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ZP3 Gene

protein-coding   GIFtS: 57
GCID: GC07P076026

Zona Pellucida Glycoprotein 3 (Sperm Receptor)

(Previous name: zona pellucida glycoprotein 3A (sperm receptor))
(Previous symbols: ZP3A, ZP3B)
  See ZP3-related disease

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Zona Pellucida Glycoprotein 3 (Sperm Receptor)1 2     ZPC2 3
ZP3A1 2 3 5     Zp-32 3
ZP3B1 2 3 5     Zona Pellucida Glycoprotein 3B2
Zona Pellucida Glycoprotein 3A (Sperm Receptor)1 2     Zona Pellucida Glycoprotein ZP32
Sperm Receptor2 3     Zona Pellucida Sperm-Binding Protein 32
Zona Pellucida Protein C2 3     Zona Pellucida Glycoprotein 33
ZP3A/ZP3B2 3     

External Ids:    HGNC: 131891   Entrez Gene: 77842   Ensembl: ENSG000001883727   OMIM: 1828895   UniProtKB: P217543   

Export aliases for ZP3 gene to outside databases

Previous GC identifiers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671 GC07P075864 GC07P071113

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZP3 Gene:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily
of three or four glycoproteins with various functions during fertilization and preimplantation development. The
protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and
induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a
conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized
that furin cleavage results in release of the mature protein from the plasma membrane for subsequent
incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains
controversial based on mouse studies. A variation in the last exon of this gene has previously served as the
basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one
full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3
contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely
to this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZP3 Gene:
ZP3 (zona pellucida glycoprotein 3 (sperm receptor)) is a protein-coding gene. Diseases associated with ZP3 include oophoritis. GO annotations related to this gene include store-operated calcium channel activity and signal transducer activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
and ZP4. ZP3 is essential for sperm binding and zona matrix formation

Gene Wiki entry for ZP3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZP3 gene promoter:
         E2F-4   E2F-3a   SRY   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZP3 promoter sequence
   Search Chromatin IP Primers for ZP3

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

ZP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076026:  view genomic region     (about GC identifiers)

76,026,835 bp from pter      End:
76,071,388 bp from pter
44,554 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,359,905-75,404,452     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 3 precursor  
Size: 424 amino acids; 47018 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)
Secondary accessions: Q06633 Q29RW0
Alternative splicing: 3 isoforms:  P21754-1   P21754-2   P21754-3   (Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids)

Explore the universe of human proteins at neXtProt for ZP3: NX_P21754

Explore proteomics data for ZP3 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona
  • N-glycosylated (By similarity)1
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to
    polyspermy (By similarity)1
  • Glycosylation2 at Asn125, Asn147, Thr156, Thr162, Thr163, Asn272
  • Modification sites at PhosphoSitePlus

  • See ZP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001103824.1  NP_009086.4  

    ENSEMBL proteins: 
     ENSP00000337310   ENSP00000378326   ENSP00000411955   ENSP00000378329  
    Reactome Protein details: P21754

    ZP3 Human Recombinant Protein Products:

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    Novus Biologicals ZP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZP3

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    antibodies-online proteins for ZP3 (9 products) 

    antibodies-online peptides for ZP3

    Search GeneTex for Proteins for ZP3 

    ZP3 Antibody Products:

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    antibodies-online antibodies for ZP3 (13 products) 

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    ZP3 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZP3
    Cloud-Clone Corp. CLIAs for ZP3
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    antibodies-online kits for ZP3 (16 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    ZP: Zona pellucida glycoproteins

    2 InterPro protein domains:
     IPR017977 ZP_dom_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P21754

    ProtoNet protein and cluster: P21754

    1 Blocks protein domain: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
    Similarity: Belongs to the ZP domain family. ZPC subfamily
    Similarity: Contains 1 ZP domain

    Find genes that share domains with ZP3           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZP3_HUMAN, P21754
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
    reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
    and ZP4. ZP3 is essential for sperm binding and zona matrix formation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP18667750
    GO:0005384manganese ion transmembrane transporter activity ISS--
    GO:0005515protein binding IPI19945174
    GO:0015279store-operated calcium channel activity IDA--
    GO:0030246carbohydrate binding IDA19246320
    Find genes that share ontologies with ZP3           About GenesLikeMe

