Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZP3 Gene

protein-coding   GIFtS: 56
GCID: GC07P076026

Zona Pellucida Glycoprotein 3 (Sperm Receptor)

(Previous name: zona pellucida glycoprotein 3A (sperm receptor))
(Previous symbols: ZP3A, ZP3B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zona Pellucida Glycoprotein 3 (Sperm Receptor)1 2     ZPC2 3
ZP3A1 2 3 5     Zp-32 3
ZP3B1 2 3 5     Zona Pellucida Glycoprotein 3B2
Zona Pellucida Glycoprotein 3A (Sperm Receptor)1 2     Zona Pellucida Glycoprotein ZP32
Sperm Receptor2 3     Zona Pellucida Sperm-Binding Protein 32
Zona Pellucida Protein C2 3     Zona Pellucida Glycoprotein 33
ZP3A/ZP3B2 3     

External Ids:    HGNC: 131891   Entrez Gene: 77842   Ensembl: ENSG000001883727   OMIM: 1828895   UniProtKB: P217543   

Export aliases for ZP3 gene to outside databases

Previous GC identifers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671 GC07P075864 GC07P071113


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZP3 Gene:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily
of three or four glycoproteins with various functions during fertilization and preimplantation development. The
protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and
induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a
conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized
that furin cleavage results in release of the mature protein from the plasma membrane for subsequent
incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains
controversial based on mouse studies. A variation in the last exon of this gene has previously served as the
basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one
full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3
contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely
to this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZP3 Gene: 
ZP3 (zona pellucida glycoprotein 3 (sperm receptor)) is a protein-coding gene. Diseases associated with ZP3 include haverhill fever, and sodoku disease, and among its related super-pathways are Interaction With The Zona Pellucida and Cellular Effects of Sildenafil. GO annotations related to this gene include store-operated calcium channel activity and signal transducer activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
and ZP4. ZP3 is essential for sperm binding and zona matrix formation

Gene Wiki entry for ZP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZP3 gene promoter:
         E2F-4   E2F-3a   SRY   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

ZP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076026:  view genomic region     (about GC identifiers)

Start:
76,026,835 bp from pter      End:
76,071,388 bp from pter
Size:
44,554 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,359,905-75,404,452     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 3 precursor  
Size: 424 amino acids; 47018 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)
Subcellular location: Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space,
extracellular matrix
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q06633 Q29RW0
Alternative splicing: 3 isoforms:  P21754-1   P21754-2   P21754-3   (Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids)

Explore the universe of human proteins at neXtProt for ZP3: NX_P21754

Explore proteomics data for ZP3 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona
    pellucida
  • UniProtKB: N-glycosylated (By similarity)
  • UniProtKB: O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to
    polyspermy (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21754

  • ZP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001103824.1  NP_009086.4  

    ENSEMBL proteins: 
     ENSP00000337310   ENSP00000378326   ENSP00000411955   ENSP00000378329  
    Reactome Protein details: P21754
    Human Recombinant Protein Products for ZP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZP3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZP3
    GenScript Custom Purified and Recombinant Proteins Services for ZP3
    Novus Biologicals ZP3 Protein
    Novus Biologicals ZP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZP3 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669colocalizes with acrosomal vesicle ISS--
    GO:0002081outer acrosomal membrane ISS--
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IMP19246320

    ZP3 for ontologies           About GeneDecksing



    ZP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZP3
    GenScript Custom Superior Antibodies Services for ZP3
    Novus Biologicals ZP3 Antibodies
    Abcam antibodies for ZP3
    Cloud-Clone Corp. Antibodies for ZP3 
    Search ThermoFisher Antibodies for ZP3
    LSBio Antibodies in human, mouse, rat for ZP3 

    Assay Products for ZP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZP3 
    Cloud-Clone Corp. CLIAs for ZP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZP: Zona pellucida glycoproteins

    2 InterPro protein domains:
     IPR017977 ZP_dom_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P21754

    ProtoNet protein and cluster: P21754

    1 Blocks protein domain: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
    Similarity: Belongs to the ZP domain family. ZPC subfamily
    Similarity: Contains 1 ZP domain


    ZP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZP3_HUMAN, P21754
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
    reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
    and ZP4. ZP3 is essential for sperm binding and zona matrix formation

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP18667750
    GO:0005384manganese ion transmembrane transporter activity ISS--
    GO:0005515protein binding IPI19945174
    GO:0015279store-operated calcium channel activity IDA--
    GO:0030246carbohydrate binding IDA19246320
         
    ZP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZP3:
     Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zp3):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    ZP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZP3: Zp3tm1Dean Zp3tm1Pmw

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZP3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZP3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZP3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZP3
    Sirion Biotech Customized adenovirus for overexpression of ZP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZP3 (see all 11)
    OriGene ORF clones in mouse, rat for ZP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZP3 (NM_001110354)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP3
    Sirion Biotech Customized lentivirus for stable overexpression of ZP3 
                         Customized lentivirus expression plasmids for stable overexpression of ZP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZP3
    Search LifeMap BioReagents cell lines for ZP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fertilization
    Fertilization0.38
    Interaction With The Zona Pellucida0.38
    Reproduction0.38
    2Sweet Taste Signaling
    Sperm Motility0.37
    3Ovarian Infertility Genes
    Ovarian Infertility Genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ZP3
        Sperm Motility

    1 BioSystems Pathway for ZP3
        Ovarian Infertility Genes

    3        Reactome Pathways for ZP3
        Fertilization
    Reproduction
    Interaction With The Zona Pellucida



    ZP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ZP3 (P217543 ENSP000003783264) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACRP103233, ENSP000002161394I2D: score=2 STRING: ENSP00000216139
    C4BPAP040033, ENSP000003560374I2D: score=1 STRING: ENSP00000356037
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    ENGASEQ8NFI33, ENSP000003006824I2D: score=1 STRING: ENSP00000300682
    UBAP2LENSP000003553434STRING: ENSP00000355343
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001809positive regulation of type IV hypersensitivity ISS--
    GO:0001825blastocyst formation ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0002687positive regulation of leukocyte migration ISS--
    GO:0002922positive regulation of humoral immune response IDA19004505

