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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZP3 Gene

protein-coding   GIFtS: 55
GCID: GC07P076026

zona pellucida glycoprotein 3 (sperm receptor)

(Previous name: zona pellucida glycoprotein 3A (sperm receptor) )
(Previous symbols: ZP3A, ZP3B)
 Explore 7 diseases affiliated with
ZP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZP3    

Aliases
for ZP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zona Pellucida Glycoprotein 3 (Sperm Receptor)1 2     Zp-32 3
ZP3A1 2 3 5     ZP3-3721
ZP3B1 2 3 5     ZP3-4241
Zona Pellucida Glycoprotein 3A (Sperm Receptor)1 2     Zona Pellucida Glycoprotein 3B2
Sperm Receptor2 3     Zona Pellucida Glycoprotein ZP32
Zona Pellucida Protein C2 3     Zona Pellucida Sperm-Binding Protein 32
ZP3A/ZP3B2 3     Zona Pellucida Glycoprotein 33
ZPC2 3     

External Ids:    HGNC: 131891   Entrez Gene: 77842   Ensembl: ENSG000001883727   OMIM: 1828895   UniProtKB: P217543   

Export aliases for ZP3 gene to outside databases

Previous GC identifers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671 GC07P075864 GC07P071113


Summaries
for ZP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZP3:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of
three or four glycoproteins with various functions during fertilization and preimplantation development. The protein
encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of
the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain,
a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results
in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix.
However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation
in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and
literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a
bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above
described variation, and maps closely to this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and
ZP4. ZP3 is essential for sperm binding and zona matrix formation

Gene Wiki entry for ZP3


Genomic Views
for ZP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZP3 gene promoter:
         E2F-4   E2F-3a   SRY   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

ZP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076026:  view genomic region     (about GC identifiers)

Start:
 76,026,835 bp from pter      End:
 76,071,388 bp from pter
Size:
 44,554 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,359,905-75,404,452     

Proteins
for ZP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 3 precursor  
Size: 424 amino acids; 47018 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)
Subcellular location: Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular
matrix
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q06633 Q29RW0
Alternative splicing: 3 isoforms:  P21754-1   P21754-2   P21754-3   (Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids)

Explore the universe of human proteins at neXtProt for ZP3: NX_P21754

Post-translational modifications:

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona
    • pellucida1
  • N-glycosylated (By similarity)1
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy
    • (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21754

    • ZP3 Protein expression data from MOPED and PaxDb:    About this image 
    ZP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001103824.1  NP_009086.4  

    ENSEMBL proteins: 
     ENSP00000337310   ENSP00000378326   ENSP00000411955   ENSP00000378329  

    Human Recombinant Protein Products for ZP3: 
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    Novus Biologicals ZP3 Protein
    Novus Biologicals ZP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZP3

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669colocalizes with acrosomal vesicle ISS--
    GO:0002081outer acrosomal membrane ISS--
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IMP19246320

    ZP3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZP3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017977 ZP_dom_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P21754

    ProtoNet protein and cluster: P21754

    1 Blocks protein family: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
    Similarity: Belongs to the ZP domain family. ZPC subfamily
    Similarity: Contains 1 ZP domain


    Function
    for ZP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZP3_HUMAN, P21754
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
    reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and
    ZP4. ZP3 is essential for sperm binding and zona matrix formation

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP18667750
    GO:0004872receptor activity ----
    GO:0005384manganese ion transmembrane transporter activity ISS--
    GO:0005515protein binding IPI19945174
    GO:0015279store-operated calcium channel activity IDA--
         
    ZP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZP3:
     Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zp3):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    ZP3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for ZP3: Zp3tm1Dean Zp3tm1Pmw
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZP3 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Pathways & Interactions
    for ZP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ovarian Infertility Genes
    		Ovarian Infertility Genes1.00
    2Sweet Taste Signaling
    		Sperm Motility0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ZP3
        Sperm Motility

    1 BioSystems Pathway for ZP3 
        Ovarian Infertility Genes


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ZP3 (P217543 ENSP000003783264) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACRP103233, ENSP000002161394I2D: score=2 STRING: ENSP00000216139
    C4BPAP040033, ENSP000003560374I2D: score=1 STRING: ENSP00000356037
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    ENGASEQ8NFI33, ENSP000003006824I2D: score=1 STRING: ENSP00000300682
    UBAP2LENSP000003553434STRING: ENSP00000355343
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001809positive regulation of type IV hypersensitivity ISS--
    GO:0001825blastocyst formation ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0002687positive regulation of leukocyte migration ISS--
    GO:0002922positive regulation of humoral immune response IDA19004505

