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Aliases for ZRANB2 Gene

Aliases for ZRANB2 Gene

  • Zinc Finger, RAN-Binding Domain Containing 2 2 3
  • Zinc Finger Protein 265 2 3 4
  • ZNF265 3 4 6
  • ZIS 3 4 6
  • Zinc Finger, Splicing 3 4
  • Zinc Finger Ran-Binding Domain-Containing Protein 2 3
  • Zinc-Finger Protein 265 3
  • Zinc-Finger, Splicing 3
  • ZIS1 3
  • ZIS2 3

External Ids for ZRANB2 Gene

Previous HGNC Symbols for ZRANB2 Gene

  • ZNF265

Previous GeneCards Identifiers for ZRANB2 Gene

  • GC01M071301
  • GC01M071528
  • GC01M069639

Summaries for ZRANB2 Gene

GeneCards Summary for ZRANB2 Gene

ZRANB2 (Zinc Finger, RAN-Binding Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA binding.

UniProtKB/Swiss-Prot for ZRANB2 Gene

  • Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5-splice site selection.

Gene Wiki entry for ZRANB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZRANB2 Gene

Genomics for ZRANB2 Gene

Regulatory Elements for ZRANB2 Gene

Genomic Location for ZRANB2 Gene

Start:
71,063,291 bp from pter
End:
71,081,297 bp from pter
Size:
18,007 bases
Orientation:
Minus strand

Genomic View for ZRANB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZRANB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZRANB2 Gene

Proteins for ZRANB2 Gene

  • Protein details for ZRANB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95218-ZRAB2_HUMAN
    Recommended name:
    Zinc finger Ran-binding domain-containing protein 2
    Protein Accession:
    O95218
    Secondary Accessions:
    • D3DQ75
    • Q53GS3
    • Q59F92
    • Q5VV33
    • Q5VV34
    • Q8IXN6
    • Q9UP63

    Protein attributes for ZRANB2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37404 Da
    Quaternary structure:
    • Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
    SequenceCaution:
    • Sequence=AAD09746.1; Type=Frameshift; Positions=236; Evidence={ECO:0000305}; Sequence=AAD09747.1; Type=Frameshift; Positions=236; Evidence={ECO:0000305}; Sequence=BAD92805.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB66879.1; Type=Frameshift; Positions=236; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZRANB2 Gene

    Alternative splice isoforms for ZRANB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZRANB2 Gene

Proteomics data for ZRANB2 Gene at MOPED

Post-translational modifications for ZRANB2 Gene

  • Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR
  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

Other Protein References for ZRANB2 Gene

Antibody Products

No data available for DME Specific Peptides for ZRANB2 Gene

Domains for ZRANB2 Gene

Gene Families for ZRANB2 Gene

HGNC:
  • ZRANB :Zinc fingers, RAN-binding domain containing

Protein Domains for ZRANB2 Gene

Suggested Antigen Peptide Sequences for ZRANB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95218

UniProtKB/Swiss-Prot:

ZRAB2_HUMAN :
  • O95218
Domain:
  • The RanBP2-type zinc fingers mediate binding to RNA
Family:
  • Belongs to the ZRANB2 family.
Similarity:
  • Contains 2 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with ZRANB2: view

Function for ZRANB2 Gene

Molecular function for ZRANB2 Gene

UniProtKB/Swiss-Prot Function:
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5-splice site selection.

Gene Ontology (GO) - Molecular Function for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9931435
GO:0003723 RNA binding TAS 9931435
GO:0005515 protein binding IPI 16982639
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZRANB2: view

Phenotypes for ZRANB2 Gene

genes like me logo Genes that share phenotypes with ZRANB2: view

Animal Model Products

miRNA for ZRANB2 Gene

miRTarBase miRNAs that target ZRANB2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZRANB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZRANB2 Gene

Localization for ZRANB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRANB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZRANB2 Gene COMPARTMENTS Subcellular localization image for ZRANB2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9931435
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZRANB2: view

Pathways for ZRANB2 Gene

SuperPathways for ZRANB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9931435
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with ZRANB2: view

No data available for Pathways by source for ZRANB2 Gene

Compounds for ZRANB2 Gene

(1) HMDB Compounds for ZRANB2 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with ZRANB2: view

Transcripts for ZRANB2 Gene

Unigene Clusters for ZRANB2 Gene

Zinc finger, RAN-binding domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZRANB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - -
SP7: - - - - - - - - - - -
SP8:

Relevant External Links for ZRANB2 Gene

GeneLoc Exon Structure for
ZRANB2
ECgene alternative splicing isoforms for
ZRANB2

Expression for ZRANB2 Gene

mRNA expression in normal human tissues for ZRANB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZRANB2 Gene

This gene is overexpressed in Adrenal (45.1) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZRANB2 Gene

SOURCE GeneReport for Unigene cluster for ZRANB2 Gene Hs.194718

genes like me logo Genes that share expressions with ZRANB2: view

Expression partners for ZRANB2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZRANB2 Gene

Orthologs for ZRANB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZRANB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZRANB2 35
  • 96.44 (n)
  • 99.68 (a)
ZRANB2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZRANB2 35
  • 95.28 (n)
  • 97.8 (a)
ZRANB2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZRANB2 35
  • 99.8 (n)
  • 100 (a)
ZRANB2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zranb2 16
Zranb2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZRANB2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZRANB2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZRANB2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZRANB2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zranb2 35
  • 69.73 (n)
  • 75.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.520 35
zebrafish
(Danio rerio)
Actinopterygii wufa96h03 35
zranb2 35
  • 75.14 (n)
  • 81.62 (a)
zranb2 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3732 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y25C1A.8 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for ZRANB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZRANB2 Gene

ENSEMBL:
Gene Tree for ZRANB2 (if available)
TreeFam:
Gene Tree for ZRANB2 (if available)

Paralogs for ZRANB2 Gene

No data available for Paralogs for ZRANB2 Gene

Variants for ZRANB2 Gene

Sequence variations from dbSNP and Humsavar for ZRANB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1138177 -- 71,069,925(-) TTAAA(A/G)TTTGT intron-variant
rs4650100 -- 71,078,194(+) ACCCC(A/C)CGATT intron-variant
rs5775049 -- 71,073,834(+) TGGTA(-/AGGTA)TGTTC intron-variant
rs7552415 -- 71,074,076(+) TCCAC(A/C)AACAG intron-variant
rs9425055 -- 71,075,320(+) ACATC(C/T)AGATT intron-variant

Relevant External Links for ZRANB2 Gene

HapMap Linkage Disequilibrium report
ZRANB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZRANB2 Gene

Disorders for ZRANB2 Gene

No disorders were found for ZRANB2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZRANB2 Gene

Publications for ZRANB2 Gene

  1. Identification, characterization and mapping of the human ZIS (zinc- finger, splicing) gene. (PMID: 9931435) Nakano M. … Niikawa N. (Gene 1998) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. ZNF265 -- a novel spliceosomal protein able to induce alternative splicing. (PMID: 11448987) Adams D.J. … Rasko J.E.J. (J. Cell Biol. 2001) 3 4
  4. Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. (PMID: 10773668) Adams D.J. … Morris B.J. (Cytogenet. Cell Genet. 2000) 3 23
  5. The structure of the zinc finger domain from human splicing factor ZNF265 fold. (PMID: 12657633) Plambeck C.A. … Mackay J.P. (J. Biol. Chem. 2003) 3 4

Products for ZRANB2 Gene

Sources for ZRANB2 Gene

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