    ZP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZP3

    9 Novoseek inferred chemical compound relationships for ZP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 30.9 2 7507936 (1)
    calcium 24.6 4 9239670 (1), 12464273 (1), 9651467 (1), 8088433 (1)
    tyrosine 22.5 9 8045346 (2), 9665632 (1), 15317909 (1), 9872364 (1) (see all 6)
    carbohydrates 19.5 3 1311731 (1), 11358873 (1), 9225165 (1)
    cysteine 17.3 3 10216911 (1), 10216914 (1)
    progesterone 17.1 2 12464273 (1), 9651467 (1)
    serine 7.14 2 9600940 (1), 10216914 (1)
    proline 0 2 10216914 (2)
    polysaccharide 0 1 11358873 (1)

    Search CenterWatch for drugs/clinical trials and news about ZP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZP3 gene (2 alternative transcripts): 
    NM_001110354.1  NM_007155.5  

    Unigene Cluster for ZP3:

    Zona pellucida glycoprotein 3 (sperm receptor)
    Hs.656137  [show with all ESTs]
    Unigene Representative Sequence: BC113949
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336517(uc003ufc.4) ENST00000394857(uc003ufd.4) ENST00000416245(uc003ufe.3)
    ENST00000394860 ENST00000466960 ENST00000479793 ENST00000467555
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZP3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZP3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZP3
    Clone
    Products:
         
    OriGene clones in human, mouse for ZP3 (see all 11)
    OriGene ORF clones in mouse, rat for ZP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZP3 (NM_001110354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP3
    Sirion Biotech Customized lentivirus for stable overexpression of ZP3 
                         Customized lentivirus expression plasmids for stable overexpression of ZP3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZP3

    Additional mRNA sequence: 

    AK292763.1 BC113949.1 M60504.1 S52509.1 

    13 DOTS entries:

    DT.95145133  DT.121067326  DT.92469787  DT.100027278  DT.95145163  DT.100790706  DT.121637693  DT.95145124 
    DT.95266574  DT.95293148  DT.97769393  DT.121090535  DT.95362005 

    24/159 AceView cDNA sequences (see all 159):

    BF195407 CR616549 BQ446470 AI075996 BF063092 AI802299 AW162786 BF726964 
    AI359326 CR603033 AA479708 CB120286 BQ961240 BF983753 BU681121 BU754600 
    AI042214 AW163456 BV205867 AI640266 BU186061 AW249685 BX427701 NM_012230 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      
    SP3:                                -     -               


    ECgene alternative splicing isoforms for ZP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZP3 expression in normal human tissues (normalized intensities)      ZP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAGAGCA
    ZP3 Expression
    About this image


    ZP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 7 entries
             Pre-Granulosa Cells Primordial Follicle
             Ovarian tissue-dissociated cells (human)
             oocyte   
     
     Testis (Reproductive System)
             sperm   
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
     
     Gonad
             Ovum Ovigerous Cord

    See ZP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZP3

    SOURCE GeneReport for Unigene cluster: Hs.656137

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Tissue specificity: Oocytes

        SABiosciences Custom PCR Arrays for ZP3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZP3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zp31 , 5 zona pellucida glycoprotein 31, 5 74.54(n)1
    68.26(a)1
      5 (75.62 cM)5
    227881  NM_011776.11  NP_035906.11 
     1359800995 
    chicken
    (Gallus gallus)
    Aves LOC4153141 zona pellucida glycoprotein 3 (sperm receptor)-like 62.64(n)
    56.54(a)
      415314  XM_413701.3  XP_413701.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    45(a)
    28(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    GL343492.1(388222-397508)
    1(90830340-90843428)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37152 Xenopus laevis transcribed sequence with weak similarity more 73.25(n)    BX851629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zp3a.21 zona pellucida glycoprotein 3a.2 52.13(n)
    41.49(a)
      558677  NM_001030120.1  NP_001025291.1 


    ENSEMBL Gene Tree for ZP3 (if available)
    TreeFam Gene Tree for ZP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZP3 gene
    POMZP32  
    2 SIMAP similar genes for ZP3 using alignment to 3 protein entries:     ZP3_HUMAN (see all proteins):
    ZP3A    POMZP3

    ZP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZP3
    PGOHUM00000235302 PGOHUM00000233581


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    756/873 SNPs in ZP3 are shown (see all 873)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102332641,2
    C,H--76041038(+) gatacT/Cctgaa 1 -- int16Minor allele frequency- C:0.00NS EA NA 424
    rs1929065001,2
    --76041118(+) GCATTC/TATCCA 1 -- int10--------
    rs602664061,2
    C,F--76041135(+) ATGAAA/CACTTA 1 -- int14Minor allele frequency- C:0.20WA CSA 124
    rs1166812041,2
    F--76041143(+) TTACAT/CCTTCA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs745704371,2
    C--76041252(+) TGCCTG/TTAGTC 1 -- int10--------
    rs102335361,2
    C--76041292(+) atcacT/Ctgagc 1 -- int14Minor allele frequency- C:0.09NA WA EA 242
    rs1178259781,2
    F--76041340(+) CTCCAA/GCTCTA 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1452610461,2
    --76041344(+) AACTCA/TACAAA 1 -- int10--------
    rs733615931,2
    C,F--76041380(+) GATTCT/CTGTGG 1 -- int13Minor allele frequency- C:0.11WA CSA 122
    rs1852646391,2
    --76041397(+) CTACAC/TGAGAG 1 -- int10--------
    rs21087681,2
    C,F,A--76041449(-) CAGCTC/GACTGC 1 -- int17Minor allele frequency- G:0.15NA CSA WA EA 365
    rs2000424241,2
    C--76041504(+) AAAAA-/A/AA  
            