         1 GenomeRNAi human phenotype for ZP3:
     Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zp3):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with ZP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ZP3: Zp3tm1Dean Zp3tm1Pmw

       genOway: Develop your customized and physiologically relevant rodent model for ZP3

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for ZP3

    miRTarBase miRNAs that target ZP3:
    hsa-mir-7-5p (MIRT025811)

    Block miRNA regulation of human, mouse, rat ZP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZP3
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZP3

    OriGene clones in human, mouse for ZP3 (see all 9)
    OriGene ORF clones in mouse, rat for ZP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZP3 (NM_001110354)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP3
    Addgene plasmids for ZP3 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for ZP3
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    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    ZP3_HUMAN, P21754: Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space,
    extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian
    oocyte is called zona pellucida
    ZP3_HUMAN, P21754: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    plasma membrane5
    endoplasmic reticulum4
    golgi apparatus4

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669colocalizes with acrosomal vesicle ISS--
    GO:0002081outer acrosomal membrane ISS--
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IMP19246320

    Find genes that share ontologies with ZP3           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for ZP3 About    
    See pathways by source

    SuperPathContained pathways About
    Interaction With The Zona Pellucida0.00
    2Sweet Taste Signaling
    Sperm Motility0.37
    3Ovarian Infertility Genes
    Ovarian Infertility Genes

    Find genes that share SuperPaths with ZP3           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ZP3
        Sperm Motility

    1 BioSystems Pathway for ZP3
        Ovarian Infertility Genes

    1 Reactome Pathway for ZP3
        Interaction With The Zona Pellucida

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZP3

        Search GeneGlobe Interaction Network for ZP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ZP3 (P217543 ENSP000003783264) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACRP103233, ENSP000002161394I2D: score=2 STRING: ENSP00000216139
    C4BPAP040033, ENSP000003560374I2D: score=1 STRING: ENSP00000356037
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    ENGASEQ8NFI33, ENSP000003006824I2D: score=1 STRING: ENSP00000300682
    UBAP2LENSP000003553434STRING: ENSP00000355343
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001809positive regulation of type IV hypersensitivity ISS--
    GO:0001825blastocyst formation ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0002687positive regulation of leukocyte migration ISS--
    GO:0002922positive regulation of humoral immune response IDA19004505

    Find genes that share ontologies with ZP3           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZP3

    9 Novoseek inferred chemical compound relationships for ZP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 30.9 2 7507936 (1)
    calcium 24.6 4 9239670 (1), 12464273 (1), 9651467 (1), 8088433 (1)
    tyrosine 22.5 9 8045346 (2), 9665632 (1), 15317909 (1), 9872364 (1) (see all 6)
    carbohydrates 19.5 3 1311731 (1), 11358873 (1), 9225165 (1)
    cysteine 17.3 3 10216911 (1), 10216914 (1)
    progesterone 17.1 2 12464273 (1), 9651467 (1)
    serine 7.14 2 9600940 (1), 10216914 (1)
    proline 0 2 10216914 (2)
    polysaccharide 0 1 11358873 (1)

    Find genes that share compounds with ZP3           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for ZP3 gene (2 alternative transcripts): 
    NM_001110354.1  NM_007155.5  

    Unigene Cluster for ZP3:

    Zona pellucida glycoprotein 3 (sperm receptor)
    Hs.656137  [show with all ESTs]
    Unigene Representative Sequence: BC113949
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336517(uc003ufc.4) ENST00000394857(uc003ufd.4) ENST00000416245(uc003ufe.3)
    ENST00000394860 ENST00000466960 ENST00000479793 ENST00000467555
    Block miRNA regulation of human, mouse, rat ZP3 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat ZP3
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    OriGene ORF clones in mouse, rat for ZP3
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZP3 (NM_001110354)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZP3
    Addgene plasmids for ZP3 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZP3
      QuantiTect SYBR Green Assays in human, mouse, rat ZP3
      QuantiFast Probe-based Assays in human, mouse, rat ZP3

    Additional mRNA sequence: 

