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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZSCAN10 Gene

protein-coding GIFtS: 44
GCID: GC16M003138

zinc finger and SCAN domain containing 10

(Previous name: zinc finger protein 206 )
(Previous symbol: ZNF206)

Explore 1 disease affiliated with
ZSCAN10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger And SCAN Domain Containing 10¹ ²
Zinc Finger Protein 206¹ ² ³
ZNF206¹ ² ³
Zinc Finger And SCAN Domain-Containing Protein 10²

External Ids:	HGNC: 12997¹	Entrez Gene: 84891²	Ensembl: ENSG00000130182⁷	UniProtKB: Q96SZ4³

Export aliases for ZSCAN10 gene to outside databases

Previous GC identifers: GC16M003079 GC16M003110

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZSC10_HUMAN, Q96SZ4

Function: Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both

activate and /or repress expression of target genes, depending on the context. Specifically binds the

5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4 (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZSCAN10 gene promoter:
Egr-1 HSF1 (long) Lmo2 LUN-1 MIF-1 NF-kappaB Ik-3 NF-kappaB2 HSF1short NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZSCAN10 promoter sequence

Search SABiosciences Chromatin IP Primers for ZSCAN10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZSCAN10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

ZSCAN10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZSCAN10 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M003138: view genomic region (about GC identifiers)

Start:	3,138,891 bp from pter	End:	3,149,318 bp from pter
Size:	10,428 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZSC10_HUMAN, Q96SZ4 (See protein sequence)

Recommended Name: Zinc finger and SCAN domain-containing protein 10

Size: 725 amino acids; 80387 Da

Subunit: Interacts with POU5F1/OCT4 and SOX2 (By similarity)

Subcellular location: Nucleus (By similarity)

Secondary accessions: B3KQD3

Alternative splicing: 2 isoforms: Q96SZ4-1 Q96SZ4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZSCAN10: NX_Q96SZ4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96SZ4

ZSCAN10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_116194.1

ENSEMBL proteins:

ENSP00000252463 ENSP00000459520 ENSP00000440047 ENSP00000458879 ENSP00000460473

ENSP00000461871 ENSP00000458260

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	Uscn Proteins for ZSCAN10

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	ISS	--

ZSCAN10 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ZSCAN10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZSCAN10 for domains About GeneDecksing

5 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR008916 Retrov_capsid_C

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

IPR003309 Tscrpt_reg_SCAN

Graphical View of Domain Structure for InterPro Entry Q96SZ4

ProtoNet protein and cluster: Q96SZ4

1 Blocks protein family: IPB003309 Transcriptional regulator SCAN

UniProtKB/Swiss-Prot: ZSC10_HUMAN, Q96SZ4

Similarity: Contains 14 C2H2-type zinc fingers

Similarity: Contains 1 SCAN box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZSC10_HUMAN, Q96SZ4

Function: Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both

activate and /or repress expression of target genes, depending on the context. Specifically binds the

5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4 (By

similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN10

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	ISS	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	ISS	--

ZSCAN10 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ZSCAN10:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:
1 MGI phenotypic allele

for Zscan10 (no phenotypes)

ZSCAN10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZSCAN10

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0016032	viral reproduction	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	ISS	--

ZSCAN10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZSCAN10
Search CenterWatch for drugs/clinical trials and news about ZSCAN10 / ZSC10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZSCAN10 gene:

NM_032805.1

Unigene Cluster for ZSCAN10:

Zinc finger and SCAN domain containing 10

Hs.334515 [show with all ESTs]

Unigene Representative Sequence: AK027455

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000252463(uc002ctv.1 uc002ctw.1 uc002ctx.1) ENST00000575108(uc002cty.1)

ENST00000538082 ENST00000571903 ENST00000576985 ENST00000572431 ENST00000572548

ENST00000576483 ENST00000577059 ENST00000573931

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZSCAN10

Additional cDNA sequence:

AK027455.1 AK074736.1 BC111367.1 BC114452.1

7 DOTS entries:

DT.102828033 DT.102828030 DT.102828035 DT.99933490 DT.120683298 DT.120683301 DT.120683303

21 AceView cDNA sequences:

AK027455 NM_032805 AK074736 CD634380 CD634388 CD634383 AA206569 CD634390

CD634389 CD634384 BF511528 CD634386 CD634381 CD634387 CD634391 CD634382

AW003251 CD634379 AA206496 CD634385 AI971717

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN10 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b
SP1:
SP2:					-		-
SP3:							-

