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Aliases for ZPBP Gene

Aliases for ZPBP Gene

  • Zona Pellucida Binding Protein 2 3 5
  • Inner Acrosomal Membrane IAM38 3 4
  • ZPBP1 3 4
  • Zona Pellucida-Binding Protein 1 3
  • Sp38 4

External Ids for ZPBP Gene

Previous GeneCards Identifiers for ZPBP Gene

  • GC07M049526
  • GC07M049687
  • GC07M049721
  • GC07M049754
  • GC07M049947

Summaries for ZPBP Gene

Entrez Gene Summary for ZPBP Gene

  • ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ZPBP Gene

ZPBP (Zona Pellucida Binding Protein) is a Protein Coding gene. An important paralog of this gene is ZPBP2.

UniProtKB/Swiss-Prot for ZPBP Gene

  • Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPBP Gene

Genomics for ZPBP Gene

Regulatory Elements for ZPBP Gene

Enhancers for ZPBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G050382 2.3 VISTA dbSUPER 10.1 -260.8 -260785 0.8 ATF1 CREB3L1 E2F7 ARID4B SIN3A DMAP1 ZNF48 ZNF2 TCF12 GLIS2 RNU6-1091P ENSG00000228005 ZPBP C7orf72 GC07P050382 IKZF1
GH07G050341 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -234.5 -234469 28.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ZNF2 ZNF766 CBX5 ZNF143 FOS IKZF1 FIGNL1 ENSG00000228005 ZPBP GC07P050382
GH07G050145 1.1 FANTOM5 ENCODE 17.6 -26.9 -26897 5.1 HDGF PKNOX1 NFIB ZNF143 RELB IKZF2 CREM CEBPB JUNB GATAD2B C7orf72 ZPBP IKZF1 ENSG00000228005 ENSG00000231681
GH07G050409 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -289.3 -289262 3.0 FOXA2 ELK1 ZNF143 RELB IKZF2 CREM CBFB GATAD2B TBX21 MAFF FIGNL1 RNU6-1091P ENSG00000228005 ZPBP IKZF1 GC07P050435 GC07P050382
GH07G050067 1 Ensembl ENCODE 18.3 +52.2 52189 3.0 CTCF PKNOX1 TEAD4 RBBP5 CBX5 ZNF652 BHLHE40 HLF MNT REST C7orf72 ZPBP GNL2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZPBP on UCSC Golden Path with GeneCards custom track

Genomic Location for ZPBP Gene

Chromosome:
7
Start:
49,850,322 bp from pter
End:
50,121,329 bp from pter
Size:
271,008 bases
Orientation:
Minus strand

Genomic View for ZPBP Gene

Genes around ZPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP Gene

Proteins for ZPBP Gene

  • Protein details for ZPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS86-ZPBP1_HUMAN
    Recommended name:
    Zona pellucida-binding protein 1
    Protein Accession:
    Q9BS86
    Secondary Accessions:
    • A4D253
    • C9JPU1
    • Q15941
    • Q75KX9
    • Q75MI3

    Protein attributes for ZPBP Gene

    Size:
    351 amino acids
    Molecular mass:
    40142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAS07517.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZPBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZPBP Gene

Post-translational modifications for ZPBP Gene

Antibody Products

  • Abcam antibodies for ZPBP
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZPBP

No data available for DME Specific Peptides for ZPBP Gene

Domains & Families for ZPBP Gene

Gene Families for ZPBP Gene

Protein Domains for ZPBP Gene

Suggested Antigen Peptide Sequences for ZPBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS86

UniProtKB/Swiss-Prot:

ZPBP1_HUMAN :
  • Belongs to the zona pellucida-binding protein Sp38 family.
Family:
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP: view

Function for ZPBP Gene

Molecular function for ZPBP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).
genes like me logo Genes that share phenotypes with ZPBP: view

Animal Models for ZPBP Gene

MGI Knock Outs for ZPBP:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP Gene

Localization for ZPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein. Secreted. Note=First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction. {ECO:0000250 UniProtKB:Q62522}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZPBP gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZPBP: view

Pathways & Interactions for ZPBP Gene

No Data Available

Interacting Proteins for ZPBP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000046087%0d%0a9606.ENSP00000219593%0d%0a9606.ENSP00000366702%0d%0a
Selected Interacting proteins: Q9BS86-ZPBP1_HUMAN ENSP00000046087 for ZPBP Gene via IID STRING

Gene Ontology (GO) - Biological Process for ZPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with ZPBP: view

No data available for Pathways by source and SIGNOR curated interactions for ZPBP Gene

