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ZRANB3 Gene

protein-coding   GIFtS: 50
GCID: GC02M135894

Zinc Finger, RAN-Binding Domain Containing 3

  See ZRANB3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, RAN-Binding Domain Containing 31 2     4933425L19Rik2
Annealing Helicase 22 3     DNA Annealing Helicase And Endonuclease ZRANB32
Zinc Finger Ran-Binding Domain-Containing Protein 32 3     EC 3.6.18
AH22 3     

External Ids:    HGNC: 252491   Entrez Gene: 840832   Ensembl: ENSG000001219887   UniProtKB: Q5FWF43   

Export aliases for ZRANB3 gene to outside databases

Previous GC identifers: GC02M135728 GC02M127950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZRANB3 Gene:
ZRANB3 (zinc finger, RAN-binding domain containing 3) is a protein-coding gene. Diseases associated with ZRANB3 include speech disorder. GO annotations related to this gene include DNA helicase activity and endodeoxyribonuclease activity. An important paralog of this gene is BTAF1.

UniProtKB/Swiss-Prot: ZRAB3_HUMAN, Q5FWF4
Function: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed
replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during
template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts
as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an
accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase.
In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order
to prevent disintegration of the replication fork and the formation of double-strand breaks




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZRANB3 gene promoter:
         USF1   AP-2alpha isoform 3   Tal-1   AML1a   p300   AP-2alpha isoform 2   E47   USF-1   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZRANB3 promoter sequence
   Search Chromatin IP Primers for ZRANB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZRANB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

ZRANB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZRANB3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M135894:  view genomic region     (about GC identifiers)

Start:
135,894,486 bp from pter      End:
136,288,806 bp from pter
Size:
394,321 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZRAB3_HUMAN, Q5FWF4 (See protein sequence)
Recommended Name: DNA annealing helicase and endonuclease ZRANB3  
Size: 1079 amino acids; 123248 Da
Subunit: Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via
'Lys-63'-linked polyubiquitin)
Miscellaneous: In contrast to classical helicases that unwing DNA, annealing helicases rewind it (PubMed:21078962)
Sequence caution: Sequence=AAX93066.1; Type=Erroneous gene model prediction; Sequence=BAG54763.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG65387.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAX11631.1; Type=Erroneous gene model prediction;
Sequence=EAX11633.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KYA1 B4E375 B5MDI3 D3DP76 E9PBP0 Q53SM1 Q6P2C4 Q8N1P4 Q9H0E8
Alternative splicing: 5 isoforms:  Q5FWF4-1   Q5FWF4-2   Q5FWF4-3   Q5FWF4-4   Q5FWF4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZRANB3: NX_Q5FWF4

Explore proteomics data for ZRANB3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys179, Lys322
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ZRANB3 (Q5FWF4)
     RAHRIGQ  KFLVFAHH  MGLGKTIQ  DEMGLGKT 


    See ZRANB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273497.1  NP_001273498.1  NP_115519.2  

    ENSEMBL proteins: 
     ENSP00000383979   ENSP00000264159   ENSP00000384245   ENSP00000441320  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZRANB: Zinc fingers, RAN-binding domain containing

    Selected InterPro protein domains (see all 7):
     IPR002711 HNH
     IPR000330 SNF2_N
     IPR003615 HNH_nuc
     IPR027417 P-loop_NTPase
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q5FWF4

    ProtoNet protein and cluster: Q5FWF4

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB001876 Zn-finger
    IPB003615 HNH nuclease


    UniProtKB/Swiss-Prot: ZRAB3_HUMAN, Q5FWF4
    Domain: The PIP-box mediates the interaction with PCNA, while the RanBP2-type zinc finger mediates binding to
    'Lys-63'-linked polyubiquitin (PubMed:22704558, PubMed:22705370 and PubMed:22759634)
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 HNH domain
    Similarity: Contains 1 RanBP2-type zinc finger