    AK292763.1 BC113949.1 M60504.1 S52509.1 

    13 DOTS entries:

    DT.95145133  DT.121067326  DT.92469787  DT.100027278  DT.95145163  DT.100790706  DT.121637693  DT.95145124 
    DT.95266574  DT.95293148  DT.97769393  DT.121090535  DT.95362005 

    Selected AceView cDNA sequences (see all 159):

    BQ446470 AI802299 BF195407 CR603033 AW162786 AI075996 BF063092 BF726964 
    AI359326 CR616549 BU172163 BG460523 H22333 AI144523 BQ673059 NM_152992 
    AW163456 AA333786 CA421411 U10099 BQ961240 AA334719 AA334331 AW249685 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP3:                                -     -               

    ECgene alternative splicing isoforms for ZP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    ZP3 Expression
    About this image

    ZP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     Ovary (Reproductive System)    fully expand to see all 8 entries
             Pre-Granulosa Cells Primordial Follicle
             Ovarian tissue-dissociated cells (human)
             Ovum Ovigerous Cord
             Human oogonial stem cells
     Germ Cells (Reproductive System)
             Human oogonial stem cells
     NULL (Uncategorized)
             Short-term differentiated embryoid bodies
     Inner Cell Mass (Early Embryonic Tissues)
    ZP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656137

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Tissue specificity: Oocytes

        Custom PCR Arrays for ZP3
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    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Zp31 , 5 zona pellucida glycoprotein 31, 5 74.54(n)1
      5 (75.62 cM)5
    227881  NM_011776.11  NP_035906.11 
    (Gallus gallus)
    Aves ZP31 zona pellucida sperm-binding protein 3 61.78(n)
      378906  NM_204389.2  NP_989720.3 
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    1 → many
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37152 Xenopus laevis transcribed sequence with weak similarity more 73.25(n)    BX851629.1 
    (Danio rerio)
    Actinopterygii zp3a.21 zona pellucida glycoprotein 3a, tandem duplicate 2 52.13(n)
      558677  NM_001030120.1  NP_001025291.1 

    ENSEMBL Gene Tree for ZP3 (if available)
    TreeFam Gene Tree for ZP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for ZP3 gene
    2 SIMAP similar genes for ZP3 using alignment to 3 protein entries:     ZP3_HUMAN (see all proteins):
    ZP3A    POMZP3

    Find genes that share paralogs with ZP3           About GenesLikeMe

    2 Pseudogenes for ZP3
    PGOHUM00000235302 PGOHUM00000233581

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for ZP3 (see all 873)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 7 posSequence#AA
    C,H--76041038(+) gatacT/Cctgaa 1 -- int16Minor allele frequency- C:0.00NS EA NA 424
    --76041118(+) GCATTC/TATCCA 1 -- int10--------
    C,F--76041135(+) ATGAAA/CACTTA 1 -- int14Minor allele frequency- C:0.20WA CSA 124
    F--76041143(+) TTACAT/CCTTCA 1 -- int11Minor allele frequency- C:0.01WA 118
    C--76041252(+) TGCCTG/TTAGTC 1 -- int10--------
    C--76041292(+) atcacT/Ctgagc 1 -- int14Minor allele frequency- C:0.09NA WA EA 242
    F--76041340(+) CTCCAA/GCTCTA 1 -- int11Minor allele frequency- G:0.01EA 120
    --76041344(+) AACTCA/TACAAA 1 -- int10--------
    C,F--76041380(+) GATTCT/CTGTGG 1 -- int13Minor allele frequency- C:0.11WA CSA 122
    --76041397(+) CTACAC/TGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZP3 (76026835 - 76071388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZP3 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669174CNV Deletion23128226
    dgv120n16CNV Deletion17901297
    esv2422494CNV Duplication17116639
    dgv21n31CNV Duplication19718026
    esv2584656CNV Insertion19546169
    dgv233e55CNV Loss17911159
    nsv888387CNV Loss21882294
    dgv235e55CNV Loss17911159
    esv33074CNV Gain17666407
    nsv428174CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 182889    OMIM disorders: --

    1 disease for ZP3:    
    About MalaCards

    4 inferred disease relationships from the University of Copenhagen DISEASES database for ZP3:
    Oophoritis     Infertility     Ovarian dysfunction     Diphtheria

