ZP3 Gene

Aliases
for ZP3 gene

Previous GC identifers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671 GC07P075864 GC07P071113

Summaries
for ZP3 gene

Genomic Views
for ZP3 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZP3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP3

ZP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076026:  view genomic region     (about GC identifiers)

Proteins
for ZP3 gene

Explore the universe of human proteins at neXtProt for ZP3: NX_P21754

Post-translational modifications:

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	Novus Biologicals ZP3 Protein Novus Biologicals ZP3 Lysates
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	Uscn Proteins for ZP3

Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

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	Uscn ELISAs and CLIAs for ZP3

Protein Domains /
Families
for ZP3 gene

ProtoNet protein and cluster: P21754

Function
for ZP3 gene

     Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 2 alleles) (MGI details for Zp3)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZP3

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZP3
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

Pathways & Interactions
for ZP3 gene

	Super-pathway	contained gene-specific pathways
1	Ovarian Infertility Genes	Ovarian Infertility Genes 1.00
2	Sweet Taste Signaling	Sperm Motility 0.36

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ZP3

Sperm Motility

1 BioSystems Pathway for ZP3

Ovarian Infertility Genes

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

Drugs & Compounds
for ZP3 gene

Transcripts
for ZP3 gene

Expression
for ZP3 gene

ZP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTAGAGCA

About this image

ZP3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryOvigerous CordOvum			Female Gametocytes, Germ Cells
	OvaryPrimary FollicleGranulosa Cells			Ovary
	OvaryPrimordial FolliclePre-Granulosa Cells			Ovary
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10 LifeMap Cells
	Name			Category
	Ovarian tissue-dissociated cells (Primary Cell)			Reproductive System
	Ovarian tissue-dissociated cells (human) (Primary Cell)			Ovary, Reproductive System
	ES-J1 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Secondary follicles (Primary Cell)			Ovary, Reproductive System
	Long-time differentiated EBs (Derivation of embryo...)
	Short-term differentiated embryoid bodies (Derivation of embryo...)
	Oocytes (Oocyte formation by ...)
	Human oogonial stem cells (Oocyte formation by ...)
	Human oogonial stem cells (Oocyte formation by ...)
	Oocytes (Oocyte formation by ...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZP3 Browse OriGene validated miRNA SYBR primer pairs
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

Orthologs
for ZP3 gene

Paralogs
for ZP3 gene

Paralogs for ZP3 gene

POMZP3²  

2 SIMAP similar genes for ZP3 using alignment to 3 protein entries:     ZP3_HUMAN (see all proteins):

ZP3A    POMZP3

ZP3 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for ZP3
PGOHUM00000235302 PGOHUM00000233581

Genomic Variants
for ZP3 gene

10/1036 NCBI SNPs in ZP3 are shown (see all 1036)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1119194791,2		--	76024890(+)	CGCTTG/TCATTT	2	--	int1 us2k1		1		CSA	1
rs1823837171,2		--	76024966(+)	CTTGCC/TCATCA	2	--	int1 us2k1		0	--	--	--	--
rs1399479411,2		--	76025008(+)	TATCC-/TCCTCT TTTCTTTTTTTTGA	2	--	int1 us2k1		0	--	--	--	--
rs624768011,2	C	--	76025112(+)	CAAGCA/GATTCC	2	--	int1 us2k1		2		NA	4
rs1380184121,2		--	76025204(+)	ATGGGA/GTTTCA	2	--	int1 us2k1		0	--	--	--	--
rs1128990551,2	C	--	76025240(+)	CACCCG/AACCTC	2	--	int1 us2k1		2		WA	120
rs1115526541,2	C	--	76025264(+)	ATCTCG/AGCCTC	2	--	int1 us2k1		1		NA	2
rs1890661711,2		--	76025417(+)	CTCCTA/GCAGCC	2	--	int1 us2k1		0	--	--	--	--
rs286063981,2	C	--	76025447(+)	AAAAAA/CCAAAA	2	--	int1 us2k1		1		NA	2
rs768472491,2		--	76025455(+)	AAAAAC/ACAACT	2	--	us2k1 int1		1		CSA	2

