Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZRANB2 Gene

protein-coding   GIFtS: 51
GCID: GC01M071528

Zinc Finger, RAN-Binding Domain Containing 2

(Previous name: zinc finger protein 265)
(Previous symbol: ZNF265)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger, RAN-Binding Domain Containing 21 2     ZIS12
ZNF2651 2 3 5     ZIS22
Zinc Finger Protein 2651 2 3     Zinc Finger Ran-Binding Domain-Containing Protein 22
ZIS2 3 5     Zinc-Finger Protein 2652
Zinc Finger, Splicing2 3     Zinc-Finger, Splicing2

External Ids:    HGNC: 130581   Entrez Gene: 94062   Ensembl: ENSG000001324857   OMIM: 6043475   UniProtKB: O952183   

Export aliases for ZRANB2 gene to outside databases

Previous GC identifers: GC01M071301 GC01M069639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ZRANB2 Gene:
ZRANB2 (zinc finger, RAN-binding domain containing 2) is a protein-coding gene. GO annotations related to this gene include RNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZRAB2_HUMAN, O95218
Function: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with
constitutive 5'-splice site selection

Gene Wiki entry for ZRANB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZRANB2 gene promoter:
         Sox5   RFX1   AML1a   AP-4   Tal-1beta   Evi-1   C/EBPalpha   YY1   IRF-7A   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZRANB2 promoter sequence
   Search Chromatin IP Primers for ZRANB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZRANB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31

ZRANB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZRANB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M071528:  view genomic region     (about GC identifiers)

Start:
71,528,974 bp from pter      End:
71,546,980 bp from pter
Size:
18,007 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZRAB2_HUMAN, O95218 (See protein sequence)
Recommended Name: Zinc finger Ran-binding domain-containing protein 2  
Size: 330 amino acids; 37404 Da
Subunit: Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1
and CLK1
Sequence caution: Sequence=AAD09746.1; Type=Frameshift; Positions=236; Sequence=AAD09747.1; Type=Frameshift;
Positions=236; Sequence=BAD92805.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAB66879.1;
Type=Frameshift; Positions=236;
3 PDB 3D structures from and Proteopedia for ZRANB2:
1N0Z (3D)        2K1P (3D)        3G9Y (3D)    
Secondary accessions: D3DQ75 Q53GS3 Q59F92 Q5VV33 Q5VV34 Q8IXN6 Q9UP63
Alternative splicing: 2 isoforms:  O95218-1   O95218-2   (Contains a phosphoserine at position 305. Contains a phosphoserine at position 307. Contains a phosphoserine at position 310. Contains a phosphothreonine at position 303)

Explore the universe of human proteins at neXtProt for ZRANB2: NX_O95218

Explore proteomics data for ZRANB2 at MOPED

Post-translational modifications: 

  • Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR1
  • Ubiquitination2 at Lys72
  • Modification sites at PhosphoSitePlus

  • See ZRANB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005446.2  NP_976225.1  

    ENSEMBL proteins: 
     ENSP00000359958   ENSP00000254821  

    ZRANB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZRANB2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZRANB2
    GenScript Custom Purified and Recombinant Proteins Services for ZRANB2
    Novus Biologicals ZRANB2 Proteins
    Novus Biologicals ZRANB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZRANB2

     
    Search eBioscience for Proteins for ZRANB2 

     
    antibodies-online proteins for ZRANB2 (8 products) 

     
    antibodies-online peptides for ZRANB2

    ZRANB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZRANB2
    OriGene Custom Antibody Services for ZRANB2
    Novus Biologicals ZRANB2 Antibodies
    Abcam antibodies for ZRANB2
    Cloud-Clone Corp. Antibodies for ZRANB2
    Search ThermoFisher Antibodies for ZRANB2
    antibodies-online antibodies for ZRANB2 (47 products) 

    ZRANB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZRANB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZRANB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZRANB2
    Cloud-Clone Corp. CLIAs for ZRANB2
    Search eBioscience for ELISAs for ZRANB2 
    antibodies-online kits for ZRANB2 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZRANB: Zinc fingers, RAN-binding domain containing

    2 InterPro protein domains:
     IPR017337 UCP037956_Znf_RanB2
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry O95218

    ProtoNet protein and cluster: O95218

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: ZRAB2_HUMAN, O95218
    Domain: The RanBP2-type zinc fingers mediate binding to RNA
    Similarity: Belongs to the ZRANB2 family
    Similarity: Contains 2 RanBP2-type zinc fingers


    Find genes that share domains with ZRANB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZRAB2_HUMAN, O95218
    Function: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with
    constitutive 5'-splice site selection

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9931435
    GO:0003723RNA binding TAS9931435
    GO:0005515protein binding IPI16982639
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ZRANB2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZRANB2:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zranb2):
     cardiovascular system  mortality/aging  vision/eye 

    Find genes that share phenotypes with ZRANB2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZRANB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZRANB2:
    hsa-mir-877-3p (MIRT036824), hsa-mir-16-5p (MIRT032034)