    GAAAA
    1 -- int10--------
    rs1379542361,2
    --76041520(+) AAAAA-/GAAAAG 1 -- int10--------
    rs2022193691,2
    C--76041520(-) CTTTTC/TTTTTT 1 -- int10--------
    rs1476112641,2
    --76041673(+) TGCACA/GGGTGA 1 -- int10--------
    rs1428167931,2
    C--76041764(+) TATTT-/ATGATGAT 1 -- int10--------
    rs1423119741,2
    C--76041836(+) TATCAC/TGTCAT 1 -- int10--------
    rs1114000951,2
    C,F--76042043(+) TGCCTG/ATAATC 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1881311771,2
    --76042090(+) GAACCC/TGGGAG 1 -- int10--------
    rs1917163731,2
    C--76042098(+) GAGGCA/GGAAGT 1 -- int10--------
    rs1132207911,2
    C,F--76042162(+) ACTCCG/ATCTCA 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1838840991,2
    --76042227(+) ACACAG/TCCCTA 1 -- int10--------
    rs1175851041,2
    C,F--76042270(+) GTCTTC/ATTCTT 1 -- int11Minor allele frequency- A:0.08EA 120
    rs2011430801,2
    C--76042279(+) TTCTT-/T/TT  
            
    TCTTT
    1 -- int10--------
    rs1129043251,2
    C--76042282(+) TTCTTC/TTTTTT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs2022389461,2
    C--76042282(+) TTCTT-/CTTTTT 1 -- int10--------
    rs759102041,2
    C--76042409(+) CAAGTG/AGCTGG 1 -- int12Minor allele frequency- A:0.25WA CSA 4
    rs1883810551,2
    --76042445(+) CAGCTA/TATTGT 1 -- int10--------
    rs102787061,2
    C,F,A,H--76042518(+) catggC/Tctccc 1 -- int16Minor allele frequency- T:0.14NS EA WA 658
    rs1388331291,2
    --76042570(+) GCTGTG/TCCTGG 1 -- int10--------
    rs1405972751,2
    --76042650(+) TACTGA/CAGCCT 1 -- int10--------
    rs102485831,2
    C,F--76042684(+) cttccG/Acctca 1 -- int12Minor allele frequency- A:0.16WA EA 238
    rs1159146791,2
    --76042707(+) CCTGCA/GTAGCT 1 -- int10--------
    rs2001827071,2
    --76042754(+) CTGTA-/TTTTTT 1 -- int10--------
    rs69570801,2
    C,F--76042776(+) tcaggG/Tttttg 1 -- int15Minor allele frequency- T:0.24NA WA CSA 125
    rs1807482811,2
    --76042781(+) GTTTTA/GCCATG 1 -- int10--------
    rs763533531,2
    C--76042923(+) AAAAC-/TTTTTT 1 -- int10--------
    rs357620691,2
    C,F--76042931(+) AAAAA-/AGCCTC 1 -- int14Minor allele frequency- A:0.38NA CSA 8
    rs1849589641,2
    --76043036(+) TGGAGG/TGTAGT 1 -- int10--------
    rs1904537271,2
    --76043129(+) CAGGCA/GTGCGC 1 -- int10--------
    rs1458367271,2
    --76043164(+) TTTTTC/TGAAGA 1 -- int10--------
    rs64651231,2
    C,A--76043166(+) ttttgA/Tagaga 1 -- int15Minor allele frequency- T:0.40WA CSA EA 243
    rs1134884661,2
    C--76043316(+) TCTTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2012629241,2
    --76043331(+) TTTTT-/TGAGACA 1 -- int10--------
    rs1138845511,2
    C,F--76043396(+) GCAACC/TTCCAC 1 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1112566351,2
    C,F--76043442(+) CCAAGC/TAGCTG 1 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1117526571,2
    C,F--76043515(+) TGCCAC/TGTTGC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs102525721,2
    C--76043598(+) tgtgaA/Gccact 1 -- int10--------
    rs1172203581,2
    C,F--76043715(+) CTGACA/CTGAGA 1 -- int11Minor allele frequency- C:0.04NA 120
    rs1160133371,2
    C--76043787(+) GCCTGA/GCATGA 1 -- int10--------
    rs1819108241,2
    --76043953(+) TCATGA/CAGGAA 1 -- int10--------
    rs81807311,2
    C,A--76044031(+) tttttT/Attttt 1 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs772192321,2
    C--76044075(+) GTGCAG/ATGCTG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs81808021,2
    C,A--76044087(+) gatctC/Tggctc 1 -- int11Minor allele frequency- T:0.00NA 2
    rs733631031,2
    C--76044103(+) CCCACG/CTGCGC 1 -- int12Minor allele frequency- C:0.25WA CSA 4
    rs3741526001,2
    C--76044145(-) TACTTA/GGGAGG 1 -- int10--------
    rs2012723981,2
    C--76044146(-) CTACTC/TGGGAG 1 -- int10--------
    rs1112615111,2
    C,F--76044151(+) AAGTAG/ACTGGC 1 -- int13Minor allele frequency- A:0.50NA WA 6
    rs1507134861,2
    C--76044378(+) TTACAA/GTTACG 1 -- int10--------
    rs1120952341,2
    C--76044458(+) AAGGCC/GGAGGT 1 -- int10--------
    rs593233491,2
    C--76044459(+) AGGCCA/GAGGTG 1 -- int10--------
    rs1869333941,2
    --76044474(+) GATCAC/TGTGAG 1 -- int10--------
    rs1850687051,2
    C--76044580(+) TGGGAA/GGCTGA 1 -- int10--------
    rs800330371,2
    C--76044638(+) AGATCG/ACGCCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1404611631,2
    C--76044648(+) ACTGCA/CCTTCA 1 -- int10--------
    rs1913218301,2
    --76044676(+) GACTCC/TGTCTC 1 -- int10--------
    rs733631051,2
    C,F--76044717(+) AGCACA/C/TAACTA 1 -- int13WA CSA 6
    rs1441850441,2
    C--76044725(+) CTATT-/AAC   
      TATGAC
    AACTA
    1 -- int10--------
    rs2015938941,2
    --76044737(+) ACAAC-/TATGACAA 1 -- int10--------
    rs1997352421,2
    --76044741(+) CTATG-/ACAACT
            
