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Aliases for ZRANB2 Gene

Aliases for ZRANB2 Gene

  • Zinc Finger RANBP2-Type Containing 2 2 3
  • Zinc Finger, RAN-Binding Domain Containing 2 2 3 5
  • Zinc Finger Protein 265 2 3 4
  • Zinc Finger, Splicing 3 4
  • ZNF265 3 4
  • ZIS 3 4
  • Zinc-Finger Protein 265 3
  • Zinc-Finger, Splicing 3
  • ZIS1 3
  • ZIS2 3

External Ids for ZRANB2 Gene

Previous HGNC Symbols for ZRANB2 Gene

  • ZNF265

Previous GeneCards Identifiers for ZRANB2 Gene

  • GC01M071301
  • GC01M071528
  • GC01M069639

Summaries for ZRANB2 Gene

GeneCards Summary for ZRANB2 Gene

ZRANB2 (Zinc Finger RANBP2-Type Containing 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for ZRANB2 Gene

  • Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5-splice site selection.

Gene Wiki entry for ZRANB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZRANB2 Gene

Genomics for ZRANB2 Gene

Regulatory Elements for ZRANB2 Gene

Promoters for ZRANB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZRANB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZRANB2 Gene

71,063,291 bp from pter
71,081,297 bp from pter
18,007 bases
Minus strand

Genomic View for ZRANB2 Gene

Genes around ZRANB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZRANB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZRANB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZRANB2 Gene

Proteins for ZRANB2 Gene

  • Protein details for ZRANB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger Ran-binding domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DQ75
    • Q53GS3
    • Q59F92
    • Q5VV33
    • Q5VV34
    • Q8IXN6
    • Q9UP63

    Protein attributes for ZRANB2 Gene

    330 amino acids
    Molecular mass:
    37404 Da
    Quaternary structure:
    • Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
    • Sequence=AAD09746.1; Type=Frameshift; Positions=236; Evidence={ECO:0000305}; Sequence=AAD09747.1; Type=Frameshift; Positions=236; Evidence={ECO:0000305}; Sequence=BAD92805.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB66879.1; Type=Frameshift; Positions=236; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZRANB2 Gene

    Alternative splice isoforms for ZRANB2 Gene


neXtProt entry for ZRANB2 Gene

Proteomics data for ZRANB2 Gene at MOPED

Post-translational modifications for ZRANB2 Gene

  • Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.
  • Ubiquitination at Lys 72
  • Modification sites at PhosphoSitePlus

Other Protein References for ZRANB2 Gene

Antibody Products

No data available for DME Specific Peptides for ZRANB2 Gene

Domains & Families for ZRANB2 Gene

Gene Families for ZRANB2 Gene

Protein Domains for ZRANB2 Gene

Suggested Antigen Peptide Sequences for ZRANB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RanBP2-type zinc fingers mediate binding to RNA.
  • Belongs to the ZRANB2 family.
  • Contains 2 RanBP2-type zinc fingers.
  • The RanBP2-type zinc fingers mediate binding to RNA.
  • Belongs to the ZRANB2 family.
  • Contains 2 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with ZRANB2: view

Function for ZRANB2 Gene

Molecular function for ZRANB2 Gene

UniProtKB/Swiss-Prot Function:
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5-splice site selection.

Gene Ontology (GO) - Molecular Function for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16982639
genes like me logo Genes that share ontologies with ZRANB2: view
genes like me logo Genes that share phenotypes with ZRANB2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZRANB2 Gene

Localization for ZRANB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRANB2 Gene

Subcellular locations from

Jensen Localization Image for ZRANB2 Gene COMPARTMENTS Subcellular localization image for ZRANB2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZRANB2 Gene

Pathways & Interactions for ZRANB2 Gene

SuperPathways for ZRANB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZRANB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZRANB2 Gene

Drugs & Compounds for ZRANB2 Gene

(1) Drugs for ZRANB2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
genes like me logo Genes that share compounds with ZRANB2: view

Transcripts for ZRANB2 Gene

Unigene Clusters for ZRANB2 Gene

Zinc finger, RAN-binding domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3: -
SP6: - -
SP7: - - - - - - - - - - -

Relevant External Links for ZRANB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZRANB2 Gene

mRNA expression in normal human tissues for ZRANB2 Gene

Protein differential expression in normal tissues from HIPED for ZRANB2 Gene

This gene is overexpressed in Adrenal (45.1) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZRANB2 Gene

SOURCE GeneReport for Unigene cluster for ZRANB2 Gene Hs.194718

genes like me logo Genes that share expression patterns with ZRANB2: view

Protein tissue co-expression partners for ZRANB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZRANB2 Gene

Orthologs for ZRANB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZRANB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZRANB2 35
  • 96.44 (n)
  • 99.68 (a)
  • 96 (a)
(Canis familiaris)
Mammalia ZRANB2 35
  • 95.28 (n)
  • 97.8 (a)
  • 95 (a)
(Pan troglodytes)
Mammalia ZRANB2 35
  • 99.8 (n)
  • 100 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia ZRANB2 36
  • 97 (a)
(Mus musculus)
Mammalia Zranb2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia ZRANB2 36
  • 96 (a)
(Gallus gallus)
Aves ZRANB2 36
  • 94 (a)
(Anolis carolinensis)
Reptilia ZRANB2 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zranb2 35
  • 69.73 (n)
  • 75.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.520 35
(Danio rerio)
Actinopterygii wufa96h03 35
zranb2 35
  • 75.14 (n)
  • 81.62 (a)
zranb2 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3732 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea Y25C1A.8 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for ZRANB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZRANB2 Gene

Gene Tree for ZRANB2 (if available)
Gene Tree for ZRANB2 (if available)

Paralogs for ZRANB2 Gene

No data available for Paralogs for ZRANB2 Gene

Variants for ZRANB2 Gene

Sequence variations from dbSNP and Humsavar for ZRANB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11583800 - 71,070,891(+) AGATC(C/G)AGACT nc-transcript-variant, reference, missense
rs1138177 -- 71,069,925(-) TTAAA(A/G)TTTGT intron-variant
rs4650100 -- 71,078,194(+) ACCCC(A/C)CGATT intron-variant
rs5775049 -- 71,073,834(+) TGGTA(-/AGGTA)TGTTC intron-variant
rs7552415 -- 71,074,076(+) TCCAC(A/C)AACAG intron-variant

Variation tolerance for ZRANB2 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZRANB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZRANB2 Gene

Disorders for ZRANB2 Gene

Relevant External Links for ZRANB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZRANB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZRANB2 Gene

Publications for ZRANB2 Gene

  1. Identification, characterization and mapping of the human ZIS (zinc- finger, splicing) gene. (PMID: 9931435) Nakano M. … Niikawa N. (Gene 1998) 2 3 4 67
  2. Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. (PMID: 10773668) Adams D.J. … Morris B.J. (Cytogenet. Cell Genet. 2000) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PMID: 23184937) Xie Y. … Cong F. (J. Biol. Chem. 2013) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for ZRANB2 Gene

Sources for ZRANB2 Gene

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