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Aliases for ZSCAN10 Gene

Aliases for ZSCAN10 Gene

  • Zinc Finger And SCAN Domain Containing 10 2 3
  • Zinc Finger Protein 206 2 3 4
  • ZNF206 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 10 3

External Ids for ZSCAN10 Gene

Previous Symbols for ZSCAN10 Gene

  • ZNF206

Summaries for ZSCAN10 Gene

GeneCards Summary for ZSCAN10 Gene

ZSCAN10 (Zinc Finger And SCAN Domain Containing 10) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is MZF1.

UniProtKB/Swiss-Prot for ZSCAN10 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5-[GA]CGCNNGCG[CT]-3 DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN10 Gene

Genomics for ZSCAN10 Gene

Genomic Location for ZSCAN10 Gene

Start:
3,088,890 bp from pter
End:
3,099,317 bp from pter
Size:
10,428 bases
Orientation:
Minus strand

Genomic View for ZSCAN10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZSCAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN10 Gene

Regulatory Elements for ZSCAN10 Gene

Proteins for ZSCAN10 Gene

  • Protein details for ZSCAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ4-ZSC10_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 10
    Protein Accession:
    Q96SZ4
    Secondary Accessions:
    • B3KQD3
    • H0YFS6
    • Q1WWM2

    Protein attributes for ZSCAN10 Gene

    Size:
    725 amino acids
    Molecular mass:
    80387 Da
    Quaternary structure:
    • Interacts with POU5F1/OCT4 and SOX2.
    SequenceCaution:
    • Sequence=AAI14453.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN10 Gene

Proteomics data for ZSCAN10 Gene at MOPED

Post-translational modifications for ZSCAN10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN10 Gene

No data available for DME Specific Peptides for ZSCAN10 Gene

Domains for ZSCAN10 Gene

Gene Families for ZSCAN10 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZSC10_HUMAN
Domain:
  • Contains 1 SCAN box domain.:
    • Q96SZ4
Similarity:
  • Contains 14 C2H2-type zinc fingers.:
    • Q96SZ4
genes like me logo Genes that share domains with ZSCAN10: view

Function for ZSCAN10 Gene

Molecular function for ZSCAN10 Gene

UniProtKB/Swiss-Prot Function: Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5-[GA]CGCNNGCG[CT]-3 DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4 (By similarity).

Gene Ontology (GO) - Molecular Function for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN10: view

Phenotypes for ZSCAN10 Gene

genes like me logo Genes that share phenotypes with ZSCAN10: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZSCAN10 Gene

Localization for ZSCAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN10 Gene COMPARTMENTS Subcellular localization image for ZSCAN10 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZSCAN10: view

Pathways for ZSCAN10 Gene

SuperPathways for ZSCAN10 Gene

No Data Available

Interacting Proteins for ZSCAN10 Gene

Gene Ontology (GO) - Biological Process for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0035019 somatic stem cell maintenance TAS --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZSCAN10: view

No data available for Pathways by source for ZSCAN10 Gene

Transcripts for ZSCAN10 Gene

Unigene Clusters for ZSCAN10 Gene

Zinc finger and SCAN domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2: - -
SP3: -

Relevant External Links for ZSCAN10 Gene

GeneLoc Exon Structure for
ZSCAN10
ECgene alternative splicing isoforms for
ZSCAN10

Expression for ZSCAN10 Gene

mRNA expression in normal human tissues for ZSCAN10 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN10 Gene

This gene is overexpressed in Brain - Cerebellum (8.8), Brain - Cerebellar Hemisphere (6.8), Muscle - Skeletal (5.9), and Testis (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZSCAN10 Gene

SOURCE GeneReport for Unigene cluster for ZSCAN10 Gene Hs.334515

genes like me logo Genes that share expressions with ZSCAN10: view

Orthologs for ZSCAN10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN10 36
  • 99.03 (n)
  • 99.03 (a)
ZSCAN10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN10 36
  • 83.47 (n)
  • 79.83 (a)
ZSCAN10 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN10 36
  • 84.77 (n)
  • 80.94 (a)
ZSCAN10 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan10 36
  • 75.37 (n)
  • 72.78 (a)
Zscan10 16
Zscan10 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZSCAN10 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zscan10 36
  • 76.04 (n)
  • 72.03 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
Species with no ortholog for ZSCAN10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSCAN10 Gene

ENSEMBL:
Gene Tree for ZSCAN10 (if available)
TreeFam:
Gene Tree for ZSCAN10 (if available)

Paralogs for ZSCAN10 Gene

Paralogs for ZSCAN10 Gene

Selected SIMAP similar genes for ZSCAN10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZSCAN10: view

Variants for ZSCAN10 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs909405 -- 3,098,990(+) CTCCC(G/T)CGTCC intron-variant
rs909406 -- 3,099,517(+) CTTTC(C/T)TTTGG upstream-variant-2KB
rs909407 -- 3,099,773(+) CCATC(C/T)ACACG upstream-variant-2KB
rs2017820 -- 3,094,469(-) actca(C/G)gaagc intron-variant, upstream-variant-2KB
rs2037983 -- 3,096,027(+) GTCAT(C/T)TATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN10 Gene

Variant ID Type Subtype PubMed ID
nsv905170 CNV Loss 21882294
nsv905185 CNV Loss 21882294
nsv833125 CNV Loss 17160897
nsv509589 CNV Insertion 20534489
dgv2580n71 CNV Loss 21882294

Relevant External Links for ZSCAN10 Gene

HapMap Linkage Disequilibrium report
ZSCAN10

Disorders for ZSCAN10 Gene

No disorders were found for ZSCAN10 Gene.

No data available for UniProtKB/Swiss-Prot for ZSCAN10 Gene

Publications for ZSCAN10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A transcriptional map of the FMF region. (PMID: 9653642) Bernot A. … Weissenbach J. (Genomics 1998) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for ZSCAN10 Gene

Sources for ZSCAN10 Gene

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