    GTTAC
    1 -- int10--------
    rs763116421,2
    C,F--76044746(+) ACAACT/GGTTAC 1 -- int11Minor allele frequency- G:0.11WA 118
    rs1116666141,2
    C,F--76044757(+) CAATGG/TCTGGG 1 -- int13Minor allele frequency- T:0.06NA WA 240
    rs1497487711,2
    --76044808(+) TTATTA/TTTTAT 1 -- int10--------
    rs1853297741,2
    --76044842(+) GTCTCA/GCTTTG 1 -- int10--------
    rs1897463711,2
    --76044879(+) AGTCTC/GGGCTC 1 -- int10--------
    rs624768451,2
    C--76044896(+) ACCTCC/TGCCTC 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1820476391,2
    --76044897(+) CCTCTA/GCCTCC 1 -- int10--------
    rs624768461,2
    C--76044969(+) CCACAC/ACCGGC 1 -- int12Minor allele frequency- A:0.00NA CSA 3
    rs1422902741,2
    C--76044972(+) CAACCA/GGCTAA 1 -- int10--------
    rs1467840361,2
    --76045166(+) CTAGGA/GCTAGC 1 -- int10--------
    rs1889552171,2
    --76045173(+) TAGCCA/GCAGTG 1 -- int10--------
    rs1922421571,2
    --76045239(+) GTCAGA/GATTTC 1 -- int10--------
    rs624768471,2
    C,F--76045245(+) ATTTCG/AAGACC 1 -- int15Minor allele frequency- A:0.22NA WA CSA 9
    rs1456666301,2
    C--76045283(+) CTCTAC/TTAAAA 1 -- int10--------
    rs1835700431,2
    --76045317(+) TGTTGC/TACACC 1 -- int10--------
    rs624768481,2
    C--76045513(+) GCTGAA/GGCAGG 1 -- int13Minor allele frequency- G:0.20NA CSA 5
    rs1885628211,2
    --76045673(+) CCCTGG/TAAGTC 1 -- int10--------
    rs1139863161,2
    C,F--76045682(+) TCGAGG/ACTGCA 1 -- int11Minor allele frequency- A:0.10EA 120
    rs1132512291,2
    C,F--76045993(+) CACCTA/GTAGTC 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1413322801,2
    --76046028(+) GGAGAA/GTCGCT 1 -- int10--------
    rs1842424751,2
    --76046035(+) CGCTTA/GAGCCT 1 -- int10--------
    rs1870274431,2
    --76046074(+) TCATGC/TCATTG 1 -- int10--------
    rs1914491311,2
    --76046081(+) ATTGCA/TCTCCA 1 -- int10--------
    rs2020674661,2
    C--76046112(+) TGCTG-/TCTCTCT 1 -- int10--------
    rs10190981,2
    C--76046133(-) ATATAG/TAGAGA 1 -- int1 trp32Minor allele frequency- T:0.42NA EA 122
    rs132257001,2
    --76046135(+) TCTCTA/CTATAT 1 -- int10--------
    rs1117557161,2
    F--76046144(+) ATATAC/TACATA 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1905518531,2
    --76046164(+) ATATAA/CACACA 1 -- int10--------
    rs10190971,2
    C,F,A,H--76046184(-) tatgtG/Atgtat 1 -- int12Minor allele frequency- A:0.50NA 4
    rs2008299451,2
    --76046198(+) CACAC-/ATATACA 1 -- int10--------
    rs2018983541,2
    --76046201(+) CACAT-/ACATATA 1 -- int10--------
    rs1466426991,2
    C--76046211(+) TATAT-/ACACATA 1 -- int10--------
    rs2002276271,2
    --76046222(+) ACATA-/TGTATAC 1 -- int10--------
    rs715211231,2
    C--76046263(+) CATAC-/AT    
       
