ZPBP2 Gene
protein-coding GIFtS: 44
GCID: GC17P038024
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zona pellucida binding protein 2
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Aliases
for ZPBP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zona Pellucida Binding Protein 21 2 | | ZPBPL1 2 3 5 | | ZPBP-Like Protein2 3 | | MGC419301 | | Zona Pellucida-Binding Protein 22 |
Export aliases for ZPBP2 gene to outside databasesPrevious GC identifers: GC17P038399 GC17P035277 GC17P033818 |
Summaries
for ZPBP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784Function: May be implicated in gamete interaction during fertilization
|
Genomic Views
for ZPBP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZPBP2 gene promoter:
SRF Pax-5 AML1a MAZR SRF (504 AA) ATF-2 RORalpha2 FAC1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZPBP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZPBP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.1ZPBP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P038024: view genomic region
(about GC identifiers)
Start:
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38,024,417 bp from pter |
End:
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38,034,149 bp from pter |
Size:
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9,733 bases |
Orientation:
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plus strand |
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Proteins
for ZPBP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784 (See
protein sequence)Recommended Name: Zona pellucida-binding protein 2 precursor Size: 338 amino acids; 38652 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A8K8L8 Q6X783 Q86XL5Alternative splicing: 2 isoforms: Q6X784-1 Q6X784-2 Explore the universe of human proteins at neXtProt for ZPBP2: NX_Q6X784
ZPBP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_942141.2 NP_955353.1
ENSEMBL proteins: ENSP00000335384 ENSP00000462463 ENSP00000462067 ENSP00000367174
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001669 | acrosomal vesicle |
IEA | -- | | GO:0005576 | extracellular region |
IEA | -- |
ZPBP2 for ontologies About GeneDecksing
ZPBP2 Antibody Products:
Assay Products for ZPBP2: |
Protein
Domains /
Families
for ZPBP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZPBP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6X784ProtoNet protein and cluster: Q6X784 1 Blocks protein family: IPB010857 Zona-pellucida-binding
UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784Similarity: Belongs to the zona pellucida-binding protein Sp38 family |
Function
for ZPBP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZPBP2_HUMAN, Q6X784Function: May be implicated in gamete interaction during fertilization
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZPBP2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZPBP2 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPBP2 |
Animal Models:
Mouse knock-out Zpbp2tm1Zuk for ZPBP2
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zpbp2):
ZPBP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZPBP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZPBP2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001675 | acrosome assembly |
IEA | -- | | GO:0007339 | binding of sperm to zona pellucida |
IEA | -- |
ZPBP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZPBP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZPBP2
Search CenterWatch for drugs/clinical trials and news about ZPBP2
|
Transcripts
for ZPBP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZPBP2 gene (2 alternative transcripts): NM_198844.2 NM_199321.2 Unigene Cluster for ZPBP2: Zona pellucida binding protein 2 Hs.367245 [show with all ESTs]Unigene Representative Sequence: NM_1993214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000348931 ENST00000583811 ENST00000584588 ENST00000377940(uc002hte.3 uc002htf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZPBP2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZPBP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZPBP2 (NM_198844) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZPBP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZPBP2 |
Additional cDNA sequence: AK292383.1 AY251603.1 AY251604.1 BC043152.2 3 DOTS entries: DT.102821029 DT.111469 DT.100748342 24/47 AceView cDNA sequences (see all 47): BU570505 AA993353 NM_198844 AY251604 AA383678 BC043152 AY251603 NM_199321 AA917527 BI830456 AI964005 AI024879 AW628901 AA923754 AI240624 BU852267 BI829458 AI218027 AW172510 AW172596 BI830195 AA971057 AI220227 AI799048
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZPBP2
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Expression
for ZPBP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZPBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZPBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZPBP2
SOURCE GeneReport for Unigene cluster: Hs.367245
SABiosciences Custom PCR Arrays for ZPBP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZPBP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZPBP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZPBP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZPBP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPBP2 |
Orthologs
for ZPBP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZPBP2 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for ZPBP2 (if available)
TreeFam Gene Tree for ZPBP2 (if available) |
Paralogs
for ZPBP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZPBP2 gene
- ZPBP2
1 SIMAP similar gene for ZPBP2 using alignment to 3 protein entries: ZPBP2_HUMAN (see all proteins):ZPBP
ZPBP2 for paralogs About GeneDecksing
|
Genomic Variants
for ZPBP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZPBP2 (38024417 - 38034149 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZPBP2: --
Human Gene Mutation Database (HGMD): ZPBP2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZPBP2 |
|
Disorders
/ Diseases
for ZPBP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZPBP2 for disorders About GeneDecksing
OMIM gene information: 608499
OMIM disorders: --
5  diseases for ZPBP2: About MalaCardsosteogenesis imperfecta primary biliary cirrhosis hyperuricemia rabies
asthma
Human Genome Epidemiology (HuGE) Navigator: ZPBP2 (2 documents)
Export disorders for ZPBP2 gene to outside databases
|
Publications
for ZPBP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZPBP2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZPBP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human ZPBP-like gene in silico. (PubMed id 12883658)1, 2, 9 Katoh M. and Katoh M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as su sceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. (PubMed id 22464253)1 Lessard C.J.... . (2012)
- Interaction between genetic and epigenetic variation d efines gene expression patterns at the asthma-associated locus 17q12-q21 in lymp hoblastoid cell lines. (PubMed id 22271045)1 Berlivet S....Naumova A.K. (2012)
- Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8. (PubMed id 21594610)2 Kaneko H.... Ohno K. (2011)
- Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (2011)
- Genome-wide meta-analyses identify three loci associa ted with primary biliary cirrhosis. (PubMed id 20639880)1 Liu X....Seldin M.F. (2010)
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1 Franke A....Parkes M. (2010)
- Allele-specific chromatin remodeling in the ZPBP2/GSD MB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. (PubMed id 19732864)1 Verlaan D.J....Naumova A.K. (2009)
- Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PubMed id 17664285)1 Lin Y.N....Matzuk M.M. (2007)
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External Searches for ZPBP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZPBP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZPBP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZPBP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZPBP2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZPBP2 gene:
Search GeneIP for patents involving ZPBP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZPBP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZPBP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZPBP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZPBP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZPBP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZPBP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZPBP2 |
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 | | | ZPBP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPBP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZPBP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZPBP2 |
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