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Aliases for ZSCAN1 Gene

Aliases for ZSCAN1 Gene

  • Zinc Finger And SCAN Domain Containing 1 2 3 5
  • Zinc Finger With SCAN Domain 1 2 3
  • ZNF915 3
  • MZF-1 3

External Ids for ZSCAN1 Gene

Previous GeneCards Identifiers for ZSCAN1 Gene

  • GC19P063238
  • GC19P063239
  • GC19P058547
  • GC19P054858

Summaries for ZSCAN1 Gene

GeneCards Summary for ZSCAN1 Gene

ZSCAN1 (Zinc Finger And SCAN Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF274.

UniProtKB/Swiss-Prot for ZSCAN1 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN1 Gene

Genomics for ZSCAN1 Gene

Regulatory Elements for ZSCAN1 Gene

Promoters for ZSCAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZSCAN1 Gene

Chromosome:
19
Start:
58,033,989 bp from pter
End:
58,058,907 bp from pter
Size:
24,919 bases
Orientation:
Plus strand

Genomic View for ZSCAN1 Gene

Genes around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN1 Gene

Proteins for ZSCAN1 Gene

  • Protein details for ZSCAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBB4-ZSCA1_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 1
    Protein Accession:
    Q8NBB4
    Secondary Accessions:
    • Q3B798
    • Q6WLH8
    • Q86WS8

    Protein attributes for ZSCAN1 Gene

    Size:
    408 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN1 Gene

Proteomics data for ZSCAN1 Gene at MOPED

Post-translational modifications for ZSCAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZSCAN1 Gene

Domains & Families for ZSCAN1 Gene

Gene Families for ZSCAN1 Gene

Suggested Antigen Peptide Sequences for ZSCAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBB4

UniProtKB/Swiss-Prot:

ZSCA1_HUMAN :
  • Contains 1 SCAN box domain.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • Contains 1 SCAN box domain.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZSCAN1: view

Function for ZSCAN1 Gene

Molecular function for ZSCAN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN1: view
genes like me logo Genes that share phenotypes with ZSCAN1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZSCAN1 Gene

Selected GeneGlobe predicted Target genes for ZSCAN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for ZSCAN1 Gene

Localization for ZSCAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZSCAN1 Gene COMPARTMENTS Subcellular localization image for ZSCAN1 gene
Compartment Confidence
nucleus 5
cytosol 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZSCAN1 Gene

Pathways & Interactions for ZSCAN1 Gene

SuperPathways for ZSCAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN1: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN1 Gene

Drugs & Compounds for ZSCAN1 Gene

No Compound Related Data Available

Transcripts for ZSCAN1 Gene

mRNA/cDNA for ZSCAN1 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN1 Gene

Zinc finger and SCAN domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN1 Gene

No ASD Table

Relevant External Links for ZSCAN1 Gene

GeneLoc Exon Structure for
ZSCAN1
ECgene alternative splicing isoforms for
ZSCAN1

Expression for ZSCAN1 Gene

mRNA expression in normal human tissues for ZSCAN1 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN1 Gene

This gene is overexpressed in Pituitary (x7.6) and Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ZSCAN1 Gene

This gene is overexpressed in Liver (45.9) and Fetal gut (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN1 Gene



SOURCE GeneReport for Unigene cluster for ZSCAN1 Gene Hs.643437

genes like me logo Genes that share expression patterns with ZSCAN1: view

Protein tissue co-expression partners for ZSCAN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZSCAN1 Gene

Orthologs for ZSCAN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZSCAN1 35
  • 73.18 (n)
  • 64.72 (a)
ZSCAN1 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN1 35
  • 99.26 (n)
  • 98.53 (a)
ZSCAN1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
Species with no ortholog for ZSCAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN1 Gene

ENSEMBL:
Gene Tree for ZSCAN1 (if available)
TreeFam:
Gene Tree for ZSCAN1 (if available)

Paralogs for ZSCAN1 Gene

Paralogs for ZSCAN1 Gene

(16) SIMAP similar genes for ZSCAN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZSCAN1: view

Variants for ZSCAN1 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs292827 -- 58,033,104(+) CTCCC(A/G)AGTAG upstream-variant-2KB
rs292828 -- 58,033,765(+) TGGAA(C/T)GCCGT upstream-variant-2KB
rs295349 -- 58,047,876(+) ATGGT(C/T)GGGCT intron-variant
rs384702 -- 58,041,433(+) GCACT(A/G)CACCC intron-variant
rs620297 -- 58,034,065(+) CGCAG(C/G)GTGCG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN1 Gene

Variant ID Type Subtype PubMed ID
nsv833885 CNV Loss 17160897
nsv912533 CNV Loss 21882294
nsv912534 CNV Loss 21882294

Variation tolerance for ZSCAN1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZSCAN1 Gene

HapMap Linkage Disequilibrium report
ZSCAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Disorders for ZSCAN1 Gene

Relevant External Links for ZSCAN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZSCAN1

No disorders were found for ZSCAN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN1 Gene

Publications for ZSCAN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZSCAN1 Gene

Sources for ZSCAN1 Gene

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