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Aliases for ZPBP2 Gene

Aliases for ZPBP2 Gene

  • Zona Pellucida Binding Protein 2 2 3
  • ZPBPL 3 4 6
  • ZPBP-Like Protein 3 4
  • Zona Pellucida-Binding Protein 2 3

External Ids for ZPBP2 Gene

Previous GeneCards Identifiers for ZPBP2 Gene

  • GC17P038399
  • GC17P035277
  • GC17P038024
  • GC17P033818

Summaries for ZPBP2 Gene

GeneCards Summary for ZPBP2 Gene

ZPBP2 (Zona Pellucida Binding Protein 2) is a Protein Coding gene. Diseases associated with ZPBP2 include primary biliary cirrhosis. An important paralog of this gene is ZPBP.

UniProtKB/Swiss-Prot for ZPBP2 Gene

  • May be implicated in gamete interaction during fertilization

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPBP2 Gene

Genomics for ZPBP2 Gene

Regulatory Elements for ZPBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZPBP2 Gene

Start:
39,868,164 bp from pter
End:
39,877,896 bp from pter
Size:
9,733 bases
Orientation:
Plus strand

Genomic View for ZPBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZPBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP2 Gene

Proteins for ZPBP2 Gene

  • Protein details for ZPBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6X784-ZPBP2_HUMAN
    Recommended name:
    Zona pellucida-binding protein 2
    Protein Accession:
    Q6X784
    Secondary Accessions:
    • A8K8L8
    • Q6X783
    • Q86XL5

    Protein attributes for ZPBP2 Gene

    Size:
    338 amino acids
    Molecular mass:
    38652 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZPBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZPBP2 Gene

Proteomics data for ZPBP2 Gene at MOPED

Post-translational modifications for ZPBP2 Gene

  • Glycosylation at Asn87, Asn221, Asn257, and Asn309

Other Protein References for ZPBP2 Gene

No data available for DME Specific Peptides for ZPBP2 Gene

Domains for ZPBP2 Gene

Gene Families for ZPBP2 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for ZPBP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZPBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6X784

UniProtKB/Swiss-Prot:

ZPBP2_HUMAN :
  • Q6X784
Family:
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP2: view

Function for ZPBP2 Gene

Molecular function for ZPBP2 Gene

UniProtKB/Swiss-Prot Function: May be implicated in gamete interaction during fertilization

Gene Ontology (GO) - Molecular Function for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ZPBP2: view

Phenotypes for ZPBP2 Gene

genes like me logo Genes that share phenotypes with ZPBP2: view

Animal Models for ZPBP2 Gene

MGI Knock Outs for ZPBP2:

Animal Model Products

CRISPR Products

miRNA for ZPBP2 Gene

miRTarBase miRNAs that target ZPBP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZPBP2 Gene

Localization for ZPBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZPBP2 Gene COMPARTMENTS Subcellular localization image for ZPBP2 gene
Compartment Confidence
extracellular 3
plasma membrane 2
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0002199 zona pellucida receptor complex IEA --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 21630459
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

Pathways for ZPBP2 Gene

SuperPathways for ZPBP2 Gene

No Data Available

Interacting Proteins for ZPBP2 Gene

Gene Ontology (GO) - Biological Process for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

No data available for Pathways by source for ZPBP2 Gene

Transcripts for ZPBP2 Gene

Unigene Clusters for ZPBP2 Gene

Zona pellucida binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZPBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - -

Relevant External Links for ZPBP2 Gene

GeneLoc Exon Structure for
ZPBP2
ECgene alternative splicing isoforms for
ZPBP2

Expression for ZPBP2 Gene

mRNA expression in normal human tissues for ZPBP2 Gene

mRNA differential expression in normal tissues according to GTEx for ZPBP2 Gene

This gene is overexpressed in Testis (51.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZPBP2 Gene

SOURCE GeneReport for Unigene cluster for ZPBP2 Gene Hs.367245

genes like me logo Genes that share expressions with ZPBP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZPBP2 Gene

Orthologs for ZPBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZPBP2 35
  • 99.41 (n)
  • 98.22 (a)
ZPBP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZPBP2 35
  • 83.7 (n)
  • 72.59 (a)
ZPBP2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZPBP2 35
  • 89.35 (n)
  • 83.87 (a)
mouse
(Mus musculus)
Mammalia Zpbp2 35
  • 79.75 (n)
  • 73.01 (a)
Zpbp2 16
Zpbp2 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZPBP2 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZPBP2 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zpbp2 35
  • 79.55 (n)
  • 73.31 (a)
chicken
(Gallus gallus)
Aves ZPBP2 35
  • 57.81 (n)
  • 51.16 (a)
ZPBP2 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZPBP2 36
  • 48 (a)
OneToOne
Species with no ortholog for ZPBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZPBP2 Gene

ENSEMBL:
Gene Tree for ZPBP2 (if available)
TreeFam:
Gene Tree for ZPBP2 (if available)

Paralogs for ZPBP2 Gene

Paralogs for ZPBP2 Gene

Selected SIMAP similar genes for ZPBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP2: view

Variants for ZPBP2 Gene

Sequence variations from dbSNP and Humsavar for ZPBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1054609 -- 39,877,024(+) GTTTT(A/C)ATGGA utr-variant-3-prime
rs1453560 -- 39,867,188(-) AGCAA(A/C)CTTTG upstream-variant-2KB
rs4622539 -- 39,866,778(-) gaaaa(A/T)ttgca upstream-variant-2KB
rs4795397 -- 39,867,492(+) GGCCA(A/G)TCGGG upstream-variant-2KB
rs7218216 -- 39,878,180(+) tctga(G/T)gttga downstream-variant-500B

Relevant External Links for ZPBP2 Gene

HapMap Linkage Disequilibrium report
ZPBP2
Human Gene Mutation Database (HGMD)
ZPBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZPBP2 Gene

Disorders for ZPBP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZPBP2 Gene including...

Search for ZPBP2 Gene in MalaCards »

Relevant External Links for ZPBP2

Genetic Association Database (GAD)
ZPBP2
Human Genome Epidemiology (HuGE) Navigator
ZPBP2
genes like me logo Genes that share disorders with ZPBP2: view

No data available for UniProtKB/Swiss-Prot for ZPBP2 Gene

Publications for ZPBP2 Gene

  1. Identification and characterization of human ZPBP-like gene in silico. (PMID: 12883658) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. (PMID: 19732864) Verlaan D.J. … Naumova A.K. (Am. J. Hum. Genet. 2009) 3 48
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 48
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for ZPBP2 Gene

Sources for ZPBP2 Gene

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