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Aliases for ZP4 Gene

Aliases for ZP4 Gene

  • Zona Pellucida Glycoprotein 4 2 3 4 5
  • Zona Pellucida Protein B 3 4
  • Zp-4 3 4
  • ZPB 3 4
  • Zona Pellucida Sperm-Binding Protein 4 3
  • ZBP 3
  • ZP1 3

External Ids for ZP4 Gene

Previous GeneCards Identifiers for ZP4 Gene

  • GC01M236178
  • GC01M233499
  • GC01M234342
  • GC01M235086
  • GC01M234371
  • GC01M236112
  • GC01M238045
  • GC01M208497

Summaries for ZP4 Gene

Entrez Gene Summary for ZP4 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP4 Gene

ZP4 (Zona Pellucida Glycoprotein 4) is a Protein Coding gene. Diseases associated with ZP4 include Ovarian Disease. Among its related pathways are Fertilization. GO annotations related to this gene include signal transducer activity and acrosin binding. An important paralog of this gene is ZP1.

UniProtKB/Swiss-Prot for ZP4 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Gene Wiki entry for ZP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP4 Gene

Genomics for ZP4 Gene

Regulatory Elements for ZP4 Gene

Enhancers for ZP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G237864 1.3 Ensembl ENCODE 11.2 +26.4 26422 0.6 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF143 DEK ZP4 LOC100130331
GH01G238018 0.4 FANTOM5 11.4 -127.8 -127795 0.2 POU5F1 ZP4 MTND5P18 YWHAQP9
GH01G237932 0.4 ENCODE 11 -42.1 -42104 0.2 CEBPG ZP4 ENSG00000283174 ENSG00000243781
GH01G237775 0.5 FANTOM5 1.8 +115.7 115662 0.4 CTCF ZNF654 RAD21 ZP4 LOC100130331 ENSG00000252290
GH01G237872 0.9 ENCODE 0.4 +17.2 17224 1.4 TBP INSM2 KLF17 ZNF2 ZEB1 RFX5 ZNF366 FOS DEK ZNF263 LOC100130331 ZP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZP4 Gene

Chromosome:
1
Start:
237,877,864 bp from pter
End:
237,890,922 bp from pter
Size:
13,059 bases
Orientation:
Minus strand

Genomic View for ZP4 Gene

Genes around ZP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP4 Gene

Proteins for ZP4 Gene

  • Protein details for ZP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12836-ZP4_HUMAN
    Recommended name:
    Zona pellucida sperm-binding protein 4
    Protein Accession:
    Q12836
    Secondary Accessions:
    • B2RAE1

    Protein attributes for ZP4 Gene

    Size:
    540 amino acids
    Molecular mass:
    59400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZP4 Gene

Post-translational modifications for ZP4 Gene

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • Glycosylation at posLast=6969, isoforms=202, isoforms=219, posLast=267267, isoforms=302, posLast=470470, and isoforms=474
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZP4 Gene

Domains & Families for ZP4 Gene

Gene Families for ZP4 Gene

Suggested Antigen Peptide Sequences for ZP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12836

UniProtKB/Swiss-Prot:

ZP4_HUMAN :
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Domain:
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPB subfamily.
genes like me logo Genes that share domains with ZP4: view

Function for ZP4 Gene

Molecular function for ZP4 Gene

UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Gene Ontology (GO) - Molecular Function for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP --
GO:0032190 acrosin binding IPI 15950651
genes like me logo Genes that share ontologies with ZP4: view
genes like me logo Genes that share phenotypes with ZP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZP4 Gene

Localization for ZP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP4 Gene

Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000305}.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZP4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ZP4: view

Pathways & Interactions for ZP4 Gene

SuperPathway Contained pathways
1 Fertilization
genes like me logo Genes that share pathways with ZP4: view

Pathways by source for ZP4 Gene

Interacting Proteins for ZP4 Gene

Gene Ontology (GO) - Biological Process for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002922 positive regulation of humoral immune response IDA 19004505
GO:0007338 single fertilization IEA --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0010737 protein kinase A signaling IDA --
GO:0035556 intracellular signal transduction IMP --
genes like me logo Genes that share ontologies with ZP4: view

