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ZP3 Gene

protein-coding   GIFtS: 53

GC07P075864
zona pellucida glycoprotein 3 (sperm receptor)
(Previous name: zona pellucida glycoprotein 3A (sperm receptor) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ZP3A, ZP3B)
Services    

Aliases &
Descriptions
for ZP3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ZP3-372 1
ZP3-424 1
ZP3A 2, 3, 5
ZP3A/ZP3B 3
ZP3B 2, 3, 5
ZPC 2, 3
Descriptions
Sperm receptor 3
Zona pellucida glycoprotein ZP3 3
Zona pellucida protein C 2, 3
zona pellucida glycoprotein 3 2
zona pellucida glycoprotein 3 (sperm receptor) 2
zona pellucida glycoprotein 3A (sperm receptor) 1, 2
zona pellucida glycoprotein 3B 2
zona pellucida sperm-binding protein 3 2
External Ids
HGNC: 131891
Entrez Gene: 77842
UniProtKB: P217543
Ensembl: ENSG000001883727
Search outside databases for aliases for ZP3 gene

Previous GC identifers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671

Summaries
for ZP3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for ZP3:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is
composed primarily of three or four glycoproteins with various functions during fertilization and
preimplantation development. The protein encoded by this gene is a structural component of the
zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The
nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal
consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage
results in release of the mature protein from the plasma membrane for subsequent incorporation
into the zona pellucida matrix. However, the requirement for furin cleavage in this process
remains controversial based on mouse studies. A variation in the last exon of this gene has
previously served as the basis for an additional ZP3 locus; however, sequence and literature
review reveals that there is only one full-length ZP3 locus in the human genome. Another locus
encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of
ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of
the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four
glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix
formation

Genomic Location
for ZP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZP3 gene  

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC chromosome: 7

ZP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P075864:     (about GC identifiers)

Start:
 75,864,777 bp from pter
End:
 75,909,324 bp from pter
Size:
 44,548 bases
Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,359,932-75,404,452     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079595.2  

Proteins
for ZP3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 3 precursor  
Size: 424 amino acids; 47029 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By
similarity)
Subcellular location: Processed zona pellucida sperm-binding protein 3: Secreted, extracellular
space, extracellular matrix
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q06633
Alternative splicing: 2 isoforms:  P21754-1   P21754-2   

Post-translational modifications:

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain
    incorporated in the zona pellucida1
  • N-glycosylated (By similarity)1
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization
    block to polyspermy (By similarity)1


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001103824.1  NP_009086.4  


    ENSEMBL proteins: 
    ENSP00000378329 ENSP00000378326 ENSP00000337310 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZP3)
    Human Recombinant Proteins from Abnova (ZP3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ZP3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZP3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZP3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ZP3)
    Novus Biologicals Antibody for ZP3

    Assays for ZP3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ZP3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR017977 Endoglin/CD105_CS
     IPR017976 Endoglin/CD105_subgr
     IPR001507 Endoglin/CD105


       GeneDecks  ZP3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P21754

    ProtoNet protein and cluster: P21754

    1 Blocks protein family: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona
    pellucida
    Similarity: Belongs to the ZP domain family. ZPC subfamily
    Similarity: Contains 1 ZP domain

    Gene Function
    for ZP3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZP3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZP3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001110354

                  Applied Biosystems Silencer® siRNAs for ZP3

                  Sigma-Aldrich siRNA and siRNA Panels for ZP3  
                         Sigma-Aldrich shRNA Panels and shRNA for ZP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001110354
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001110354
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001110354 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001110354

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of
    the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four
    glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix
    formation

    3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zp3):

    embryogenesisendocrine/exocrine glandreproductive system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0032190 acrosin binding IPI15950651
    About this table

    Pathways & Interactions
    for ZP3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/9 Interacting proteins for ZP3 (ENSP000003373103) via UniProtKB, MINT, and/or STRING (see all 9 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIGLAENSP000003330973STRING (score=.948)
    FURINENSP000002681713STRING (score=.927)
    ACRENSP000002161393STRING (score=.886)
    RNF130ENSP000002619473STRING (score=.841)
    PLAC1ENSP000003521733STRING (score=.834)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007338 single fertilization IEA--
    About this table

    Drugs & Compounds
    for ZP3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZP3
    5 Novoseek chemical compound relationships for ZP3 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 32.27 2 7507936 (1)
    tyrosine 23.75 9 8045346 (2), 9665632 (1), 15317909 (1), 9872364 (1) (see all 6)
    calcium 21.58 4 9239670 (1), 12464273 (1), 9651467 (1), 8088433 (1)
    progesterone 18.34 2 12464273 (1), 9651467 (1)
    proline 1.28 2 10216914 (2)
    About this table


    Transcripts
    for ZP3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZP3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZP3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001110354

                  Sigma-Aldrich siRNA and siRNA Panels for ZP3  
                         Sigma-Aldrich shRNA Panels and shRNA for ZP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001110354  NM_007155  

    REFSEQ mRNAs for ZP3 gene (2 alternative transcripts): 

    NM_001110354.1   NM_007155.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001110354  NM_007155  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001110354
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001110354
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001110354 

    Additional cDNA sequence: 

    AK292763.1 BC113949.1 CR606111.1 CR623130.1 M60504.1 S52509.1 

    13 DOTS entries:

    DT.95145133  DT.121067326  DT.92469787  DT.100027278  DT.95145124  DT.95145163  DT.100790706  DT.121637693 
    DT.95266574  DT.95293148  DT.97769393  DT.121090535  DT.95362005 

    24/159 AceView cDNA sequences (see all 159 ):

