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ZRANB1 Gene

protein-coding   GIFtS: 50
GCID: GC10P126620

Zinc Finger, RAN-Binding Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, RAN-Binding Domain Containing 11 2     TRAF-Binding Protein Domain2
TRABID2 3 5     Ubiquitin Thioesterase ZRANB12
Zinc Finger Ran-Binding Domain-Containing Protein 12 3     EC 3.4.19.123
hTrabid2 3     EC 3.1.28
TRAF-Binding Domain-Containing Protein2 3     

External Ids:    HGNC: 182241   Entrez Gene: 547642   Ensembl: ENSG000000199957   OMIM: 6117495   UniProtKB: Q9UGI03   

Export aliases for ZRANB1 gene to outside databases

Previous GC identifers: GC10P126671 GC10P126205 GC10P120317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZRANB1 Gene:
ZRANB1 (zinc finger, RAN-binding domain containing 1) is a protein-coding gene. GO annotations related to this gene include K63-linked polyubiquitin binding and ubiquitin thiolesterase activity. An important paralog of this gene is TNFAIP3.

UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0
Function: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked
chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt
signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a
role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics
and cell migration. May also modulate TNF-alpha signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZRANB1 gene promoter:
         AREB6   S8   Lmo2   AP-4   CUTL1   MRF-2   E4BP4   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZRANB1 promoter sequence
   Search Chromatin IP Primers for ZRANB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZRANB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.12

ZRANB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZRANB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P126620:  view genomic region     (about GC identifiers)

Start:
126,630,692 bp from pter      End:
126,676,758 bp from pter
Size:
46,067 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0 (See protein sequence)
Recommended Name: Ubiquitin thioesterase ZRANB1  
Size: 708 amino acids; 80967 Da
Subunit: Interacts with APC and TRAF6
Sequence caution: Sequence=BAG64010.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZRANB1:
3ZRH (3D)    
Secondary accessions: B4DZ98 D3DRF4 Q5SQP6 Q69YK3

Explore the universe of human proteins at neXtProt for ZRANB1: NX_Q9UGI0

Explore proteomics data for ZRANB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ZRANB1 (Q9UGI0) (see all 15)
     DCSHWFY  CTYLNWPR  DWLFLNAC  DFKKLKQI 


    See ZRANB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060050.2  
    ENSEMBL proteins: 
     ENSP00000352676  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OTUD: OTU domain containing
    ZRANB: Zinc fingers, RAN-binding domain containing

    2 InterPro protein domains:
     IPR003323 OTU
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q9UGI0

    ProtoNet protein and cluster: Q9UGI0

    2 Blocks protein domains:
    IPB001876 Zn-finger
    IPB003323 OTU-like cysteine protease


    UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0
    Domain: The OTU domain mediates the deubiquitinating activity
    Domain: The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin
    Domain: The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and
    contributes to linkage specificity
    Domain: The RanBP2-type zinc fingers, also called NZFs, may provide additional ubiquitin-binding sites when
    hydrolyzing long 'Lys-63'-linked chains
    Similarity: Belongs to the peptidase C64 family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 OTU domain
    Similarity: Contains 3 RanBP2-type zinc fingers


    Find genes that share domains with ZRANB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZRAN1_HUMAN, Q9UGI0
    Function: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked
    chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt
    signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a
    role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics
    and cell migration. May also modulate TNF-alpha signaling
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.22 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP18281465
    GO:0004843ubiquitin-specific protease activity IDA18281465
    GO:0005515protein binding IPI11463333
    GO:0008270zinc ion binding IEA--
    GO:0070530K63-linked polyubiquitin binding IDA18281465
         
    Find genes that share ontologies with ZRANB1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Zranb1 (no phenotypes)

    Find genes that share phenotypes with ZRANB1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZRANB1

    miRNA
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    miRTarBase miRNAs that target ZRANB1:
    hsa-mir-16-5p (MIRT031505), hsa-mir-103a-3p (MIRT027006), hsa-mir-21-5p (MIRT030762)

    Block miRNA regulation of human, mouse, rat ZRANB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZRANB1 (see all 79):
    hsa-miR-3130-5p hsa-miR-520f hsa-miR-361-5p hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidZRANB1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZRAN1_HUMAN, Q9UGI0: Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ZRANB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZRANB1
    Interactions:

        GeneGlobe Interaction Network for ZRANB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZRANB1 (Q9UGI01, 2, 3 ENSP000003526764) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG481, 2, 3, ENSP000003448184EBI-527853,EBI-3390054 MINT-7288925 MINT-7288900 I2D: score=2 STRING: ENSP00000344818
    CTTNBP2Q8WZ743, ENSP000001603734I2D: score=2 STRING: ENSP00000160373
    CTTNBP2NLQ9P2B43, ENSP000002712774I2D: score=2 STRING: ENSP00000271277
    FGFR1OP2Q9NVK53, ENSP000002293954I2D: score=2 STRING: ENSP00000229395
    HECTD1Q9ULT83, ENSP000003822694I2D: score=2 STRING: ENSP00000382269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IMP--
    GO:0016055Wnt signaling pathway IEA--
    GO:0016477cell migration IMP--
    GO:0022604regulation of cell morphogenesis IMP--
    GO:0030177positive regulation of Wnt signaling pathway IMP18281465

