAN12 Gene

genes like me logo Genes that share paralogs with ZSCAN12: view

Variants for ZSCAN12 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000158810 -- 28,390,933(+) ACTCT(G/T)ACTGA intron-variant, nc-transcript-variant, reference, missense
rs1000448916 -- 28,382,572(+) AGAGT(A/G)ATTTT nc-transcript-variant, utr-variant-3-prime
rs1000607880 -- 28,399,736(+) CGGAA(C/G)CCATC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000610328 -- 28,391,421(+) GTTCT(A/G)TGAGG intron-variant, nc-transcript-variant, reference, missense
rs1000725769 -- 28,383,820(+) GGGCT(-/AGG)AGGAC intron-variant, upstream-variant-2KB, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN12 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897
esv2731752 CNV deletion 23290073
esv2182271 CNV deletion 18987734

Variation tolerance for ZSCAN12 Gene

Gene Damage Index Score: 8.95; 87.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Disorders for ZSCAN12 Gene

Relevant External Links for ZSCAN12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN12

No disorders were found for ZSCAN12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN12 Gene

Publications for ZSCAN12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  3. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 2 3 60
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZSCAN12 Gene

Sources for ZSCAN12 Gene

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