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Aliases for ZRANB3 Gene

Aliases for ZRANB3 Gene

  • Zinc Finger, RAN-Binding Domain Containing 3 2 3
  • Zinc Finger Ran-Binding Domain-Containing Protein 3 3 4
  • Annealing Helicase 2 3 4
  • AH2 3 4
  • DNA Annealing Helicase And Endonuclease ZRANB3 3
  • 4933425L19Rik 3
  • EC 3.6.1 64

External Ids for ZRANB3 Gene

Summaries for ZRANB3 Gene

GeneCards Summary for ZRANB3 Gene

ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3) is a Protein Coding gene. Diseases associated with ZRANB3 include speech disorder. GO annotations related to this gene include DNA helicase activity and endodeoxyribonuclease activity. An important paralog of this gene is BTAF1.

UniProtKB/Swiss-Prot for ZRANB3 Gene

  • DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZRANB3 Gene

Genomics for ZRANB3 Gene

Genomic Location for ZRANB3 Gene

Start:
135,136,916 bp from pter
End:
135,531,236 bp from pter
Size:
394,321 bases
Orientation:
Minus strand

Genomic View for ZRANB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZRANB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZRANB3 Gene

Proteins for ZRANB3 Gene

  • Protein details for ZRANB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FWF4-ZRAB3_HUMAN
    Recommended name:
    DNA annealing helicase and endonuclease ZRANB3
    Protein Accession:
    Q5FWF4
    Secondary Accessions:
    • B3KYA1
    • B4E375
    • B5MDI3
    • D3DP76
    • E9PBP0
    • Q53SM1
    • Q6P2C4
    • Q8N1P4
    • Q9H0E8

    Protein attributes for ZRANB3 Gene

    Size:
    1079 amino acids
    Molecular mass:
    123248 Da
    Quaternary structure:
    • Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via Lys-63-linked polyubiquitin).
    Miscellaneous:
    • In contrast to classical helicases that unwing DNA, annealing helicases rewind it.
    SequenceCaution:
    • Sequence=AAX93066.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG54763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG65387.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX11631.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX11633.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZRANB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZRANB3 Gene

Proteomics data for ZRANB3 Gene at MOPED

Selected DME Specific Peptides for ZRANB3 Gene

Post-translational modifications for ZRANB3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys179 and Lys322

Other Protein References for ZRANB3 Gene

Domains for ZRANB3 Gene

Gene Families for ZRANB3 Gene

HGNC:
  • ZRANB :Zinc fingers, RAN-binding domain containing

UniProtKB/Swiss-Prot:

ZRAB3_HUMAN
Domain:
  • The PIP-box mediates the interaction with PCNA, while the RanBP2-type zinc finger mediates binding to Lys-63-linked polyubiquitin (PubMed:22704558, PubMed:22705370 and PubMed:22759634).:
    • Q5FWF4
  • Contains 1 helicase ATP-binding domain.:
    • Q5FWF4
  • Contains 1 helicase C-terminal domain.:
    • Q5FWF4
  • Contains 1 HNH domain.:
    • Q5FWF4
Family:
  • Belongs to the SNF2/RAD54 helicase family.:
    • Q5FWF4
Similarity:
  • Contains 1 RanBP2-type zinc finger.:
    • Q5FWF4
genes like me logo Genes that share domains with ZRANB3: view

Function for ZRANB3 Gene

Molecular function for ZRANB3 Gene

UniProtKB/Swiss-Prot Function: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Enzyme Numbers (IUBMB) for ZRANB3 Gene

Gene Ontology (GO) - Molecular Function for ZRANB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003678 NOT DNA helicase activity IDA 21078962
GO:0004519 endonuclease activity --
GO:0004520 endodeoxyribonuclease activity IDA 22759634
genes like me logo Genes that share ontologies with ZRANB3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZRANB3 Gene

Localization for ZRANB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRANB3 Gene

Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZRANB3 Gene COMPARTMENTS Subcellular localization image for ZRANB3 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
golgi apparatus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZRANB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043596 nuclear replication fork IDA 22704558
genes like me logo Genes that share ontologies with ZRANB3: view

Pathways for ZRANB3 Gene

SuperPathways for ZRANB3 Gene

No Data Available

Interacting Proteins for ZRANB3 Gene

Gene Ontology (GO) - Biological Process for ZRANB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000733 DNA strand renaturation IDA 21078962
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006281 DNA repair IDA 22759634
GO:0006974 cellular response to DNA damage stimulus IDA 22704558
GO:0009411 response to UV IDA 22704558
genes like me logo Genes that share ontologies with ZRANB3: view