No data available for SIGNOR curated interactions for ZP4 Gene

Drugs & Compounds for ZP4 Gene

No Compound Related Data Available

Transcripts for ZP4 Gene

mRNA/cDNA for ZP4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP4 Gene

Zona pellucida glycoprotein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZP4 Gene

No ASD Table

Relevant External Links for ZP4 Gene

GeneLoc Exon Structure for
ZP4
ECgene alternative splicing isoforms for
ZP4

Expression for ZP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZP4 Gene

mRNA differential expression in normal tissues according to GTEx for ZP4 Gene

This gene is overexpressed in Ovary (x45.9).

NURSA nuclear receptor signaling pathways regulating expression of ZP4 Gene:

ZP4

SOURCE GeneReport for Unigene cluster for ZP4 Gene:

Hs.136241

mRNA Expression by UniProt/SwissProt for ZP4 Gene:

Q12836-ZP4_HUMAN
Tissue specificity: Oocytes.
genes like me logo Genes that share expression patterns with ZP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZP4 Gene

Orthologs for ZP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZP4 34 35
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia ZP4 34 35
  • 80.29 (n)
cow
(Bos Taurus)
Mammalia ZP4 34 35
  • 79.99 (n)
rat
(Rattus norvegicus)
Mammalia Zp4 34
  • 73.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZP4 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZP4 34 35
  • 63.62 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 14 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zp4 34
  • 53.83 (n)
zebrafish
(Danio rerio)
Actinopterygii zp2l1 35
  • 36 (a)
ManyToMany
si:zfos-1505d6.3 35
  • 34 (a)
ManyToMany
zp2.1 35
  • 34 (a)
ManyToMany
zp2.2 35
  • 34 (a)
ManyToMany
zp2.3 35
  • 34 (a)
ManyToMany
zp2.5 35
  • 34 (a)
ManyToMany
zp2.6 35
  • 34 (a)
ManyToMany
zp2l2 35
  • 31 (a)
ManyToMany
CABZ01074647.1 35
  • 20 (a)
ManyToMany
CABZ01051901.1 35
  • 11 (a)
ManyToMany
Species where no ortholog for ZP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP4 Gene

ENSEMBL:
Gene Tree for ZP4 (if available)
TreeFam:
Gene Tree for ZP4 (if available)

Paralogs for ZP4 Gene

Paralogs for ZP4 Gene

(2) SIMAP similar genes for ZP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZP4: view

Variants for ZP4 Gene

Sequence variations from dbSNP and Humsavar for ZP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920872 Uncertain significance 237,890,138(-) ACTCC(A/G)ACTGT intron-variant, reference, missense
rs1000056763 -- 237,885,639(+) ACTGT(-/CA)CACCC intron-variant
rs1000847358 -- 237,887,113(+) CAGTC(A/G)GCATC intron-variant
rs1000926223 -- 237,884,568(+) GAGGG(C/T)TACCC intron-variant
rs1000978407 -- 237,891,710(+) GCATG(A/G)AAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZP4 Gene

Variant ID Type Subtype PubMed ID
esv2725729 CNV deletion 23290073
esv2759008 CNV gain 17122850
esv34468 CNV gain 17911159
esv3589241 CNV gain 21293372

Variation tolerance for ZP4 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.90; 83.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZP4 Gene

Human Gene Mutation Database (HGMD)
ZP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP4 Gene

Disorders for ZP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian disease
  • ovarian dysfunction
- elite association - COSMIC cancer census association via MalaCards
Search ZP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZP4

Genetic Association Database (GAD)
ZP4
Human Genome Epidemiology (HuGE) Navigator
ZP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZP4
genes like me logo Genes that share disorders with ZP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZP4 Gene

Publications for ZP4 Gene

  1. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. (PMID: 7841460) Harris J.D. … Sacco A.G. (DNA Seq. 1994) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 46 64
  4. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PMID: 19004505) Choudhury S. … Gupta S.K. (J. Reprod. Immunol. 2009) 3 22 64
  5. Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. (PMID: 19625618) Nakano M. … Tashiro K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 46 64

Products for ZP4 Gene

Sources for ZP4 Gene

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