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Aliases for ZRSR2 Gene

Aliases for ZRSR2 Gene

  • Zinc Finger (CCCH Type), RNA-Binding Motif And Serine/Arginine Rich 2 2 3
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 2 2 3 4
  • U2AF1RS2 3 4 6
  • Renal Carcinoma Antigen NY-REN-20 3 4
  • U2AF35-Related Protein 3 4
  • U2AF1-RS2 3 4
  • U2AF1L2 3 4
  • URP 3 4
  • U2 Small Nuclear Ribonucleoprotein Auxiliary Factor 35 KDa Subunit-Related Protein 2 3
  • CCCH Type Zinc Finger, RNA-Binding Motif And Serine/Arginine Rich Protein 2 4
  • U2 Small Nuclear Ribonucleoprotein Auxiliary Factor, Small Subunit 2 3
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 2 2

External Ids for ZRSR2 Gene

Previous HGNC Symbols for ZRSR2 Gene

  • U2AF1L2

Previous GeneCards Identifiers for ZRSR2 Gene

  • GC0XP015719
  • GC0XP015720
  • GC0XP013562

Summaries for ZRSR2 Gene

Entrez Gene Summary for ZRSR2 Gene

  • This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZRSR2 Gene

ZRSR2 (Zinc Finger (CCCH Type), RNA-Binding Motif And Serine/Arginine Rich 2) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and pre-mRNA 3-splice site binding. An important paralog of this gene is ZRSR1.

UniProtKB/Swiss-Prot for ZRSR2 Gene

  • Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Gene Wiki entry for ZRSR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZRSR2 Gene

Genomics for ZRSR2 Gene

Regulatory Elements for ZRSR2 Gene

Genomic Location for ZRSR2 Gene

Start:
15,790,451 bp from pter
End:
15,823,260 bp from pter
Size:
32,810 bases
Orientation:
Plus strand

Genomic View for ZRSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZRSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZRSR2 Gene

Proteins for ZRSR2 Gene

  • Protein details for ZRSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15696-U2AFM_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
    Protein Accession:
    Q15696
    Secondary Accessions:
    • Q14D69

    Protein attributes for ZRSR2 Gene

    Size:
    482 amino acids
    Molecular mass:
    58045 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts (via RS domain) with SRSF1 and SRSF2. Interacts with U2AF2/U2AF65.

neXtProt entry for ZRSR2 Gene

Proteomics data for ZRSR2 Gene at MOPED

Post-translational modifications for ZRSR2 Gene

Other Protein References for ZRSR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZRSR2 Gene

Domains for ZRSR2 Gene

Gene Families for ZRSR2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • ZC3H :Zinc fingers, CCCH-type domain containing

Suggested Antigen Peptide Sequences for ZRSR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15696

UniProtKB/Swiss-Prot:

U2AFM_HUMAN :
  • Q15696
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZRSR2: view

Function for ZRSR2 Gene

Molecular function for ZRSR2 Gene

UniProtKB/Swiss-Prot Function: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Gene Ontology (GO) - Molecular Function for ZRSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 23602568
GO:0030628 pre-mRNA 3-splice site binding IDA 21041408
genes like me logo Genes that share ontologies with ZRSR2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZRSR2 Gene

Localization for ZRSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRSR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZRSR2 Gene COMPARTMENTS Subcellular localization image for ZRSR2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZRSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with ZRSR2: view

Pathways for ZRSR2 Gene

SuperPathways for ZRSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZRSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IMP 21041408
GO:0000398 mRNA splicing, via spliceosome IMP 9237760
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with ZRSR2: view

No data available for Pathways by source for ZRSR2 Gene

Transcripts for ZRSR2 Gene

Unigene Clusters for ZRSR2 Gene

Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZRSR2 Gene

No ASD Table

Relevant External Links for ZRSR2 Gene

GeneLoc Exon Structure for
ZRSR2
ECgene alternative splicing isoforms for
ZRSR2

Expression for ZRSR2 Gene

mRNA expression in normal human tissues for ZRSR2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZRSR2 Gene

SOURCE GeneReport for Unigene cluster for ZRSR2 Gene Hs.171909

mRNA Expression by UniProt/SwissProt for ZRSR2 Gene

Q15696-U2AFM_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ZRSR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZRSR2 Gene

Orthologs for ZRSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZRSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZRSR2 35
  • 99.52 (n)
  • 99.28 (a)
ZRSR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
ZRSR2 35
  • 87.72 (n)
  • 89.28 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 65 (a)
ManyToMany
ZRSR2 35
  • 88.59 (n)
  • 90.6 (a)
mouse
(Mus musculus)
Mammalia Zrsr1 36
  • 75 (a)
ManyToMany
Zrsr2 35
  • 82.57 (n)
  • 81.53 (a)
Zrsr2 16
Zrsr2 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zrsr2 35
  • 84.58 (n)
  • 84.02 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 71 (a)
OneToMany
ZRSR2 35
  • 72.65 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.19556 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zrsr2 35
  • 66.32 (n)
  • 69.07 (a)
zebrafish
(Danio rerio)
Actinopterygii zrsr2 35
  • 64.01 (n)
  • 61.94 (a)
zrsr2 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3294 36
  • 28 (a)
OneToMany
Species with no ortholog for ZRSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZRSR2 Gene

ENSEMBL:
Gene Tree for ZRSR2 (if available)
TreeFam:
Gene Tree for ZRSR2 (if available)

Paralogs for ZRSR2 Gene

Paralogs for ZRSR2 Gene

genes like me logo Genes that share paralogs with ZRSR2: view

Variants for ZRSR2 Gene

Sequence variations from dbSNP and Humsavar for ZRSR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs764083 -- 15,816,229(-) AGCTT(C/T)TAAGT intron-variant
rs1056181 -- 15,804,693(-) ATGTG(A/G)AAACA intron-variant
rs1056182 -- 15,804,689(-) GAAAA(A/C)AAAAA intron-variant
rs1557807 -- 15,809,917(+) TGAGT(G/T)TGCCC intron-variant
rs1557808 -- 15,811,312(+) GGGTA(C/G)TTGAA intron-variant

Relevant External Links for ZRSR2 Gene

HapMap Linkage Disequilibrium report
ZRSR2
Locus Specific Mutation Databases (LSDB)
ZRSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZRSR2 Gene

Disorders for ZRSR2 Gene

Relevant External Links for ZRSR2

Genetic Association Database (GAD)
ZRSR2
Human Genome Epidemiology (HuGE) Navigator
ZRSR2
genes like me logo Genes that share disorders with ZRSR2: view

No data available for UniProtKB/Swiss-Prot for ZRSR2 Gene

Publications for ZRSR2 Gene

  1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 2 3 4
  2. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (PMID: 8586425) Kitagawa K. … Mukai T. (Genomics 1995) 2 3 4
  3. A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. (PMID: 9237760) Tronchere H. … Fu X.D. (Nature 1997) 2 3 4
  4. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZRSR2 Gene

Sources for ZRSR2 Gene

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