No data available for Pathways by source for ZRANB3 Gene

Transcripts for ZRANB3 Gene

Unigene Clusters for ZRANB3 Gene

Zinc finger, RAN-binding domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB3 Gene

No ASD Table

Relevant External Links for ZRANB3 Gene

GeneLoc Exon Structure for
ZRANB3
ECgene alternative splicing isoforms for
ZRANB3

Expression for ZRANB3 Gene

mRNA expression in normal human tissues for ZRANB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZRANB3 Gene

SOURCE GeneReport for Unigene cluster for ZRANB3 Gene Hs.658422

genes like me logo Genes that share expressions with ZRANB3: view

Orthologs for ZRANB3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZRANB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZRANB3 36
  • 99.44 (n)
  • 99.26 (a)
ZRANB3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZRANB3 36
  • 88.45 (n)
  • 85.58 (a)
ZRANB3 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZRANB3 36
  • 88.43 (n)
  • 84.24 (a)
ZRANB3 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zranb3 36
  • 81.26 (n)
  • 78.26 (a)
Zranb3 16
Zranb3 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZRANB3 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZRANB3 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zranb3 36
  • 79.38 (n)
  • 77.42 (a)
chicken
(Gallus gallus)
Aves ZRANB3 36
  • 69.02 (n)
  • 67.34 (a)
ZRANB3 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZRANB3 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7449 36
zranb3 36
  • 63.87 (n)
  • 63.96 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01044943.1 37
  • 47 (a)
OneToMany
LOC100331496 36
  • 57.73 (n)
  • 56.11 (a)
zranb3 37
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea btf-1 37
  • 7 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOT1 37
  • 7 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G07810 36
  • 45.92 (n)
  • 37.22 (a)
rice
(Oryza sativa)
Liliopsida Os07g0598300 36
  • 47.74 (n)
  • 38.96 (a)
Species with no ortholog for ZRANB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZRANB3 Gene

ENSEMBL:
Gene Tree for ZRANB3 (if available)
TreeFam:
Gene Tree for ZRANB3 (if available)

Paralogs for ZRANB3 Gene

Paralogs for ZRANB3 Gene

Selected SIMAP similar genes for ZRANB3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZRANB3: view

Variants for ZRANB3 Gene

Sequence variations from dbSNP and Humsavar for ZRANB3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs737388 -- 135,315,641(+) TTTCA(C/T)TGATA intron-variant
rs935613 -- 135,265,228(+) CTTTA(C/T)TATTT intron-variant
rs935615 - 135,230,846(-) GTGAC(A/G)AATCA missense, reference
rs1115194 -- 135,212,295(-) TTGAA(A/G)AAATT intron-variant
rs1370533 -- 135,492,715(-) CTTCA(A/G)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZRANB3 Gene

Variant ID Type Subtype PubMed ID
nsv834386 CNV Gain 17160897
nsv875146 CNV Loss 21882294
nsv875147 CNV Loss 21882294
esv34026 CNV Loss 18971310
nsv2940 CNV Loss 18451855
esv2467285 CNV Deletion 19546169
esv2058333 CNV Deletion 18987734
esv2668909 CNV Deletion 23128226
nsv498936 CNV Loss 21111241
esv2421388 CNV Deletion 20811451
esv29203 CNV Loss 19812545
nsv514095 CNV Loss 21397061
esv2661092 CNV Deletion 23128226
nsv2941 CNV Insertion 18451855
esv268290 CNV Insertion 20981092
nsv441786 CNV CNV 18776908
esv2720861 CNV Deletion 23290073
esv2410901 CNV Deletion 18987734
esv2664308 CNV Deletion 23128226
esv2720863 CNV Deletion 23290073

Relevant External Links for ZRANB3 Gene

HapMap Linkage Disequilibrium report
ZRANB3

Disorders for ZRANB3 Gene

(1) MalaCards Diseases for ZRANB3 Gene

Search for ZRANB3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZRANB3 Gene

Relevant External Links for ZRANB3

Genetic Association Database (GAD)
ZRANB3
Human Genome Epidemiology (HuGE) Navigator
ZRANB3
genes like me logo Genes that share disorders with ZRANB3: view

No data available for UniProtKB/Swiss-Prot for ZRANB3 Gene

Publications for ZRANB3 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. (PMID: 21078962) Yusufzai T. … Kadonaga J.T. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for ZRANB3 Gene

Sources for ZRANB3 Gene

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