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Aliases for ZRANB1 Gene

Aliases for ZRANB1 Gene

  • Zinc Finger RANBP2-Type Containing 1 2 3
  • Zinc Finger, RAN-Binding Domain Containing 1 2 3 5
  • Zinc Finger Ran-Binding Domain-Containing Protein 1 3 4
  • TRAF-Binding Domain-Containing Protein 3 4
  • HTrabid 3 4
  • TRABID 3 4
  • TRAF-Binding Protein Domain 3
  • EC 3.4.19.12 4
  • EC 3.1.2 63

External Ids for ZRANB1 Gene

Previous GeneCards Identifiers for ZRANB1 Gene

  • GC10P126671
  • GC10P126205
  • GC10P126620
  • GC10P120317

Summaries for ZRANB1 Gene

GeneCards Summary for ZRANB1 Gene

ZRANB1 (Zinc Finger RANBP2-Type Containing 1) is a Protein Coding gene. Among its related pathways are Ubiquitination Cascade Pathway. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and K63-linked polyubiquitin binding. An important paralog of this gene is TNFAIP3.

UniProtKB/Swiss-Prot for ZRANB1 Gene

  • Specifically hydrolyzes Lys-29-linked and Lys-33-linked diubiquitin. Also cleaves Lys-63-linked chains, but with 40-fold less efficiency compared to Lys-29-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZRANB1 Gene

Genomics for ZRANB1 Gene

Regulatory Elements for ZRANB1 Gene

Promoters for ZRANB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZRANB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZRANB1 Gene

Chromosome:
10
Start:
124,916,899 bp from pter
End:
124,988,189 bp from pter
Size:
71,291 bases
Orientation:
Plus strand

Genomic View for ZRANB1 Gene

Genes around ZRANB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZRANB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZRANB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZRANB1 Gene

Proteins for ZRANB1 Gene

  • Protein details for ZRANB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGI0-ZRAN1_HUMAN
    Recommended name:
    Ubiquitin thioesterase ZRANB1
    Protein Accession:
    Q9UGI0
    Secondary Accessions:
    • B4DZ98
    • D3DRF4
    • Q5SQP6
    • Q69YK3

    Protein attributes for ZRANB1 Gene

    Size:
    708 amino acids
    Molecular mass:
    80967 Da
    Quaternary structure:
    • Interacts with APC and TRAF6.
    SequenceCaution:
    • Sequence=BAG64010.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZRANB1 Gene

neXtProt entry for ZRANB1 Gene

Proteomics data for ZRANB1 Gene at MOPED

Post-translational modifications for ZRANB1 Gene

  • Ubiquitination at Lys 77
  • Modification sites at PhosphoSitePlus

Other Protein References for ZRANB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ZRANB1 Gene

Gene Families for ZRANB1 Gene

Protein Domains for ZRANB1 Gene

Suggested Antigen Peptide Sequences for ZRANB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGI0

UniProtKB/Swiss-Prot:

ZRAN1_HUMAN :
  • The OTU domain mediates the deubiquitinating activity.
  • Belongs to the peptidase C64 family.
  • Contains 2 ANK repeats.
Domain:
  • The OTU domain mediates the deubiquitinating activity.
  • The RanBP2-type zinc fingers mediate the specific interaction with Lys-63-linked ubiquitin.
  • The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.
  • The RanBP2-type zinc fingers, also called NZFs, may provide additional ubiquitin-binding sites when hydrolyzing long Lys-63-linked chains.
  • Contains 1 OTU domain.
Family:
  • Belongs to the peptidase C64 family.
Similarity:
  • Contains 2 ANK repeats.
  • Contains 3 RanBP2-type zinc fingers.
genes like me logo Genes that share domains with ZRANB1: view

Function for ZRANB1 Gene

Molecular function for ZRANB1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Specifically hydrolyzes Lys-29-linked and Lys-33-linked diubiquitin. Also cleaves Lys-63-linked chains, but with 40-fold less efficiency compared to Lys-29-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.