ECgene alternative splicing isoforms for ZSCAN10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZSCAN10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAGCCCGG

About this image

ZSCAN10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Induced pluripotent stem cells (using UTF1) (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

Line H1 (WA01) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZSCAN10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZSCAN10

SOURCE GeneReport for Unigene cluster: Hs.334515

SABiosciences Custom PCR Arrays for ZSCAN10

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZSCAN10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZSCAN10 gene from 2/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	AI617093.1²	--	78.34(n)		337732 AI617093.1
fruit fly (Drosophila melanogaster)	Insecta	jim⁶	jim	16(a)	1 → many	3L(22782333-22828294)

ENSEMBL Gene Tree for ZSCAN10 (if available)
TreeFam Gene Tree for ZSCAN10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZSCAN10 gene

ZKSCAN5² MZF1² ZNF444²

18/499 SIMAP similar genes for ZSCAN10 using alignment to 6 protein entries: ZSC10_HUMAN (see all proteins) (see all similar genes):

ZNF18 ZNF818P ZSCAN31 ZNF500 ZNF24 ZNF396

ZNF444 ZFS-5 ZKSCAN8 ZNF213 LOC100128510 ZKSCAN7

ZNF167 ZNF78L1 ZSCAN32 kr-znf3 ZNF410 ZNF826P

ZSCAN10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189262874^1,2		--	3138439(+)	`TCTCCA/CAGGAT`	1	--	ds500¹		0	--	--	--	--
rs115019667^1,2	F,	--	3138472(+)	`ACCACG/ACCCGG`	1	--	ds500¹		1		WA	118
rs4786385^1,2	C,F,A,H,	--	3138486(+)	`ATTTTG/TGTATT`	1	--	ds500¹		7		NA WA	250
rs181301073^1,2		--	3138487(+)	`TTTTGC/GTATTT`	1	--	ds500¹		0	--	--	--	--
rs77828326^1,2	C	--	3138550(+)	`ACCTCG/ATGATC`	1	--	ds500¹		2		NA	4
rs140209105^1,2		--	3138568(+)	`GCCTCA/GGCCTC`	1	--	ds500¹		0	--	--	--	--
rs145367068^1,2		--	3138949(+)	`AAAGCA/TATGCC`	1	--	ut3¹		0	--	--	--	--
rs149187078^1,2		--	3139036(+)	`CTCCGA/CTGTGG`	1	--	ut3¹		0	--	--	--	--
rs200764017^1,2		--	3139048(+)	`GGACCC/TCGGGT`	1	--	ut3¹		0	--	--	--	--
rs75291351^1,2	F	--	3139078(+)	`TGGCGG/AAAGGC`	1	--	ut3¹		1		NA	4

HapMap Linkage Disequilibrium report for ZSCAN10 (3138891 - 3149318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZSCAN10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZSCAN10

DNA2.0 Custom Variant and Variant Library Synthesis for ZSCAN10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZSCAN10 for disorders About GeneDecksing

1 disease for ZSCAN10: About MalaCards

neuronitis

Export disorders for ZSCAN10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZSCAN10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZSCAN10)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A transcriptional map of the FMF region. (PubMed id 9653642)^{1, 3} Bernot A.... Weissenbach J. (1998)
DNA hypomethylation at the ZNF206-exon 5 CpG island a ssociated with neuronal differentiation in mice and development of neuroblastom a in humans. (PubMed id 22011711)¹ Kawashima H....Nagase H. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)¹ Hillier L.D....Marra M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84891	HGNC: 12997	AceView: ZNF206	Ensembl:ENSG00000130182	euGenes: HUgn84891
ECgene: ZSCAN10	H-InvDB: ZSCAN10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZSCAN10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZSCAN10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZSCAN10 gene:
Search GeneIP for patents involving ZSCAN10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZSCAN10
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	GenScript Custom Purified and Recombinant Proteins Services for ZSCAN10		GenScript cDNA clones with any tag delivered in your preferred vector for ZSCAN10
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZSCAN10 gene at Home site.

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ZSCAN10 Gene

zinc finger and SCAN domain containing 10

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ZSCAN10 Gene

zinc finger and SCAN domain containing 10

Aliasesfor ZSCAN10 gene

Summariesfor ZSCAN10 gene

Genomic Viewsfor ZSCAN10 gene

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Protein Domains /Familiesfor ZSCAN10 gene

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