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Aliases for ZP4 Gene

Aliases for ZP4 Gene

  • Zona Pellucida Glycoprotein 4 2 3 4
  • ZPB 3 4 6
  • Zona Pellucida Protein B 3 4
  • Zp-4 3 4
  • Zona Pellucida Sperm-Binding Protein 4 3
  • Zona Pellucida B Protein 3
  • ZBP 3
  • ZP1 3

External Ids for ZP4 Gene

Previous GeneCards Identifiers for ZP4 Gene

  • GC01M236178
  • GC01M233499
  • GC01M234342
  • GC01M235086
  • GC01M234371
  • GC01M236112
  • GC01M238045
  • GC01M208497

Summaries for ZP4 Gene

Entrez Gene Summary for ZP4 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP4 Gene

ZP4 (Zona Pellucida Glycoprotein 4) is a Protein Coding gene. Diseases associated with ZP4 include oophoritis. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include signal transducer activity and acrosin binding. An important paralog of this gene is ZP2.

UniProtKB/Swiss-Prot for ZP4 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor

Gene Wiki entry for ZP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP4 Gene

Genomics for ZP4 Gene

Regulatory Elements for ZP4 Gene

Genomic Location for ZP4 Gene

237,877,864 bp from pter
237,890,922 bp from pter
13,059 bases
Minus strand

Genomic View for ZP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP4 Gene

Proteins for ZP4 Gene

  • Protein details for ZP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida sperm-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RAE1

    Protein attributes for ZP4 Gene

    540 amino acids
    Molecular mass:
    59400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZP4 Gene

Proteomics data for ZP4 Gene at MOPED

Post-translational modifications for ZP4 Gene

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida
  • Glycosylation at Asn69, Asn202, Asn219, Asn267, Thr302, Asn470, and Asn474
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZP4 Gene

Domains for ZP4 Gene

Gene Families for ZP4 Gene

  • ZP :Zona pellucida glycoproteins

Protein Domains for ZP4 Gene

Suggested Antigen Peptide Sequences for ZP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q12836
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
  • Belongs to the ZP domain family. ZPB subfamily.
  • Contains 1 P-type (trefoil) domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with ZP4: view

Function for ZP4 Gene

Molecular function for ZP4 Gene

UniProtKB/Swiss-Prot Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor

Gene Ontology (GO) - Molecular Function for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 18667750
GO:0032190 acrosin binding IPI 15950651
genes like me logo Genes that share ontologies with ZP4: view

Phenotypes for ZP4 Gene

GenomeRNAi human phenotypes for ZP4:
genes like me logo Genes that share phenotypes with ZP4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZP4 Gene

Localization for ZP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP4 Gene

Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ZP4 Gene COMPARTMENTS Subcellular localization image for ZP4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZP4: view

Pathways for ZP4 Gene

SuperPathways for ZP4 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ZP4: view

Pathways by source for ZP4 Gene

Gene Ontology (GO) - Biological Process for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002922 positive regulation of humoral immune response IDA 19004505
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0010737 protein kinase A signaling IDA 18667750
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with ZP4: view

Transcripts for ZP4 Gene

mRNA/cDNA for ZP4 Gene

(6) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP4 Gene

Zona pellucida glycoprotein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZP4 Gene

No ASD Table

Relevant External Links for ZP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZP4 Gene

mRNA expression in normal human tissues for ZP4 Gene

mRNA differential expression in normal tissues according to GTEx for ZP4 Gene

This gene is overexpressed in Ovary (45.9).

SOURCE GeneReport for Unigene cluster for ZP4 Gene Hs.136241

mRNA Expression by UniProt/SwissProt for ZP4 Gene

Tissue specificity: Oocytes
genes like me logo Genes that share expressions with ZP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for ZP4 Gene

Orthologs for ZP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZP4 35
  • 98.89 (n)
  • 98.89 (a)
ZP4 36
  • 99 (a)
(Bos Taurus)
Mammalia ZP4 35
  • 79.99 (n)
  • 69.89 (a)
ZP4 36
  • 69 (a)
(Canis familiaris)
Mammalia ZP4 35
  • 80.29 (n)
  • 70.34 (a)
ZP4 36
  • 68 (a)
(Mus musculus)
Mammalia Zp4-ps 16
(Ornithorhynchus anatinus)
Mammalia ZP4 36
  • 40 (a)
(Rattus norvegicus)
Mammalia Zp4 35
  • 73.63 (n)
  • 66.48 (a)
(Gallus gallus)
Aves ZP4 35
  • 63.62 (n)
  • 53.75 (a)
ZP4 36
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 14 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zp4 35
  • 53.83 (n)
  • 46.39 (a)
(Danio rerio)
Actinopterygii CABZ01051901.1 36
  • 11 (a)
CABZ01074647.1 36
  • 20 (a)
si:zfos-1505d6.3 36
  • 34 (a)
zp2.1 36
  • 34 (a)
zp2.2 36
  • 34 (a)
zp2.3 36
  • 34 (a)
zp2.5 36
  • 34 (a)
zp2.6 36
  • 34 (a)
zp2l1 36
  • 36 (a)
zp2l2 36
  • 31 (a)
Species with no ortholog for ZP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP4 Gene

Gene Tree for ZP4 (if available)
Gene Tree for ZP4 (if available)

Paralogs for ZP4 Gene

Paralogs for ZP4 Gene

Selected SIMAP similar genes for ZP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZP4: view

Variants for ZP4 Gene

Sequence variations from dbSNP and Humsavar for ZP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_052997 -
VAR_052998 -

Structural Variations from Database of Genomic Variants (DGV) for ZP4 Gene

Variant ID Type Subtype PubMed ID
dgv193e1 CNV Complex 17122850
nsv873342 CNV Gain 21882294
esv34468 CNV Gain 17911159
esv2725729 CNV Deletion 23290073

Relevant External Links for ZP4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP4 Gene

Disorders for ZP4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZP4 Gene including...

Search for ZP4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ZP4 Gene

Relevant External Links for ZP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZP4: view

No data available for UniProtKB/Swiss-Prot for ZP4 Gene

Publications for ZP4 Gene

  1. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. (PMID: 7841460) Harris J.D. … Sacco A.G. (DNA Seq. 1994) 2 3 4 23
  2. Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. (PMID: 11291774) Eberspaecher U. … Donner P. (Cell Tissue Res. 2001) 3 23
  3. Proteolytic processing of human zona pellucida proteins. (PMID: 11804956) Kiefer S.M. … Saling P. (Biol. Reprod. 2002) 3 23
  4. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PMID: 15950651) Furlong L.I. … Vazquez-Levin M.H. (Fertil. Steril. 2005) 3 23
  5. Biological effects of recombinant human zona pellucida proteins on sperm function. (PMID: 16407501) Caballero-Campo P. … Gerton G.L. (Biol. Reprod. 2006) 3 23

Products for ZP4 Gene

Sources for ZP4 Gene

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