    Find genes that share disorders with ZP3           About GenesLikeMe

    2 Novoseek inferred disease relationships for ZP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian dysfunction 80.7 2 10321806 (1)
    infertility 51.9 7 8984175 (1), 17936279 (1), 11730908 (1), 1576251 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: ZP3 (2 documents)

    Export disorders for ZP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZP3 gene, integrated from 10 sources (see all 136) (see top 10):
    (articles sorted by number of sources associating them with ZP3)

    1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PubMed id 1478648)1, 2, 3, 9 van Duin M.... Aitken R.J. (Genomics 1992)
    2. Human homolog of the mouse sperm receptor. (PubMed id 2385582)1, 2, 9 Chamberlin M.E. and Dean J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PubMed id 15379548)1, 2, 9 Zhao M....Dean J. (Biochemistry 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Binding characteristics of sperm with recombinant human zona pellucida glycoprotein-3 coated beads. (PubMed id 19700799)1, 9 Bansal P. and Gupta S.K. (Indian J. Med. Res. 2009)
    6. Species specificity of human and murine anti-ZP3 synthetic peptide antisera and use of the antibodies for localization and identification of ZP3 or ZPC domains of functional significance. (PubMed id 10099990)1, 9 Hinsch E....Hinsch K.D. (Hum. Reprod. 1999)
    7. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PubMed id 7789967)1, 9 Kipersztok S.... Dean J. (Genomics 1995)
    8. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PubMed id 19004505)1, 9 Choudhury S....Gupta S.K. (J. Reprod. Immunol. 2009)
    9. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. (PubMed id 18667750)1, 9 Chiu P.C....Yeung W.S. (Biol. Reprod. 2008)
    10. Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus. (PubMed id 19246320)1, 9 Bansal P....Gupta S.K. (Biol. Reprod. 2009)
    11. Zona pellucida components are present in human fetal ovary before follicle formation. (PubMed id 18502569)1, 9 TAPrmAolAo R.M....Vaskivuo T.E. (Mol. Cell. Endocrinol. 2008)
    12. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)1, 9 Furlong L.I....Vazquez-Levin M.H. (Fertil. Steril. 2005)
    13. Detection of zona pellucida proteins during human folliculogenesis. (PubMed id 18033806)1, 9 Gook D.A....Martic M. (Hum. Reprod. 2008)
    14. Biological effects of recombinant human zona pellucida proteins on sperm function. (PubMed id 16407501)1, 9 Caballero-Campo P....Gerton G.L. (Biol. Reprod. 2006)
    15. Proteolytic processing of human zona pellucida proteins. (PubMed id 11804956)1, 9 Kiefer S.M. and Saling P. (Biol. Reprod. 2002)
    16. The human gene for the zona pellucida glycoprotein ZP3 and a second polymorphic locus are located on chromosome 7. (PubMed id 8467708)1, 9 van Duin M....Olijve W. (Cytogenet. Cell Genet. 1993)
    17. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    18. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    19. Genetic and physiological study of morphologically abnormal human zona pellucida. (PubMed id 22889493)1 Margalit M....Kleiman S.E. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2012)
    20. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    21. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    22. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. (PubMed id 19945174)1 Naz R.K. and Dhandapani L. (J. Reprod. Immunol. 2010)
    23. Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism. (PubMed id 17192598)1 Ni Y....Shi Q.X. (J. Androl. 2007)
    24. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    25. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    26. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    27. Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans. (PubMed id 14673092)1 Dell A....Clark G.F. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    28. A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3. (PubMed id 11751269)1 Bray C....Meizel S. (Biol. Reprod. 2002)
