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ZPBP2 Gene

protein-coding   GIFtS: 48
GCID: GC17P038024

Zona Pellucida Binding Protein 2

  See ZPBP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zona Pellucida Binding Protein 21 2
ZPBPL2 3 5
ZPBP-Like Protein2 3
Zona Pellucida-Binding Protein 22

External Ids:    HGNC: 206781   Entrez Gene: 1246262   Ensembl: ENSG000001860757   OMIM: 6084995   UniProtKB: Q6X7843   

Export aliases for ZPBP2 gene to outside databases

Previous GC identifers: GC17P038399 GC17P035277 GC17P033818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZPBP2 Gene:
ZPBP2 (zona pellucida binding protein 2) is a protein-coding gene. Diseases associated with ZPBP2 include primary biliary cirrhosis. An important paralog of this gene is ZPBP.

UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784
Function: May be implicated in gamete interaction during fertilization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZPBP2 gene promoter:
         SRF   Pax-5   AML1a   MAZR   SRF (504 AA)   ATF-2   RORalpha2   FAC1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZPBP2 promoter sequence
   Search Chromatin IP Primers for ZPBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZPBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

ZPBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZPBP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038024:  view genomic region     (about GC identifiers)

Start:
38,024,417 bp from pter      End:
38,034,149 bp from pter
Size:
9,733 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784 (See protein sequence)
Recommended Name: Zona pellucida-binding protein 2 precursor  
Size: 338 amino acids; 38652 Da
Secondary accessions: A8K8L8 Q6X783 Q86XL5
Alternative splicing: 2 isoforms:  Q6X784-1   Q6X784-2   

Explore the universe of human proteins at neXtProt for ZPBP2: NX_Q6X784

Explore proteomics data for ZPBP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn87, Asn221, Asn257, Asn309

  • See ZPBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_942141.2  NP_955353.1  

    ENSEMBL proteins: 
     ENSP00000335384   ENSP00000462463   ENSP00000462067   ENSP00000367174  

    ZPBP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZPBP2

     
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    Cloud-Clone Corp. ELISAs for ZPBP2
    Cloud-Clone Corp. CLIAs for ZPBP2
    Search eBioscience for ELISAs for ZPBP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR010857 Sp38-bd
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6X784

    ProtoNet protein and cluster: Q6X784

    1 Blocks protein domain: IPB010857 Zona-pellucida-binding

    UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784
    Similarity: Belongs to the zona pellucida-binding protein Sp38 family


    Find genes that share domains with ZPBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZPBP2_HUMAN, Q6X784
    Function: May be implicated in gamete interaction during fertilization

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ZPBP2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zpbp2):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with ZPBP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zpbp2tm1Zuk for ZPBP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZPBP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZPBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZPBP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZPBP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZPBP2:
    hsa-mir-335-5p (MIRT017875)

    Block miRNA regulation of human, mouse, rat ZPBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZPBP2 (see all 21):
    hsa-miR-30c hsa-miR-3607-3p hsa-let-7a-2* hsa-miR-30d hsa-miR-192 hsa-miR-550a* hsa-miR-30a hsa-miR-550b
    SwitchGear 3'UTR luciferase reporter plasmidZPBP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZPBP2

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    Sino Biological Human cDNA Clone for ZPBP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZPBP2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPBP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZPBP2_HUMAN, Q6X784: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    lysosome1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005576extracellular region IEA--
    GO:0044297cell body IEA--

    Find genes that share ontologies with ZPBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZPBP2
    Interactions:

        GeneGlobe Interaction Network for ZPBP2

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001675acrosome assembly IEA--
    GO:0007339binding of sperm to zona pellucida IEA--

    Find genes that share ontologies with ZPBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZPBP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZPBP2 gene (2 alternative transcripts): 
    NM_198844.2  NM_199321.2  

    Unigene Cluster for ZPBP2:

    Zona pellucida binding protein 2
    Hs.367245  [show with all ESTs]
    Unigene Representative Sequence: NM_199321
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348931 ENST00000583811 ENST00000584588 ENST00000377940(uc002hte.3 uc002htf.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZPBP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZPBP2 (see all 21):
    hsa-miR-30c hsa-miR-3607-3p hsa-let-7a-2* hsa-miR-30d hsa-miR-192 hsa-miR-550a* hsa-miR-30a hsa-miR-550b
    SwitchGear 3'UTR luciferase reporter plasmidZPBP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZPBP2
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZPBP2 (NM_198844)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZPBP2
    Primer
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    OriGene qPCR primer pairs and template standards for ZPBP2
    OriGene qSTAR qPCR primer pairs in human, mouse for ZPBP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZPBP2
      QuantiTect SYBR Green Assays in human, mouse, rat ZPBP2
      QuantiFast Probe-based Assays in human, mouse, rat ZPBP2

