Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZRANB1 Gene

protein-coding   GIFtS: 47
GCID: GC10P126620

Zinc Finger, RAN-Binding Domain Containing 1

  Search for ZRANB1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, RAN-Binding Domain Containing 11 2     TRAF-Binding Protein Domain2
TRABID2 3 5     Ubiquitin Thioesterase ZRANB12
Zinc Finger Ran-Binding Domain-Containing Protein 12 3     EC 3.4.19.123
hTrabid2 3     EC 3.1.28
TRAF-Binding Domain-Containing Protein2 3     

External Ids:    HGNC: 182241   Entrez Gene: 547642   Ensembl: ENSG000000199957   OMIM: 6117495   UniProtKB: Q9UGI03   

Export aliases for ZRANB1 gene to outside databases

Previous GC identifers: GC10P126671 GC10P126205 GC10P120317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZRANB1 Gene: 
ZRANB1 (zinc finger, RAN-binding domain containing 1) is a protein-coding gene. GO annotations related to this gene include K63-linked polyubiquitin binding and ubiquitin thiolesterase activity. An important paralog of this gene is TNFAIP3.

UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0
Function: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked
chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt
signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a
role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics
and cell migration. May also modulate TNF-alpha signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZRANB1 gene promoter:
         AREB6   S8   Lmo2   AP-4   CUTL1   MRF-2   E4BP4   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZRANB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZRANB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZRANB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.12

ZRANB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZRANB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P126620:  view genomic region     (about GC identifiers)

Start:
126,630,692 bp from pter      End:
126,676,758 bp from pter
Size:
46,067 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0 (See protein sequence)
Recommended Name: Ubiquitin thioesterase ZRANB1  
Size: 708 amino acids; 80967 Da
Subunit: Interacts with APC and TRAF6
Subcellular location: Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm
Sequence caution: Sequence=BAG64010.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZRANB1:
3ZRH (3D)    
Secondary accessions: B4DZ98 D3DRF4 Q5SQP6 Q69YK3

Explore the universe of human proteins at neXtProt for ZRANB1: NX_Q9UGI0

Explore proteomics data for ZRANB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UGI0

  • 4/15 DME Specific Peptides for ZRANB1 (Q9UGI0) (see all 15)
     DCSHWFY  CTYLNWPR  DWLFLNAC  DFKKLKQI 

    ZRANB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZRANB1 Protein Expression
    REFSEQ proteins: NP_060050.2  
    ENSEMBL proteins: 
     ENSP00000352676  

    Human Recombinant Protein Products for ZRANB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ZRANB1 (ZRANB1/Trabid)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZRANB1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZRANB1
    GenScript Custom Purified and Recombinant Proteins Services for ZRANB1
    Novus Biologicals ZRANB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZRANB1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11463333
    GO:0005737cytoplasm IDA11463333

    ZRANB1 for ontologies           About GeneDecksing



    ZRANB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZRANB1
    OriGene Custom Antibody Services for ZRANB1
    GenScript Custom Superior Antibodies Services for ZRANB1
    Novus Biologicals ZRANB1 Antibodies
    Abcam antibodies for ZRANB1
    Cloud-Clone Corp. Antibodies for ZRANB1 
    ThermoFisher Antibody for ZRANB1
    LSBio Antibodies in human, mouse, rat for ZRANB1 

    Assay Products for ZRANB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZRANB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZRANB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZRANB1 
    Cloud-Clone Corp. CLIAs for ZRANB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZRANB: Zinc fingers, RAN-binding domain containing

    2 InterPro protein domains:
     IPR003323 OTU
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q9UGI0

    ProtoNet protein and cluster: Q9UGI0

    2 Blocks protein domains:
    IPB001876 Zn-finger
    IPB003323 OTU-like cysteine protease


    UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0
    Domain: The OTU domain mediates the deubiquitinating activity
    Domain: The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin
    Domain: The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and
    contributes to linkage specificity
    Domain: The RanBP2-type zinc fingers, also called NZFs, may provide additional ubiquitin-binding sites when
    hydrolyzing long 'Lys-63'-linked chains
    Similarity: Belongs to the peptidase C64 family
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 OTU domain
    Similarity: Contains 3 RanBP2-type zinc fingers


    ZRANB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZRAN1_HUMAN, Q9UGI0
    Function: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked
    chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt
    signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a
    role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics
    and cell migration. May also modulate TNF-alpha signaling
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.22 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP18281465
    GO:0004843ubiquitin-specific protease activity IDA18281465
    GO:0005515protein binding IPI11463333
    GO:0008270zinc ion binding IEA--
    GO:0070530K63-linked polyubiquitin binding IDA18281465
         