    29. Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. (PubMed id 11854410)1 Qi H....Wassarman P.M. (Mol. Biol. Cell 2002)
    30. Sperm receptors and fertilization in mammals. (PubMed id 12035074)1 Wassarman P.M. (Mt. Sinai J. Med. 2002)
    31. Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. (PubMed id 11940668)1 Zhao M....Dean J. (Mol. Cell. Biol. 2002)
    32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    33. Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. (PubMed id 11739644)1 Howes E....Jones R. (J. Cell. Sci. 2001)
    34. The zona pellucida: using molecular genetics to study the mammalian egg coat. (PubMed id 10864856)1 Rankin T. and Dean J. (Rev. Reprod. 2000)
    35. Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding. (PubMed id 9609824)1 Rankin T.L....Dean J. (Development 1998)
    36. Immunocytochemical localization of ZP3 in primordial follicles of rabbit, marmoset, rhesus monkey and human ovaries using antibodies against human ZP3. (PubMed id 8984187)1 Grootenhuis A.J....van Duin M. (J. Reprod. Fertil. Suppl. 1996)
    37. Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida. (PubMed id 8269854)1 Miller D.J....Shur B.D. (Development 1993)
    38. Cloning, sequencing and site of origin of the rat sperm receptor protein, ZP3. (PubMed id 10216914)9 Scobie G.A....Aitken R.J. (Zygote 1999)
    39. Nucleotide sequence of cDNA encoding bonnet monkey (Macaca radiata) zona pellucida glycoprotein-ZP3. (PubMed id 8848588)9 Kolluri S.K....Gupta S.K. (Reprod. Fertil. Dev. 1995)
    40. Anti-ZP3 antibodies binding to the human zona pellucida: effect of oocyte-storage conditions. (PubMed id 7880395)9 Hinsch K.D....Oehninger S. (Am. J. Reprod. Immunol. 1994)
    41. Identification of mouse ZP3 protein in mammalian oocytes with antisera against synthetic ZP3 peptides. (PubMed id 7524697)9 Hinsch K.D....Schill W.B. (Biol. Reprod. 1994)
    42. The contraceptive potential of ZP3 and ZP3 peptides in a primate model. (PubMed id 11730908)9 Paterson M....Aitken R.J. (J. Reprod. Immunol. 2002)
    43. Comparison of ZP3 protein sequences among vertebrate species: to obtain a consensus sequence for immunocontraception. (PubMed id 10051457)9 Zhu X. and Naz R.K. (Front. Biosci. 1999)
    44. Cloning and characterisation of a zona pellucida 3 cDNA from a marsupial, the brushtail possum Trichosurus vulpecula. (PubMed id 10216911)9 McCartney C.A. and Mate K.E. (Zygote 1999)
    45. The polypeptide backbone of recombinant human zona pellucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in vitro. (PubMed id 9480899)9 Chapman N....Barratt C.R. (Biochem. J. 1998)
    46. Analysis of the contraceptive potential of antibodies against native and deglycosylated porcine ZP3 in vivo and in vitro. (PubMed id 1576251)9 Paterson M....Aitken R.J. (Biol. Reprod. 1992)
    47. Testing for adaptive evolution of the female reproductive protein ZPC in mammals, birds and fishes reveals problems with the M7-M8 likelihood ratio test. (PubMed id 16283938)9 Berlin S. and Smith N.G. (BMC Evol. Biol. 2005)
    48. Inactivation of the mouse sperm receptor, mZP3, by site-directed mutagenesis of individual serine residues located at the combining site for sperm. (PubMed id 9600940)9 Chen J....Wassarman P.M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    49. Generation of antisera against mouse and human synthetic ZP3 peptides. (PubMed id 9017090)9 Hinsch E. and Hinsch K.D. (Andrologia 1996)
    50. Cloning, sequencing and oocyte-specific expression of the marmoset sperm receptor protein, ZP3. (PubMed id 8081814)9 Thillai-Koothan P....Aitken R.J. (Zygote 1993)
    51. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor. (PubMed id 1313375)9 Bork P. and Sander C. (FEBS Lett. 1992)
