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Aliases for ZP3 Gene

Aliases for ZP3 Gene

  • Zona Pellucida Glycoprotein 3 2 3 4 5
  • Zona Pellucida Protein C 3 4
  • Sperm Receptor 3 4
  • ZP3A/ZP3B 3 4
  • ZP3A 3 4
  • ZP3B 3 4
  • Zp-3 3 4
  • ZPC 3 4
  • Zona Pellucida Glycoprotein 3A (Sperm Receptor) 2
  • Zona Pellucida Sperm-Binding Protein 3 3
  • Zona Pellucida Glycoprotein ZP3 3
  • Zona Pellucida Glycoprotein 3B 3

External Ids for ZP3 Gene

Previous HGNC Symbols for ZP3 Gene

  • ZP3A
  • ZP3B

Previous GeneCards Identifiers for ZP3 Gene

  • GC07P074589
  • GC07P071749
  • GC07P071763
  • GC07P075638
  • GC07P075671
  • GC07P075864
  • GC07P076026
  • GC07P071113

Summaries for ZP3 Gene

Entrez Gene Summary for ZP3 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP3 Gene

ZP3 (Zona Pellucida Glycoprotein 3) is a Protein Coding gene. Diseases associated with ZP3 include Infertility and Ovarian Disease. Among its related pathways are Reproduction and Ovarian Infertility Genes. GO annotations related to this gene include signal transducer activity and store-operated calcium channel activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot for ZP3 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Gene Wiki entry for ZP3 Gene

Additional gene information for ZP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP3 Gene

Genomics for ZP3 Gene

Regulatory Elements for ZP3 Gene

Enhancers for ZP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H076568 0.9 ENCODE dbSUPER 67.1 +171.5 171461 0.3 SOX5 SOX13 PRDM6 JUND FOXA2 TEAD1 JUN FOS ZP3 LOC100133091 PIR43157
GH07H076548 1 ENCODE 58.7 +152.1 152075 1.9 HDGF ATF1 ARNT ARID4B SIN3A DMAP1 ETS1 ELK1 ZNF207 ZNF143 ZP3 UPK3B POMZP3 LOC100133091 PIR43157
GH07H076575 0.8 Ensembl dbSUPER 69.2 +178.6 178583 1 NFIC NFIA NFIB ZNF600 PRDM10 ZP3 UPK3B LOC100133091 PIR43157
GH07H076420 1.7 FANTOM5 Ensembl ENCODE dbSUPER 30 +25.5 25450 5.4 PKNOX1 SIN3A NFXL1 BMI1 BRCA1 ZEB1 RFX5 ZNF121 ZNF366 SCRT2 UPK3B ZP3 POMZP3 SRRM3 LOC100133091 SSC4D DTX2
GH07H076605 1.2 Ensembl ENCODE dbSUPER 38.3 +209.1 209083 3.2 HDAC1 PKNOX1 ATF1 SIN3A CTBP1 FOXK2 IKZF2 SMARCE1 NRF1 DPF2 ZP3 UPK3B LOC100133091 ENSG00000230305 PIR43157 GC07P076622 PIR56287 GC07P076625 GC07P076623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZP3 on UCSC Golden Path with GeneCards custom track

Promoters for ZP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000213919 -18 201 ATF1 SIN3A YY1 ATF7 SP3 YY2 SMARCB1 ZNF592 SMARCA4 MYNN

Genomic Locations for ZP3 Gene

Genomic Locations for ZP3 Gene
44,554 bases
Plus strand

Genomic View for ZP3 Gene

Genes around ZP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP3 Gene

Proteins for ZP3 Gene

  • Protein details for ZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida sperm-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • Q06633
    • Q29RW0

    Protein attributes for ZP3 Gene

    424 amino acids
    Molecular mass:
    47018 Da
    Quaternary structure:
    • Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

    Alternative splice isoforms for ZP3 Gene


neXtProt entry for ZP3 Gene

Post-translational modifications for ZP3 Gene

  • N-glycosylated.
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • Glycosylation at isoforms=3, 2125, Asn147, Thr156, isoforms=3, 2162, Thr163, isoforms=3, 2226, and isoforms=3, 2272
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP3 Gene

No data available for DME Specific Peptides for ZP3 Gene

Domains & Families for ZP3 Gene

Gene Families for ZP3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ZP3 Gene


Suggested Antigen Peptide Sequences for ZP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPC subfamily.
genes like me logo Genes that share domains with ZP3: view

Function for ZP3 Gene

Molecular function for ZP3 Gene

UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Phenotypes From GWAS Catalog for ZP3 Gene

Gene Ontology (GO) - Molecular Function for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005384 manganese ion transmembrane transporter activity ISS --
GO:0005515 protein binding IPI 19945174
GO:0030246 carbohydrate binding IDA 19246320
GO:0032190 acrosin binding IPI 15950651
GO:0042802 identical protein binding IPI 26879157
genes like me logo Genes that share ontologies with ZP3: view
genes like me logo Genes that share phenotypes with ZP3: view

Animal Models for ZP3 Gene

MGI Knock Outs for ZP3:

Animal Model Products

CRISPR Products

miRNA for ZP3 Gene

miRTarBase miRNAs that target ZP3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZP3 Gene