HapMap Linkage Disequilibrium report for ZP3 (76026835 - 76071388 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for ZP3
     10 CNVs: 2700 64866 8569 8568 9060 22956 7646 9061 3686 5241
     1 Indel: 99992

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZP3

DNA2.0 Custom Variant and Variant Library Synthesis for ZP3

Disorders / Diseases
for ZP3 gene

7 diseases for ZP3

2 Novoseek disease relationships for ZP3 gene    About this table

Publications
for ZP3 gene

PubMed articles for ZP3 gene integrated from 9 sources (see top 10): (articles sorted by number of sources associating them with ZP3)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PubMed id 1478648)^{1, 2, 3, 9} van Duin M.... Aitken R.J. (1992)
2. Human homolog of the mouse sperm receptor. (PubMed id 2385582)^{1, 2, 9} Chamberlin M.E. and Dean J. (1990)
3. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PubMed id 15379548)^{1, 2, 9} Zhao M....Dean J. (2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. Species specificity of human and murine anti-ZP3 synthetic peptide antisera and use of the antibodies for localization and identification of ZP3 or ZPC domains of functional significance. (PubMed id 10099990)^{1, 9} Hinsch E....Hinsch K.D. (1999)
6. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PubMed id 7789967)^{1, 9} Kipersztok S.... Dean J. (1995)
7. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PubMed id 19004505)^{1, 9} Choudhury S....Gupta S.K. (2009)
8. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. (PubMed id 18667750)^{1, 9} Chiu P.C....Yeung W.S. (2008)
9. Functional activity of human ZP3 primary sperm recept or resides toward its C-terminus. (PubMed id 19246320)^{1, 9} Bansal P....Gupta S.K. (2009)
10. Zona pellucida components are present in human fetal ovary before follicle formation. (PubMed id 18502569)^{1, 9} Tormala R.M....Vaskivuo T.E. (2008)
11. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)^{1, 9} Furlong L.I....Vazquez-Levin M.H. (2005)
12. Detection of zona pellucida proteins during human folliculogenesis. (PubMed id 18033806)^{1, 9} Gook D.A....Martic M. (2008)
13. Biological effects of recombinant human zona pellucida proteins on sperm function. (PubMed id 16407501)^{1, 9} Caballero-Campo P....Gerton G.L. (2006)
14. Proteolytic processing of human zona pellucida proteins. (PubMed id 11804956)^{1, 9} Kiefer S.M. and Saling P. (2002)
15. The human gene for the zona pellucida glycoprotein ZP3 and a second polymorphic locus are located on chromosome 7. (PubMed id 8467708)^{1, 9} van Duin M....Olijve W. (1993)
16. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
17. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
18. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. (PubMed id 19945174)¹ Naz R.K. and Dhandapani L. (2010)
19. Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism. (PubMed id 17192598)¹ Ni Y....Shi Q.X. (2007)
20. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
21. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
22. The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (2003)
23. Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans. (PubMed id 14673092)¹ Dell A....Clark G.F. (2003)
24. A role for the human sperm glycine receptor/Cl(-) cha nnel in the acrosome reaction initiated by recombinant ZP3. (PubMed id 11751269)¹ Bray C....Meizel S. (2002)
25. Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. (PubMed id 11854410)¹ Qi H....Wassarman P.M. (2002)
26. Sperm receptors and fertilization in mammals. (PubMed id 12035074)¹ Wassarman P.M. (2002)
27. Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. (PubMed id 11940668)¹ Zhao M....Dean J. (2002)
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
29. Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization. (PubMed id 11739644)¹ Howes E....Jones R. (2001)
