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ZRSR1 Gene

protein-coding   GIFtS: 31
GCID: GC05P112228

Zinc Finger (CCCH Type), RNA-Binding Motif And Serine/Arginine...

(Previous names: U2(RNU2) small nuclear RNA auxiliary factor binding protein-like,...)
(Previous symbols: U2AFBPL, U2AF1P, U2AF1L1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger (CCCH Type), RNA-Binding Motif And Serine/Arginine Rich
11 2
     U2 Small Nuclear RNA Auxillary Factor 1-Like 11
U2AF1L11 2 3     U2(RNU2) Small Nuclear RNA Auxiliary Factor Binding Protein-Like1
U2AF1P1 2 3     U2(RNU2) Small Nuclear RNA Auxiliary Factor Pseudogene 11
U2AFBPL1 2 3     U2(RNU2) Small Nuclear RNA Auxillary Factor 1-Like 11
U2AF1RS12 3 5     CCCH Type Zinc Finger, RNA-Binding Motif And Serine/Arginine Rich Protein
13
U2AF1-RS12 3     U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 13

External Ids:    HGNC: 124561   Entrez Gene: 73102   Ensembl: ENSG000002126437   OMIM: 6010795   UniProtKB: Q156953   

Export aliases for ZRSR1 gene to outside databases

Previous GC identifers: GC05P112256 GC05P107407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZRSR1 Gene:
ZRSR1 (zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1) is a protein-coding gene. Diseases associated with ZRSR1 include lung cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is ENSG00000267120.

Gene Wiki entry for ZRSR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZRSR1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZRSR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZRSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.2   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q22.2

ZRSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZRSR1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P112228:  view genomic region     (about GC identifiers)

Start:
112,227,313 bp from pter      End:
112,228,794 bp from pter
Size:
1,482 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: U2AFL_HUMAN, Q15695 (See protein sequence)
Recommended Name: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1  
Size: 479 amino acids; 57643 Da
Secondary accessions: B2R901 Q13570 Q2M3R8

Explore the universe of human proteins at neXtProt for ZRSR1: NX_Q15695

Explore proteomics data for ZRSR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZRSR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000375133  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC3H: Zinc fingers, CCCH-type domain containing
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR009145 U2_small

    Graphical View of Domain Structure for InterPro Entry Q15695

    ProtoNet protein and cluster: Q15695

    3 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB000571 Zn-finger
    IPB009145 U2 auxiliary factor small subunit signature


    UniProtKB/Swiss-Prot: U2AFL_HUMAN, Q15695
    Similarity: Contains 2 C3H1-type zinc fingers
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    ZRSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZRSR1 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    U2AFL_HUMAN, Q15695: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0030529ribonucleoprotein complex IEA--

    ZRSR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZRSR1
    Interactions:

        Search GeneGlobe Interaction Network for ZRSR1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZRSR1 (ENSP000003751334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CWC25ENSP000002254284STRING: ENSP00000225428
    HTATSF1ENSP000002183644STRING: ENSP00000218364
    SRP68ENSP000003120664STRING: ENSP00000312066
    SRSF3ENSP000003628204STRING: ENSP00000362820
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    ZRSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZRSR1 (U2AFL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000391338(uc021ycm.1)
    miRNA
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    Selected AceView cDNA sequences (see all 445):

    F04853 BI333071 AL535988 AI907587 BQ549147 F09958 AA421913 M79108 
    AA151217 BQ549628 F04846 CB990609 BP360258 AL706482 M74088 CB158849 
    BQ423807 BM712557 BM975470 BQ898700 BG142221 AI831854 CB055159 T05594 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZRSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZRSR1 Expression
    About this image

    ZRSR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZRSR1 Protein Expression
        Custom PCR Arrays for ZRSR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZRSR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    67(a)
    1 → many
    1(121271446-121287881)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    3(121600569-121620123)
    zebrafish
    (Danio rerio)
    Actinopterygii zrsr26
    zinc finger (CCCH type), RNA-binding motif and ser...
    41(a)
    1 → many
    11(12790179-12802015) ENSDARG00000058448
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32946
    --
    27(a)
    1 → many
    2L(4794549-4796581)
            Species with no ortholog for ZRSR1

    ENSEMBL Gene Tree for ZRSR1 (if available)
    TreeFam Gene Tree for ZRSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZRSR1 gene
    ENSG000002671202  ZRSR22  U2AF12  U2AF1L42  
    1 SIMAP similar gene for ZRSR1 using alignment to 1 protein entry:     U2AFL_HUMAN:
    ZRSR2

    ZRSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601079    OMIM disorders: --

    1 disease for ZRSR1:    About MalaCards
    lung cancer


    ZRSR1 for disorders           About GeneDecksing


    Export disorders for ZRSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZRSR1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZRSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. (PubMed id 8586425)1, 2, 9 Kitagawa K.... Mukai T. (Genomics 1995)
    2. Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs. (PubMed id 8630064)1, 2 Pearsall R.S.... Held W.A. (Biochem. Biophys. Res. Commun. 1996)
    3. Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5. (PubMed id 7956352)1, 3 Kalcheva I....Takagi N. (Cytogenet. Cell Genet. 1995)
    4. Mouse U2af1-rs1 is a neomorphic imprinted gene. (PubMed id 9001233)1, 9 Nabetani A....Mukai T. (Mol. Cell. Biol. 1997)
    5. Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice. (PubMed id 16305817)1, 9 Zhang Z....Mukai T. (Gene 2006)
    6. A case-by-case evolutionary analysis of four imprinted retrogenes. (PubMed id 21166792)1 McCole R.B....Oakey R.J. ( international journal of organic evolution 2011)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sites. (PubMed id 12558503)1 FAPrch P....ValcA!rcel J. (Biochem. J. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7310 HGNC: 12456 AceView: APCandSRP19andU2AF1L1 Ensembl:ENSG00000212643 euGenes: HUgn7310
    ECgene: ZRSR1 H-InvDB: ZRSR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZRSR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZRSR1 gene:
    Search GeneIP for patents involving ZRSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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