    ZRANB1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZRANB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZRANB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZRANB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZRANB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZRANB1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate ZRANB1 (see all 79):
    hsa-miR-3130-5p hsa-miR-520f hsa-miR-361-5p hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidZRANB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZRANB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZRANB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZRANB1
    Sirion Biotech Customized adenovirus for overexpression of ZRANB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZRANB1 (see all 7)
    OriGene ORF clones in mouse, rat for ZRANB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZRANB1 (NM_017580)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZRANB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZRANB1
    Sirion Biotech Customized lentivirus for stable overexpression of ZRANB1 
                         Customized lentivirus expression plasmids for stable overexpression of ZRANB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZRANB1
    Search LifeMap BioReagents cell lines for ZRANB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRANB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZRANB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for ZRANB1 (Q9UGI02, 3 ENSP000003526764) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-7288925 MINT-7288900 I2D: score=2 STRING: ENSP00000344818
    CTTNBP2Q8WZ743, ENSP000001603734I2D: score=2 STRING: ENSP00000160373
    CTTNBP2NLQ9P2B43, ENSP000002712774I2D: score=2 STRING: ENSP00000271277
    FGFR1OP2Q9NVK53, ENSP000002293954I2D: score=2 STRING: ENSP00000229395
    HECTD1Q9ULT83, ENSP000003822694I2D: score=2 STRING: ENSP00000382269
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IMP--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0016477cell migration IMP--
    GO:0022604regulation of cell morphogenesis IMP--
    GO:0030177positive regulation of Wnt receptor signaling pathway IMP18281465

    ZRANB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZRANB1 (ZRAN1)

    Search CenterWatch for drugs/clinical trials and news about ZRANB1 / ZRAN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZRANB1 gene: 
    NM_017580.2  

    Unigene Cluster for ZRANB1:

    Zinc finger, RAN-binding domain containing 1
    Hs.595158  [show with all ESTs]
    Unigene Representative Sequence: NM_017580
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359653(uc010qug.2 uc001lic.3) ENST00000471421
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZRANB1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate ZRANB1 (see all 79):
    hsa-miR-3130-5p hsa-miR-520f hsa-miR-361-5p hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidZRANB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZRANB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZRANB1
    Clone
    Products:
         
    OriGene clones in human, mouse for ZRANB1 (see all 7)
    OriGene ORF clones in mouse, rat for ZRANB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZRANB1 (NM_017580)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZRANB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZRANB1
    Sirion Biotech Customized lentivirus for stable overexpression of ZRANB1 
                         Customized lentivirus expression plasmids for stable overexpression of ZRANB1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZRANB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZRANB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZRANB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZRANB1

    Additional mRNA sequence: 

    AJ252060.1 AK302810.1 AK307386.1 AL832925.1 

    12 DOTS entries:

    DT.455998  DT.449458  DT.100784115  DT.101975491  DT.96085296  DT.121277001  DT.91724439  DT.95269973 
    DT.91724422  DT.92061884  DT.92417554  DT.97797629 

    24/227 AceView cDNA sequences (see all 227):

    CF455633 BE551292 AW276231 BQ215969 CB216838 AA902898 AW084989 BQ898370 
    AI984423 AA602708 AW468776 F01421 CA413606 AA689564 BU167699 BE670363 
    BF002491 Z45207 AA694301 Z40934 BM697868 BM716596 AI193184 AA456294 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZRANB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZRANB1 Expression
    About this image


    See ZRANB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZRANB1

    SOURCE GeneReport for Unigene cluster: Hs.595158

    UniProtKB/Swiss-Prot: ZRAN1_HUMAN, Q9UGI0
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for ZRANB1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZRANB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZRANB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZRANB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZRANB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRANB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZRANB1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zranb11 , 5 zinc finger, RAN-binding domain containing 11, 5 93.31(n)1
    99.29(a)1
      7 (76.32 cM)5
    3602161  NM_207302.11  NP_997185.11 
     1329311425 
    chicken
    (Gallus gallus)
    Aves ZRANB11 zinc finger, RAN-binding domain containing 1 85.83(n)
    96.89(a)
      423953  XM_421816.3  XP_421816.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZRANB16
    Uncharacterized protein
    96(a)
    1 ↔ 1
    3(62276525-62304559)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98662 Xenopus laevis transcribed sequence with moderate similarity more 78.2(n)    BU904278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145482 Transcribed sequence with moderate similarity to protein more 74.13(n)    BI673760.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trbd1 trabid 50.57(n)
    49.38(a)
      41179  NM_141674.2  NP_649931.1 