    /ATAT
    ATATA
    1 -- int11NA 2
    rs2012735841,2
    --76046284(+) ATATA-/TA    
       TATAT
    AATTT
    1 -- int10--------
    rs102323331,2
    C,A,H--76046290(+) atataA/TaATTT 1 -- int10--------
    rs10190961,2
    C,F,A,H--76046324(-) GGGGAC/TGCTTT 1 -- int135Minor allele frequency- N:0.00NS EA NA WA CSA 3400
    rs586468821,2
    C,F--76046460(+) ACCTCC/TGCCTC 1 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1823252571,2
    --76046490(+) CTGCCA/GCAGCC 1 -- int10--------
    rs1435316451,2
    --76046532(+) ACCATA/GCCCGG 1 -- int10--------
    rs1852834821,2
    --76046535(+) ATGCCC/TGGCTA 1 -- int10--------
    rs1471565651,2
    --76046556(+) TTTTCA/GGTAAA 1 -- int10--------
    rs117717271,2
    C,F,H--76046603(+) ACTCCC/TAACCT 1 -- int12Minor allele frequency- T:0.10NA EA 240
    rs119830261,2
    C,F,A,H--76046898(+) TGACAC/AGTAGA 1 -- int120Minor allele frequency- A:0.30NS EA NA WA CSA 2238
    rs1889987621,2
    --76047114(+) CTTGCA/GGAGAT 1 -- int10--------
    rs1813941651,2
    --76047185(+) CTCCAC/TCTCCC 1 -- int10--------
    rs119831121,2
    C,F,H--76047206(+) gattaC/Taggca 1 -- int13Minor allele frequency- T:0.33NA WA CSA 6
    rs1421799381,2
    --76047217(+) TGAGCC/TACCAT 1 -- int10--------
    rs1995883611,2
    --76047253(+) CTTTC-/TTTTCT 1 -- int10--------
    rs2006697321,2
    --76047256(+) TTCTT-/TCTTTTT 1 -- int10--------
    rs119831331,2
    C,F,H--76047257(+) tctttT/Cttttt 1 -- int1 trp34Minor allele frequency- C:0.29NA WA CSA 7
    rs1127534971,2
    C--76047257(+) TCTTTC/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2010958641,2
    --76047260(+) TCTTT-/CTTTTT 1 -- int10--------
    rs569843481,2
    --76047297(+) TTGCCA/CAGGCT 1 -- int10--------
    rs1900894021,2
    --76047562(+) TTTTTA/TAAAAC 1 -- int10--------
    rs1125743261,2
    C,F--76047683(+) GCCAAC/TGTGGT 1 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1392056871,2
    --76047783(+) GAATCA/GCTTGA 1 -- int10--------
    rs1809889261,2
    --76047807(+) AGGTTA/GCAGTG 1 -- int10--------
    rs624768491,2
    C--76047811(+) TGCAGT/CGAGCC 1 -- int13Minor allele frequency- C:0.23NA 124
    rs1860141921,2
    --76047850(+) GCCACC/GGAGCG 1 -- int10--------
    rs78084021,2
    C,A--76047900(+) tgggcG/Acagtg 1 -- int14Minor allele frequency- A:0.12NA WA 8
    rs1121322881,2
    C--76047940(+) AGGCCAAGGCGG 
     GCAGA
    /-
    TCACG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs77900931,2
    C,A--76047965(+) tcaggA/Cggtcg 1 -- int16Minor allele frequency- C:0.09NA WA CSA 11
    rs1119430221,2
    C,F--76048014(+) TAAAAG/ATACAA 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1920459351,2
    --76048021(+) ACAAAA/CAATTA 1 -- int10--------
    rs1841215841,2
    --76048029(+) TTAGCC/TGGGCG 1 -- int10--------
    rs1886516581,2
    C--76048030(+) TAGCCA/GGGCGT 1 -- int10--------
    rs1906852431,2
    --76048045(+) GCAGGA/CGCCTA 1 -- int10--------
    rs1828707651,2
    --76048046(+) CAGGCA/GCCTAT 1 -- int10--------
    rs1873433931,2
    C--76048154(+) GGCCAC/TAGAGG 1 -- int10--------
    rs733631151,2
    C,F--76048314(+) CCTCAT/CTGGCT 1 -- int14Minor allele frequency- C:0.23WA CSA 124
    rs751180871,2
    C,F--76048439(+) CCTGCC/TGTATT 1 -- int12Minor allele frequency- T:0.07NA EA 240
    rs756737361,2
    C,F--76048440(+) CTGCCG/ATATTG 1 -- int13Minor allele frequency- A:0.10WA NA EA 358
    rs7501031,2
    C,F,H--76048535(+) TGATTT/GGTGCA 1 -- int126Minor allele frequency- G:0.10NS EA NA WA CSA 2672
    rs1917541611,2
    --76048607(+) TCATAC/TTTTCT 1 -- int10--------
    rs102412431,2
    C,F,H--76048676(+) TTTTAT/CGTGGG 1 -- int115Minor allele frequency- C:0.12NS EA NA WA 2214
    rs563148321,2
    C,F--76048958(+) TTCTTC/TCTTTT 1 -- int12Minor allele frequency- T:0.25WA 4
    rs678784411,2
    C--76048975(+) CTCTC-/TCTT  
            