30. The zona pellucida: using molecular genetics to study the mammalian egg coat. (PubMed id 10864856)¹ Rankin T. and Dean J. (2000)
31. Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding. (PubMed id 9609824)¹ Rankin T.L....Dean J. (1998)
32. Immunocytochemical localization of ZP3 in primordial follicles of rabbit, marmoset, rhesus monkey and human ovaries using antibodies against human ZP3. (PubMed id 8984187)¹ Grootenhuis A.J....van Duin M. (1996)
33. Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida. (PubMed id 8269854)¹ Miller D.J....Shur B.D. (1993)
34. Binding characteristics of sperm with recombinant hum an zona pellucida glycoprotein-3 coated beads. (PubMed id 19700799)⁹ Bansal P. and Gupta S.K. (2009)
35. Cloning, sequencing and site of origin of the rat sperm receptor protein, ZP3. (PubMed id 10216914)⁹ Scobie G.A....Aitken R.J. (1999)
36. Nucleotide sequence of cDNA encoding bonnet monkey (M acaca radiata) zona pellucida glycoprotein-ZP3. (PubMed id 8848588)⁹ Kolluri S.K....Gupta S.K. (1995)
37. Anti-ZP3 antibodies binding to the human zona pellucida: effect of oocyte-storage conditions. (PubMed id 7880395)⁹ Hinsch K.D....Oehninger S. (1994)
38. Identification of mouse ZP3 protein in mammalian oocy tes with antisera against synthetic ZP3 peptides. (PubMed id 7524697)⁹ Hinsch K.D....Schill W.B. (1994)
39. The contraceptive potential of ZP3 and ZP3 peptides i n a primate model. (PubMed id 11730908)⁹ Paterson M....Aitken R.J. (2002)
40. Comparison of ZP3 protein sequences among vertebrate species: to obtain a consensus sequence for immunocontraception. (PubMed id 10051457)⁹ Zhu X. and Naz R.K. (1999)
41. Cloning and characterisation of a zona pellucida 3 cDNA from a marsupial, the brushtail possum Trichosurus vulpecula. (PubMed id 10216911)⁹ McCartney C.A. and Mate K.E. (1999)
42. The polypeptide backbone of recombinant human zona pe llucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in v itro. (PubMed id 9480899)⁹ Chapman N....Barratt C.R. (1998)
43. Analysis of the contraceptive potential of antibodies against native and deglycosylated porcine ZP3 in vivo and in vitro. (PubMed id 1576251)⁹ Paterson M....Aitken R.J. (1992)
44. Testing for adaptive evolution of the female reproductive protein ZPC in mammals, birds and fishes reveals problems with the M7-M8 likelihood ratio test. (PubMed id 16283938)⁹ Berlin S. and Smith N.G. (2005)
45. Inactivation of the mouse sperm receptor, mZP3, by site-directed mutagenesis of individual serine residues located at the combining site for sperm. (PubMed id 9600940)⁹ Chen J....Wassarman P.M. (1998)
46. Generation of antisera against mouse and human synthe tic ZP3 peptides. (PubMed id 9017090)⁹ Hinsch E. and Hinsch K.D. (1996)
47. Cloning, sequencing and oocyte-specific expression of the marmoset sperm receptor protein, ZP3. (PubMed id 8081814)⁹ Thillai-Koothan P....Aitken R.J. (1993)
48. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor. (PubMed id 1313375)⁹ Bork P. and Sander C. (1992)
49. Human zona pellucida glycoproteins: functional releva nce during fertilization. (PubMed id 19850354)⁹ Gupta S.K....Chakrabarti K. (2009)
50. Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. (PubMed id 11291774)⁹ Eberspaecher U....Donner P. (2001)
51. Design and evaluation of a ZP3 peptide vaccine in a homologous primate model. (PubMed id 10321806)⁹ Paterson M....Aitken R.J. (1999)
52. The expression and localization of zona pellucida glycoproteins and mRNA in cynomolgus monkeys (Macaca fascicularis). (PubMed id 8984186)⁹ Martinez M.L....Harris J.D. (1996)
53. Mapping of type I loci from human chromosome 7 reveals segments of conserved synteny on pig chromosomes 3, 9, and 18. (PubMed id 8697800)⁹ Bruch J....Hameister H. (1996)
54. Oocyte-specific factors bind a conserved upstream sequence required for mouse zona pellucida promoter activity. (PubMed id 1944285)⁹ Millar S.E....Dean J. (1991)
55. Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis. (PubMed id 17486637)⁹ Chakravarty S....Gupta S.K. (2008)
56. Role of proteasomal activity in the induction of acrosomal exocytosis in human spermatozoa. (PubMed id 18339263)⁹ Chakravarty S....Gupta S.K. (2008)
57. Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm-zona pellucida interaction. (PubMed id 17936279)⁹ Marin-Briggiler C.I....Vazquez-Levin M.H. (2008)
58. Crystal structure of the ZP-N domain of ZP3 reveals t he core fold of animal egg coats. (PubMed id 19052627)⁹ MonnAc M....Jovine L. (2008)
59. Structural and functional attributes of zona pellucida glycoproteins. (PubMed id 17566274)⁹ Gupta S.K....Bhandari B. (2007)
60. The zona pellucida 'receptors' ZP1, ZP2 and ZP3. (PubMed id 10526650)⁹ Hinsch K.D. and Hinsch E. (1999)
61. Evaluation of the contraceptive potential of recombin ant human ZP3 and human ZP3 peptides in a primate model: their safety and effic acy. (PubMed id 9764365)⁹ Paterson M....Aitken R.J. (1998)
62. The potential of the zona pellucida as a target for immunocontraception. (PubMed id 8962643)⁹ Aitken R.J....van Duin M. (1996)
63. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PubMed id 8385033)⁹ Liang L.-F. and Dean J. (1993)
64. [Molecules involved in sperm-zona pellucida interaction in mammals. Role in human fertility] (PubMed id 18547509)⁹ Serres C....Jouannet P. (2008)
65. Differential O-glycosylation of a conserved domain expressed in murine and human ZP3. (PubMed id 16401092)⁹ Chalabi S....Dell A. (2006)
66. Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs. (PubMed id 12852850)⁹ Rankin T.L....Dean J. (2003)
67. The mouse zona pellucida: folliculogenesis, fertility and pre-implantation development. (PubMed id 10963869)⁹ Rankin T....Dean J. (2000)
68. Structure and function of the proteins of the mammalian Zona pellucida. (PubMed id 10729725)⁹ Prasad S.V....Dunbar B.S. (2000)
69. Characterization of human zona pellucida glycoproteins. (PubMed id 10341000)⁹ Bauskin A.R....Donner P. (1999)
70. Rat zona pellucida glycoproteins: molecular cloning and characterization of the three major components. (PubMed id 9820205)⁹ Akatsuka K....Araki Y. (1998)
71. Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida: FA-1 antigen may be a sperm receptor for zona pellucida in humans. (PubMed id 8531189)⁹ Kadam A.L....Naz R.K. (1995)
72. Recombinant human zona pellucida protein ZP3 produced by chinese hamster ovary cells induces the human sperm acrosome reaction and p romotes sperm-egg fusion. (PubMed id 7819440)⁹ van Duin M....Aitken R.J. (1994)
73. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. (PubMed id 7841460)⁹ Harris J.D....Sacco A.G. (1994)
74. Sequential focal and global elevations of sperm intracellular Ca2+ are initiated by the zona pellucida during acrosomal exocytosis. (PubMed id 8088433)⁹ Florman H.M. (1994)
75. Zona pellucida glycoprotein ZP3 and fertilization in mammals. (PubMed id 19504560)⁹ Litscher E.S....Wassarman P.M. (2009)
76. Efficacy of antibodies against a chimeric synthetic peptide encompassing epitopes of bonnet monkey (Macaca radiata) zona pellucida-1 and zona pellucida-3 glycoproteins to inhibit in vitro human sperm-egg binding. (PubMed id 15625695)⁹ Sivapurapu N....Gupta S.K. (2005)
77. Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition. (PubMed id 16096325)⁹ Ziyyat A....Wolf J.P. (2005)
78. Isolation and mapping the chicken zona pellucida genes: an insight into the evolution of orthologous genes in different species. (PubMed id 15570621)⁹ Smith J....Burt D.W. (2005)
79. Oocyte-specific gene signaling and its regulation of mammalian reproductive potential. (PubMed id 15970499)⁹ Acevedo N. and Smith G.D. (2005)
80. Four zona pellucida glycoproteins are expressed in the human. (PubMed id 15142998)⁹ Lefievre L....Barratt C.L. (2004)
