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ZPR1 Gene

protein-coding   GIFtS: 43
GCID: GC11M116649

ZPR1 Zinc Finger

(Previous name: zinc finger protein 259)
(Previous symbol: ZNF259)
  Search for ZPR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZPR1 Zinc Finger1 2
Zinc Finger Protein 2591 2 3
ZNF2591 2 5
Zinc Finger Protein ZPR12

External Ids:    HGNC: 130511   Entrez Gene: 88822   Ensembl: ENSG000001099177   OMIM: 6039015   UniProtKB: O753123   

Export aliases for ZPR1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZPR1 Gene:
ZPR1 (ZPR1 zinc finger) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312
Function: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus

Gene Wiki entry for ZPR1 (ZNF259) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZPR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZPR1 promoter sequence
   Search Chromatin IP Primers for ZPR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

ZPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZPR1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M116649:  view genomic region     (about GC identifiers)

Start:
116,648,436 bp from pter      End:
116,658,766 bp from pter
Size:
10,331 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312 (See protein sequence)
Recommended Name: Zinc finger protein ZPR1  
Size: 459 amino acids; 50925 Da
Subunit: Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A (By similarity).
Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259
Secondary accessions: Q2TAA0

Explore the universe of human proteins at neXtProt for ZPR1: NX_O75312

Explore proteomics data for ZPR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZPR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003895.1  
    ENSEMBL proteins: 
     ENSP00000394495   ENSP00000390391   ENSP00000227322   ENSP00000415505   ENSP00000391077  
     ENSP00000410141  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004457 Znf_ZPR1

    Graphical View of Domain Structure for InterPro Entry O75312

    ProtoNet protein and cluster: O75312

    1 Blocks protein domain: IPB004457 Zn-finger

    UniProtKB/Swiss-Prot: ZPR1_HUMAN, O75312
    Similarity: Belongs to the ZPR1 family


    ZPR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZPR1_HUMAN, O75312
    Function: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0031369translation initiation factor binding IPI9852145
         
    ZPR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZPR1:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zfp259):
     cellular  embryogenesis  mortality/aging 

    ZPR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zpr1tm1Rjd for ZPR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZPR1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZPR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZPR1_HUMAN, O75312: Cytoplasm. Nucleus, nucleolus. Note=Translocates to the nucleolus after treatment with
    mitogens

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852145
    GO:0005730nucleolus IDA9852145
    GO:0005737cytoplasm IDA9852145

    ZPR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZPR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ZPR1
        Translational Control

    1 BioSystems Pathway for ZPR1
        EGFR1 Signaling Pathway



    ZPR1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZPR1
    Interactions:

        Search GeneGlobe Interaction Network for ZPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ZPR1 (O753122, 3 ENSP000002273224) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5RAP2Q96SN82, 3MINT-65250 I2D: score=5 
    PSMC3P179803, ENSP000002988524I2D: score=2 STRING: ENSP00000298852
    EEF1A1P681043, ENSP000003300544I2D: score=11 STRING: ENSP00000330054
    FKBP1AP629423, ENSP000003711384I2D: score=1 STRING: ENSP00000371138
    SNUPNO951493, ENSP000003098314I2D: score=1 STRING: ENSP00000309831
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ISS--
    GO:0007165signal transduction TAS8650580
    GO:0008283cell proliferation TAS9763455
    GO:0061564axon development ISS--
    GO:0071364cellular response to epidermal growth factor stimulus IDA9852145

    ZPR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZPR1

    1 Novoseek inferred chemical compound relationship for ZPR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.5 8 9763455 (2), 17068332 (2), 19966453 (2), 8650580 (1) (see all 5)



    ZPR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZPR1 gene: 
    NM_003904.3  

    Unigene Cluster for ZPR1:

    Zinc finger protein 259
    Hs.7165  [show with all ESTs]
    Unigene Representative Sequence: BC111028
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429220 ENST00000444935 ENST00000227322(uc001ppp.3) ENST00000449430
    ENST00000431973 ENST00000425791 ENST00000498065 ENST00000487030
    miRNA
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    Primer
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    OriGene qPCR primer pairs and template standards for ZPR1
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      QuantiTect SYBR Green Assays in human, mouse, rat ZPR1
      QuantiFast Probe-based Assays in human, mouse, rat ZPR1

    Additional mRNA sequence: 

    AF019767.1 AK301227.1 BC004256.1 BC011929.2 BC012162.1 BC017349.2 BC017380.2 BC111028.1 
    BT006642.1 

    11 DOTS entries:

    DT.411006  DT.100757686  DT.95340942  DT.100818718  DT.120746555  DT.120746536  DT.75172205  DT.86852865 
    DT.95340939  DT.121328635  DT.97847038 

    Selected AceView cDNA sequences (see all 288):

