Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZP4 Gene

protein-coding GIFtS: 50
GCID: GC01M238045

zona pellucida glycoprotein 4

Explore 6 diseases affiliated with
ZP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zona Pellucida Glycoprotein 4¹ ² ³		ZBP²
ZPB¹ ² ³ ⁵		ZP1²
Zona Pellucida Protein B² ³		Zona Pellucida B Protein²
Zp-4² ³		Zona Pellucida Sperm-Binding Protein 4²

External Ids:	HGNC: 15770¹	Entrez Gene: 57829²	Ensembl: ENSG00000116996⁷	OMIM: 613514⁵	UniProtKB: Q12836³

Export aliases for ZP4 gene to outside databases

Previous GC identifers: GC01M236178 GC01M233499 GC01M234342 GC01M235086 GC01M234371 GC01M236112 GC01M208497

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZP4:

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of

three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent

protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a

C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from

the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin

cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as

ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and

chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZP4_HUMAN, Q12836

Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome

reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and

ZP4. ZP4 may act as a sperm receptor

Gene Wiki entry for ZP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZP4 gene promoter:
c-Fos AP-1 NRSF form 1 HTF FOXD1 NRSF form 2 LCR-F1 CREB Zic1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZP4 promoter sequence

Search SABiosciences Chromatin IP Primers for ZP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43 Ensembl cytogenetic band: 1q43 HGNC cytogenetic band: 1q43

ZP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M238045: view genomic region (about GC identifiers)

Start:	238,041,164 bp from pter	End:	238,054,222 bp from pter
Size:	13,059 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZP4_HUMAN, Q12836 (See protein sequence)

Recommended Name: Zona pellucida sperm-binding protein 4 precursor

Size: 540 amino acids; 59400 Da

Subcellular location: Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular

matrix

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: B2RAE1

Explore the universe of human proteins at neXtProt for ZP4: NX_Q12836

Post-translational modifications:

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona

pellucida¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12836

ZP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067009.1

ENSEMBL proteins:

ENSP00000355529

Human Recombinant Protein Products for ZP4:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ZP4
	GenScript Custom Purified and Recombinant Proteins Services for ZP4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ZP4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005622	intracellular	--	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

ZP4 for ontologies About GeneDecksing

ZP4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ZP4
	GenScript Custom Superior Antibodies Services for ZP4
	Novus Biologicals ZP4 Antibodies
	Abcam antibodies for ZP4
	Uscn Antibodies for ZP4
	Search ThermoFisher Antibodies for ZP4

Assay Products for ZP4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ZP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZP4 for domains About GeneDecksing

4 InterPro domains/families:

IPR017977 ZP_dom_CS

IPR000519 P_trefoil

IPR001507 ZP_dom

IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry Q12836

ProtoNet protein and cluster: Q12836

2 Blocks protein families:

IPB000519 P-type trefoil domain

IPB001507 Endoglin/CD105 antigen

UniProtKB/Swiss-Prot: ZP4_HUMAN, Q12836

Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida

Similarity: Belongs to the ZP domain family. ZPB subfamily

Similarity: Contains 1 P-type (trefoil) domain

Similarity: Contains 1 ZP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZP4_HUMAN, Q12836

Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome

reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and

ZP4. ZP4 may act as a sperm receptor

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IMP	18667750
GO:0004872	receptor activity	--	--
GO:0032190	acrosin binding	IPI	15950651

ZP4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZP4:

Decreased viability with pacli

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZP4

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZP4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZP4:
		hsa-miR-607 hsa-miR-29b-1*
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZP4 OriGene shRNA RFP: ZP4 OriGene siRNA: ZP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZP4
		Sirion Biotech Custom design and validation of potent shRNA sequences against ZP4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ZP4
			Sirion Biotech Customized adenovirus for overexpression of ZP4 Sirion Biotech Customized adenovirus for potent knockdown of ZP4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZP4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for ZP4
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZP4
		Search LifeMap BioReagents cell lines for ZP4
		Sirion Biotech Customized stable knockdown cell line services for ZP4 Sirion Biotech Customized inducible knockdown cell line services for ZP4 Sirion Biotech Customized stable overexpressing cell line services for ZP4 Sirion Biotech Customized inducible overexpressing cell line services for ZP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZP4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZP4 (Q12836³ ENSP00000355529⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FURIN	P09958³, ENSP00000268171⁴	I2D: score=1 STRING: ENSP00000268171

