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Aliases for ZPLD1 Gene

Aliases for ZPLD1 Gene

  • Zona Pellucida Like Domain Containing 1 2 3 5
  • ZP Domain-Containing Protein 1 4

External Ids for ZPLD1 Gene

Previous GeneCards Identifiers for ZPLD1 Gene

  • GC03P103637
  • GC03P103303
  • GC03P101818
  • GC03P099524

Summaries for ZPLD1 Gene

GeneCards Summary for ZPLD1 Gene

ZPLD1 (Zona Pellucida Like Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TECTB.

Additional gene information for ZPLD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPLD1 Gene

Genomics for ZPLD1 Gene

Regulatory Elements for ZPLD1 Gene

Enhancers for ZPLD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H101901 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -196.5 -196488 2.3 ATF1 INSM2 SIN3A BATF BRCA1 ZEB1 ZNF366 FOS ATF7 ETV6 NFKBIZ ZPLD1 NXPE3 GC03M101929 GC03P101864
GH03H101935 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -160.0 -160048 8.1 HDGF PKNOX1 ATF1 FEZF1 GATA2 ELK1 FOS ATF7 RUNX3 NCOA1 NFKBIZ ZPLD1 NXPE3 SENP7 ZBTB11-AS1 ZBTB11 LINC02085 GC03M101929
GH03H102188 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +93.4 93405 8.1 PKNOX1 FOXA2 MAX FEZF1 BATF RAD21 ZNF121 NFE2 ELF1 ZNF843 ZPLD1 NFKBIZ PIR36108 GC03P102210 GC03P102209 LOC101929411
GH03H102122 1.3 FANTOM5 ENCODE dbSUPER 14 +25.3 25253 3 MAX CEBPG RAD21 RFX5 POLR2A HNF4G DEK NFE2L2 CHD2 TCF7L2 ZPLD1 GC03M102109 LOC101929411
GH03H101898 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -200.0 -200020 1.7 PKNOX1 TBL1XR1 BMI1 RELA RFX5 EED ZNF143 ATF7 ETV6 RUNX3 NFKBIZ ZPLD1 ZBTB11-AS1 NXPE3 ZBTB11 GC03M101929 GC03P101864
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZPLD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZPLD1 Gene

Genomic Locations for ZPLD1 Gene
chr3:102,099,244-102,479,841
(GRCh38/hg38)
Size:
380,598 bases
Orientation:
Plus strand
chr3:101,818,088-102,198,685
(GRCh37/hg19)

Genomic View for ZPLD1 Gene

Genes around ZPLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPLD1 Gene

Proteins for ZPLD1 Gene

  • Protein details for ZPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCW7-ZPLD1_HUMAN
    Recommended name:
    Zona pellucida-like domain-containing protein 1
    Protein Accession:
    Q8TCW7
    Secondary Accessions:
    • Q49AS1
    • Q8WU36

    Protein attributes for ZPLD1 Gene

    Size:
    415 amino acids
    Molecular mass:
    45530 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW79766.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZPLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZPLD1 Gene

Post-translational modifications for ZPLD1 Gene

  • Glycosylation at isoforms=2121 and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for ZPLD1 Gene

No data available for DME Specific Peptides for ZPLD1 Gene

Domains & Families for ZPLD1 Gene

Gene Families for ZPLD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ZPLD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZPLD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZPLD1: view

No data available for UniProtKB/Swiss-Prot for ZPLD1 Gene

Function for ZPLD1 Gene

Phenotypes From GWAS Catalog for ZPLD1 Gene

genes like me logo Genes that share phenotypes with ZPLD1: view

miRNA for ZPLD1 Gene

miRTarBase miRNAs that target ZPLD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZPLD1 Gene

Localization for ZPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPLD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZPLD1 gene
Compartment Confidence
plasma membrane 2
extracellular 2
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ZPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZPLD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZPLD1 Gene

