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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZPBP Gene

protein-coding GIFtS: 51
GCID: GC07M049947

zona pellucida binding protein

Explore 2 diseases affiliated with
ZPBP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zona Pellucida Binding Protein¹ ²
ZPBP1¹ ² ³
SP38¹
Zona Pellucida Binding Protein 1²
Zona Pellucida-Binding Protein 1²
Sp38³

External Ids:	HGNC: 15662¹	Entrez Gene: 11055²	Ensembl: ENSG00000042813⁷	OMIM: 608498⁵	UniProtKB: Q9BS86³

Export aliases for ZPBP gene to outside databases

Previous GC identifers: GC07M049526 GC07M049687 GC07M049721 GC07M049754

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZPBP:

ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and

the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 (PubMed 9378618)).(supplied by OMIM,

Aug 2008)

UniProtKB/Swiss-Prot: ZPBP1_HUMAN, Q9BS86

Function: May be implicated in gamete interaction during fertilization

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZPBP gene promoter:
Bach1 Sox5 GATA-3 p53 CUTL1 POU3F2 GATA-1 GATA-2 POU2F1b POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZPBP promoter sequence

Search SABiosciences Chromatin IP Primers for ZPBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZPBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3 Ensembl cytogenetic band: 7p12.2 HGNC cytogenetic band: 7p14.3

ZPBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZPBP gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M049947: view genomic region (about GC identifiers)

Start:	49,890,017 bp from pter	End:	50,160,925 bp from pter
Size:	270,909 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 50,014,145-50,170,048

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZPBP1_HUMAN, Q9BS86 (See protein sequence)

Recommended Name: Zona pellucida-binding protein 1 precursor

Size: 351 amino acids; 40142 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=AAS07517.1; Type=Erroneous initiation;

Secondary accessions: A4D253 C9JPU1 Q15941 Q75KX9 Q75MI3

Alternative splicing: 2 isoforms: Q9BS86-1 Q9BS86-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZPBP: NX_Q9BS86

ZPBP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001153350.1 NP_008940.2

ENSEMBL proteins:

ENSP00000046087 ENSP00000402071 ENSP00000390054 ENSP00000414755

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001669	acrosomal vesicle	IEA	--
GO:0005576	extracellular region	IEA	--

ZPBP for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZPBP for domains About GeneDecksing

3 InterPro domains/families:

IPR007110 Ig-like_dom

IPR010857 Sp38-bd

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q9BS86

ProtoNet protein and cluster: Q9BS86

1 Blocks protein family: IPB010857 Zona-pellucida-binding

UniProtKB/Swiss-Prot: ZPBP1_HUMAN, Q9BS86

Similarity: Belongs to the zona pellucida-binding protein Sp38 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZPBP1_HUMAN, Q9BS86

Function: May be implicated in gamete interaction during fertilization

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In Situ Assay
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Animal Models:
Mouse knock-out Zpbp^tm1Zuk for ZPBP
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Zpbp):

endocrine/exocrine gland

reproductive system

ZPBP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ZPBP

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ZPBP (Q9BS86³ ENSP00000046087⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZP2	Q05996³, ENSP00000219593⁴	I2D: score=1 STRING: ENSP00000219593
CALU	ENSP00000249364⁴	STRING: ENSP00000249364

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001675	acrosome assembly	IEA	--
GO:0007339	binding of sperm to zona pellucida	IEA	--

ZPBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZPBP
Search CenterWatch for drugs/clinical trials and news about ZPBP / ZPBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZPBP gene (2 alternative transcripts):

NM_001159878.1 NM_007009.2

Unigene Cluster for ZPBP:

Zona pellucida binding protein

Hs.388841 [show with all ESTs]

Unigene Representative Sequence: NM_007009

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000491129 ENST00000465922 ENST00000046087(uc003tou.3 uc010kyw.3)

ENST00000419417 ENST00000450231 ENST00000413331

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Additional cDNA sequence:

AK312799.1 BC005223.1 BT006822.1 D17570.1

4 DOTS entries:

DT.108754 DT.108755 DT.70101032 DT.97794021

24/41 AceView cDNA sequences (see all 41):

AA905152 BC005223 BE969829 BT006822 BG773016 AW594602 BQ432865 AI953672

AW269451 BG724025 AW003304 BI826648 AA400474 AA789324 NM_007009 BM564137

AI621019 AA400581 D17570 BI463818 BI830077 BU854520 BG720325 AI961063

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9
SP1:									-
SP2:									-
SP3:											-		-

ECgene alternative splicing isoforms for ZPBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZPBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTCCCTG

About this image

ZPBP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Elongated Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZPBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZPBP

SOURCE GeneReport for Unigene cluster: Hs.388841

SABiosciences Custom PCR Arrays for ZPBP

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPBP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZPBP¹	zona pellucida binding protein	65.88(n) 56.93(a)		404537 XM_001233973.2 XP_001233974.1
lizard (Anolis carolinensis)	Reptilia	ZPBP⁶	--	49(a)	1 ↔ 1	6(54151419-54181048)

ENSEMBL Gene Tree for ZPBP (if available)
TreeFam Gene Tree for ZPBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZPBP gene

ZPBP2²

1 SIMAP similar gene for ZPBP using alignment to 3 protein entries: ZPBP1_HUMAN (see all proteins):

ZPBP2

ZPBP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148985695^1,2		--	49976583(+)	`TAAGAC/TAGTCA`	2	--	ds500¹		0	--	--	--	--
rs192528704^1,2		--	49976622(+)	`GTGGTC/TGGAAC`	2	--	ds500¹		0	--	--	--	--
rs184437220^1,2		--	49976673(+)	`ACAGGC/TTTTAA`	2	--	ds500¹		0	--	--	--	--
rs1483093^1,2	C,F,	--	49976757(-)	`AATTTT/CAGTTT`	2	--	ds500¹		12		NA WA CSA EA	504
rs1483092^1,2	C,F,	--	49976769(-)	`TATAAA/TAACTT`	2	--	ds500¹		12		NA WA CSA EA	501
rs13231386^1,2	C,H	--	49976821(+)	`ATAAAA/CCAGAA`	2	--	ds500¹		4		NS EA	418
rs143696681^1,2		--	49976927(+)	`AATCAC/TATGTA`	2	--	ds500¹		0	--	--	--	--
rs148121086^1,2		--	49976962(+)	`TAGAGA/GATTTT`	2	--	ds500¹		0	--	--	--	--
rs144349829^1,2		--	49977018(+)	`GACAC-/ATTTTT`	2	--	ds500¹		0	--	--	--	--
rs141832800^1,2	C,F,	--	49977123(+)	`AATGGC/TTTATA`	2	--	ut3¹		1		NA	4542

HapMap Linkage Disequilibrium report for ZPBP (49890017 - 50140017 bp, first 250kb of ZPBP)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for ZPBP
5 CNVs: 99948 64812 44312 99949 94480
6 Indels: 81933 81931 94481 94482 60657 81932
Human Gene Mutation Database (HGMD): ZPBP

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZPBP for disorders           About GeneDecksing

OMIM gene information: 608498    OMIM disorders: --

2 diseases for ZPBP:    About MalaCards

epididymitis alzheimer's disease

Human Genome Epidemiology (HuGE) Navigator: ZPBP (1 document)

Export disorders for ZPBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZPBP gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with ZPBP)

Utopia: connect your pdf to the dynamic
world of online information

Molecules involved in mammalian sperm-egg interaction. (PubMed id 9378618)^{1, 2, 3, 9} McLeskey S.B.... Saling P.M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Identification and characterization of human ZPBP-like gene in silico. (PubMed id 12883658)^{1, 9} Katoh M. and Katoh M. (2003)
Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men. (PubMed id 21911476)¹ Yatsenko A.N....Matzuk M.M. (2012)
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)¹ Franke A....Parkes M. (2010)
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)¹ Furney S.J....Lovestone S. (2010)
Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PubMed id 17664285)¹ Lin Y.N....Matzuk M.M. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)² Scherer S.W.... Tsui L.-C. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11055	HGNC: 15662	AceView: ZPBP	Ensembl:ENSG00000042813	euGenes: HUgn11055
ECgene: ZPBP	H-InvDB: ZPBP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZPBP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZPBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZPBP gene:
Search GeneIP for patents involving ZPBP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZPBP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZPBP
	OriGene Protein Over-expression Lysate for ZPBP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ZPBP		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZPBP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZPBP
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	OriGene Custom Antibody Services for ZPBP		OriGene Custom Protein Services for ZPBP
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZPBP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZPBP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZPBP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZPBP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZPBP
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	GenScript Custom Purified and Recombinant Proteins Services for ZPBP		GenScript cDNA clones with any tag delivered in your preferred vector for ZPBP
	GenScript Custom Assay Services for ZPBP		GenScript Custom Superior Antibodies Services for ZPBP
	GenScript Custom overexpressing Cell Line Services for ZPBP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Search for Antibodies for ZPBP at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ZPBP
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ZPBP Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZPBP

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ZPBP
	SwitchGear Promoter luciferase reporter plasmids for ZPBP

ThermoFisher Antibodies for ZPBP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZPBP

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZPBP gene at Home site.

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ZPBP Gene

zona pellucida binding protein

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ZPBP Gene

zona pellucida binding protein

Aliasesfor ZPBP gene

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