    BQ718326 BU728594 BQ651632 BM982523 AW594693 BU521186 BQ670096 NM_052968 
    BM928675 BM910418 AI638510 BE746720 BQ649624 BC017380 BQ671401 BU189482 
    BM917066 BU623976 AI198352 BT006642 BQ928228 BU502732 BF514945 CR594434 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZPR1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                
    SP2:        -                                                                                       
    SP3:                                                                                                


    ECgene alternative splicing isoforms for ZPR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZPR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZPR1 Expression
    About this image

    ZPR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZPR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7165
        Custom PCR Arrays for ZPR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZPR1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp2591 , 5 zinc finger protein 2591, 5 87.15(n)1
    90.41(a)1
      9 (25.38 cM)5
    226871  NM_011752.21  NP_035882.11 
     462730645 
    chicken
    (Gallus gallus)
    Aves ZNF2591 zinc finger protein 259 73.66(n)
    76.89(a)
      428256  XM_003642595.2  XP_003642643.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF2596
    zinc finger protein 259
    71(a)
    1 ↔ 1
    GL343949.1(74516-83300)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66332 Xenopus laevis transcribed sequence with weak similarity more 78.46(n)    48047047 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17g092 Danio rerio mRNA similar to zinc finger protein 259 more 76.62(n)    BC052111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Zpr11 Zpr1 56.56(n)
    50.36(a)
      31851  NM_132304.3  NP_572532.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_W03F9.11 CELE_W03F9.1 50.36(n)
    41.81(a)
      189162  NM_070737.3  NP_503138.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZPR1(YGR211W)4
    ZPR11
    Essential protein with two zinc fingers, present in more4
    ZPR11
    53.38(n)1
    50.37(a)1
      7(915241-916701)4
    8531251, 4  NP_011727.31  NP_011727.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G224801 AT5G22480 53.1(n)
    44.12(a)
      832309  NM_122153.4  NP_197640.1 
    rice
    (Oryza sativa)
    Liliopsida Os.271082 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.61(n)    AK069434.1 


    ENSEMBL Gene Tree for ZPR1 (if available)
    TreeFam Gene Tree for ZPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZPR1 gene

    ZPR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZPR1
    PGOHUM00000243320


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZPR1 (see all 276)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782965221,2
    C,F--116648776(+) TCCTCC/ATCAGC 1 -- int12Minor allele frequency- A:0.07NA EA 240
    rs1387330821,2
    C--116648802(+) AATTAC/TCACCT 1 -- int10--------
    rs1427319941,2
    --116648851(+) CACAAC/TCCAGC 1 -- int10--------
    rs6411691,2
    C,F,H--116648900(+) ccatcT/Cgatgt 1 -- int1 ese34Minor allele frequency- C:0.01NS EA 410
    rs1394294541,2
    --116648911(+) ACTGTC/TTTCCT 1 -- int10--------
    rs9641841,2
    C,F,O,H--116648917(+) TTCCTC/GATCTG 1 -- int1 ese331Minor allele frequency- G:0.24NS EA MN NA WA CSA 2742
    rs1117325541,2
    C,F--116649131(+) ACAAGG/CATAGG 1 -- int12Minor allele frequency- C:0.03NA 122
    rs118235431,2
    C,F,H--116649135(+) GGATAG/AGGTCA 1 -- int1 ese317Minor allele frequency- A:0.12NS EA NA WA CSA 1892
    rs1826905841,2
    --116649367(+) TGATAA/TGAAAA 1 -- ut310--------
    rs1868757491,2
    --116649436(+) CCAAAA/GTAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZPR1 (116648436 - 116658766 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZPR1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZPR1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZPR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603901    OMIM disorders: --


    ZPR1 for disorders           About GeneDecksing


    Export disorders for ZPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZPR1 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with ZPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. (PubMed id 9763455)1, 2, 3, 9 Galcheva-Gargova Z.... Davis R.J. (Mol. Biol. Cell 1998)
    2. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. (PubMed id 8650580)1, 3, 9 Galcheva-Gargova Z....Davis R.J. (Science 1996)
    3. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. (PubMed id 22422766)1, 3 Ahmad S....Gangwani L. (Hum. Mol. Genet. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PubMed id 12095920)1, 2 Narayanan U.... Matera A.G. (Hum. Mol. Genet. 2002)
    6. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. (PubMed id 9852145)1, 2 Gangwani L.... Davis R.J. (J. Cell Biol. 1998)
    7. Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. (PubMed id 17068332)1, 9 Gangwani L. (J. Biol. Chem. 2006)
    8. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    9. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. (PubMed id 23726366)1 Coram M.A....Tang H. (Am. J. Hum. Genet. 2013)
    10. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PubMed id 22399527)1 Kristiansson K....Salomaa V. (Circ Cardiovasc Genet 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8882 HGNC: 13051 AceView: ZNF259andAPOA5 Ensembl:ENSG00000109917 euGenes: HUgn8882
    ECgene: ZPR1 H-InvDB: ZPR1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZPR1 Pharmacogenomics, SNPs, Pathways

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    Patent Information for ZPR1 gene:
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