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Aliases for ZPBP2 Gene

Aliases for ZPBP2 Gene

  • Zona Pellucida Binding Protein 2 2 3 5
  • ZPBP-Like Protein 3 4
  • ZPBPL 3 4

External Ids for ZPBP2 Gene

Previous GeneCards Identifiers for ZPBP2 Gene

  • GC17P038399
  • GC17P035277
  • GC17P038024
  • GC17P033818

Summaries for ZPBP2 Gene

GeneCards Summary for ZPBP2 Gene

ZPBP2 (Zona Pellucida Binding Protein 2) is a Protein Coding gene. An important paralog of this gene is ZPBP.

UniProtKB/Swiss-Prot for ZPBP2 Gene

  • May be implicated in gamete interaction during fertilization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPBP2 Gene

Genomics for ZPBP2 Gene

Regulatory Elements for ZPBP2 Gene

Enhancers for ZPBP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZPBP2 on UCSC Golden Path with GeneCards custom track

Promoters for ZPBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZPBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZPBP2 Gene

Chromosome:
17
Start:
39,868,164 bp from pter
End:
39,877,896 bp from pter
Size:
9,733 bases
Orientation:
Plus strand

Genomic View for ZPBP2 Gene

Genes around ZPBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP2 Gene

Proteins for ZPBP2 Gene

  • Protein details for ZPBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6X784-ZPBP2_HUMAN
    Recommended name:
    Zona pellucida-binding protein 2
    Protein Accession:
    Q6X784
    Secondary Accessions:
    • A8K8L8
    • Q6X783
    • Q86XL5

    Protein attributes for ZPBP2 Gene

    Size:
    338 amino acids
    Molecular mass:
    38652 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZPBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZPBP2 Gene

Proteomics data for ZPBP2 Gene at MOPED

Post-translational modifications for ZPBP2 Gene

  • Glycosylation at Asn 87, Asn 221, Asn 257, and Asn 309

Other Protein References for ZPBP2 Gene

No data available for DME Specific Peptides for ZPBP2 Gene

Domains & Families for ZPBP2 Gene

Gene Families for ZPBP2 Gene

Protein Domains for ZPBP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZPBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6X784

UniProtKB/Swiss-Prot:

ZPBP2_HUMAN :
  • Belongs to the zona pellucida-binding protein Sp38 family.
Family:
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP2: view

Function for ZPBP2 Gene

Molecular function for ZPBP2 Gene

UniProtKB/Swiss-Prot Function:
May be implicated in gamete interaction during fertilization.
genes like me logo Genes that share phenotypes with ZPBP2: view

Animal Models for ZPBP2 Gene

MGI Knock Outs for ZPBP2:

Animal Model Products

miRNA for ZPBP2 Gene

miRTarBase miRNAs that target ZPBP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP2 Gene

Localization for ZPBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZPBP2 Gene COMPARTMENTS Subcellular localization image for ZPBP2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with ZPBP2: view

Pathways & Interactions for ZPBP2 Gene

SuperPathways for ZPBP2 Gene

No Data Available

Interacting Proteins for ZPBP2 Gene

Gene Ontology (GO) - Biological Process for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

No data available for Pathways by source and SIGNOR curated interactions for ZPBP2 Gene

Drugs & Compounds for ZPBP2 Gene

No Compound Related Data Available

Transcripts for ZPBP2 Gene

Unigene Clusters for ZPBP2 Gene

Zona pellucida binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - -

Relevant External Links for ZPBP2 Gene

GeneLoc Exon Structure for
ZPBP2
ECgene alternative splicing isoforms for
ZPBP2

Expression for ZPBP2 Gene

mRNA expression in normal human tissues for ZPBP2 Gene

mRNA differential expression in normal tissues according to GTEx for ZPBP2 Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for ZPBP2 Gene

This gene is overexpressed in Testis (41.3) and Ovary (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZPBP2 Gene



SOURCE GeneReport for Unigene cluster for ZPBP2 Gene Hs.367245

genes like me logo Genes that share expression patterns with ZPBP2: view

Protein tissue co-expression partners for ZPBP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZPBP2 Gene

Orthologs for ZPBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZPBP2 35
  • 83.7 (n)
  • 72.59 (a)
ZPBP2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZPBP2 35
  • 89.35 (n)
  • 83.87 (a)
mouse
(Mus musculus)
Mammalia Zpbp2 35
  • 79.75 (n)
  • 73.01 (a)
Zpbp2 16
Zpbp2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZPBP2 35
  • 99.41 (n)
  • 98.22 (a)
ZPBP2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zpbp2 35
  • 79.55 (n)
  • 73.31 (a)
oppossum
(Monodelphis domestica)
Mammalia ZPBP2 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZPBP2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZPBP2 35
  • 57.81 (n)
  • 51.16 (a)
ZPBP2 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZPBP2 36
  • 48 (a)
OneToOne
Species with no ortholog for ZPBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZPBP2 Gene

ENSEMBL:
Gene Tree for ZPBP2 (if available)
TreeFam:
Gene Tree for ZPBP2 (if available)

Paralogs for ZPBP2 Gene

Paralogs for ZPBP2 Gene

(1) SIMAP similar genes for ZPBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP2: view

Variants for ZPBP2 Gene

Sequence variations from dbSNP and Humsavar for ZPBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs35591738 - 39,870,777(+) TGGAC(C/G/T)CCACC reference, missense
rs35829084 - 39,871,571(+) TTAAA(A/G/T)CAGAA reference, missense
rs11557467 - 39,872,381(+) GGATA(G/T)TCTAA reference, missense
rs35302660 - 39,876,795(+) ATCAG(C/G)AATAT reference, missense
rs189660050 - 39,870,781(+) CCCCA(C/T)CTACT reference, missense

Variation tolerance for ZPBP2 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZPBP2 Gene

Human Gene Mutation Database (HGMD)
ZPBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZPBP2 Gene

Disorders for ZPBP2 Gene

Relevant External Links for ZPBP2

Genetic Association Database (GAD)
ZPBP2
Human Genome Epidemiology (HuGE) Navigator
ZPBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZPBP2

No disorders were found for ZPBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZPBP2 Gene

Publications for ZPBP2 Gene

  1. Identification and characterization of human ZPBP-like gene in silico. (PMID: 12883658) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 23 67
  2. The allele T of rs10852936 confers risk for early-onset psoriasis. (PMID: 25620289) Li L. … Zhang X. (J. Dermatol. Sci. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (PMID: 24315451) van der Valk R.J. … de Jongste J.C. (J. Allergy Clin. Immunol. 2014) 3
  5. Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. (PMID: 22271045) Berlivet S. … Naumova A.K. (Hum. Genet. 2012) 3

Products for ZPBP2 Gene

Sources for ZPBP2 Gene

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