    52. Human zona pellucida glycoproteins: functional relevance during fertilization. (PubMed id 19850354)9 Gupta S.K....Chakrabarti K. (J. Reprod. Immunol. 2009)
    53. Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. (PubMed id 11291774)9 Eberspaecher U....Donner P. (Cell Tissue Res. 2001)
    54. Design and evaluation of a ZP3 peptide vaccine in a homologous primate model. (PubMed id 10321806)9 Paterson M....Aitken R.J. (Mol. Hum. Reprod. 1999)
    55. The expression and localization of zona pellucida glycoproteins and mRNA in cynomolgus monkeys (Macaca fascicularis). (PubMed id 8984186)9 Martinez M.L....Harris J.D. (J. Reprod. Fertil. Suppl. 1996)
    56. Mapping of type I loci from human chromosome 7 reveals segments of conserved synteny on pig chromosomes 3, 9, and 18. (PubMed id 8697800)9 Bruch J....Hameister H. (Cytogenet. Cell Genet. 1996)
    57. Oocyte-specific factors bind a conserved upstream sequence required for mouse zona pellucida promoter activity. (PubMed id 1944285)9 Millar S.E....Dean J. (Mol. Cell. Biol. 1991)
    58. Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis. (PubMed id 17486637)9 Chakravarty S....Gupta S.K. (Mol. Reprod. Dev. 2008)
    59. Role of proteasomal activity in the induction of acrosomal exocytosis in human spermatozoa. (PubMed id 18339263)9 Chakravarty S....Gupta S.K. (Reprod. Biomed. Online 2008)
    60. Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm-zona pellucida interaction. (PubMed id 17936279)9 MarA-n-Briggiler C.I....Vazquez-Levin M.H. (Fertil. Steril. 2008)
    61. Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats. (PubMed id 19052627)9 MonnAc M....Jovine L. (Nature 2008)
    62. Structural and functional attributes of zona pellucida glycoproteins. (PubMed id 17566274)9 Gupta S.K....Bhandari B. (Soc Reprod Fertil Suppl 2007)
    63. The zona pellucida 'receptors' ZP1, ZP2 and ZP3. (PubMed id 10526650)9 Hinsch K.D. and Hinsch E. (Andrologia 1999)
    64. Evaluation of the contraceptive potential of recombinant human ZP3 and human ZP3 peptides in a primate model: their safety and efficacy. (PubMed id 9764365)9 Paterson M....Aitken R.J. (Am. J. Reprod. Immunol. 1998)
    65. The potential of the zona pellucida as a target for immunocontraception. (PubMed id 8962643)9 Aitken R.J....van Duin M. (Am. J. Reprod. Immunol. 1996)
    66. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PubMed id 8385033)9 Liang L.-F. and Dean J. (Dev. Biol. 1993)
    67. [Molecules involved in sperm-zona pellucida interaction in mammals. Role in human fertility]. (PubMed id 18547509)9 Serres C....Jouannet P. (J. Soc. Biol. 2008)
    68. Differential O-glycosylation of a conserved domain expressed in murine and human ZP3. (PubMed id 16401092)9 Chalabi S....Dell A. (Biochemistry 2006)
    69. Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs. (PubMed id 12852850)9 Rankin T.L....Dean J. (Dev. Cell 2003)
    70. The mouse zona pellucida: folliculogenesis, fertility and pre-implantation development. (PubMed id 10963869)9 Rankin T....Dean J. (Mol. Cell. Endocrinol. 2000)
    71. Structure and function of the proteins of the mammalian Zona pellucida. (PubMed id 10729725)9 Prasad S.V....Dunbar B.S. (Cells Tissues Organs (Print) 2000)
    72. Characterization of human zona pellucida glycoproteins. (PubMed id 10341000)9 Bauskin A.R....Donner P. (Mol. Hum. Reprod. 1999)
    73. Rat zona pellucida glycoproteins: molecular cloning and characterization of the three major components. (PubMed id 9820205)9 Akatsuka K....Araki Y. (Mol. Reprod. Dev. 1998)
    74. Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida: FA-1 antigen may be a sperm receptor for zona pellucida in humans. (PubMed id 8531189)9 Kadam A.L....Naz R.K. (J. Reprod. Immunol. 1995)
    75. Recombinant human zona pellucida protein ZP3 produced by chinese hamster ovary cells induces the human sperm acrosome reaction and promotes sperm-egg fusion. (PubMed id 7819440)9 van Duin M....Aitken R.J. (Biol. Reprod. 1994)
