Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZRSR2 Gene

Aliases for ZRSR2 Gene

  • Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2 2 3
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 2 2 3 4
  • Zinc Finger (CCCH Type), RNA Binding Motif And Serine/Arginine Rich 2 3 5
  • Renal Carcinoma Antigen NY-REN-20 3 4
  • U2AF35-Related Protein 3 4
  • U2AF1-RS2 3 4
  • U2AF1RS2 3 4
  • U2AF1L2 3 4
  • URP 3 4
  • CCCH Type Zinc Finger, RNA-Binding Motif And Serine/Arginine Rich Protein 2 4
  • Zinc Finger (CCCH Type), RNA-Binding Motif And Serine/Arginine Rich 2 3
  • U2 Small Nuclear Ribonucleoprotein Auxiliary Factor, Small Subunit 2 3
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 2 2
  • ZC3H22 3

External Ids for ZRSR2 Gene

Previous HGNC Symbols for ZRSR2 Gene

  • U2AF1L2

Previous GeneCards Identifiers for ZRSR2 Gene

  • GC0XP015719
  • GC0XP015720
  • GC0XP013562

Summaries for ZRSR2 Gene

Entrez Gene Summary for ZRSR2 Gene

  • This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZRSR2 Gene

ZRSR2 (Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2) is a Protein Coding gene. Diseases associated with ZRSR2 include hematologic cancer. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ZRSR1.

UniProtKB/Swiss-Prot for ZRSR2 Gene

  • Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Gene Wiki entry for ZRSR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZRSR2 Gene

Genomics for ZRSR2 Gene

Regulatory Elements for ZRSR2 Gene

Promoters for ZRSR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZRSR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZRSR2 Gene

Chromosome:
X
Start:
15,790,269 bp from pter
End:
15,823,260 bp from pter
Size:
32,992 bases
Orientation:
Plus strand

Genomic View for ZRSR2 Gene

Genes around ZRSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZRSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZRSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZRSR2 Gene

Proteins for ZRSR2 Gene

  • Protein details for ZRSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15696-U2AFM_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
    Protein Accession:
    Q15696
    Secondary Accessions:
    • Q14D69

    Protein attributes for ZRSR2 Gene

    Size:
    482 amino acids
    Molecular mass:
    58045 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts (via RS domain) with SRSF1 and SRSF2. Interacts with U2AF2/U2AF65.

neXtProt entry for ZRSR2 Gene

Proteomics data for ZRSR2 Gene at MOPED

Post-translational modifications for ZRSR2 Gene

Other Protein References for ZRSR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZRSR2 Gene

Domains & Families for ZRSR2 Gene

Suggested Antigen Peptide Sequences for ZRSR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15696

UniProtKB/Swiss-Prot:

U2AFM_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 2 C3H1-type zinc fingers.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZRSR2: view

Function for ZRSR2 Gene

Molecular function for ZRSR2 Gene

UniProtKB/Swiss-Prot Function:
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Gene Ontology (GO) - Molecular Function for ZRSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZRSR2: view

Phenotypes for ZRSR2 Gene

genes like me logo Genes that share phenotypes with ZRSR2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZRSR2 Gene

Localization for ZRSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRSR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZRSR2 Gene COMPARTMENTS Subcellular localization image for ZRSR2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZRSR2 Gene

Pathways & Interactions for ZRSR2 Gene

SuperPathways for ZRSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZRSR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZRSR2 Gene

Drugs & Compounds for ZRSR2 Gene

No Compound Related Data Available

Transcripts for ZRSR2 Gene

Unigene Clusters for ZRSR2 Gene

Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZRSR2 Gene

No ASD Table

Relevant External Links for ZRSR2 Gene

GeneLoc Exon Structure for
ZRSR2
ECgene alternative splicing isoforms for
ZRSR2

Expression for ZRSR2 Gene

mRNA expression in normal human tissues for ZRSR2 Gene

Protein differential expression in normal tissues from HIPED for ZRSR2 Gene

This gene is overexpressed in Liver (62.5) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZRSR2 Gene



SOURCE GeneReport for Unigene cluster for ZRSR2 Gene Hs.171909

mRNA Expression by UniProt/SwissProt for ZRSR2 Gene

Q15696-U2AFM_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZRSR2: view

Protein tissue co-expression partners for ZRSR2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZRSR2 Gene

Orthologs for ZRSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZRSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZRSR2 35
  • 99.52 (n)
  • 99.28 (a)
ZRSR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
ZRSR2 35
  • 87.72 (n)
  • 89.28 (a)
dog
(Canis familiaris)
Mammalia ZRSR2 35
  • 88.59 (n)
  • 90.6 (a)
-- 36
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zrsr2 16
Zrsr2 35
  • 82.57 (n)
  • 81.53 (a)
Zrsr1 36
  • 75 (a)
ManyToMany
Zrsr2 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zrsr2 35
  • 84.58 (n)
  • 84.02 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 71 (a)
OneToMany
ZRSR2 35
  • 72.65 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.19556 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zrsr2 35
  • 66.32 (n)
  • 69.07 (a)
zebrafish
(Danio rerio)
Actinopterygii zrsr2 36
  • 42 (a)
OneToMany
zrsr2 35
  • 64.01 (n)
  • 61.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3294 36
  • 28 (a)
OneToMany
Species with no ortholog for ZRSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZRSR2 Gene

ENSEMBL:
Gene Tree for ZRSR2 (if available)
TreeFam:
Gene Tree for ZRSR2 (if available)

Paralogs for ZRSR2 Gene

Paralogs for ZRSR2 Gene

genes like me logo Genes that share paralogs with ZRSR2: view

Variants for ZRSR2 Gene

Sequence variations from dbSNP and Humsavar for ZRSR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs764083 -- 15,816,229(-) AGCTT(C/T)TAAGT intron-variant
rs1056181 -- 15,804,693(-) ATGTG(A/G)AAACA intron-variant
rs1056182 -- 15,804,689(-) GAAAA(A/C)AAAAA intron-variant
rs2238917 -- 15,804,848(+) GAAGA(C/T)AATTG intron-variant
rs2238918 -- 15,805,249(+) GCAAG(A/T)TCATG intron-variant

Variation tolerance for ZRSR2 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZRSR2 Gene

HapMap Linkage Disequilibrium report
ZRSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZRSR2 Gene

Disorders for ZRSR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZRSR2 Gene - From: GeneTests and DISEASES

Disorder Aliases PubMed IDs
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards
Search ZRSR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZRSR2

Genetic Association Database (GAD)
ZRSR2
Human Genome Epidemiology (HuGE) Navigator
ZRSR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZRSR2
genes like me logo Genes that share disorders with ZRSR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZRSR2 Gene

Publications for ZRSR2 Gene

  1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 2 3 4 67
  2. A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. (PMID: 9237760) Tronchere H. … Fu X.D. (Nature 1997) 2 3
  3. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (PMID: 8586425) Kitagawa K. … Mukai T. (Genomics 1995) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome. (PMID: 25964599) Hong J.Y. … Jang J.H. (Anticancer Res. 2015) 3

Products for ZRSR2 Gene

Sources for ZRSR2 Gene

Back to Top

Content