    TCTTT
    1 -- int10--------
    rs1998251171,2
    C--76049019(+) TTCCT-/TCCT  
            
    CCCTC
    1 -- int10--------
    rs760902731,2
    C--76049028(+) TTCCTC/TCCTCC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1465704791,2
    C--76049267(+) GCGCGC/TGACAC 1 -- int10--------
    rs1117859841,2
    C,F--76049276(+) ACCACG/CCCCAG 1 -- int12Minor allele frequency- C:0.50WA CSA 4
    rs1827124981,2
    --76049398(+) ACAGGC/TATTAG 1 -- int10--------
    rs1877821551,2
    --76049474(+) TTCCTA/CTTCCT 1 -- int10--------
    rs1167015451,2
    C,F--76049516(+) TCTTCA/GTAGAG 1 -- int12Minor allele frequency- G:0.06WA EA 238
    rs1433494511,2
    --76049530(+) AAGTCG/TCACTA 1 -- int10--------
    rs1512893351,2
    C--76049691(+) TTCCAC/TATAAA 1 -- int10--------
    rs102585401,2
    C,F--76049733(+) atacaG/Actaaa 1 -- int13Minor allele frequency- A:0.12WA NA EA 358
    rs1921913551,2
    --76049785(+) AGAATG/TGAAAT 1 -- int10--------
    rs765548691,2
    C,F--76050101(+) AAACCT/CGTTTA 1 -- int12Minor allele frequency- C:0.15WA EA 238
    rs1180616461,2
    C,F--76050102(+) AACCTG/ATTTAC 1 -- int11Minor allele frequency- A:0.06EA 120
    rs28683661,2
    C,F,A,H--76050132(-) atcttC/Tatatt 1 -- int126Minor allele frequency- T:0.40NS EA NA WA CSA 2560
    rs604256011,2
    C,F--76050165(+) CCTGTA/GTCTCT 1 -- int14Minor allele frequency- G:0.23WA CSA 123
    rs1391626741,2
    C--76050193(+) ATAAC-/ATATATA 1 -- int10--------
    rs558283301,2
    C--76050223(+) TGTGT-/GTCTCCA 1 -- int10--------
    rs722091721,2
    C--76050224(+) TCCAC-/GTGTGTG 1 -- int10--------
    rs3688434021,2
    C--76050224(+) TCCAC-/GTGT  
      GTGTGT
    GTGTG
    1 -- int10--------
    rs1857212341,2
    --76050309(+) GAGCAA/GTGGCA 1 -- int10--------
    rs1891414841,2
    --76050368(+) TTGCCC/TCAGCC 1 -- int10--------
    rs1922807231,2
    --76050371(+) CCTCAC/GCCTCC 1 -- int10--------
    rs1842945611,2
    --76050395(+) TTATAA/GGCGTG 1 -- int10--------
    rs1406040761,2
    --76050515(+) CAAAGA/TGCTGG 1 -- int10--------
    rs1124511861,2
    F--76050539(+) AGCCAG/CTGCGC 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1379459291,2
    --76050547(+) CGCCCC/TGCCAT 1 -- int10--------
    rs1153509611,2
    C,F--76050548(+) GCCCCG/ACCATT 1 -- int13Minor allele frequency- A:0.12WA NA EA 358
    rs115057701,2
    C--76050558(+) TTCCAC/TATTTT 1 -- int14Minor allele frequency- T:0.12NA WA EA 360
    rs1434003621,2
    --76050586(+) CTCTAC/TTGCCC 1 -- int10--------
    rs1886712151,2
    --76050728(+) CAACAG/TGCCTG 1 -- int10--------
    rs349055361,2
    C,F--76050790(+) GGTCTC/TGAACT 1 -- int12Minor allele frequency- T:0.11NA 122
    rs102341971,2
    C--76050796(+) GAACTC/GCTGGG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1811934871,2
    --76050899(+) ATATAA/TATACA 1 -- int10--------
    rs77877891,2
    C,F--76050914(+) catatA/Gtatgt 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1862271581,2
    --76051075(+) CCCAGC/GTAATG 1 -- int10--------
    rs1492610471,2
    --76051096(+) TTGTAA/TTCTTC 1 -- int10--------
    rs733631231,2
    C,F--76051097(+) TGTATT/ACTTCC 1 -- int13Minor allele frequency- A:0.10WA 122
    rs1418396791,2
    C--76051211(+) GACTT-/TTGGTTGT 1 -- int10--------
    rs77923041,2
    C,A--76051306(+) cctccC/Tgggtt 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1484548711,2
    C--76051367(+) TGCCAC/TCACAC 1 -- int10--------
    rs1895305571,2
    --76051450(+) CTCAGA/GTGATC 1 -- int10--------
    rs1461450031,2
    C--76051456(+) TGATCC/TGCCCA 1 -- int10--------
    rs78049341,2
    C,F--76051466(+) acctcG/Tgcctc 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1395442501,2
    C--76051476(+) CCCAAA/CATGCT 1 -- int10--------
    rs1424429801,2
    C--76051482(+) ATGCTG/TGGATT 1 -- int10--------
    rs78049521,2
    C,F,H--76051510(+) cgcccG/AgccAA 1 -- int116Minor allele frequency- A:0.14NS EA NA WA 2212
    rs794099471,2
    C--76051721(+) CCAGGC/GGCGGT 1 -- int10--------
    rs763250501,2
    C--76051722(+) CAGGCG/TCGGTG 1 -- int10--------
    rs753539371,2
    C--76051724(+) GGCGCG/TGTGGC 1 -- int10--------
    rs746591681,2
    C--76051725(+) GCGCGA/GTGGCT 1 -- int10--------
    rs1807257541,2
    --76051928(+) GAGGAA/GGAGGT 1 -- int10--------
    rs286321141,2
    C--76051951(+) AGATCA/GCGCCA 1 -- int12Minor allele frequency- G:0.25NA 4
    rs1508942541,2
    C--76052080(+) GAGGCC/TGAGGA 1 -- int10--------
    rs47287221,2
    C,A--76052091(+) gggagG/Aatcac 1 -- int1 trp34Minor allele frequency- A:0.00NA WA CSA 7
    rs1874141971,2
    --76052246(+) GAGGCA/GGAGGT 1 -- int10--------
    rs69606111,2
    C,A--76052324(+) aaaGaA/Gagaga 2 -- int1 us2k10--------
    rs102676411,2
    C--76052328(+) aaagaG/Aagaga 2 -- int1 us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs69778471,2
    C,A--76052342(+) agagaA/Gagaaa 2 -- int1 us2k1 trp30--------
    rs1998188881,2
    --76052342(+) AGAGA-/GAGAAA 2 -- int1 us2k10--------
    rs600186371,2
    C--76052345(+) AGAGA-/AA/GA/GAG
    AGAGAGAAAGA
    AAGAA
    2 -- int1 us2k11NA 2
    rs1132501781,2
    C--76052346(+) AGAGAA/GAGAAA 2 -- int1 us2k10--------
    rs1481816241,2
    --76052358(+) AAAGAA/GAGAAA 2 -- int1 us2k10--------
    rs102676591,2
    C--76052380(+) agaaaG/Caaaga 2 -- int1 us2k1 trp31Minor allele frequency- C:0.00NA 2
    rs1380532461,2
    --76052384(+) AGAAAC/GAAAGA 2 -- int1 us2k10--------
    rs1910308041,2
    --76052397(+) GAAAGA/GAAGAA 2 -- int1 us2k10--------
    rs1128200611,2
    C--76052401(+) GAAAG-/AAAAGA 2 -- int1 us2k11Minor allele frequency- A:0.50CSA 2
    rs1116507441,2
    C--76052405(+) GAAAAG/TAAATT 2 -- int1 us2k10--------
    rs3719415551,2
    C--76052549(+) GGGAA-/AGAGAGA 2 -- int1 us2k10--------
    rs617032771,2
    C,F--76052702(+) GGTTGG/TCATTA 2 -- int1 us2k11Minor allele frequency- T:0.06EA 120
    rs1860368051,2
    --76052828(+) TTGATA/GTTTGA 2 -- int1 us2k10--------
    rs1425377321,2
    --76052887(+) CCACAC/TGATGA 2 -- int1 us2k10--------
    rs1459911331,2