    Block miRNA regulation of human, mouse, rat ZRANB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZRANB2 (see all 39):
    hsa-miR-21* hsa-miR-328 hsa-miR-139-5p hsa-miR-632 hsa-miR-578 hsa-miR-3923 hsa-miR-4275 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidZRANB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZRANB2
    Predesigned siRNA for gene silencing in human, mouse, rat ZRANB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZRANB2

    Clone
    Products:
         
    OriGene clones in human, mouse for ZRANB2 (see all 13)
    OriGene ORF clones in mouse, rat for ZRANB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZRANB2 (NM_005455)
    Sino Biological Human cDNA Clone for ZRANB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZRANB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZRANB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZRANB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZRANB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRANB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZRAB2_HUMAN, O95218: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with ZRANB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZRANB2
    Interactions:

        GeneGlobe Interaction Network for ZRANB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for ZRANB2 (O952181, 3 ENSP000003599584) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494071, 3, ENSP000003771414EBI-1051583,EBI-743313 I2D: score=2 STRING: ENSP00000377141
    ARRB2P321211, 3EBI-1051583,EBI-714559 I2D: score=1 
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    AKAP17AQ020401, 3, ENSP000003248274EBI-1051583,EBI-1042725 I2D: score=2 STRING: ENSP00000324827
    SNRNP70P086213, ENSP000002214484I2D: score=2 STRING: ENSP00000221448
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS9931435
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with ZRANB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZRANB2 (ZRAB2)

    1 HMDB Compound for ZRANB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZRANB2 gene (2 alternative transcripts): 
    NM_005455.4  NM_203350.2  

    Unigene Cluster for ZRANB2:

    Zinc finger, RAN-binding domain containing 2
    Hs.194718  [show with all ESTs]
    Unigene Representative Sequence: CR749325
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370920(uc001dfs.3 uc001dft.3) ENST00000477096 ENST00000254821
    ENST00000487510 ENST00000479947 ENST00000473260
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZRANB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZRANB2 (see all 39):
    hsa-miR-21* hsa-miR-328 hsa-miR-139-5p hsa-miR-632 hsa-miR-578 hsa-miR-3923 hsa-miR-4275 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidZRANB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZRANB2
    Predesigned siRNA for gene silencing in human, mouse, rat ZRANB2
    Clone
    Products:
         
    OriGene clones in human, mouse for ZRANB2 (see all 13)
    OriGene ORF clones in mouse, rat for ZRANB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZRANB2 (NM_005455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZRANB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZRANB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZRANB2
    OriGene qSTAR qPCR primer pairs in human, mouse for ZRANB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZRANB2
      QuantiTect SYBR Green Assays in human, mouse, rat ZRANB2
      QuantiFast Probe-based Assays in human, mouse, rat ZRANB2

    Additional mRNA sequence: 

    AB209568.1 AF065391.1 AF065392.1 AK023252.1 AK055983.1 AK123114.1 AK222858.1 AL136945.1 
    BC010962.1 BC033648.1 BC039814.1 BX538141.1 CR749325.1 CR749665.1 

    24 DOTS entries:

    DT.100769875  DT.100882663  DT.101977548  DT.86841210  DT.101983576  DT.116786  DT.101959624  DT.92448821 
    DT.92448803  DT.95362850  DT.100882666  DT.95312166  DT.116784  DT.121367260  DT.100861393  DT.100882661 
    DT.121367289  DT.121367306  DT.121367379  DT.307119  DT.91886733  DT.92448817  DT.95248205  DT.116780 

    Selected AceView cDNA sequences (see all 486):

    AA604727 AI445964 AA281302 AA448200 AA653194 AL138008 AL134444 AW196063 
    BF439568 BM788740 CD251496 AW440614 AA732727 BX538141 CB117804 AI587415 
    AA333403 BM465883 BU956528 BQ185440 AI374803 BC039814 CA844284 AA318310 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
    SP1:                                                                          -     -           -                     
    SP2:                                      -                                                                           
    SP3:                                      -                                                                           
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ZRANB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZRANB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACCATTGG
    ZRANB2 Expression
    About this image


    ZRANB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZRANB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZRANB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194718
        Custom PCR Arrays for ZRANB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZRANB2
    OriGene qSTAR qPCR primer pairs in human, mouse for ZRANB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZRANB2
    QuantiTect SYBR Green Assays in human, mouse, rat ZRANB2
    QuantiFast Probe-based Assays in human, mouse, rat ZRANB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRANB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ZRANB2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zranb25 zinc finger, RAN-binding domain containing 2   --   3 (81.29 cM) 157534160 
    chicken
    (Gallus gallus)
    Aves ZRANB26
    Gallus gallus zinc finger, RAN-binding domain cont...
    94(a)
    1 ↔ 1
    8(28011855-28023641)
    lizard
    (Anolis carolinensis)
    Reptilia ZRANB26
    zinc finger, RAN-binding domain containing 2
    93(a)
    1 ↔ 1
    GL343194.1(108932-129290)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5202 X.laevis mRNA for C4SR protein 82.67(n)    X96469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa96h032 Danio rerio cDNA clone MGC56597 IMAGE5915268, complete more 77.35(n)    BC052752.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37326
    --
    45(a)
    1 ↔ 1
    2R(18526310-18527668)
    worm
    (Caenorhabditis elegans)
    Secernentea Y25C1A.86
    Protein Y25C1A.8, isoform a (Y25C1A.8) mRNA, compl...
    39(a)
    1 ↔ 1
    II(3071165-3076946) WBGene00021295