Transcripts for ZPBP Gene

Unigene Clusters for ZPBP Gene

Zona pellucida binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: -
SP3: - -

Relevant External Links for ZPBP Gene

GeneLoc Exon Structure for
ZPBP
ECgene alternative splicing isoforms for
ZPBP

Expression for ZPBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZPBP Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for ZPBP Gene

This gene is overexpressed in Testis (30.9), Ovary (21.1), and Heart (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZPBP Gene



Protein tissue co-expression partners for ZPBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZPBP Gene:

ZPBP

SOURCE GeneReport for Unigene cluster for ZPBP Gene:

Hs.388841

mRNA Expression by UniProt/SwissProt for ZPBP Gene:

Q9BS86-ZPBP1_HUMAN
Tissue specificity: Expressed specifically in testis.

Evidence on tissue expression from TISSUES for ZPBP Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with ZPBP: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZPBP Gene

Orthologs for ZPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZPBP 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia ZPBP 34 35
  • 87.39 (n)
cow
(Bos Taurus)
Mammalia ZPBP 34 35
  • 86.81 (n)
mouse
(Mus musculus)
Mammalia Zpbp 34 16 35
  • 81.81 (n)
rat
(Rattus norvegicus)
Mammalia Zpbp 34
  • 81.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZPBP 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZPBP 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZPBP 34 35
  • 66.87 (n)
lizard
(Anolis carolinensis)
Reptilia ZPBP 35
  • 41 (a)
OneToOne
Species where no ortholog for ZPBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZPBP Gene

ENSEMBL:
Gene Tree for ZPBP (if available)
TreeFam:
Gene Tree for ZPBP (if available)

Paralogs for ZPBP Gene

Paralogs for ZPBP Gene

(1) SIMAP similar genes for ZPBP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP: view

Variants for ZPBP Gene

Sequence variations from dbSNP and Humsavar for ZPBP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000000584 -- 50,094,801(+) ACCCT(C/T)GACAG upstream-variant-2KB
rs1000012260 -- 49,949,496(+) CTTAA(A/C)AATAT intron-variant
rs1000018716 -- 49,882,754(+) CAAAA(C/T)TGTAT intron-variant
rs1000023447 -- 49,929,704(+) CATAT(A/G)AGCCC intron-variant
rs1000028091 -- 49,996,821(+) CCATA(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZPBP Gene

Variant ID Type Subtype PubMed ID
dgv11330n54 CNV loss 21841781
dgv11331n54 CNV loss 21841781
esv1138876 CNV deletion 17803354
esv1958519 CNV deletion 18987734
esv2141038 CNV deletion 18987734
esv22697 CNV loss 19812545
esv2547949 CNV deletion 19546169
esv2576953 CNV loss 19546169
esv2658187 CNV deletion 23128226
esv2665122 CNV deletion 23128226
esv2669911 CNV deletion 23128226
esv3400481 CNV insertion 20981092
esv3431840 CNV insertion 20981092
esv3448606 CNV insertion 20981092
esv3541615 CNV deletion 23714750
esv3613117 CNV loss 21293372
esv3613118 CNV gain 21293372
esv3613119 CNV loss 21293372
esv3613121 CNV loss 21293372
esv6775 CNV gain 19470904
nsv1074502 CNV deletion 25765185
nsv1137216 CNV deletion 24896259
nsv1140768 CNV deletion 24896259
nsv366512 CNV deletion 16902084
nsv477601 CNV novel sequence insertion 20440878
nsv510079 OTHER sequence alteration 20534489
nsv606897 CNV gain 21841781
nsv606898 CNV loss 21841781
nsv830997 CNV gain 17160897
nsv830998 CNV loss 17160897

Variation tolerance for ZPBP Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZPBP Gene

Human Gene Mutation Database (HGMD)
ZPBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZPBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPBP Gene

Disorders for ZPBP Gene

Relevant External Links for ZPBP

Human Genome Epidemiology (HuGE) Navigator
ZPBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZPBP

No disorders were found for ZPBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZPBP Gene

Publications for ZPBP Gene

  1. Molecules involved in mammalian sperm-egg interaction. (PMID: 9378618) McLeskey S.B. … Saling P.M. (Int. Rev. Cytol. 1998) 2 3 4 22 64
  2. Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men. (PMID: 21911476) Yatsenko A.N. … Matzuk M.M. (Mol. Hum. Reprod. 2012) 3 4 64
  3. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PMID: 17664285) Lin Y.N. … Matzuk M.M. (Mol. Cell. Biol. 2007) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for ZPBP Gene

Sources for ZPBP Gene

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