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002922	positive regulation of humoral immune response	IDA	19004505
GO:0010737	protein kinase A signaling cascade	IDA	18667750
GO:0035556	intracellular signal transduction	IMP	18667750
GO:0042102	positive regulation of T cell proliferation	IDA	19004505
GO:0045860	positive regulation of protein kinase activity	IDA	18667750

ZP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZP4
Search CenterWatch for drugs/clinical trials and news about ZP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZP4 gene:

NM_021186.3

Unigene Cluster for ZP4:

Zona pellucida glycoprotein 4

Hs.136241 [show with all ESTs]

Unigene Representative Sequence: NM_021186

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000366570(uc001hym.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZP4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZP4:
		hsa-miR-607 hsa-miR-29b-1*
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZP4 OriGene shRNA RFP: ZP4 OriGene siRNA: ZP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZP4
		Sirion Biotech Custom design and validation of potent shRNA sequences against ZP4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZP4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for ZP4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat ZP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZP4

Additional cDNA sequence:

AK314151.1 BC069521.1

1 DOTS entry:

DT.91924499

6 AceView cDNA sequences:

NM_021186 BC069521 CB126151 AA169152 CB126325 AA169775

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTACTCC

About this image

ZP4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

CD31, CD144 positive cells (Two-step protocol fo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZP4

SOURCE GeneReport for Unigene cluster: Hs.136241

UniProtKB/Swiss-Prot: ZP4_HUMAN, Q12836

Tissue specificity: Oocytes

SABiosciences Custom PCR Arrays for ZP4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat ZP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZP4 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZP4¹	zona pellucida glycoprotein 4	63.69(n) 53.75(a)		395692 NM_204879.1 NP_990210.1
zebrafish (Danio rerio)	Actinopterygii	BM037412.1²	--	71.36(n)		BM037412.1

ENSEMBL Gene Tree for ZP4 (if available)
TreeFam Gene Tree for ZP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZP4 gene

ZP1² ZP2²

2 SIMAP similar genes for ZP4 using alignment to 1 protein entry: ZP4_HUMAN:

ZP1 ZP2

ZP4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183929792^1,2		--	238040679(+)	`CCCAAA/CGTGCT`	2	--	int¹ ds500¹		0	--	--	--	--
rs142745828^1,2		--	238040707(+)	`CCACCC/GCATCC`	2	--	ds500¹ int¹		0	--	--	--	--
rs188212596^1,2		--	238040719(+)	`GCCAGG/TTACAA`	2	--	ds500¹ int¹		0	--	--	--	--
rs57602791^1,2	C,F	--	238040727(+)	`CAACTT/GATTTT`	2	--	int¹ ds500¹		6		WA NA CSA EA	364
rs181990035^1,2		--	238040746(+)	`TCATCA/GGAGCC`	2	--	int¹ ds500¹		0	--	--	--	--
rs115089082^1,2		--	238040880(+)	`GGAGGC/TATCGG`	2	--	ds500¹ int¹		0	--	--	--	--
rs2893607^1,2	C,F,A,H	--	238040922(-)	`AAAGAG/CACTGT`	2	--	int¹ ds500¹		32		NS EA NA WA CSA	2956
rs185551887^1,2		--	238040993(+)	`GGCACA/TGCTAT`	2	--	ds500¹ int¹		0	--	--	--	--
rs190030561^1,2		--	238041063(+)	`AAACAA/GTAGCT`	2	--	ds500¹ int¹		0	--	--	--	--
rs181616044^1,2		--	238041073(+)	`TGACAG/TTTAGC`	2	--	ds500¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZP4 (238041164 - 238054222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZP4
3 CNVs: 8350 2353 3336

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZP4

DNA2.0 Custom Variant and Variant Library Synthesis for ZP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZP4 for disorders           About GeneDecksing

OMIM gene information: 613514    OMIM disorders: --

6 diseases for ZP4:    About MalaCards

oophoritis fatty liver disease liver disease glaucoma

multiple sclerosis infertility

2 diseases from the University of Copenhagen DISEASES database for ZP4:

Oophoritis Infertility

Human Genome Epidemiology (HuGE) Navigator: ZP4 (3 documents)

