Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZPBP Gene

Aliases for ZPBP Gene

  • Zona Pellucida Binding Protein 2 3 5
  • ZPBP1 3 4
  • Zona Pellucida Binding Protein 1 3
  • Sp38 4

External Ids for ZPBP Gene

Previous GeneCards Identifiers for ZPBP Gene

  • GC07M049526
  • GC07M049687
  • GC07M049721
  • GC07M049754
  • GC07M049947

Summaries for ZPBP Gene

Entrez Gene Summary for ZPBP Gene

  • ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ZPBP Gene

ZPBP (Zona Pellucida Binding Protein) is a Protein Coding gene. An important paralog of this gene is ZPBP2.

UniProtKB/Swiss-Prot for ZPBP Gene

  • May be implicated in gamete interaction during fertilization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPBP Gene

Genomics for ZPBP Gene

Regulatory Elements for ZPBP Gene

Enhancers for ZPBP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZPBP on UCSC Golden Path with GeneCards custom track

Genomic Location for ZPBP Gene

49,850,322 bp from pter
50,121,329 bp from pter
271,008 bases
Minus strand

Genomic View for ZPBP Gene

Genes around ZPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP Gene

Proteins for ZPBP Gene

  • Protein details for ZPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D253
    • C9JPU1
    • Q15941
    • Q75KX9
    • Q75MI3

    Protein attributes for ZPBP Gene

    351 amino acids
    Molecular mass:
    40142 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS07517.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZPBP Gene


neXtProt entry for ZPBP Gene

Proteomics data for ZPBP Gene at MOPED

Post-translational modifications for ZPBP Gene

  • Glycosylation at Asn 114, Asn 187, and Asn 340
  • Modification sites at PhosphoSitePlus

Other Protein References for ZPBP Gene

Antibody Products

  • Abcam antibodies for ZPBP1

No data available for DME Specific Peptides for ZPBP Gene

Domains & Families for ZPBP Gene

Gene Families for ZPBP Gene

Protein Domains for ZPBP Gene

Suggested Antigen Peptide Sequences for ZPBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zona pellucida-binding protein Sp38 family.
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP: view

Function for ZPBP Gene

Molecular function for ZPBP Gene

UniProtKB/Swiss-Prot Function:
May be implicated in gamete interaction during fertilization.

Phenotypes for ZPBP Gene

genes like me logo Genes that share phenotypes with ZPBP: view

Animal Models for ZPBP Gene

MGI Knock Outs for ZPBP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP Gene

Localization for ZPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP Gene


Subcellular locations from

Jensen Localization Image for ZPBP Gene COMPARTMENTS Subcellular localization image for ZPBP gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ZPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ZPBP: view

Pathways & Interactions for ZPBP Gene

SuperPathways for ZPBP Gene

No Data Available

Interacting Proteins for ZPBP Gene

Gene Ontology (GO) - Biological Process for ZPBP Gene


No data available for Pathways by source and SIGNOR curated interactions for ZPBP Gene

Drugs & Compounds for ZPBP Gene

No Compound Related Data Available

Transcripts for ZPBP Gene

Unigene Clusters for ZPBP Gene

Zona pellucida binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: -
SP3: - -

Relevant External Links for ZPBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZPBP Gene

mRNA expression in normal human tissues for ZPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZPBP Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for ZPBP Gene

This gene is overexpressed in Testis (30.9), Ovary (21.1), and Heart (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZPBP Gene

SOURCE GeneReport for Unigene cluster for ZPBP Gene Hs.388841

genes like me logo Genes that share expression patterns with ZPBP: view

Protein tissue co-expression partners for ZPBP Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZPBP Gene

Orthologs for ZPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZPBP 35
  • 86.81 (n)
  • 82.24 (a)
  • 81 (a)
(Canis familiaris)
Mammalia ZPBP 35
  • 87.39 (n)
  • 82.28 (a)
  • 85 (a)
(Mus musculus)
Mammalia Zpbp 35
  • 81.81 (n)
  • 78.57 (a)
Zpbp 16
Zpbp 36
  • 67 (a)
(Pan troglodytes)
Mammalia ZPBP 35
  • 99.15 (n)
  • 98.86 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Zpbp 35
  • 81.62 (n)
  • 78.57 (a)
(Monodelphis domestica)
Mammalia ZPBP 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia ZPBP 36
  • 67 (a)
(Gallus gallus)
Aves ZPBP 35
  • 66.87 (n)
  • 58.26 (a)
  • 54 (a)
(Anolis carolinensis)
Reptilia ZPBP 36
  • 41 (a)
Species with no ortholog for ZPBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZPBP Gene

Gene Tree for ZPBP (if available)
Gene Tree for ZPBP (if available)

Paralogs for ZPBP Gene

Paralogs for ZPBP Gene

(1) SIMAP similar genes for ZPBP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP: view

Variants for ZPBP Gene

Sequence variations from dbSNP and Humsavar for ZPBP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs958242 -- 50,030,989(+) TATGG(G/T)GTTTA intron-variant
rs959676 -- 50,021,294(-) tgaag(C/G)catca intron-variant
rs959677 -- 50,021,261(-) tcatg(A/G)ttttc intron-variant
rs959678 -- 50,021,014(-) gtatg(A/G)gttgt intron-variant
rs977422 -- 49,923,077(+) TCAAA(G/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZPBP Gene

Variant ID Type Subtype PubMed ID
nsv830997 CNV Gain 17160897
esv2576953 CNV Loss 19546169
esv2658187 CNV Deletion 23128226
esv1138876 CNV Deletion 17803354
nsv366512 CNV Loss 16902084
nsv510079 CNV Loss 20534489
esv2665122 CNV Deletion 23128226
esv269973 CNV Insertion 20981092
nsv830998 CNV Loss 17160897
esv2547949 CNV Deletion 19546169
esv1958519 CNV Deletion 18987734
esv2669911 CNV Deletion 23128226
esv22697 CNV Loss 19812545
esv2141038 CNV Deletion 18987734

Variation tolerance for ZPBP Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZPBP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPBP Gene

Disorders for ZPBP Gene

Relevant External Links for ZPBP

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZPBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZPBP Gene

Publications for ZPBP Gene

  1. Molecules involved in mammalian sperm-egg interaction. (PMID: 9378618) McLeskey S.B. … Saling P.M. (Int. Rev. Cytol. 1998) 2 3 4 23 67
  2. Identification and characterization of human ZPBP-like gene in silico. (PMID: 12883658) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 23
  3. Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men. (PMID: 21911476) Yatsenko A.N. … Matzuk M.M. (Mol. Hum. Reprod. 2012) 3
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3

Products for ZPBP Gene

Sources for ZPBP Gene