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Aliases for ZSCAN10 Gene

Aliases for ZSCAN10 Gene

  • Zinc Finger And SCAN Domain Containing 10 2 3 5
  • Zinc Finger Protein 206 2 3 4
  • ZNF206 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 10 3

External Ids for ZSCAN10 Gene

Previous HGNC Symbols for ZSCAN10 Gene

  • ZNF206

Previous GeneCards Identifiers for ZSCAN10 Gene

  • GC16M003079
  • GC16M003138
  • GC16M003110

Summaries for ZSCAN10 Gene

GeneCards Summary for ZSCAN10 Gene

ZSCAN10 (Zinc Finger And SCAN Domain Containing 10) is a Protein Coding gene. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is MZF1.

UniProtKB/Swiss-Prot for ZSCAN10 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5-[GA]CGCNNGCG[CT]-3 DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN10 Gene

Genomics for ZSCAN10 Gene

Regulatory Elements for ZSCAN10 Gene

Enhancers for ZSCAN10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003063 0.9 FANTOM5 ENCODE 7.3 +33.3 33260 5.8 HDGF PKNOX1 ATF1 MLX WRNIP1 ARID4B DMAP1 ZNF48 YY1 ZNF121 IL32 MMP25 LOC105371058 ZNF597 CREBBP BICDL2 ZSCAN10 LOC100128770 LOC107984895 ENSG00000260447
GH16F003190 1.2 FANTOM5 ENCODE 5.1 -92.0 -91993 0.8 ATF1 ZNF2 GTF3C2 FOS ZHX2 ZNF623 ZNF264 MYNN SP7 ZNF785 CREBBP ZNF597 THOC6 LOC105371055 ZNF263 ZNF213-AS1 CLUAP1 RNPS1 TIGD7 ENSG00000279473
GH16F003097 1.5 FANTOM5 Ensembl ENCODE 5 -0.8 -770 6.2 MLX CREB3L1 ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 CREBBP THOC6 ZNF263 ZNF597 SNHG19 LOC105371055 SNORD60 ZNF213-AS1 ENSG00000200059
GH16F003233 0.7 FANTOM5 ENCODE 2.3 -135.7 -135717 2.2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 CREBBP LOC105371055 ZNF263 THOC6 ZNF205 ERVK13-1 MTCO1P28 ENSG00000269937 MEFV ZNF174
GH16F003095 1 Ensembl ENCODE 0.8 +3.2 3217 1.4 BCOR CTCF MXI1 ZMYM3 RAD21 RELA ZKSCAN1 POLR2A SMC3 NFE2 ZNF213-AS1 RNU1-125P IL32 MMP25 BICDL2 LOC100128770 HCFC1R1 THOC6 CLDN6 TNFRSF12A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZSCAN10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSCAN10 Gene

Chromosome:
16
Start:
3,088,890 bp from pter
End:
3,099,317 bp from pter
Size:
10,428 bases
Orientation:
Minus strand

Genomic View for ZSCAN10 Gene

Genes around ZSCAN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN10 Gene

Proteins for ZSCAN10 Gene

  • Protein details for ZSCAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ4-ZSC10_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 10
    Protein Accession:
    Q96SZ4
    Secondary Accessions:
    • B3KQD3
    • H0YFS6
    • Q1WWM2

    Protein attributes for ZSCAN10 Gene

    Size:
    725 amino acids
    Molecular mass:
    80387 Da
    Quaternary structure:
    • Interacts with POU5F1/OCT4 and SOX2.
    SequenceCaution:
    • Sequence=AAI14453.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN10 Gene

Post-translational modifications for ZSCAN10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN10 Gene

Domains & Families for ZSCAN10 Gene

Gene Families for ZSCAN10 Gene

Suggested Antigen Peptide Sequences for ZSCAN10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SZ4

UniProtKB/Swiss-Prot:

ZSC10_HUMAN :
  • Contains 1 SCAN box domain.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN10: view

Function for ZSCAN10 Gene

Molecular function for ZSCAN10 Gene

UniProtKB/Swiss-Prot Function:
Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5-[GA]CGCNNGCG[CT]-3 DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4 (By similarity).

