ZP3 Gene
protein-coding GIFtS : 55 GCID: GC07 P076026
zona pellucida glycoprotein 3 (sperm receptor) zona pellucida glycoprotein 3A (sperm receptor) )ZP3A, ZP3B )
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Aliasesfor ZP3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zona Pellucida Glycoprotein 3 (Sperm Receptor) 1 2 Zp-32 3 ZP3A1 2 3 5 ZP3-3721 ZP3B1 2 3 5 ZP3-4241 Zona Pellucida Glycoprotein 3A (Sperm Receptor)1 2 Zona Pellucida Glycoprotein 3B2 Sperm Receptor2 3 Zona Pellucida Glycoprotein ZP32 Zona Pellucida Protein C2 3 Zona Pellucida Sperm-Binding Protein 32 ZP3A/ZP3B2 3 Zona Pellucida Glycoprotein 33 ZPC2 3
Export aliases for ZP3 gene to outside databases Previous GC identifers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671 GC07P075864 GC07P071113
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Summariesfor ZP3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ZP3 : The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 Function : The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosomereaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation Gene Wiki entry for ZP3
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Genomic Viewsfor ZP3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZP3 gene promoter:E2F-4 E2F-3a SRY E2F-1 E2F E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for ZP3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23 ZP3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P076026: view genomic region
(about GC identifiers )
Start: 76,026,835 bp from pter End:
76,071,388 bp from pter
Size: 44,554 bases Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 75,359,905-75,404,452
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Proteinsfor ZP3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 See
protein sequence )Recommended Name: Size : 424 amino acids; 47018 DaSubunit : Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)Subcellular location : Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellularmatrix
Subcellular location : Cell membrane; Single-pass type I membrane proteinSecondary accessions : Q06633 Q29RW0Alternative splicing : 3 isoforms : P21754-1 P21754-2 P21754-3 (Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids)Explore the universe of human proteins at neXtProt for ZP3: NX_P21754 Post-translational modifications:
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida1
N-glycosylated (By similarity)1 O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P21754 ZP3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001103824.1 NP_009086.4 ENSEMBL proteins: ENSP00000337310 ENSP00000378326 ENSP00000411955 ENSP00000378329 Human Recombinant Protein Products: Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15 ): About this table
About GeneDecksing ZP3 Antibody Products: Assay Products for ZP3:
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Protein
Domains /for ZP3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P21754 ProtoNet protein and cluster: P21754
1 Blocks protein family : IPB001507 UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 Domain : The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucidaSimilarity : Belongs to the ZP domain family. ZPC subfamilySimilarity : Contains 1 ZP domain
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Functionfor ZP3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 Function : The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosomereaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ZP3 (NM_001110354 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZP3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZP3
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for ZP3 :Animal Models: Zp3 tm1Dean Zp3 tm1Pmw 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zp3) :About GeneDecksing
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Pathways & Interactionsfor ZP3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ovarian Infertility Genes 2 Sweet Taste Signaling
1 1 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZP3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)5/11 Interacting proteins for ZP3 (P21754 3 ENSP00000378326 4 via UniProtKB, MINT, STRING , and/or I2D (see all 11 )About this table Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001809 positive regulation of type IV hypersensitivity
ISS -- GO:0001825 blastocyst formation
ISS -- GO:0002455 humoral immune response mediated by circulating immunoglobulin
ISS -- GO:0002687 positive regulation of leukocyte migration
ISS -- GO:0002922 positive regulation of humoral immune response
IDA 19004505
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Drugs & Compoundsfor ZP3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for ZP3 9 Novoseek chemical compound relationships for ZP3 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
mannose
30.9
2
7507936 (1)
calcium
24.6
4
9239670 (1), 12464273 (1), 9651467 (1), 8088433 (1)
tyrosine
22.5
9
8045346 (2), 9665632 (1), 15317909 (1), 9872364 (1) (see all 6 )
carbohydrates
19.5
3
1311731 (1), 11358873 (1), 9225165 (1)
cysteine
17.3
3
10216911 (1), 10216914 (1)
progesterone
17.1
2
12464273 (1), 9651467 (1)
serine
7.14
2
9600940 (1), 10216914 (1)
proline
0
2
10216914 (2)
polysaccharide
0
1
11358873 (1)
ZP3
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Transcriptsfor ZP3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZP3 gene (2 alternative transcripts): NM_001110354.1 NM_007155.5 Unigene Cluster for ZP3:
Zona pellucida glycoprotein 3 (sperm receptor) Hs.656137 [show with all ESTs ] Unigene Representative Sequence: BC113949 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000336517 (uc003ufc.4 ) ENST00000394857 (uc003ufd.4 ) ENST00000416245 (uc003ufe.3 )ENST00000394860 ENST00000466960 ENST00000479793 ENST00000467555 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ZP3 (NM_001110354 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZP3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZP3
Additional cDNA sequence: AK292763.1 BC113949.1 M60504.1 S52509.1
13 DOTS entries : DT.95145133 DT.121067326
DT.92469787 DT.100027278 DT.95145163 DT.100790706 DT.121637693 DT.95145124 DT.95266574 DT.95293148 DT.97769393 DT.121090535 DT.95362005 24/159 AceView cDNA sequences (see all 159 ):
AI075996 BF726964 CR603033 AI359326 AW162786 BQ446470 BF063092 AI802299 BF195407 CR616549 BU186061 BQ670433 CD389947 AI144523 BE893300 AA334331 CB120286 BC000487 BF983753 AA333786 AW249685 BV205866 AI051631 BX427701 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP3 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b SP1 : SP2 : SP3 : - -
ECgene alternative splicing isoforms for ZP3
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Expression for ZP3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZP3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAGTAGAGCA
About this image ZP3 expression in embryonic tissues and stem cells About this table See ZP3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZP3 SOURCE GeneReport for Unigene cluster: Hs.656137 UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 Tissue specificity : OocytesSABiosciences Custom PCR Arrays for ZP3 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3
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Orthologsfor ZP3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ZP3 gene from 4/11 species (see all 11 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves LOC4153141
zona pellucida glycoprotein 3 (sperm receptor)-like
62.64(n) 56.54(a)
415314 XM_413701.3 XP_413701.3
lizard Reptilia ----
--
52(a) 35(a)
possible orthologpossible ortholog
GL343492.1(388222-397209) 1(90834853-90840023)
African clawed frog Amphibia Xl.37152
Xenopus laevis transcribed sequence with weak similarity more
73.25(n)
BX851629.1
zebrafish Actinopterygii zp3a.21
zona pellucida glycoprotein 3a.2
52.13(n) 41.49(a)
558677 NM_001030120.1 NP_001025291.1
ENSEMBL Gene Tree for ZP3 (if available)TreeFam Gene Tree for ZP3 (if available)
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Paralogsfor ZP3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZP3 gene POMZP3 2 2 SIMAP similar genes for ZP3 using alignment to 3 protein entries: ZP3_HUMAN (see all proteins ):ZP3A POMZP3 About GeneDecksing 2 Pseudogenes.org Pseudogenes for ZP3 PGOHUM00000235302 PGOHUM00000233581
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Genomic Variantsfor ZP3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 7 pos Sequence # AA Type More # Allele Pop Total More
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
In-situ hybridization