Localization for ZP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP3 Gene

Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000305}.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZP3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
endosome 4
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002081 colocalizes_with outer acrosomal membrane ISS --
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IMP 19246320
GO:0005737 cytoplasm IDA 9609824
genes like me logo Genes that share ontologies with ZP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZP3 Gene

Pathways & Interactions for ZP3 Gene

genes like me logo Genes that share pathways with ZP3: view

Pathways by source for ZP3 Gene

1 BioSystems pathway for ZP3 Gene
1 Qiagen pathway for ZP3 Gene

Gene Ontology (GO) - Biological Process for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001809 positive regulation of type IV hypersensitivity ISS --
GO:0001825 blastocyst formation ISS --
GO:0002455 humoral immune response mediated by circulating immunoglobulin ISS --
GO:0002687 positive regulation of leukocyte migration ISS --
GO:0002922 positive regulation of humoral immune response IDA 19004505
genes like me logo Genes that share ontologies with ZP3: view

No data available for SIGNOR curated interactions for ZP3 Gene

Drugs & Compounds for ZP3 Gene

(7) Drugs for ZP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZP3: view

Transcripts for ZP3 Gene

Unigene Clusters for ZP3 Gene

Zona pellucida glycoprotein 3 (sperm receptor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP3: - -

Relevant External Links for ZP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZP3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZP3 Gene

Protein tissue co-expression partners for ZP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZP3 Gene:


SOURCE GeneReport for Unigene cluster for ZP3 Gene:


mRNA Expression by UniProt/SwissProt for ZP3 Gene:

Tissue specificity: Oocytes.

Evidence on tissue expression from TISSUES for ZP3 Gene

  • Nervous system(4.5)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZP3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZP3 Gene

Orthologs for ZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZP3 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia ZP3 33 34
  • 79.63 (n)
(Canis familiaris)
Mammalia ZP3 33 34
  • 79.17 (n)
(Mus musculus)
Mammalia Zp3 33 16 34
  • 74.54 (n)
(Rattus norvegicus)
Mammalia Zp3 33
  • 73.99 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
(Gallus gallus)
Aves ZP3 33
  • 61.78 (n)
-- 34
  • 46 (a)
-- 34
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394444 33
  • 55.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3715 33
(Danio rerio)
Actinopterygii zp3a.2 33 34
  • 52.13 (n)
zgc:171779 34
  • 27 (a)
zgc:173556 34
  • 27 (a)
zp3a.1 34
  • 27 (a)
zp3.2 34 34
  • 26 (a)
zp3b 34
  • 22 (a)
Species where no ortholog for ZP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP3 Gene

Gene Tree for ZP3 (if available)
Gene Tree for ZP3 (if available)

Paralogs for ZP3 Gene

Paralogs for ZP3 Gene

(2) SIMAP similar genes for ZP3 Gene using alignment to 3 proteins: Pseudogenes for ZP3 Gene

genes like me logo Genes that share paralogs with ZP3: view

Variants for ZP3 Gene

Sequence variations from dbSNP and Humsavar for ZP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000029426 -- 76,414,463(+) GGGAG(C/G)AGCCT intron-variant
rs1000104374 -- 76,427,838(+) CCACC(A/G)TGCCC intron-variant
rs1000116853 -- 76,414,070(+) CAGCT(C/G)GCTGC intron-variant
rs1000193036 -- 76,420,027(+) AAACT(C/G)CTGAC intron-variant
rs1000303488 -- 76,425,748(+) TCACT(C/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZP3 Gene

Variant ID Type Subtype PubMed ID
nsv970893 CNV duplication 23825009
nsv7403 OTHER inversion 18451855
nsv607585 CNV gain 21841781
nsv528969 CNV gain 19592680
nsv517634 CNV gain+loss 19592680
nsv428174 CNV gain 18775914
nsv1128344 CNV deletion 24896259
nsv1119226 CNV duplication 24896259
nsv1028665 CNV gain 25217958
esv3613763 CNV loss 21293372
esv3613762 CNV loss 21293372
esv3541928 CNV deletion 23714750
esv33074 CNV gain 17666407
esv2669174 CNV deletion 23128226
esv2584656 CNV insertion 19546169
esv2422494 CNV duplication 17116639
esv23516 CNV gain 19812545
dgv235e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv232e55 CNV gain 17911159
dgv21n31 CNV gain 19718026
dgv120n16 CNV deletion 17901297

Variation tolerance for ZP3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP3 Gene

Disorders for ZP3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian disease
  • ovarian dysfunction
retinitis pigmentosa 27
  • rp27
reproductive system disease
  • genital system disease
female reproductive system disease
  • genital diseases, female
- elite association - COSMIC cancer census association via MalaCards
Search ZP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZP3

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZP3 Gene

Publications for ZP3 Gene

  1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PMID: 1478648) van Duin M … Aitken RJ (Genomics 1992) 2 3 4 22 60
  2. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PMID: 15379548) Zhao M … Dean J (Biochemistry 2004) 3 4 22 60
  3. Human homolog of the mouse sperm receptor. (PMID: 2385582) Chamberlin ME … Dean J (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22 60
  4. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PMID: 19004505) Choudhury S … Gupta SK (Journal of reproductive immunology 2009) 3 22 60
  5. Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus. (PMID: 19246320) Bansal P … Gupta SK (Biology of reproduction 2009) 3 22 60

Products for ZP3 Gene

Sources for ZP3 Gene

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