Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZSCAN1 Gene

Aliases for ZSCAN1 Gene

  • Zinc Finger And SCAN Domain Containing 1 2 3 5
  • Zinc Finger With SCAN Domain 1 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 1 3
  • ZNF915 3
  • MZF-1 3

External Ids for ZSCAN1 Gene

Previous GeneCards Identifiers for ZSCAN1 Gene

  • GC19P063238
  • GC19P063239
  • GC19P058547
  • GC19P054858

Summaries for ZSCAN1 Gene

GeneCards Summary for ZSCAN1 Gene

ZSCAN1 (Zinc Finger And SCAN Domain Containing 1) is a Protein Coding gene. Diseases associated with ZSCAN1 include Arrhythmogenic Right Ventricular Dysplasia 1. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF274.

UniProtKB/Swiss-Prot for ZSCAN1 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN1 Gene

Genomics for ZSCAN1 Gene

Regulatory Elements for ZSCAN1 Gene

Enhancers for ZSCAN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G057849 1.2 ENCODE 14.6 -183.3 -183330 3.0 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000269867 ZNF587 ENSG00000268912 ZSCAN1 VN1R1 LOC100419848 ZSCAN18 ENSG00000268201 LETM1P2 LOC100128398
GH19G058033 0.9 ENCODE 17.9 +0.2 174 1.6 HDAC1 ARNT SIN3A DMAP1 ZNF48 PAF1 ZBTB11 GATAD2B TFDP1 MXD3 ZSCAN1 LETM1P2
GH19G057388 1.1 ENCODE 14.6 -644.0 -643990 2.2 PKNOX1 FOXA2 WRNIP1 SIN3A DMAP1 YY1 ZNF143 FOS SP3 CEBPZ ZSCAN18 ENSG00000269696 LOC100128398 ZNF470 ZNF582-AS1 ZNF583 ZNF304 ZNF264 ZNF667 ZNF667-AS1
GH19G057476 1 ENCODE 14.6 -556.5 -556512 1.5 PKNOX1 FOXA2 ATF1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 VN1R1 ZNF773 ZNF134 ZNF417 ZNF606 ZNF667 ENSG00000269696 ZNF71 ENSG00000268912 ZSCAN1
GH19G058571 1.4 ENCODE dbSUPER 10.4 +540.1 540124 4.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZSCAN18 LOC100128398 TRIM28 ZNF418 ENSG00000268201 LOC105372482 ZNF606 LOC105372483 MZF1 ENSG00000268049
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Promoters for ZSCAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111843 111 1001 HDAC1 KLF1 MXI1 SAP30 SIN3A RBBP5 HIC1 POLR2A KDM5B KLF8

Genomic Location for ZSCAN1 Gene

Chromosome:
19
Start:
58,033,989 bp from pter
End:
58,058,907 bp from pter
Size:
24,919 bases
Orientation:
Plus strand

Genomic View for ZSCAN1 Gene

Genes around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN1 Gene

Proteins for ZSCAN1 Gene

  • Protein details for ZSCAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBB4-ZSCA1_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 1
    Protein Accession:
    Q8NBB4
    Secondary Accessions:
    • Q3B798
    • Q6WLH8
    • Q86WS8

    Protein attributes for ZSCAN1 Gene

    Size:
    408 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN1 Gene

Post-translational modifications for ZSCAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN1 Gene

No data available for DME Specific Peptides for ZSCAN1 Gene

Domains & Families for ZSCAN1 Gene

Gene Families for ZSCAN1 Gene

Suggested Antigen Peptide Sequences for ZSCAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSCAN1: view

No data available for UniProtKB/Swiss-Prot for ZSCAN1 Gene

Function for ZSCAN1 Gene

Molecular function for ZSCAN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN1: view
genes like me logo Genes that share phenotypes with ZSCAN1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZSCAN1 Gene

Selected GeneGlobe predicted Target genes for ZSCAN1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for ZSCAN1 Gene

Localization for ZSCAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZSCAN1: view

Pathways & Interactions for ZSCAN1 Gene

SuperPathways for ZSCAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZSCAN1: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN1 Gene

Drugs & Compounds for ZSCAN1 Gene

No Compound Related Data Available

Transcripts for ZSCAN1 Gene

mRNA/cDNA for ZSCAN1 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN1 Gene

Zinc finger and SCAN domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN1 Gene

No ASD Table

Relevant External Links for ZSCAN1 Gene

GeneLoc Exon Structure for
ZSCAN1
ECgene alternative splicing isoforms for
ZSCAN1

Expression for ZSCAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN1 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN1 Gene

This gene is overexpressed in Pituitary (x7.6) and Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ZSCAN1 Gene

This gene is overexpressed in Liver (45.9) and Fetal gut (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN1 Gene



Protein tissue co-expression partners for ZSCAN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN1 Gene:

ZSCAN1

SOURCE GeneReport for Unigene cluster for ZSCAN1 Gene:

Hs.643437

Evidence on tissue expression from TISSUES for ZSCAN1 Gene

  • Nervous system(4.3)
  • Lung(4)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZSCAN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN1 Gene

Orthologs for ZSCAN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN1 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia ZSCAN1 34 35
  • 73.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
OneToMany
Species where no ortholog for ZSCAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN1 Gene

ENSEMBL:
Gene Tree for ZSCAN1 (if available)
TreeFam:
Gene Tree for ZSCAN1 (if available)

Paralogs for ZSCAN1 Gene

Paralogs for ZSCAN1 Gene

(16) SIMAP similar genes for ZSCAN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZSCAN1: view

Variants for ZSCAN1 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000214354 -- 58,040,308(+) CAGAA(A/T)GACAG intron-variant
rs1000263351 -- 58,034,352(+) GGAGT(A/C)CTGAG intron-variant, upstream-variant-2KB
rs1000336971 -- 58,045,009(+) GTGTA(C/G)AGCGC intron-variant
rs1000375428 -- 58,035,958(+) TTTCC(A/C)TGTTG intron-variant, utr-variant-5-prime
rs1000604168 -- 58,035,670(+) GGCAG(A/G)GAAGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN1 Gene

Variant ID Type Subtype PubMed ID
nsv1066059 CNV gain 25217958
nsv1143929 CNV deletion 24896259
nsv833885 CNV loss 17160897

Variation tolerance for ZSCAN1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Disorders for ZSCAN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSCAN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arrhythmogenic right ventricular dysplasia 1
  • arrhythmogenic right ventricular dysplasia, familial, 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZSCAN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN1
genes like me logo Genes that share disorders with ZSCAN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN1 Gene

Publications for ZSCAN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZSCAN1 Gene

Sources for ZSCAN1 Gene

Content
Loading form....