    ZP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZP3
    9 Novoseek chemical compound relationships for ZP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 30.9 2 7507936 (1)
    calcium 24.6 4 9239670 (1), 12464273 (1), 9651467 (1), 8088433 (1)
    tyrosine 22.5 9 8045346 (2), 9665632 (1), 15317909 (1), 9872364 (1) (see all 6)
    carbohydrates 19.5 3 1311731 (1), 11358873 (1), 9225165 (1)
    cysteine 17.3 3 10216911 (1), 10216914 (1)
    progesterone 17.1 2 12464273 (1), 9651467 (1)
    serine 7.14 2 9600940 (1), 10216914 (1)
    proline 0 2 10216914 (2)
    polysaccharide 0 1 11358873 (1)

    Search CenterWatch for drugs/clinical trials and news about ZP3 

    Transcripts
    for ZP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZP3 gene (2 alternative transcripts): 
    NM_001110354.1  NM_007155.5  

    Unigene Cluster for ZP3:

    Zona pellucida glycoprotein 3 (sperm receptor)
    Hs.656137  [show with all ESTs]
    Unigene Representative Sequence: BC113949
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336517(uc003ufc.4) ENST00000394857(uc003ufd.4) ENST00000416245(uc003ufe.3)
    ENST00000394860 ENST00000466960 ENST00000479793 ENST00000467555

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    Clone
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    Additional cDNA sequence: 

    AK292763.1 BC113949.1 M60504.1 S52509.1 

    13 DOTS entries:

    DT.95145133  DT.121067326  DT.92469787  DT.100027278  DT.95145163  DT.100790706  DT.121637693  DT.95145124 
    DT.95266574  DT.95293148  DT.97769393  DT.121090535  DT.95362005 

    24/159 AceView cDNA sequences (see all 159):

    AI075996 BF726964 CR603033 AI359326 AW162786 BQ446470 BF063092 AI802299 
    BF195407 CR616549 BU186061 BQ670433 CD389947 AI144523 BE893300 AA334331 
    CB120286 BC000487 BF983753 AA333786 AW249685 BV205866 AI051631 BX427701 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      
    SP3:                                -     -               


    ECgene alternative splicing isoforms for ZP3

    Expression
    for ZP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTAGAGCA
    ZP3 Expression
    About this image

    ZP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOvumFemale Gametocytes, Germ Cells
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    Ovarian tissue-dissociated cells (Primary Cell)Reproductive System
    Ovarian tissue-dissociated cells (human) (Primary Cell)Ovary, Reproductive System
    ES-J1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Long-time differentiated EBs (Derivation of embryo...)
    Short-term differentiated embryoid bodies (Derivation of embryo...)
    Oocytes (Oocyte formation by ...)
    Human oogonial stem cells (Oocyte formation by ...)
    Human oogonial stem cells (Oocyte formation by ...)
    Oocytes (Oocyte formation by ...)

    See ZP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZP3

    SOURCE GeneReport for Unigene cluster: Hs.656137

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Tissue specificity: Oocytes

        SABiosciences Custom PCR Arrays for ZP3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

    Orthologs
    for ZP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZP3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4153141 zona pellucida glycoprotein 3 (sperm receptor)-like 62.64(n)
    56.54(a)    		   415314  XM_413701.3  XP_413701.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 52(a)
    35(a)
    		 possible ortholog
    possible ortholog
    		 GL343492.1(388222-397209)
    1(90834853-90840023)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.37152 Xenopus laevis transcribed sequence with weak similarity more 73.25(n)    BX851629.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zp3a.21 zona pellucida glycoprotein 3a.2 52.13(n)
    41.49(a)    		   558677  NM_001030120.1  NP_001025291.1 


    ENSEMBL Gene Tree for ZP3 (if available)
    TreeFam Gene Tree for ZP3 (if available) 

    Paralogs
    for ZP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZP3 gene
    POMZP32  
    2 SIMAP similar genes for ZP3 using alignment to 3 protein entries:     ZP3_HUMAN (see all proteins):
    ZP3A    POMZP3