    76. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. (PubMed id 7841460)9 Harris J.D....Sacco A.G. (DNA Seq. 1994)
    77. Sequential focal and global elevations of sperm intracellular Ca2+ are initiated by the zona pellucida during acrosomal exocytosis. (PubMed id 8088433)9 Florman H.M. (Dev. Biol. 1994)
    78. Zona pellucida glycoprotein ZP3 and fertilization in mammals. (PubMed id 19504560)9 Litscher E.S....Wassarman P.M. (Mol. Reprod. Dev. 2009)
    79. Efficacy of antibodies against a chimeric synthetic peptide encompassing epitopes of bonnet monkey (Macaca radiata) zona pellucida-1 and zona pellucida-3 glycoproteins to inhibit in vitro human sperm-egg binding. (PubMed id 15625695)9 Sivapurapu N....Gupta S.K. (Mol. Reprod. Dev. 2005)
    80. Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition. (PubMed id 16096325)9 Ziyyat A....Wolf J.P. (Hum. Reprod. 2005)
    81. Isolation and mapping the chicken zona pellucida genes: an insight into the evolution of orthologous genes in different species. (PubMed id 15570621)9 Smith J....Burt D.W. (Mol. Reprod. Dev. 2005)
    82. Oocyte-specific gene signaling and its regulation of mammalian reproductive potential. (PubMed id 15970499)9 Acevedo N. and Smith G.D. (Front. Biosci. 2005)
    83. Four zona pellucida glycoproteins are expressed in the human. (PubMed id 15142998)9 LefiA"vre L....Barratt C.L. (Hum. Reprod. 2004)
    84. Recombinant human zona pellucida proteins ZP1, ZP2 and ZP3 co-expressed in a human cell line. (PubMed id 15064827)9 Martic M....Baker G.H. (Asian J. Androl. 2004)
    85. Zona pellucida glycoproteins based immunocontraceptive vaccines: strategies for development and their applications. (PubMed id 15255371)9 Gupta S.K....Ravi C. (Indian J. Exp. Biol. 2003)
    86. Stimulation of voltage-dependent calcium channels during capacitation and by progesterone in human sperm. (PubMed id 12464273)9 GonzA!lez-MartA-nez M.T....GuzmA!n-Grenfell A.M. (Arch. Biochem. Biophys. 2002)
    87. Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. (PubMed id 12468641)9 Huntriss J.... Picton H.M. (Mol. Hum. Reprod. 2002)
    88. Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals. (PubMed id 11226269)9 Swanson W.J....Aquadro C.F. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    89. Glycobiology of sperm-egg interactions in deuterostomes. (PubMed id 11358873)9 Mengerink K.J. and Vacquier V.D. (Glycobiology 2001)
    90. Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen. (PubMed id 11006142)9 Martinez M.L. and Harris J.D. (J. Reprod. Fertil. 2000)
    91. Marsupial egg and embryo coats. (PubMed id 10729728)9 Selwood L. (Cells Tissues Organs (Print) 2000)
    92. Ascidian sperm receptor attached to the vitelline coat during oocyte maturation. (PubMed id 11191289)9 Sawada H....Yokosawa H. (Zygote 2000)
    93. Mapping of dominant B-cell epitopes of a human zona pellucida protein (ZP1). (PubMed id 10569978)9 Skinner S.M....Dunbar B.S. (Biol. Reprod. 1999)
    94. Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. (PubMed id 10570015)9 Tsubamoto H....Koyama K. (Biol. Reprod. 1999)
    95. Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa. (PubMed id 11250775)9 Purohit S.B....Kumar G.P. (Asian J. Androl. 1999)
    96. American Society for Cell Biology. Homing in on a sperm receptor. (PubMed id 9925473)9 Strauss E. (Science 1999)
    97. Voltage-dependent calcium influx in human sperm assessed by simultaneous optical detection of intracellular calcium and membrane potential. (PubMed id 9651467)9 Linares-HernA!ndez L....GonzA!lez-MartA-nez M.T. (Biochim. Biophys. Acta 1998)
    98. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. (PubMed id 9872364)9 Brewis I.A....Moore H.D. (Mol. Hum. Reprod. 1998)
    99. Modelling human sperm-egg interactions in vitro: signal transduction pathways regulating the acrosome reaction. (PubMed id 9665632)9 Benoff S. (Mol. Hum. Reprod. 1998)