    Find genes that share domains with ZRANB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZRAB3_HUMAN, Q5FWF4
    Function: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed
    replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during
    template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts
    as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an
    accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase.
    In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order
    to prevent disintegration of the replication fork and the formation of double-strand breaks

         Enzyme Number (IUBMB): EC 3.6.12

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003678NOT DNA helicase activity IDA--
    GO:0004386helicase activity ----
    GO:0004519endonuclease activity ----
         
    Find genes that share ontologies with ZRANB3           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Zranb3 (no phenotypes)

    Find genes that share phenotypes with ZRANB3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZRANB3
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    hsa-miR-494
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZRANB3 (NM_032143)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZRAB3_HUMAN, Q5FWF4: Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled
    replication forks by polyubiquitinated PCNA
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol3
    golgi apparatus3
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043596nuclear replication fork IDA--

    Find genes that share ontologies with ZRANB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZRANB3
    Interactions:

        Search GeneGlobe Interaction Network for ZRANB3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZRANB3 (ENSP000002641594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    FBXO18ENSP000003693354STRING: ENSP00000369335
    MRE11AENSP000003258634STRING: ENSP00000325863
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000733DNA strand renaturation IDA--
    GO:0000737DNA catabolic process, endonucleolytic IDA--
    GO:0006281DNA repair IDA--
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0009411response to UV IDA--

    Find genes that share ontologies with ZRANB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZRANB3 (ZRAB3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZRANB3 gene (3 alternative transcripts): 
    NM_001286568.1  NM_001286569.1  NM_032143.3  

    Unigene Cluster for ZRANB3:

    Zinc finger, RAN-binding domain containing 3
    Hs.658422  [show with all ESTs]
    Unigene Representative Sequence: BX647838
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412849 ENST00000401392(uc002tul.3) ENST00000264159(uc002tum.3)
    ENST00000403017(uc002tuk.3) ENST00000474919 ENST00000495945 ENST00000452187
    ENST00000472452 ENST00000492193 ENST00000536680(uc002tun.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZRANB3:
    hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidZRANB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZRANB3
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    GenScript: all cDNA clones in your preferred vector: ZRANB3 (NM_032143)
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      QuantiTect SYBR Green Assays in human, mouse, rat ZRANB3
      QuantiFast Probe-based Assays in human, mouse, rat ZRANB3

    Additional mRNA sequence: 

    AK095362.1 AK131303.1 AK304601.1 AL136824.1 AL833322.1 BC089429.1 BX647838.1 

    10 DOTS entries:

    DT.86843971  DT.100770423  DT.40228481  DT.91893445  DT.100749754  DT.40188719  DT.75108512  DT.120977412 
    DT.102842975  DT.91870885 

    Selected AceView cDNA sequences (see all 45):

    BX647838 BF511126 BG215924 AL136824 BG548811 AW117420 BM724287 BG212670 
    AW105245 BM461609 BX331934 AL043524 NM_032143 AL833322 AI129919 AW235285 
    BX111132 CD656776 BU621352 BG194318 BG205879 BF222038 AK095362 BF476708 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZRANB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGCTCAC
    ZRANB3 Expression
    About this image