81. Recombinant human zona pellucida proteins ZP1, ZP2 and ZP3 co-expressed in a human cell line. (PubMed id 15064827)⁹ Martic M....Baker G.H. (2004)
82. Zona pellucida glycoproteins based immunocontraceptive vaccines: strategies for development and their applications. (PubMed id 15255371)⁹ Gupta S.K....Ravi C. (2003)
83. Stimulation of voltage-dependent calcium channels during capacitation and by progesterone in human sperm. (PubMed id 12464273)⁹ GonzA!lez-MartA-nez M.T....GuzmA!n-Grenfell A.M. (2002)
84. Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes. (PubMed id 12468641)⁹ Huntriss J.... Picton H.M. (2002)
85. Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals. (PubMed id 11226269)⁹ Swanson W.J....Aquadro C.F. (2001)
86. Glycobiology of sperm-egg interactions in deuterostom es. (PubMed id 11358873)⁹ Mengerink K.J. and Vacquier V.D. (2001)
87. Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen. (PubMed id 11006142)⁹ Martinez M.L. and Harris J.D. (2000)
88. Marsupial egg and embryo coats. (PubMed id 10729728)⁹ Selwood L. (2000)
89. Ascidian sperm receptor attached to the vitelline coa t during oocyte maturation. (PubMed id 11191289)⁹ Sawada H....Yokosawa H. (2000)
90. Mapping of dominant B-cell epitopes of a human zona pellucida protein (ZP1). (PubMed id 10569978)⁹ Skinner S.M....Dunbar B.S. (1999)
91. Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. (PubMed id 10570015)⁹ Tsubamoto H....Koyama K. (1999)
92. Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa. (PubMed id 11250775)⁹ Purohit S.B....Kumar G.P. (1999)
93. American Society for Cell Biology. Homing in on a spe rm receptor. (PubMed id 9925473)⁹ Strauss E. (1999)
94. Voltage-dependent calcium influx in human sperm assessed by simultaneous optical detection of intracellular calcium and membrane potential. (PubMed id 9651467)⁹ Linares-Hernandez L....Gonzalez-Martinez M.T. (1998)
95. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. (PubMed id 9872364)⁹ Brewis I.A....Moore H.D. (1998)
96. Modelling human sperm-egg interactions in vitro: signal transduction pathways regulating the acrosome reaction. (PubMed id 9665632)⁹ Benoff S. (1998)
97. [Gamete recognition in mammals: sperm and zona pellucida interactions] (PubMed id 9810129)⁹ Finaz C. and Lefevre A. (1998)
98. Binding of spermatozoa to the perivitelline layer in the presence of a protease inhibitor. (PubMed id 9154629)⁹ Kuroki M. and Mori M. (1997)
99. Identification of epitopes of monoclonal antibodies t o porcine zona pellucida 3 beta glycoprotein, a homologue of the mouse/human sp erm receptor. (PubMed id 9266007)⁹ Afzalpurkar A. and Gupta S.K. (1997)
100. Immunoreactivity and in-vitro effect on human sperm-egg binding of antibodies against peptides corresponding to bonnet monkey zona pellucida-3 glycoprotein. (PubMed id 9455832)⁹ Afzalpurkar A....Gupta S.K. (1997)
101. The role of carbohydrate residues in mammalian fertilization. (PubMed id 9225165)⁹ Shalgi R. and Raz T. (1997)
102. The molecular genetics of the zona pellucida: mouse mutations and infertility. (PubMed id 9237231)⁹ Rankin T. and Dean J. (1996)
103. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. (PubMed id 9239670)⁹ Brewis I.A....Moore H.D. (1996)
104. Early steps of sperm-egg interactions during mammalian fertilization. (PubMed id 8936405)⁹ Barros C....Moreno R.D. (1996)
105. New concepts in human sperm-zona pellucida interactio n. (PubMed id 8592038)⁹ Clark G.F....Oehninger S. (1995)
106. Tyrosine phosphorylation of the egg receptor for sperm at fertilization. (PubMed id 8045346)⁹ Abassi Y.A. and Foltz K.R. (1994)
107. Sex determination of preimplantation embryos by human testis-determining-gene amplification. (PubMed id 7903778)⁹ Cui K.H....Matthews C.D. (1994)
108. Blocking of human fertilization by carbohydrates. (PubMed id 7507936)⁹ Mori K....Aono T. (1993)