    Additional mRNA sequence: 

    AK292383.1 AY251603.1 AY251604.1 BC043152.2 

    3 DOTS entries:

    DT.102821029  DT.111469  DT.100748342 

    Selected AceView cDNA sequences (see all 47):

    AA917527 BU570505 NM_199321 BC043152 AY251603 NM_198844 AY251604 AA383678 
    AA993353 AI964005 AW172510 AI220227 AA383045 BI830456 BI830195 AI024857 
    AA971057 AA923754 AI024879 AI240624 AI218027 AW628901 AI799048 AW172596 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:        -                                             
    SP3:        -     -     -                                 


    ECgene alternative splicing isoforms for ZPBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZPBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZPBP2 Expression
    About this image

    ZPBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZPBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367245
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZPBP2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zpbp21 , 5 zona pellucida binding protein 21, 5 79.75(n)1
    73.01(a)1
      11 (61.97 cM)5
    693761  NM_027061.21  NP_081337.21 
     985511305 
    chicken
    (Gallus gallus)
    Aves ZPBP21 zona pellucida binding protein 2 57.81(n)
    51.16(a)
      404532  NM_206987.1  NP_996870.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZPBP26
    zona pellucida binding protein 2
    48(a)
    1 ↔ 1
    6(68611943-68633279)


    ENSEMBL Gene Tree for ZPBP2 (if available)
    TreeFam Gene Tree for ZPBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZPBP2 gene
    ZPBP2  
    1 SIMAP similar gene for ZPBP2 using alignment to 3 protein entries:     ZPBP2_HUMAN (see all proteins):
    ZPBP

    Find genes that share paralogs with ZPBP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZPBP2 (see all 310)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507139431,2
    C--38022517(+) GACAGC/TGGAGA 2 -- us2k10--------
    rs112844761,2
    C--38022535(+) CAAAC-/AGTACC 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1392265701,2
    C--38022825(+) CGCATA/GAGATC 2 -- us2k10--------
    rs1452925541,2
    --38022832(+) GATCCG/TGGAGC 2 -- us2k10--------
    rs1476307231,2
    C--38022920(+) GTAATA/GTATCA 2 -- us2k10--------
    rs1405116151,2
    --38023026(+) GTTTTC/TGCAAA 2 -- us2k10--------
    rs46225391,2
    C,F,A--38023031(-) gaaaaT/Attgca 2 -- us2k1 tfbs37Minor allele frequency- A:0.09NA WA CSA 248
    rs1849669351,2
    --38023069(+) AAAGTG/TTATAT 2 -- us2k10--------
    rs1909428501,2
    --38023312(+) GAACAC/GTTGAG 2 -- us2k10--------
    rs14535601,2
    C,F,A,H--38023441(-) AGCAAA/CCTTTG 2 -- us2k125Minor allele frequency- C:0.12MN NS EA NA WA CSA 2506

    HapMap Linkage Disequilibrium report for ZPBP2 (38024417 - 38034149 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZPBP2: --
    Human Gene Mutation Database (HGMD): ZPBP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZPBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZPBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608499    OMIM disorders: --

    1 disease for ZPBP2:    
    About MalaCards
    primary biliary cirrhosis


    Find genes that share disorders with ZPBP2           About GenesLikeMe

    Genetic Association Database (GAD): ZPBP2
    Human Genome Epidemiology (HuGE) Navigator: ZPBP2 (2 documents)

    Export disorders for ZPBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZPBP2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ZPBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human ZPBP-like gene in silico. (PubMed id 12883658)1, 2, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
    2. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    3. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. (PubMed id 19732864)1, 4 Verlaan D.J....Naumova A.K. (Am. J. Hum. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. (PubMed id 22464253)1 Lessard C.J.... . (Am. J. Hum. Genet. 2012)
    6. Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. (PubMed id 22271045)1 Berlivet S....Naumova A.K. (Hum. Genet. 2012)
    7. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    8. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. (PubMed id 23000144)1 Nakamura M....Ishibashi H. (Am. J. Hum. Genet. 2012)
    9. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    10. Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8. (PubMed id 21594610)2 Kaneko H.... Ohno K. (Hum. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124626 HGNC: 20678 AceView: ZPBP2 Ensembl:ENSG00000186075 euGenes: HUgn124626
    ECgene: ZPBP2 H-InvDB: ZPBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZPBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZPBP2 gene:
    Search GeneIP for patents involving ZPBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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