Export disorders for ZP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZP4 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with ZP4)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. (PubMed id 7841460)^{1, 2, 3, 9} Harris J.D....Sacco A.G. (1994)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PubMed id 19004505)^{1, 9} Choudhury S....Gupta S.K. (2009)
Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. (PubMed id 18667750)^{1, 9} Chiu P.C....Yeung W.S. (2008)
Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. (PubMed id 11291774)^{1, 9} Eberspaecher U....Donner P. (2001)
Biological effects of recombinant human zona pellucida proteins on sperm function. (PubMed id 16407501)^{1, 9} Caballero-Campo P....Gerton G.L. (2006)
Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)^{1, 9} Furlong L.I....Vazquez-Levin M.H. (2005)
Four zona pellucida glycoproteins are expressed in the human. (PubMed id 15142998)^{1, 9} Lefievre L....Barratt C.L. (2004)
Proteolytic processing of human zona pellucida proteins. (PubMed id 11804956)^{1, 9} Kiefer S.M. and Saling P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57829	HGNC: 15770	AceView: ZP4	Ensembl:ENSG00000116996	euGenes: HUgn57829
ECgene: ZP4	H-InvDB: ZP4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZP4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZP4 gene:
Search GeneIP for patents involving ZP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ZP4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZP4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZP4
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ZP4		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZP4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZP4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ZP4		OriGene Custom Protein Services for ZP4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZP4
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZP4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZP4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZP4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZP4

	GenScript Custom Purified and Recombinant Proteins Services for ZP4		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ZP4
	GenScript Custom Assay Services for ZP4		GenScript Custom Superior Antibodies Services for ZP4
	GenScript Custom overexpressing Cell Line Services for ZP4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ZP4 promoter
	Search Chromatin IP Primers for ZP4
	RT² qPCR Primer Assay in human, mouse / rat ZP4
	Search GNC Networks for ZP4
	SABiosciences Custom PCR Arrays for ZP4

Search Tocris compounds for ZP4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ZP4 antibodies

	Antibodies for ZP4
	See all of Abcam's Antibodies, Kits and Proteins for ZP4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ZP4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ZP4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP4

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ZP4
	SwitchGear Promoter luciferase reporter plasmids for ZP4

Search ThermoFisher Antibodies for ZP4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZP4

Sirion Biotech Customized:

	stable knockdown cell line services for ZP4
	inducible knockdown cell line services for ZP4
	design and validation of potent shRNA sequences against ZP4
	adenovirus for potent knockdown of ZP4
	adenovirus for overexpression of ZP4
	stable overexpressing cell line services for ZP4
	inducible overexpressing cell line services for ZP4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZP4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ZP4 Gene

zona pellucida glycoprotein 4

Aliases
for ZP4 gene

Summaries
for ZP4 gene

Genomic Views
for ZP4 gene

Proteins
for ZP4 gene

Protein Domains /
Families
for ZP4 gene

Function
for ZP4 gene

Pathways & Interactions
for ZP4 gene

Drugs & Compounds
for ZP4 gene

Transcripts
for ZP4 gene

Expression
for ZP4 gene

Orthologs
for ZP4 gene

Paralogs
for ZP4 gene

Genomic Variants
for ZP4 gene

Disorders / Diseases
for ZP4 gene

Publications
for ZP4 gene

External Searches for ZP4 gene

Genome Databases showing ZP4 gene

Other Databases showing ZP4 gene

Specialized Databases showing ZP4 gene

Intellectual Property
for ZP4 gene

Products
for ZP4 gene

View Random Gene

Advanced Search

Export list of displayed genes

ZP4 Gene

zona pellucida glycoprotein 4

Aliasesfor ZP4 gene

Summariesfor ZP4 gene

Genomic Viewsfor ZP4 gene

Proteinsfor ZP4 gene

Protein Domains /Familiesfor ZP4 gene

Functionfor ZP4 gene

Pathways & Interactionsfor ZP4 gene

Drugs & Compoundsfor ZP4 gene

Transcriptsfor ZP4 gene

Expression for ZP4 gene

Orthologsfor ZP4 gene

Paralogsfor ZP4 gene

Genomic Variantsfor ZP4 gene

Disorders / Diseasesfor ZP4 gene

Publicationsfor ZP4 gene

External Searches for ZP4 gene

Genome Databases showing ZP4 gene

Other Databases showing ZP4 gene

Specialized Databases showing ZP4 gene

Intellectual Propertyfor ZP4 gene

Productsfor ZP4 gene

View Random Gene

Aliases
for ZP4 gene

Summaries
for ZP4 gene

Genomic Views
for ZP4 gene

Proteins
for ZP4 gene

Protein Domains /
Families
for ZP4 gene

Function
for ZP4 gene

Pathways & Interactions
for ZP4 gene

Drugs & Compounds
for ZP4 gene

Transcripts
for ZP4 gene

Expression
for ZP4 gene

Orthologs
for ZP4 gene

Paralogs
for ZP4 gene

Genomic Variants
for ZP4 gene

Disorders / Diseases
for ZP4 gene

Publications
for ZP4 gene

Intellectual Property
for ZP4 gene

Products
for ZP4 gene