Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZPLD1 Gene

Aliases for ZPLD1 Gene

  • Zona Pellucida-Like Domain Containing 1 2 3
  • ZP Domain-Containing Protein 1 4

External Ids for ZPLD1 Gene

Previous GeneCards Identifiers for ZPLD1 Gene

  • GC03P103637
  • GC03P103303
  • GC03P101818
  • GC03P099524

Summaries for ZPLD1 Gene

GeneCards Summary for ZPLD1 Gene

ZPLD1 (Zona Pellucida-Like Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TECTB.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPLD1 Gene

Genomics for ZPLD1 Gene

Regulatory Elements for ZPLD1 Gene

Genomic Location for ZPLD1 Gene

Start:
102,099,244 bp from pter
End:
102,479,841 bp from pter
Size:
380,598 bases
Orientation:
Plus strand

Genomic View for ZPLD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZPLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPLD1 Gene

Proteins for ZPLD1 Gene

  • Protein details for ZPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCW7-ZPLD1_HUMAN
    Recommended name:
    Zona pellucida-like domain-containing protein 1
    Protein Accession:
    Q8TCW7
    Secondary Accessions:
    • Q49AS1
    • Q8WU36

    Protein attributes for ZPLD1 Gene

    Size:
    415 amino acids
    Molecular mass:
    45530 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW79766.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZPLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZPLD1 Gene

Proteomics data for ZPLD1 Gene at MOPED

Post-translational modifications for ZPLD1 Gene

  • Glycosylation at Asn121 and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for ZPLD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZPLD1 Gene

Domains for ZPLD1 Gene

Protein Domains for ZPLD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZPLD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCW7

UniProtKB/Swiss-Prot:

ZPLD1_HUMAN :
  • Q8TCW7
Domain:
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with ZPLD1: view

No data available for Gene Families for ZPLD1 Gene

Function for ZPLD1 Gene

genes like me logo Genes that share phenotypes with ZPLD1: view

Animal Model Products

CRISPR Products

miRNA for ZPLD1 Gene

miRTarBase miRNAs that target ZPLD1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZPLD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZPLD1 Gene

Localization for ZPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPLD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZPLD1 Gene COMPARTMENTS Subcellular localization image for ZPLD1 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZPLD1: view

Pathways for ZPLD1 Gene

SuperPathways for ZPLD1 Gene

No Data Available

Interacting Proteins for ZPLD1 Gene

Gene Ontology (GO) - Biological Process for ZPLD1 Gene

None

No data available for Pathways by source for ZPLD1 Gene

Transcripts for ZPLD1 Gene

mRNA/cDNA for ZPLD1 Gene

(5) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZPLD1 Gene

Zona pellucida-like domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZPLD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZPLD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPLD1 Gene

No ASD Table

Relevant External Links for ZPLD1 Gene

GeneLoc Exon Structure for
ZPLD1
ECgene alternative splicing isoforms for
ZPLD1

Expression for ZPLD1 Gene

mRNA expression in normal human tissues for ZPLD1 Gene

mRNA differential expression in normal tissues according to GTEx for ZPLD1 Gene

This gene is overexpressed in Kidney - Cortex (8.3) and Testis (5.0).

SOURCE GeneReport for Unigene cluster for ZPLD1 Gene Hs.352213

mRNA Expression by UniProt/SwissProt for ZPLD1 Gene

Q8TCW7-ZPLD1_HUMAN
Tissue specificity: Detected in placenta, kidney, lung, pancreas and at very low level in other tissues.
genes like me logo Genes that share expressions with ZPLD1: view

In Situ Assay Products

No data available for Protein expression for ZPLD1 Gene

Orthologs for ZPLD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZPLD1 35
  • 99.12 (n)
  • 99.28 (a)
ZPLD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZPLD1 35
  • 90.76 (n)
  • 95.42 (a)
ZPLD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZPLD1 35
  • 92.53 (n)
  • 95.66 (a)
ZPLD1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zpld1 35
  • 87.63 (n)
  • 91.57 (a)
Zpld1 16
Zpld1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZPLD1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZPLD1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zpld1 35
  • 90.78 (n)
  • 95.82 (a)
chicken
(Gallus gallus)
Aves ZPLD1 35
  • 81.34 (n)
  • 85.41 (a)
ZPLD1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZPLD1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732051 35
  • 46.15 (n)
  • 40.21 (a)
zebrafish
(Danio rerio)
Actinopterygii zpld1a 35
  • 67.4 (n)
  • 72.44 (a)
zpld1a 36
  • 67 (a)
OneToMany
zpld1b 36
  • 69 (a)
OneToMany
Species with no ortholog for ZPLD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZPLD1 Gene

ENSEMBL:
Gene Tree for ZPLD1 (if available)
TreeFam:
Gene Tree for ZPLD1 (if available)

Paralogs for ZPLD1 Gene

Paralogs for ZPLD1 Gene

genes like me logo Genes that share paralogs with ZPLD1: view

Variants for ZPLD1 Gene

Sequence variations from dbSNP and Humsavar for ZPLD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs883818 -- 102,479,896(+) TATTC(C/T)TACTT downstream-variant-500B
rs892791 -- 102,445,727(-) TGTGT(A/G)GTTTT intron-variant
rs892792 -- 102,411,328(-) CCCAA(A/G)TAAGT intron-variant
rs899483 -- 102,302,091(-) ACTTT(C/T)ACTGA intron-variant
rs985374 -- 102,348,410(-) TCGAC(C/T)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZPLD1 Gene

Variant ID Type Subtype PubMed ID
nsv877227 CNV Loss 21882294

Relevant External Links for ZPLD1 Gene

HapMap Linkage Disequilibrium report
ZPLD1
Human Gene Mutation Database (HGMD)
ZPLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPLD1 Gene

Disorders for ZPLD1 Gene

Relevant External Links for ZPLD1

Genetic Association Database (GAD)
ZPLD1
Human Genome Epidemiology (HuGE) Navigator
ZPLD1
genes like me logo Genes that share disorders with ZPLD1: view

No data available for UniProtKB/Swiss-Prot for ZPLD1 Gene

Publications for ZPLD1 Gene

  1. ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations. (PMID: 18632209) Gianfrancesco F. … Squitieri F. (Neuroscience 2008) 2 3 4
  2. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner J.T. … Grant S.F. (Am. J. Hum. Genet. 2010) 3 48
  3. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 48
  4. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards D.R. … Edwards T.L. (Hum. Genet. 2013) 3
  5. Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy. (PMID: 23834954) Kobayashi D. … Fukuda K. (Mol Pain 2013) 3

Products for ZPLD1 Gene

Sources for ZPLD1 Gene

Back to Top

Content