    BQ446470 CR603033 AW162786 BF195407 AI802299 AI075996 CR616549 AI359326 
    BF726964 BF063092 BU681121 BC000487 AW249685 CB120286 BX427701 NM_152992 
    AA383329 BQ673059 AW163456 AI149712 BE893300 AA334331 BV205866 BU754600 

    highest scoring ESTs for ZP3:

    AA483619 AI634746 AK056788 AL578043 AL581007 AW672729 BG180872 BG459642 BG459670 BG459764 

    Unigene Cluster for ZP3:

    Zona pellucida glycoprotein 3 (sperm receptor)
    Hs.656137  [show with all ESTs]
    Unigene Representative Sequence: BC113949


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP3

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      
    SP3:                                -     -               

    About this scheme

    ECgene alternative splicing isoforms for ZP3

    3 Ensembl transcripts including schematic representations:
    ENST00000394860  ENST00000394857  ENST00000336517  

    Expression
    for ZP3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZP3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZP3

    1 / 2 / 3

    6 probe-sets matching ZP3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		39719_at2, 3 U95-A 2 1.00 0.50 0.97 0.82 X56777 0.60 0.83 0.73 1

    		39720_g_at2, 3 U95-A 2 0.94 0.47 0.88 1.18 X56777 0.60 0.83 0.73 1

    		204148_s_at2, 3 U133-A 2 1.00 0.50 -- -- NM_012230 0.20 0.17 0.18 2

    		210910_s_at2, 3 U133-A 2 1.00 0.50 -- -- BC000487 0.20 0.17 0.18 2

    		204148_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --

    		210910_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAGTAGAGCA

    SOURCE GeneReport for Unigene cluster: Hs.656137

    Expression variation in blood from EXPOLDB for ZP3

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Tissue specificity: Oocytes

    Orthologs
    for ZP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZP3 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ZP31   -- zona pellucida glycoprotein 3 (sperm receptor) 80.74(n)
    74.66(a)    		 403894  NM_001003224.1  NP_001003224.1 
    chimpanzee
    (Pan troglodytes)    		 ZP31   -- zona pellucida glycoprotein 3 (sperm receptor) 99.56(n)
    99.12(a)    		 472662  XM_528035.2  XP_528035.2 
    cow
    (Bos taurus)    		 ZP31   -- zona pellucida glycoprotein 3 (sperm receptor) 81.59(n)
    74.45(a)    		 280964  NM_173974.2  NP_776399.1 
    rat
    (Rattus norvegicus)    		 Zp31   -- zona pellucida glycoprotein 3 (sperm receptor) 75.18(n)
    68.21(a)    		 114639  NM_053762.1  NP_446214.1 
    mouse
    (Mus musculus)    		 Zp31, 5 5 (77.00 cM)5
    		 zona pellucida glycoprotein 31, 5 75.82(n)1
    69.57(a)1    		 227881  NM_011776.11  NP_035906.11 
     AK1319345  BC0994655  (see all 14)
    About this table        Species with no ortholog for ZP3

    ENSEMBL Gene Tree for ZP3

    Paralogs
    for ZP3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZP3 gene
    POMZP32  

    SNPs/Variants
    for ZP3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/263 NCBI SNPs in ZP3 are shown (see all 263 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 33)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs29069991,2
    		C,F,H,O75907747(-) AGCCGG/AGCCTT 2 P/S mis17Minor allele frequency- A:0.40EU EA WA NA 542
    rs22864281,2
    		C,F,H75892308(-) GGCTCC/TACCCT 2 G/R mis1 ut514Minor allele frequency- T:0.11EU EA WA 420
    --
    rs29069971,2
    		F,H75907822(-) GCTCAT/CGACAT 2 V/M mis14Minor allele frequency- C:0.04EU EA WA 400
    rs28683661,2
    		A,C,F,H75888068(-) atcttC/Tatatt 1 -- int18Minor allele frequency- T:0.44EU EA WA NA 632
    rs119830261,2
    		A,C,F,H75884834(+) TGACAC/AGTAGA 1 -- int14Minor allele frequency- A:0.25EU EA WA 366
    rs96405781,2
    		A,C,F,H75892825(+) GCCTGC/GGTGAT 1 -- int18Minor allele frequency- G:0.29EU EA WA 834
    --
    rs10190961,2
    		A,C,F,H75884260(-) GGGGAC/TGCTTT 1 -- int116Minor allele frequency- N:0.00EU EA WA NA 1466
    rs37898391,2
    		A,C,F,H75898469(+) CTATGA/TGGGTA 1 -- int17Minor allele frequency- T:0.46EA EU WA NA 2098
    rs37898331,2
    		C,F,H75897497(+) GCGTTC/TTAGAA 1 -- int111Minor allele frequency- T:0.20EU EA WA NA 982
    --
    rs102787061,2
    		A,F,H75880454(+) catggC/Tctccc 1 -- int14Minor allele frequency- T:0.12EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for ZP3 (up to first 250kb)

    Disorders & Mutations
    for ZP3

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 182889

    2 Novoseek disease relationships for ZP3 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian dysfunction 79.34 2 10321806 (1)
    infertility 51.18 7 8984175 (1), 17936279 (1), 11730908 (1), 1576251 (1) (see all 6)
    About this table

    Medical News
    for ZP3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ZP3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/122 PubMed articles for ZP3 gene (see all 122 ):

    Search for ZP3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZP3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 7784 HGNC: 13189 AceView: POMZP3 Ensembl:ENSG00000188372 euGenes: HUgn7784
    ECgene: ZP3 H-InvDB: ZP3

    Other Databases showing ZP3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing ZP3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Protein Spotlighthttp://www.expasy.org/spotlight/back_issues/sptlt093.shtml

    Licensable Technologies
    for ZP3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ZP3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZP3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZP3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZP3 Antibodies for ZP3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZP3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
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     Antibodies for ZP3

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