Gene Ontology (GO) - Molecular Function for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding ISS,IBA --
GO:0043565 sequence-specific DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN10: view
genes like me logo Genes that share phenotypes with ZSCAN10: view

Animal Models for ZSCAN10 Gene

MGI Knock Outs for ZSCAN10:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN10 Gene

Localization for ZSCAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN10 Gene COMPARTMENTS Subcellular localization image for ZSCAN10 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZSCAN10: view

Pathways & Interactions for ZSCAN10 Gene

genes like me logo Genes that share pathways with ZSCAN10: view

Pathways by source for ZSCAN10 Gene

Gene Ontology (GO) - Biological Process for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0035019 somatic stem cell population maintenance TAS --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZSCAN10: view

No data available for SIGNOR curated interactions for ZSCAN10 Gene

Transcripts for ZSCAN10 Gene

Unigene Clusters for ZSCAN10 Gene

Zinc finger and SCAN domain containing 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2: - -
SP3: -

Relevant External Links for ZSCAN10 Gene

GeneLoc Exon Structure for
ZSCAN10
ECgene alternative splicing isoforms for
ZSCAN10

Expression for ZSCAN10 Gene

mRNA expression in normal human tissues for ZSCAN10 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN10 Gene

This gene is overexpressed in Brain - Cerebellum (x8.8), Brain - Cerebellar Hemisphere (x6.8), Muscle - Skeletal (x5.9), and Testis (x4.6).

Protein differential expression in normal tissues from HIPED for ZSCAN10 Gene

This gene is overexpressed in Liver, secretome (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN10 Gene



Protein tissue co-expression partners for ZSCAN10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN10 Gene:

ZSCAN10

SOURCE GeneReport for Unigene cluster for ZSCAN10 Gene:

Hs.334515
genes like me logo Genes that share expression patterns with ZSCAN10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZSCAN10 Gene

Orthologs for ZSCAN10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN10 34 35
  • 99.03 (n)
dog
(Canis familiaris)
Mammalia ZSCAN10 34 35
  • 84.77 (n)
cow
(Bos Taurus)
Mammalia ZSCAN10 34 35
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Zscan10 34
  • 76.04 (n)
mouse
(Mus musculus)
Mammalia Zscan10 34 16 35
  • 75.37 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSCAN10 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii -- 34
Species where no ortholog for ZSCAN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSCAN10 Gene

ENSEMBL:
Gene Tree for ZSCAN10 (if available)
TreeFam:
Gene Tree for ZSCAN10 (if available)

Paralogs for ZSCAN10 Gene

Paralogs for ZSCAN10 Gene

(485) SIMAP similar genes for ZSCAN10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZSCAN10: view

Variants for ZSCAN10 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111291324 -- 3,088,902(+) GAAGG(C/T)CATTT upstream-variant-2KB, utr-variant-3-prime
rs111369038 -- 3,089,991(+) TGGCC(A/G)CAGTG upstream-variant-2KB, reference, synonymous-codon
rs111581050 -- 3,092,242(+) GGGAC(A/C)TGGGA intron-variant, reference, missense, utr-variant-5-prime
rs111643637 -- 3,090,631(+) CTGGG(G/T)TTCTG reference, missense, utr-variant-5-prime
rs111753004 -- 3,094,142(+) CGAGT(A/G)GCTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN10 Gene

Variant ID Type Subtype PubMed ID
esv3637652 CNV loss 21293372
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897

Variation tolerance for ZSCAN10 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN10 Gene

Disorders for ZSCAN10 Gene

Relevant External Links for ZSCAN10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN10

No disorders were found for ZSCAN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN10 Gene

Publications for ZSCAN10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A transcriptional map of the FMF region. (PMID: 9653642) Bernot A. … Weissenbach J. (Genomics 1998) 2 3 64
  3. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. (PMID: 22911660) Sugito K. … Nagase H. (Pediatr Blood Cancer 2013) 3 64
  4. DNA hypomethylation at the ZNF206-exon 5 CpG island associated with neuronal differentiation in mice and development of neuroblastoma in humans. (PMID: 22011711) Kawashima H. … Nagase H. (Int. J. Oncol. 2012) 3 64
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64

Products for ZSCAN10 Gene

Sources for ZSCAN10 Gene

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