    100. [Gamete recognition in mammals: sperm and zona pellucida interactions]. (PubMed id 9810129)9 Finaz C. and LefA"vre A. (Contracept Fertil Sex 1998)
    101. Binding of spermatozoa to the perivitelline layer in the presence of a protease inhibitor. (PubMed id 9154629)9 Kuroki M. and Mori M. (Poult. Sci. 1997)
    102. Identification of epitopes of monoclonal antibodies to porcine zona pellucida 3 beta glycoprotein, a homologue of the mouse/human sperm receptor. (PubMed id 9266007)9 Afzalpurkar A. and Gupta S.K. (Am. J. Reprod. Immunol. 1997)
    103. Immunoreactivity and in-vitro effect on human sperm-egg binding of antibodies against peptides corresponding to bonnet monkey zona pellucida-3 glycoprotein. (PubMed id 9455832)9 Afzalpurkar A....Gupta S.K. (Hum. Reprod. 1997)
    104. The role of carbohydrate residues in mammalian fertilization. (PubMed id 9225165)9 Shalgi R. and Raz T. (Histol. Histopathol. 1997)
    105. The molecular genetics of the zona pellucida: mouse mutations and infertility. (PubMed id 9237231)9 Rankin T. and Dean J. (Mol. Hum. Reprod. 1996)
    106. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. (PubMed id 9239670)9 Brewis I.A....Moore H.D. (Mol. Hum. Reprod. 1996)
    107. Early steps of sperm-egg interactions during mammalian fertilization. (PubMed id 8936405)9 Barros C....Moreno R.D. (Cell Biol. Int. 1996)
    108. New concepts in human sperm-zona pellucida interaction. (PubMed id 8592038)9 Clark G.F....Oehninger S. (Hum. Reprod. 1995)
    109. Tyrosine phosphorylation of the egg receptor for sperm at fertilization. (PubMed id 8045346)9 Abassi Y.A. and Foltz K.R. (Dev. Biol. 1994)
    110. Sex determination of preimplantation embryos by human testis-determining-gene amplification. (PubMed id 7903778)9 Cui K.H....Matthews C.D. (Lancet 1994)
    111. Blocking of human fertilization by carbohydrates. (PubMed id 7507936)9 Mori K....Aono T. (Hum. Reprod. 1993)
    112. Binding of sperm to somatic cells via HLA-DR. Modulation by sulfated carbohydrates. (PubMed id 1311731)9 Scofield V.L....Raghupathy R. (J. Immunol. 1992)
    113. Role of membrane phosphotyrosine proteins in human spermatozoal function. (PubMed id 1721918)9 Naz R.K....Kumar R. (J. Cell. Sci. 1991)
    114. Genomic organization and polypeptide primary structure of zona pellucida glycoprotein hzp3, the hamster sperm receptor. (PubMed id 1850370)9 Kinloch R.A....Wassarman P.M. (Dev. Biol. 1991)
    115. Rho-kinase (ROCK) in sea urchin sperm: its role in regulating the intracellular pH during the acrosome reaction. (PubMed id 17959147)9 de la Sancha C.U....GarcA-a-Soto J. (Biochem. Biophys. Res. Commun. 2007)
    116. Evidence of amino acid diversity-enhancing selection within humans and among primates at the candidate sperm-receptor gene PKDREJ. (PubMed id 17564962)9 Hamm D.... Swanson W.J. (Am. J. Hum. Genet. 2007)
    117. Neutralization of cytokine activity at the receptor level improves sperm motility in men with spinal cord injuries. (PubMed id 17494103)9 Brackett N.L....Lynne C.M. (J. Androl. 2007)
    118. Zona pellucida from fertilised human oocytes induces a voltage-dependent calcium influx and the acrosome reaction in spermatozoa, but cannot be penetrated by sperm. (PubMed id 17147816)9 Patrat C....Serres C. (BMC Dev. Biol. 2006)
    119. The role of mannose receptor on HIV-1 entry into human spermatozoa. (PubMed id 16533334)9 Cardona-Maya W....Cadavid A.P. (Am. J. Reprod. Immunol. 2006)
    120. Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. (PubMed id 16359962)9 Jakab A....Huszar G. (Fertil. Steril. 2005)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7784 HGNC: 13189 AceView: POMZP3 Ensembl:ENSG00000188372 euGenes: HUgn7784
    ECgene: ZP3 H-InvDB: ZP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    PharmGKB entry for ZP3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlight

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