Pathways & Interactions for ZPLD1 Gene

SuperPathways for ZPLD1 Gene

No Data Available

Interacting Proteins for ZPLD1 Gene

Selected Interacting proteins: Q8TCW7-ZPLD1_HUMAN for ZPLD1 Gene via IID

Symbol External ID(s) Details
PDCD10

Gene Ontology (GO) - Biological Process for ZPLD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZPLD1 Gene

Drugs & Compounds for ZPLD1 Gene

No Compound Related Data Available

Transcripts for ZPLD1 Gene

mRNA/cDNA for ZPLD1 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZPLD1 Gene

Zona pellucida-like domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPLD1 Gene

No ASD Table

Relevant External Links for ZPLD1 Gene

GeneLoc Exon Structure for
ZPLD1
ECgene alternative splicing isoforms for
ZPLD1

Expression for ZPLD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZPLD1 Gene

mRNA differential expression in normal tissues according to GTEx for ZPLD1 Gene

This gene is overexpressed in Kidney - Cortex (x8.3) and Testis (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of ZPLD1 Gene:

ZPLD1

SOURCE GeneReport for Unigene cluster for ZPLD1 Gene:

Hs.352213

mRNA Expression by UniProt/SwissProt for ZPLD1 Gene:

Q8TCW7-ZPLD1_HUMAN
Tissue specificity: Detected in placenta, kidney, lung, pancreas and at very low level in other tissues.

Evidence on tissue expression from TISSUES for ZPLD1 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ZPLD1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZPLD1 Gene

Orthologs for ZPLD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZPLD1 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia ZPLD1 33 34
  • 92.53 (n)
oppossum
(Monodelphis domestica)
Mammalia ZPLD1 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zpld1 33
  • 90.78 (n)
cow
(Bos Taurus)
Mammalia ZPLD1 33 34
  • 90.76 (n)
mouse
(Mus musculus)
Mammalia Zpld1 33 16 34
  • 87.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZPLD1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZPLD1 33 34
  • 81.34 (n)
lizard
(Anolis carolinensis)
Reptilia ZPLD1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732051 33
  • 46.15 (n)
zebrafish
(Danio rerio)
Actinopterygii zpld1b 34
  • 69 (a)
OneToMany
zpld1a 33 34
  • 67.4 (n)
Species where no ortholog for ZPLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZPLD1 Gene

ENSEMBL:
Gene Tree for ZPLD1 (if available)
TreeFam:
Gene Tree for ZPLD1 (if available)

Paralogs for ZPLD1 Gene

Paralogs for ZPLD1 Gene

genes like me logo Genes that share paralogs with ZPLD1: view

Variants for ZPLD1 Gene

Sequence variations from dbSNP and Humsavar for ZPLD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000023602 -- 102,445,523(+) GCACC(G/T)GAATT intron-variant
rs1000023668 -- 102,408,865(+) TCTGG(A/C)AGTAT intron-variant
rs1000060112 -- 102,395,722(+) TATTA(C/G)TTTGT intron-variant
rs1000075740 -- 102,388,455(+) TCTGT(C/G)TGTGT intron-variant
rs1000081226 -- 102,446,620(+) TCAAA(-/G)CTACA intron-variant

Variation tolerance for ZPLD1 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZPLD1 Gene

Human Gene Mutation Database (HGMD)
ZPLD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZPLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZPLD1 Gene

Disorders for ZPLD1 Gene

Relevant External Links for ZPLD1

Genetic Association Database (GAD)
ZPLD1
Human Genome Epidemiology (HuGE) Navigator
ZPLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZPLD1

No disorders were found for ZPLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZPLD1 Gene

Publications for ZPLD1 Gene

  1. ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations. (PMID: 18632209) Gianfrancesco F … Squitieri F (Neuroscience 2008) 2 3 4 60
  2. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 45 60
  3. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner JT … Grant SF (American journal of human genetics 2010) 3 45 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards DR … Edwards TL (Human genetics 2013) 3 60

Products for ZPLD1 Gene

Sources for ZPLD1 Gene

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