    ENSEMBL Gene Tree for ZRANB2 (if available)
    TreeFam Gene Tree for ZRANB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZRANB2 (see all 204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821479391,2
    --71535474(+) TGGCAC/TGTGTG 2 -- int10--------
    rs1873803781,2
    --71535513(+) TCAATA/GCTTAG 2 -- int10--------
    rs1898855421,2
    --71535538(+) AATGTA/TTAATT 2 -- int10--------
    rs1807526831,2
    --71535596(+) GACATC/GGTTCG 2 -- int10--------
    rs11381771,2
    C,F,A--71535608(-) TTAAAA/GTTTGT 2 -- int18Minor allele frequency- G:0.35MN NA WA EA 686
    rs1849584521,2
    --71535662(+) CCTTAC/TAATAA 2 -- int10--------
    rs726710861,2
    C--71535717(+) AGTTAC/TAGCCC 2 -- int10--------
    rs1830932181,2
    --71535867(+) AAGAGA/GACACT 2 -- int10--------
    rs1883858891,2
    C--71535949(+) CATATA/TTTACA 2 -- int10--------
    rs1490463781,2
    --71535952(+) ATTTTA/GCATCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZRANB2 (71528974 - 71546980 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZRANB2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZRANB2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZRANB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604347    OMIM disorders: --


    Find genes that share disorders with ZRANB2           About GenesLikeMe


    Export disorders for ZRANB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZRANB2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with ZRANB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization and mapping of the human ZIS (zinc- finger, splicing) gene. (PubMed id 9931435)1, 2, 3 Nakano M.... Niikawa N. (Gene 1998)
    2. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. (PubMed id 16982639)1, 2 Mangs A.H....Morris B.J. (Nucleic Acids Res. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The structure of the zinc finger domain from human splicing factor ZNF265 fold. (PubMed id 12657633)1, 2 Plambeck C.A.... Mackay J.P. (J. Biol. Chem. 2003)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. ZNF265 -- a novel spliceosomal protein able to induce alternative splicing. (PubMed id 11448987)1, 2 Adams D.J....Rasko J.E.J. (J. Cell Biol. 2001)
    8. Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. (PubMed id 10773668)1, 9 Adams D.J....Morris B.J. (Cytogenet. Cell Genet. 2000)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9406 HGNC: 13058 AceView: ZNF265 Ensembl:ENSG00000132485 euGenes: HUgn9406
    ECgene: ZRANB2 H-InvDB: ZRANB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZRANB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZRANB2 gene:
    Search GeneIP for patents involving ZRANB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZRANB2   OriGene RNAi products in human, mouse, rat for ZRANB2  
     OriGene qPCR primer pairs and template standards for ZRANB2   OriGene Protein Over-expression Lysate for ZRANB2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZRANB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZRANB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZRANB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZRANB2   OriGene Custom Protein Services for ZRANB2  

     
     
     Block miRNA regulation of human, mouse, rat ZRANB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZRANB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZRANB2 Predesigned siRNA for gene silencing in human, mouse, rat ZRANB2
     QuantiFast Probe-based Assays in human, mouse, rat ZRANB2 QuantiTect SYBR Green Assays in human, mouse, rat ZRANB2
     Custom PCR Arrays for ZRANB2 Search Chromatin IP Primers for ZRANB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZRANB2  GeneGlobe Interaction Network for ZRANB2
     Regulatory tfbs in ZRANB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZRANB2 GenScript cDNA clones with any tag delivered in your preferred vector for ZRANB2
     GenScript Custom Assay Services for ZRANB2 GenScript Custom overexpressing Cell Line Services for ZRANB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZRANB2 (ZRAB2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ZRANB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZRANB2 antibodies
     ZRANB2 proteins
     ZRANB2 lysates
     Antibodies for ZRANB2
     See all of Abcam's Antibodies, Kits and Proteins for ZRANB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZRANB2
     Antibodies for ZRANB2
     ELISAs for ZRANB2
     CLIAs for ZRANB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZRANB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRANB2
     SwitchGear 3'UTR luciferase reporter plasmids for ZRANB2
     SwitchGear Promoter luciferase reporter plasmids for ZRANB2
     Search ThermoFisher Antibodies for ZRANB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZRANB2
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZRANB2
      Search eBioscience for proteins for ZRANB2
      Search eBioscience for elisas for ZRANB2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ZRANB2
     antibodies-online antibodies for ZRANB2 (47 products)
     antibodies-online kits for ZRANB2 (10 products)
     antibodies-online peptides for ZRANB2
     antibodies-online proteins for ZRANB2 (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZRANB2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4