    Find genes that share ontologies with ZRANB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZRANB1 (ZRAN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZRANB1 gene: 
    NM_017580.2  

    Unigene Cluster for ZRANB1:

    Zinc finger, RAN-binding domain containing 1
    Hs.595158  [show with all ESTs]
    Unigene Representative Sequence: NM_017580
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359653(uc010qug.2 uc001lic.3) ENST00000471421
    miRNA
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    hsa-miR-3130-5p hsa-miR-520f hsa-miR-361-5p hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-4326
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    Additional mRNA sequence: 

    AJ252060.1 AK302810.1 AK307386.1 AL832925.1 

    12 DOTS entries:

    DT.455998  DT.449458  DT.100784115  DT.101975491  DT.96085296  DT.121277001  DT.91724439  DT.95269973 
    DT.91724422  DT.92061884  DT.92417554  DT.97797629 

    Selected AceView cDNA sequences (see all 227):

    CA413606 AW468776 BF002491 AA602708 Z40934 BU167699 BM716596 AI984423 
    AW276231 AA902898 BM697868 Z45207 F01421 AA689564 BQ898370 AW084989 
    BE551292 BQ215969 CB216838 AA694301 CF455633 BE670363 AW612460 BM556392 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZRANB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZRANB1 Expression
    About this image


    ZRANB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    ZRANB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZRANB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595158

    UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZRANB1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zranb11 , 5 zinc finger, RAN-binding domain containing 11, 5 93.31(n)1
    99.29(a)1
      7 (76.32 cM)5
    3602161  NM_207302.11  NP_997185.11 
     1329311425 
    chicken
    (Gallus gallus)
    Aves ZRANB11 zinc finger, RAN-binding domain containing 1 85.75(n)
    96.99(a)
      423953  XM_421816.4  XP_421816.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZRANB16
    zinc finger, RAN-binding domain containing 1
    96(a)
    1 ↔ 1
    3(62276525-62304559)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98662 Xenopus laevis transcribed sequence with moderate similarity to protein spQ9UGI0 (H.sapiens) TRAB_HUMAN TRABID protein less 78.2(n)    BU904278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145482 Transcribed sequence with moderate similarity to protein spQ9UGI0 (H.sapiens) TRAB_HUMAN TRABID protein less 74.13(n)    BI673760.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbd1 trabid 50.26(n)
    49.37(a)
      41179  NM_141674.2  NP_649931.1 


    ENSEMBL Gene Tree for ZRANB1 (if available)
    TreeFam Gene Tree for ZRANB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZRANB1 gene
    TNFAIP32  OTUD7B2  OTUD7A2  

    Find genes that share paralogs with ZRANB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZRANB1 (see all 1002)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674483141,2
    C--120324547(+) ACACA-/A/CA  
            
    TTTTT
    1 -- int11NA 2
    rs1422862501,2
    C--126628704(+) CTGTGC/TACACA 1 -- us2k10--------
    rs733731221,2
    C,F--126628716(+) CACAGG/AGTTAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs733731261,2
    C,F--126628811(+) AAATTC/GTAAAT 1 -- us2k12Minor allele frequency- G:0.12WA 120
    rs1862117061,2
    --126628954(+) CTATTC/TAGTCA 1 -- us2k10--------
    rs1463957081,2
    C--126628964(+) AGACAC/GAACCA 1 -- us2k10--------
    rs1910813131,2
    --126629029(+) AGACGC/GAATCT 1 -- us2k10--------
    rs1834440231,2
    --126629058(+) CAAACC/TGTACT 1 -- us2k10--------
    rs1397346941,2
    --126629137(+) ATTTTA/GGCTAT 1 -- us2k10--------
    rs1431593051,2
    C--126629167(+) TTTTT-/TCTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZRANB1 (126630692 - 126676758 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZRANB1: --
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611749    OMIM disorders: --


    Find genes that share disorders with ZRANB1           About GenesLikeMe

    Genetic Association Database (GAD): ZRANB1

    Export disorders for ZRANB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZRANB1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZRANB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel A20-like proteins. (PubMed id 11463333)1, 2, 3, 9 Evans P.C....Kilshaw P.J. (Biochem. J. 2001)
    2. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. (PubMed id 22157957)1, 2 Licchesi J.D....Komander D. (Nat. Struct. Mol. Biol. 2012)
    3. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. (PubMed id 18281465)1, 2 Tran H.... Bienz M. (Genes Dev. 2008)
    4. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. (PubMed id 23827681)2 Mevissen T.E.... Komander D. (Cell 2013)
    5. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. (PubMed id 23277359)1 Tran H....Polakis P. (J. Biol. Chem. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (BMC Biol. 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54764 HGNC: 18224 AceView: ZRANB1 Ensembl:ENSG00000019995 euGenes: HUgn54764
    ECgene: ZRANB1 H-InvDB: ZRANB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZRANB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZRANB1 gene:
    Search GeneIP for patents involving ZRANB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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