    ENSEMBL Gene Tree for ZRANB1 (if available)
    TreeFam Gene Tree for ZRANB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZRANB1 gene
    TNFAIP32  OTUD7B2  OTUD7A2  

    ZRANB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1002 SNPs in ZRANB1 are shown (see all 1002)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674483141,2
    C--120324547(+) ACACA-/A/CA  
            
    TTTTT
    1 -- int11NA 2
    rs1422862501,2
    C--126628704(+) CTGTGC/TACACA 1 -- us2k10--------
    rs733731221,2
    C,F--126628716(+) CACAGG/AGTTAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs733731261,2
    C,F--126628811(+) AAATTC/GTAAAT 1 -- us2k12Minor allele frequency- G:0.12WA 120
    rs1862117061,2
    --126628954(+) CTATTC/TAGTCA 1 -- us2k10--------
    rs1463957081,2
    C--126628964(+) AGACAC/GAACCA 1 -- us2k10--------
    rs1910813131,2
    --126629029(+) AGACGC/GAATCT 1 -- us2k10--------
    rs1834440231,2
    --126629058(+) CAAACC/TGTACT 1 -- us2k10--------
    rs1397346941,2
    --126629137(+) ATTTTA/GGCTAT 1 -- us2k10--------
    rs1431593051,2
    C--126629167(+) TTTTT-/TCTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZRANB1 (126630692 - 126676758 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZRANB1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZRANB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZRANB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZRANB1 for disorders           About MalaCards
    OMIM gene information: 611749    OMIM disorders: --


    ZRANB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZRANB1

    Export disorders for ZRANB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZRANB1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ZRANB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel A20-like proteins. (PubMed id 11463333)1, 2, 3, 9 Evans P.C....Kilshaw P.J. (2001)
    2. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. (PubMed id 22157957)1, 2 Licchesi J.D....Komander D. (2012)
    3. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. (PubMed id 18281465)1, 2 Tran H.... Bienz M. (2008)
    4. HectD1 E3 ligase modifies adenomatous polyposis coli ( APC) with polyubiquitin to promote the APC-axin interaction. (PubMed id 23277359)1 Tran H....Polakis P. (2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Lys11-linked ubiquitin chains adopt compact conformat ions and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1 Bremm A....Komander D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54764 HGNC: 18224 AceView: ZRANB1 Ensembl:ENSG00000019995 euGenes: HUgn54764
    ECgene: ZRANB1 H-InvDB: ZRANB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZRANB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZRANB1 gene:
    Search GeneIP for patents involving ZRANB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ZRANB1 (ZRANB1/Trabid)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZRANB1   OriGene RNAi products in human, mouse, rat for ZRANB1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZRANB1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZRANB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZRANB1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZRANB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZRANB1   OriGene Custom Protein Services for ZRANB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZRANB1
     QIAGEN SeqTarget long-range PCR primers for resequencing ZRANB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZRANB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZRANB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZRANB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZRANB1
     GenScript Custom Purified and Recombinant Proteins Services for ZRANB1 GenScript cDNA clones with any tag delivered in your preferred vector for ZRANB1
     GenScript Custom Assay Services for ZRANB1 GenScript Custom Superior Antibodies Services for ZRANB1
     GenScript Custom overexpressing Cell Line Services for ZRANB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZRANB1 promoter
     Search Chromatin IP Primers for ZRANB1
     RT2 qPCR Primer Assay in human, mouse, rat ZRANB1
     GNC Network for ZRANB1
     SABiosciences Custom PCR Arrays for ZRANB1
     Search Tocris compounds for ZRANB1 (ZRAN1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZRANB1 antibodies
     ZRANB1 lysates
     Antibodies for ZRANB1
     See all of Abcam's Antibodies, Kits and Proteins for ZRANB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZRANB1
     Antibodies for ZRANB1
     ELISAs for ZRANB1
     CLIAs for ZRANB1
     Search LifeMap BioReagents cell lines for ZRANB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZRANB1
     SwitchGear 3'UTR luciferase reporter plasmids for ZRANB1
     SwitchGear Promoter luciferase reporter plasmids for ZRANB1
     ThermoFisher Antibody for ZRANB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZRANB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZRANB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZRANB1
    Customized:
     lentivirus for stable overexpression of ZRANB1
     lentivirus expression plasmids for stable overexpression of ZRANB1
     adenovirus for overexpression of ZRANB1
     LSBio Antibodies in human, mouse, rat for ZRANB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZRANB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4