    C--76052909(+) TCGTGA/GTATGG 2 -- int1 us2k10--------
    rs1136959401,2
    C,F--76053072(+) TACTCG/AGGAGA 2 -- int1 us2k14Minor allele frequency- A:0.10CSA NA EA 244
    rs1903588571,2
    --76053267(+) ACCCAA/GGAATG 2 -- int1 us2k10--------
    rs1833553571,2
    --76053339(+) CCCCCC/TGGCCT 2 -- int1 us2k10--------
    rs781745701,2
    C,F--76053372(+) CATGAA/GATTCC 2 -- int1 us2k13Minor allele frequency- G:0.11WA NA EA 358
    rs757447481,2
    C,F--76053507(+) CAGCTC/TCCTTG 2 -- int1 us2k13Minor allele frequency- T:0.15WA CSA 122
    rs360873951,2
    C,F--76053515(+) TTGCCG/AGGCTG 2 -- int1 us2k16Minor allele frequency- A:0.12NA WA 246
    rs37898321,2
    C,F,H--76053571(+) TGATAC/GATTGT 2 -- int1 us2k120Minor allele frequency- G:0.11EA NA NS CSA 3860
    rs1399796631,2
    --76053809(+) GGCGCG/TGTGGC 2 -- int1 us2k10--------
    rs1418067691,2
    --76053880(+) GGCTGA/CGAAGT 2 -- int1 us2k10--------
    rs776859041,2
    F--76054025(+) TTTAAT/GGTGGA 2 -- int1 us2k11Minor allele frequency- G:0.11EA 120
    rs773971051,2
    C,F--76054090(+) GTGAAG/AGCTGA 2 -- int1 us2k12Minor allele frequency- A:0.04NA EA 240
    rs1460604441,2
    C--76054116(+) ACAAGC/TTCCCA 2 -- int1 us2k10--------
    rs1878201551,2
    --76054181(+) GCTAGG/TGAAGG 2 -- int1 us2k10--------
    rs132321871,2
    C,F,A,H--76054195(+) GCAGCT/GGAGAA 2 -- int1 us2k115Minor allele frequency- G:0.09NS EA NA WA 1868
    rs1487158861,2
    --76054314(+) TGCCTC/TCTGCT 3 L int1 syn10--------
    rs22864281,2,4
    C,F,H--76054372(-) GGCTCC/TACCCT 3 R G ut51 mis116Minor allele frequency- T:0.13NS EA NA EU 2644
    rs1178697021,2
    C--76054389(+) CCTGAG/CACGTC 3 /D /E ut51 mis11Minor allele frequency- C:0.01NA 120
    rs1996479281,2
    C,F--76054395(+) ACGTCC/TGTACA 3 S ut51 syn11Minor allele frequency- T:0.01EU 1269
    rs1146919901,2
    C,F--76054404(+) CAGCCC/TGTACT 3 P ut51 syn11Minor allele frequency- T:0.03WA 118
    rs1153508451,2
    C,F--76054467(+) GGCACC/TGGGAA 4 T syn12Minor allele frequency- T:0.00WA NA 4666
    rs2020835211,2
    --76054519(+) GTGAGA/CCTCTG 4 T P mis10--------
    rs1512890351,2
    C,F--76054523(+) GCCTCT/CGGTCT 4 /P /L mis11Minor allele frequency- C:0.00NA 4548
    rs1406472411,2
    C,F--76054543(+) CAGAAG/TATGTG 4 D Y mis11Minor allele frequency- T:0.00NA 4552
    rs1504828261,2
    C--76054561(+) TTGAGG/ATTGGA 4 /I /V mis11Minor allele frequency- A:0.00NA 4550
    rs1423709421,2
    C--76054572(+) CTCCAC/TGAGTG 4 H syn11Minor allele frequency- T:0.00NA 4550
    rs22864291,2
    C,F,H--76054644(-) TACCCG/TGCTGC 2 -- int12Minor allele frequency- T:0.02NS NA 172
    rs1142066341,2
    C,F--76054645(+) CAGCCG/AGGTAT 2 -- int11Minor allele frequency- A:0.06WA 118
    rs1119785461,2
    C,F--76054736(+) GCCTGA/GAGCTG 2 -- int12Minor allele frequency- G:0.09NA EA 240
    rs1508462551,2
    C--76054765(+) CCAGGA/GCAGCT 2 -- int10--------
    rs1392935441,2
    --76054854(+) CCACTC/TTCTCT 2 -- int10--------
    rs788896291,2
    C--76054877(+) TGACAC/TACACA 2 -- int13Minor allele frequency- T:0.09CSA NA EA 242
    rs96405781,2
    C,F,A,H--76054889(+) GCCTGC/G/TGTGAT 2 -- int117NS EA NA WA CSA 1203
    rs1455756361,2
    --76054964(+) GAAGAA/GACCCA 2 -- int10--------
    rs1825564771,2
    --76055003(+) TGGGCC/TGGGTG 2 -- int10--------
    rs69763631,2
    C--76055216(+) CCAACA/GTGGTG 2 -- int13Minor allele frequency- G:0.17NA WA 6
    rs1879118081,2
    --76055274(+) GCGTGG/TCTGTA 2 -- int10--------
    rs351031011,2
    C--76055400(+) GGCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1426441341,2
    C--76055439(+) TATGGC/GGGCGG 2 -- int10--------
    rs715624251,2
    C,F--76055550(+) GACCAG/AGAAAT 2 -- int11Minor allele frequency- A:0.50NA 2
    rs286093591,2
    C,F--76055593(+) GGAAAC/GAGGCT 2 -- int1 trp310Minor allele frequency- G:0.32NA WA CSA EA 371
    rs1401737771,2
    C--76055829(+) CTGGG-/CTCTCTT 2 -- int10--------
    rs1449230431,2
    C--76055878(+) CCAGAA/G/TAGCTG 2 -- int10--------
    rs1129100041,2
    F--76055925(+) TCACAG/AACATG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1124268711,2
    C,F--76055970(+) CCCCCC/ACCTTC 2 -- int12Minor allele frequency- A:0.04NA 122
    rs1170434691,2
    F--76055971(+) CCCCCC/GCTTCT 2 -- int11Minor allele frequency- G:0.02NA 120
    rs1844254091,2
    --76056016(+) GTGGTA/GTTTTT 2 -- int10--------
    rs102618791,2
    C,F--76056049(+) AGACAC/GTTTTG 2 -- int17Minor allele frequency- G:0.47NA WA CSA EA 250
    rs1488199531,2
    --76056139(+) CCCGGC/GAGTTT 2 -- int10--------
    rs733631281,2
    C,F--76056170(+) AATGAG/AACCCC 2 -- int13Minor allele frequency- A:0.16WA CSA 122
    rs1490192681,2
    C--76056191(+) AAACA-/CCACAC 2 -- int10--------
    rs2000339671,2
    --76056222(+) ACACA-/CACAATAG 2 -- int10--------
    rs102335721,2
    C--76056224(+) ACACAA/CAATAG 2 -- int12Minor allele frequency- C:0.00WA 4
    rs2011006381,2
    --76056224(+) ACACA-/CAATAG 2 -- int10--------
    rs577962741,2
    C--76056225(+) ACACA-/ACAA/CACACACAAA/CAC
    ACACACACACACACACACAAA
    ATAGG
    4 -- int1 cds11NA 2
    rs733631321,2
    C,F--76056433(+) AAGGAT/CGTGGG 2 -- int14Minor allele frequency- C:0.21WA CSA 124
    rs1890138991,2
    --76056455(+) GTAATA/GAGGAT 2 -- int10--------
    rs755204281,2
    C,F--76056513(+) GTGTGG/TTGTTT 2 -- int12Minor allele frequency- T:0.07NA 122
    rs1435129831,2
    --76056540(+) GAGAAC/TCACCT 2 -- int10--------
    rs350294721,2
    C,F--76056562(+) TGCGCG/AGTGGC 2 -- int19Minor allele frequency- A:0.28NA WA CSA 18
    rs1928292651,2
    --76056643(+) CCTGGA/CCACGA 2 -- int10--------
    rs1408683961,2
    C--76056647(+) GCCACA/GATGGT 2 -- int10--------
    rs356924221,2
    C,F--76056691(+) TAGCCG/AGGTGT 2 -- int17Minor allele frequency- A:0.43NA WA CSA 14
    rs1134263151,2
    C,F--76056752(+) TGCTTG/AAACCC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1112434261,2
    C,F--76056824(+) TGAGAC/TTCCGT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs710854111,2
    C--76056842(+) AAAAA-/A/AA  
            