109. Binding of sperm to somatic cells via HLA-DR. Modulat ion by sulfated carbohydrates. (PubMed id 1311731)⁹ Scofield V.L....Raghupathy R. (1992)
110. Role of membrane phosphotyrosine proteins in human spermatozoal function. (PubMed id 1721918)⁹ Naz R.K....Kumar R. (1991)
111. Genomic organization and polypeptide primary structur e of zona pellucida glycoprotein hzp3, the hamster sperm receptor. (PubMed id 1850370)⁹ Kinloch R.A....Wassarman P.M. (1991)
112. Rho-kinase (ROCK) in sea urchin sperm: its role in re gulating the intracellular pH during the acrosome reaction. (PubMed id 17959147)⁹ de la Sancha C.U....GarcA-a-Soto J. (2007)
113. Evidence of Amino Acid Diversity-Enhancing Selection within Humans and among Primates at the Candidate Sperm-Receptor Gene PKDREJ. (PubMed id 17564962)⁹ Hamm D.... Swanson W.J. (2007)
114. Neutralization of cytokine activity at the receptor l evel improves sperm motility in men with spinal cord injuries. (PubMed id 17494103)⁹ Brackett N.L....Lynne C.M. (2007)
115. Zona pellucida from fertilised human oocytes induces a voltage-dependent calcium influx and the acrosome reaction in spermatozoa, but cannot be penetrated by sperm. (PubMed id 17147816)⁹ Patrat C....Serres C. (2006)
116. The role of mannose receptor on HIV-1 entry into huma n spermatozoa. (PubMed id 16533334)⁹ Cardona-Maya W....Cadavid A.P. (2006)
117. Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. (PubMed id 16359962)⁹ Jakab A....Huszar G. (2005)
118. Single transmembrane spanning heterotrimeric g protein-coupled receptors and their signaling cascades. (PubMed id 15317909)⁹ Patel T.B. (2004)
119. [Expression of recombinant human zona pellucida-3 protein (rhZP3) in Pichia pastoris] (PubMed id 15971594)⁹ Tang J....Sun C.J. (2003)
120. Nicotinic acid adenine dinucleotide phosphate (NAADP) is present at micromolar concentrations in sea urchin spermatozoa. (PubMed id 12356884)⁹ Billington R.A....Genazzani A.A. (2002)
121. Structural organization and evolution of the marsupial zona pellucida. (PubMed id 11869182)⁹ Breed W.G....Chapman J.A. (2002)
122. Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction. (PubMed id 11056077)⁹ Baldi E....Forti G. (2000)
123. PLAC1, an Xq26 gene with placenta-specific expression. (PubMed id 10995572)⁹ Cocchia M.... Schlessinger D. (2000)
124. DNA template amplification genetic studies on archiva l human preimplantation biopsied microtubed cell samples. (PubMed id 9510013)⁹ Smith T.A....Muggleton-Harris A.L. (1998)
125. Protein-carbohydrate interactions during fertilization. (PubMed id 9780359)⁹ Sinowatz F....Kolle S. (1998)
126. Size differences between human X and Y spermatozoa an d prefertilization diagnosis. (PubMed id 9239709)⁹ Cui K.H. (1997)
127. Integrins: expression, modulation, and signaling in fertilization, embryogenesis and implantation. (PubMed id 9095578)⁹ Yoshimura Y. (1997)
128. Human sperm activation during capacitation and acroso me reaction: role of calcium, protein phosphorylation and lipid remodelling pat hways. (PubMed id 9159227)⁹ Baldi E....Forti G. (1996)
129. Strategies for designing an immunocontraceptive vaccine based on zona pellucida synthetic peptides and recombinant antigen. (PubMed id 8984175)⁹ Kaul R....Gupta S.K. (1996)
130. Developmental expression of the sea urchin egg recept or for sperm. (PubMed id 8088450)⁹ Ohlendieck K....Lennarz W.J. (1994)
131. Human spermatozoal FA-1 binds with ZP3 of porcine zon a pellucida. (PubMed id 1875328)⁹ Naz R.K....Yurewicz E.C. (1991)
132. Glycoprotein constituents of the vitelline coat of Ph allusia mammillata (Ascidiacea) with fertilization inhibiting activity. (PubMed id 1660420)⁹ Litscher E. and Honegger T.G. (1991)
133. Multiple stores of calcium are released in the sea urchin egg during fertilization. (PubMed id 2251272)⁹ Rakow T.L. and Shen S.S. (1990)

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