Aliases for ZRANB1 Gene
External Ids for ZRANB1 Gene
GeneCards Summary for ZRANB1 Gene
ZRANB1 (Zinc Finger, RAN-Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and K63-linked polyubiquitin binding. An important paralog of this gene is TNFAIP3.
UniProtKB/Swiss-Prot for ZRANB1 Gene
Specifically hydrolyzes Lys-29-linked and Lys-33-linked diubiquitin. Also cleaves Lys-63-linked chains, but with 40-fold less efficiency compared to Lys-29-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.