Enzyme Numbers (IUBMB) for ZRANB1 Gene

Gene Ontology (GO) - Molecular Function for ZRANB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 18281465
GO:0005515 protein binding IPI 11463333
genes like me logo Genes that share ontologies with ZRANB1: view
genes like me logo Genes that share phenotypes with ZRANB1: view

Animal Models for ZRANB1 Gene

MGI Knock Outs for ZRANB1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZRANB1 Gene

Localization for ZRANB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRANB1 Gene

Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZRANB1 Gene COMPARTMENTS Subcellular localization image for ZRANB1 gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for ZRANB1 Gene

Pathways & Interactions for ZRANB1 Gene

SuperPathways for ZRANB1 Gene

genes like me logo Genes that share pathways with ZRANB1: view

Pathways by source for ZRANB1 Gene

1 R&D Systems pathway for ZRANB1 Gene

Gene Ontology (GO) - Biological Process for ZRANB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway IMP 18281465
GO:0035523 protein K29-linked deubiquitination IDA 23827681
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP 18281465
genes like me logo Genes that share ontologies with ZRANB1: view

No data available for SIGNOR curated interactions for ZRANB1 Gene

Drugs & Compounds for ZRANB1 Gene

No Compound Related Data Available

Transcripts for ZRANB1 Gene

Unigene Clusters for ZRANB1 Gene

Zinc finger, RAN-binding domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB1 Gene

No ASD Table

Relevant External Links for ZRANB1 Gene

GeneLoc Exon Structure for
ZRANB1
ECgene alternative splicing isoforms for
ZRANB1

Expression for ZRANB1 Gene

mRNA expression in normal human tissues for ZRANB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZRANB1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for ZRANB1 Gene

This gene is overexpressed in Serum (41.2) and Plasma (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZRANB1 Gene



SOURCE GeneReport for Unigene cluster for ZRANB1 Gene Hs.595158

mRNA Expression by UniProt/SwissProt for ZRANB1 Gene

Q9UGI0-ZRAN1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZRANB1: view

Protein tissue co-expression partners for ZRANB1 Gene

Primer Products

In Situ Assay Products

Orthologs for ZRANB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZRANB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZRANB1 36
  • 100 (a)
OneToOne
ZRANB1 35
  • 99.76 (n)
  • 99.86 (a)
cow
(Bos Taurus)
Mammalia ZRANB1 35
  • 93.31 (n)
  • 99.29 (a)
ZRANB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZRANB1 36
  • 96 (a)
OneToOne
ZRANB1 35
  • 94.28 (n)
  • 99.14 (a)
mouse
(Mus musculus)
Mammalia Zranb1 16
Zranb1 36
  • 99 (a)
OneToOne
Zranb1 35
  • 93.31 (n)
  • 99.29 (a)
oppossum
(Monodelphis domestica)
Mammalia ZRANB1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZRANB1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360606 35
  • 93.74 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves ZRANB1 35
  • 85.75 (n)
  • 96.99 (a)
ZRANB1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZRANB1 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9866 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zranb1 35
  • 77.78 (n)
  • 90.58 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14548 35
zranb1b 35
  • 69.59 (n)
  • 82.34 (a)
CABZ01057907.1 36
  • 80 (a)
OneToMany
zranb1b 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003853 35
  • 49.84 (n)
  • 48.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbd 35
  • 50.26 (n)
  • 49.37 (a)
trbd 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for ZRANB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZRANB1 Gene

ENSEMBL:
Gene Tree for ZRANB1 (if available)
TreeFam:
Gene Tree for ZRANB1 (if available)

Paralogs for ZRANB1 Gene

Paralogs for ZRANB1 Gene

genes like me logo Genes that share paralogs with ZRANB1: view

Variants for ZRANB1 Gene

Sequence variations from dbSNP and Humsavar for ZRANB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1025793 -- 124,943,335(+) TTTTG(C/T)GTGGG intron-variant
rs1025794 -- 124,943,547(+) tgtgt(A/G)tATAT intron-variant
rs1142778 -- 124,927,914(+) tgccc(A/G)tagtc intron-variant
rs1046373 -- 124,986,120(+) TAGAA(A/C)AACTT downstream-variant-500B, utr-variant-3-prime
rs1046386 -- 124,986,459(+) TACCC(A/C)CAAAA downstream-variant-500B, utr-variant-3-prime

Variation tolerance for ZRANB1 Gene

Residual Variation Intolerance Score: 6.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZRANB1 Gene

HapMap Linkage Disequilibrium report
ZRANB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZRANB1 Gene

Disorders for ZRANB1 Gene

Relevant External Links for ZRANB1

Genetic Association Database (GAD)
ZRANB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZRANB1

No disorders were found for ZRANB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZRANB1 Gene

Publications for ZRANB1 Gene

  1. Isolation and characterization of two novel A20-like proteins. (PMID: 11463333) Evans P.C. … Kilshaw P.J. (Biochem. J. 2001) 2 3 4 23 67
  2. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  3. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. (PMID: 25527291) Wauer T. … Komander D. (EMBO J. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin. (PMID: 25752573) Kristariyanto Y.A. … Kulathu Y. (Mol. Cell 2015) 3

Products for ZRANB1 Gene

Sources for ZRANB1 Gene

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