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Aliases for ZSCAN12 Gene

Aliases for ZSCAN12 Gene

  • Zinc Finger And SCAN Domain Containing 12 2 3
  • Zinc Finger Protein 305 2 3 4
  • Zinc Finger Protein 96 2 3 4
  • ZNF305 3 4
  • ZNF96 3 4
  • DJ29K1.2 3
  • KIAA0426 4
  • ZNF29K1 3
  • ZFP96 3

External Ids for ZSCAN12 Gene

Previous HGNC Symbols for ZSCAN12 Gene

  • ZNF305
  • ZNF96

Previous GeneCards Identifiers for ZSCAN12 Gene

  • GC06M028456
  • GC06M028152

Summaries for ZSCAN12 Gene

GeneCards Summary for ZSCAN12 Gene

ZSCAN12 (Zinc Finger And SCAN Domain Containing 12) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZSCAN12 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN12 Gene

Genomics for ZSCAN12 Gene

Regulatory Elements for ZSCAN12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZSCAN12 Gene

Chromosome:
6
Start:
28,378,821 bp from pter
End:
28,399,767 bp from pter
Size:
20,947 bases
Orientation:
Minus strand

Genomic View for ZSCAN12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSCAN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN12 Gene

Proteins for ZSCAN12 Gene

  • Protein details for ZSCAN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43309-ZSC12_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 12
    Protein Accession:
    O43309
    Secondary Accessions:
    • O43724

    Protein attributes for ZSCAN12 Gene

    Size:
    604 amino acids
    Molecular mass:
    70222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24856.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZSCAN12 Gene

Proteomics data for ZSCAN12 Gene at MOPED

Post-translational modifications for ZSCAN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSCAN12 Gene

Domains & Families for ZSCAN12 Gene

Gene Families for ZSCAN12 Gene

Suggested Antigen Peptide Sequences for ZSCAN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43309

UniProtKB/Swiss-Prot:

ZSC12_HUMAN :
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN12: view

Function for ZSCAN12 Gene

Molecular function for ZSCAN12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN12 Gene

Localization for ZSCAN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN12 Gene COMPARTMENTS Subcellular localization image for ZSCAN12 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Pathways & Interactions for ZSCAN12 Gene

SuperPathways for ZSCAN12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZSCAN12: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN12 Gene

Drugs & Compounds for ZSCAN12 Gene

No Compound Related Data Available

Transcripts for ZSCAN12 Gene

Unigene Clusters for ZSCAN12 Gene

Zinc finger and SCAN domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:

Relevant External Links for ZSCAN12 Gene

GeneLoc Exon Structure for
ZSCAN12
ECgene alternative splicing isoforms for
ZSCAN12

Expression for ZSCAN12 Gene

mRNA expression in normal human tissues for ZSCAN12 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN12 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN12 Gene



SOURCE GeneReport for Unigene cluster for ZSCAN12 Gene Hs.134816

genes like me logo Genes that share expression patterns with ZSCAN12: view

Protein tissue co-expression partners for ZSCAN12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZSCAN12 Gene

Orthologs for ZSCAN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZSCAN12 35
  • 88.74 (n)
  • 84.51 (a)
ZSCAN12 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN12 35
  • 84.55 (n)
  • 80.13 (a)
ZSCAN12 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan12 35
  • 78.25 (n)
  • 69.48 (a)
Zscan12 16
Zscan12 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN12 35
  • 99.4 (n)
  • 99.02 (a)
ZSCAN12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zscan12 35
  • 79.16 (n)
  • 69.94 (a)
Species with no ortholog for ZSCAN12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN12 Gene

ENSEMBL:
Gene Tree for ZSCAN12 (if available)
TreeFam:
Gene Tree for ZSCAN12 (if available)

Paralogs for ZSCAN12 Gene

(441) SIMAP similar genes for ZSCAN12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZSCAN12 Gene

genes like me logo Genes that share paralogs with ZSCAN12: view

Variants for ZSCAN12 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1052213 -- 28,380,600(-) CACAA(A/G)GAAAA nc-transcript-variant, utr-variant-3-prime
rs1052214 -- 28,380,599(-) ACAAG(A/G)AAAAA nc-transcript-variant, utr-variant-3-prime
rs1052215 -- 28,380,381(-) TAAAC(A/C)TGATG nc-transcript-variant, utr-variant-3-prime
rs1361385 -- 28,390,543(-) ATGTA(C/T)GTAAA missense, reference, intron-variant
rs1416918 -- 28,390,558(-) ATAGA(C/G/T)GTGGT reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN12 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV Loss 17160897
esv2731752 CNV Deletion 23290073
esv2182271 CNV Deletion 18987734

Variation tolerance for ZSCAN12 Gene

Gene Damage Index Score: 8.95; 87.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN12 Gene

HapMap Linkage Disequilibrium report
ZSCAN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Disorders for ZSCAN12 Gene

Relevant External Links for ZSCAN12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN12
genes like me logo Genes that share disorders with ZSCAN12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN12 Gene

Publications for ZSCAN12 Gene

  1. Cloning and characterization of a novel zinc finger protein (rZFP96) in the rat corpus luteum. (PMID: 16426687) Lareu R.R. … Dharmarajan A.M. (Biochim. Biophys. Acta 2005) 23 67
  2. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee P.L. … Beutler E. (Genomics 1997) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 67

Products for ZSCAN12 Gene

Sources for ZSCAN12 Gene

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