    AAAAA
    2 -- int12NA 4
    rs776673021,2
    C,F--76057081(+) ACTTCG/AACCTC 2 -- int11Minor allele frequency- A:0.03WA 118
    rs733631391,2
    C,F--76057225(+) TTCCTG/AGCCTC 2 -- int12Minor allele frequency- A:0.07WA 120
    rs286700221,2
    C,F--76057242(+) TCCTCT/CTCCCT 2 -- int1 trp37Minor allele frequency- C:0.48NA WA EA 366
    rs1387385421,2
    --76057271(+) CAGGCA/GTGAGC 2 -- int10--------
    rs1849333321,2
    --76057273(+) GGCATA/GAGCCA 2 -- int10--------
    rs1893959251,2
    --76057377(+) GGTGGC/TTCACA 2 -- int10--------
    rs1810850801,2
    --76057407(+) GGAGGA/CTGAGG 2 -- int10--------
    rs2016753801,2
    C--76057478(+) TCTCT-/TTTAAA 2 -- int10--------
    rs798525041,2
    C,F--76057482(+) TATTTT/AAAAAA 2 -- int12Minor allele frequency- A:0.50NA 4
    rs715211261,2
    C--76057497(+) AAAAA-/A/GGGCAC 2 -- int11NA 2
    rs755190571,2
    --76057497(+) AAAAAG/AGGCAC 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1896038361,2
    --76057593(+) AGTTCA/GTGCCA 2 -- int10--------
    rs1818616201,2
    --76057709(+) ACCTGA/GAAAGG 2 -- int10--------
    rs1493439561,2
    C--76057810(+) TCTTCA/GAACTT 2 -- int10--------
    rs1446614121,2
    --76057848(+) GGCAGG/TCCCTG 2 -- int10--------
    rs1863469371,2
    --76057853(+) GCCCTA/GCCTTC 2 -- int10--------
    rs1485372291,2
    --76057869(+) CCCTAA/TTGGAC 2 -- int10--------
    rs1177986461,2
    C,F--76057980(+) AGAAGC/TTGATG 2 -- int11Minor allele frequency- T:0.02NA 120
    rs1454022771,2
    --76058061(+) TGGCAC/TGATCT 2 -- int10--------
    rs1919405861,2
    --76058068(+) ATCTCA/CGCTCA 2 -- int10--------
    rs1137970151,2
    C,F--76058247(+) GCCCTC/TCTCAG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1832399281,2
    C--76058275(+) ATTACA/GGGCGT 2 -- int10--------
    rs1867465531,2
    --76058290(+) CACAGC/TGCCCA 2 -- int10--------
    rs1449611261,2
    --76058424(+) AGAAGA/GGATGT 2 -- int10--------
    rs1911417171,2
    --76058478(+) TCTGCC/TATGTG 2 -- int10--------
    rs1153479501,2
    C,F--76058596(+) GTGTTC/GTCTTT 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1513204471,2
    --76058694(+) ACAGGC/TATGAG 2 -- int10--------
    rs1405893681,2
    --76058734(+) TTTCTG/TTCCCC 2 -- int10--------
    rs1498823311,2
    C--76058743(+) CCTTGC/TGGGCT 2 -- int10--------
    rs64651281,2
    C,F,H--76058767(+) ACTCAT/GGTATG 2 -- int125Minor allele frequency- G:0.30NS EA NA WA CSA 2356
    rs2020937731,2
    C--76058787(+) TACCCA/GGGCAG 2 -- int10--------
    rs2013045131,2
    C--76058801(+) ATGGCC/TGGCAG 2 -- int11Minor allele frequency- T:0.00EU 1323
    rs2010017371,2
    C--76058816(+) AACTTC/TTCACC 2 -- int10--------
    rs1448711931,2
    C--76058841(+) CTGACA/GATGCC 4 N D mis10--------
    rs1409061091,2
    C,F--76058857(+) GTACAG/ACACCT 4 /N /S mis11Minor allele frequency- A:0.00EU 1323
    rs1829772401,2
    C--76058882(+) CCCCGC/TCCCGT 4 R syn10--------
    rs1446698071,2
    C--76058904(+) CCATCG/ATGAGG 4 /M /V mis11Minor allele frequency- A:0.00NA 4550
    rs1387111941,2
    C--76058917(+) TAACCA/GCGCAG 4 H R mis10--------
    rs1483320451,2
    C--76059073(+) CATTT-/GCAGCAGC 2 -- cds10--------
    rs77821761,2
    C,F,H--76059074(+) CATTTG/ACAGCT 2 -- int15Minor allele frequency- A:0.02NS EA WA 420
    rs69498131,2
    C,F,H--76059214(+) AGCCTC/TGGCCC 2 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1895936221,2