    ZRANB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ZRANB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZRANB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658422
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZRANB3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zranb31 , 5 zinc finger, RAN-binding domain containing 31, 5 81.26(n)1
    78.26(a)1
      1 (55.80 cM)5
    2264091  NM_001285945.11  NP_001272874.11 
     1279541845 
    chicken
    (Gallus gallus)
    Aves ZRANB31 zinc finger, RAN-binding domain containing 3 69.02(n)
    67.34(a)
      424291  XM_003641593.2  XP_003641641.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZRANB36
    zinc finger, RAN-binding domain containing 3
    62(a)
    1 ↔ 1
    1(96527049-96588828)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.74492 Transcribed sequence with moderate similarity to protein more 72.58(n)    AL901506.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003314961 DNA annealing helicase and endonuclease ZRANB3-like 57.73(n)
    56.11(a)
      100331496  XM_002666215.3  XP_002666261.3 
    worm
    (Caenorhabditis elegans)
    Secernentea btf-16
    Protein BTF-1 (btf-1) mRNA, complete cds
    7(a)
    many ↔ many
    II(13200163-13215710) WBGene00000274
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOT16
    Essential abundant protein involved in regulation ...
    7(a)
    1 → many
    XVI(398480-404083) YPL082C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G078101 AT5G07810 45.92(n)
    37.22(a)
      830674  NM_120863.3  NP_196398.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g05983001 Os07g0598300 47.74(n)
    38.96(a)
      4343803  NM_001066716.1  NP_001060181.2 


    ENSEMBL Gene Tree for ZRANB3 (if available)
    TreeFam Gene Tree for ZRANB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZRANB3 gene
    BTAF12  SMARCAL12  
    1 SIMAP similar gene for ZRANB3 using alignment to 3 protein entries:     ZRAB3_HUMAN (see all proteins):
    SMARCAL1

    Find genes that share paralogs with ZRANB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZRANB3 (see all 5780)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154245951,2
    F--135957087(+) GGTCTC/TGATCT 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1886153801,2
    C--135957138(+) GTGCTA/GGGATT 1 -- int10--------
    rs1922709731,2
    --135957152(+) TGCGTG/TAGCCA 1 -- int10--------
    rs1383622091,2
    --135957159(+) GCCACC/TGCGCC 1 -- int10--------
    rs1846139511,2
    --135957184(+) CCTAGC/TTTTAT 1 -- int10--------
    rs1439201841,2
    C--135957457(+) GGCTGC/GTCATG 1 -- int10--------
    rs1472873491,2
    C--135957519(+) TTTTGC/TAATGT 1 -- int10--------
    rs1898475071,2
    --135957634(+) GGCATA/GTTAGG 1 -- ut310--------
    rs729803601,2
    C,F--135957703(+) AAGACC/AACAGA 1 -- ut313Minor allele frequency- A:0.26WA 122
    rs1157288641,2
    C,F--135957826(+) ACTCTC/TGATAT 1 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ZRANB3 (135894486 - 136144486 bp, first 250kb of ZRANB3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZRANB3 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661092CNV Deletion23128226
    esv2720863CNV Deletion23290073
    esv2467285CNV Deletion19546169
    esv2668909CNV Deletion23128226
    esv2720861CNV Deletion23290073
    esv2664308CNV Deletion23128226
    esv2421388CNV Deletion20811451
    esv2058333CNV Deletion18987734
    esv2410901CNV Deletion18987734
    nsv2941CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZRANB3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease for ZRANB3:    
    About MalaCards
    speech disorder

    1 disease from the University of Copenhagen DISEASES database for ZRANB3:
    Speech disorder

    Find genes that share disorders with ZRANB3           About GenesLikeMe

    Genetic Association Database (GAD): ZRANB3
    Human Genome Epidemiology (HuGE) Navigator: ZRANB3 (2 documents)

    Export disorders for ZRANB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZRANB3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ZRANB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. (PubMed id 22759634)1, 2 Weston R.... Ahel D. (Genes Dev. 2012)
    3. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. (PubMed id 22705370)1, 2 Yuan J.... Chen J. (Mol. Cell 2012)
    4. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. (PubMed id 22704558)1, 2 Ciccia A.... Elledge S.J. (Mol. Cell 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. (PubMed id 21078962)1, 2 Yusufzai T. and Kadonaga J.T. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84083 HGNC: 25249 AceView: ZRANB3 Ensembl:ENSG00000121988 euGenes: HUgn84083
    ECgene: ZRANB3 H-InvDB: ZRANB3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZRANB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZRANB3 gene:
    Search GeneIP for patents involving ZRANB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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