    ZP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZP3
    PGOHUM00000235302 PGOHUM00000233581


    Genomic Variants
    for ZP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 NCBI SNPs in ZP3 are shown (see all 1036)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1119194791,2
    		--76024890(+) CGCTTG/TCATTT 2 -- int1 us2k11Minor allele frequency- T:0.00CSA 1
    rs1823837171,2
    		--76024966(+) CTTGCC/TCATCA 2 -- int1 us2k10--------
    rs1399479411,2
    		--76025008(+) TATCC-/TCCTCT
    TTTCTTTTT    TTTGA     		2 -- int1 us2k10--------
    rs624768011,2
    		C--76025112(+) CAAGCA/GATTCC 2 -- int1 us2k12Minor allele frequency- G:0.25NA 4
    rs1380184121,2
    		--76025204(+) ATGGGA/GTTTCA 2 -- int1 us2k10--------
    rs1128990551,2
    		C--76025240(+) CACCCG/AACCTC 2 -- int1 us2k12Minor allele frequency- A:0.08WA 120
    rs1115526541,2
    		C--76025264(+) ATCTCG/AGCCTC 2 -- int1 us2k11Minor allele frequency- A:0.50NA 2
    rs1890661711,2
    		--76025417(+) CTCCTA/GCAGCC 2 -- int1 us2k10--------
    rs286063981,2
    		C--76025447(+) AAAAAA/CCAAAA 2 -- int1 us2k11Minor allele frequency- C:0.00NA 2
    rs768472491,2
    		--76025455(+) AAAAAC/ACAACT 2 -- us2k1 int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZP3 (76026835 - 76071388 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for ZP3
         10 CNVs: 2700 64866 8569 8568 9060 22956 7646 9061 3686 5241
         1 Indel: 99992

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    Disorders / Diseases
    for ZP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZP3 for disorders           About GeneDecksing

    OMIM gene information: 182889    OMIM disorders: --

    7 diseases for ZP3:    About MalaCards
    spinal cord injury    haverhill fever    sodoku disease    oophoritis
    diphtheria    hepatitis b    hepatitis

    4 diseases from the University of Copenhagen DISEASES database for ZP3:
    Oophoritis     Infertility     Ovarian dysfunction     Diphtheria

    2 Novoseek disease relationships for ZP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian dysfunction 80.7 2 10321806 (1)
    infertility 51.9 7 8984175 (1), 17936279 (1), 11730908 (1), 1576251 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: ZP3 (2 documents)

    Export disorders for ZP3 gene to outside databases

    Publications
    for ZP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZP3 gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with ZP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PubMed id 1478648)1, 2, 3, 9 van Duin M.... Aitken R.J. (1992)
    2. Human homolog of the mouse sperm receptor. (PubMed id 2385582)1, 2, 9 Chamberlin M.E. and Dean J. (1990)
    3. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PubMed id 15379548)1, 2, 9 Zhao M....Dean J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Species specificity of human and murine anti-ZP3 synthetic peptide antisera and use of the antibodies for localization and identification of ZP3 or ZPC domains of functional significance. (PubMed id 10099990)1, 9 Hinsch E....Hinsch K.D. (1999)
    6. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PubMed id 7789967)1, 9 Kipersztok S.... Dean J. (1995)
    7. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PubMed id 19004505)1, 9 Choudhury S....Gupta S.K. (2009)
    8. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. (PubMed id 18667750)1, 9 Chiu P.C....Yeung W.S. (2008)
    9. Functional activity of human ZP3 primary sperm recept or resides toward its C-terminus. (PubMed id 19246320)1, 9 Bansal P....Gupta S.K. (2009)
    10. Zona pellucida components are present in human fetal ovary before follicle formation. (PubMed id 18502569)1, 9 Tormala R.M....Vaskivuo T.E. (2008)

    External Searches for ZP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7784 HGNC: 13189 AceView: POMZP3 Ensembl:ENSG00000188372 euGenes: HUgn7784
    ECgene: ZP3 H-InvDB: ZP3

    Other Databases showing ZP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZP3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt093.shtml

    Intellectual Property
    for ZP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZP3 gene:
    Search GeneIP for patents involving ZP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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