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Aliases for ZP3 Gene

Aliases for ZP3 Gene

  • Zona Pellucida Glycoprotein 3 (Sperm Receptor) 2 3
  • Zona Pellucida Glycoprotein 3A (Sperm Receptor) 2 3
  • Zona Pellucida Protein C 3 4
  • Sperm Receptor 3 4
  • ZP3A/ZP3B 3 4
  • ZP3A 3 4
  • ZP3B 3 4
  • Zp-3 3 4
  • ZPC 3 4
  • Zona Pellucida Glycoprotein ZP3 3
  • Zona Pellucida Glycoprotein 3B 3
  • Zona Pellucida Glycoprotein 3 4

External Ids for ZP3 Gene

Previous HGNC Symbols for ZP3 Gene

  • ZP3A
  • ZP3B

Previous GeneCards Identifiers for ZP3 Gene

  • GC07P074589
  • GC07P071749
  • GC07P071763
  • GC07P075638
  • GC07P075671
  • GC07P075864
  • GC07P076026
  • GC07P071113

Summaries for ZP3 Gene

Entrez Gene Summary for ZP3 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP3 Gene

ZP3 (Zona Pellucida Glycoprotein 3 (Sperm Receptor)) is a Protein Coding gene. Diseases associated with ZP3 include ovarian disease and infertility. Among its related pathways are Sweet Taste Signaling and Ovarian Infertility Genes. GO annotations related to this gene include signal transducer activity and store-operated calcium channel activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot for ZP3 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation

Gene Wiki entry for ZP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP3 Gene

Genomics for ZP3 Gene

Regulatory Elements for ZP3 Gene

Genomic Location for ZP3 Gene

Chromosome:
7
Start:
76,397,518 bp from pter
End:
76,442,071 bp from pter
Size:
44,554 bases
Orientation:
Plus strand

Genomic View for ZP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP3 Gene

Proteins for ZP3 Gene

  • Protein details for ZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21754-ZP3_HUMAN
    Recommended name:
    Zona pellucida sperm-binding protein 3
    Protein Accession:
    P21754
    Secondary Accessions:
    • Q06633
    • Q29RW0

    Protein attributes for ZP3 Gene

    Size:
    424 amino acids
    Molecular mass:
    47018 Da
    Quaternary structure:
    • Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

    Alternative splice isoforms for ZP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZP3 Gene

Proteomics data for ZP3 Gene at MOPED

Post-translational modifications for ZP3 Gene

  • N-glycosylated.
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • Glycosylation at Asn 125, Asn 147, Thr 156, Thr 162, Thr 163, Asn 226, and Asn 272
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP3 Gene

No data available for DME Specific Peptides for ZP3 Gene

Domains & Families for ZP3 Gene

Gene Families for ZP3 Gene

Protein Domains for ZP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21754

UniProtKB/Swiss-Prot:

ZP3_HUMAN :
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
Domain:
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
  • Belongs to the ZP domain family. ZPC subfamily.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with ZP3: view

Function for ZP3 Gene

Molecular function for ZP3 Gene

UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation

Gene Ontology (GO) - Molecular Function for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 18667750
GO:0005384 manganese ion transmembrane transporter activity ISS --
GO:0005515 protein binding IPI 19945174
GO:0015279 store-operated calcium channel activity IDA 20394732
GO:0030246 carbohydrate binding IDA 19246320
genes like me logo Genes that share ontologies with ZP3: view
genes like me logo Genes that share phenotypes with ZP3: view

Animal Models for ZP3 Gene

MGI Knock Outs for ZP3:

Animal Model Products

miRNA for ZP3 Gene

miRTarBase miRNAs that target ZP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZP3 Gene

Localization for ZP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP3 Gene

Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZP3 Gene COMPARTMENTS Subcellular localization image for ZP3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 colocalizes_with acrosomal vesicle ISS --
GO:0002081 outer acrosomal membrane ISS --
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IMP 19246320
genes like me logo Genes that share ontologies with ZP3: view

Pathways & Interactions for ZP3 Gene

genes like me logo Genes that share pathways with ZP3: view

Pathways by source for ZP3 Gene

1 Qiagen pathway for ZP3 Gene
1 BioSystems pathway for ZP3 Gene

Gene Ontology (GO) - Biological Process for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001809 positive regulation of type IV hypersensitivity ISS --
GO:0001825 blastocyst formation ISS --
GO:0002455 humoral immune response mediated by circulating immunoglobulin ISS --
GO:0002687 positive regulation of leukocyte migration ISS --
GO:0002922 positive regulation of humoral immune response IDA 19004505
genes like me logo Genes that share ontologies with ZP3: view

No data available for SIGNOR curated interactions for ZP3 Gene

Drugs & Compounds for ZP3 Gene

(6) Drugs for ZP3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Calcium Nutra 0
cysteine Nutra 143
proline Nutra 20
serine Nutra 420

(3) Additional Compounds for ZP3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbohydrates
mannose
polysaccharide
genes like me logo Genes that share compounds with ZP3: view

Transcripts for ZP3 Gene

Unigene Clusters for ZP3 Gene

Zona pellucida glycoprotein 3 (sperm receptor):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:
SP3: - -

Relevant External Links for ZP3 Gene

GeneLoc Exon Structure for
ZP3
ECgene alternative splicing isoforms for
ZP3

Expression for ZP3 Gene

mRNA expression in normal human tissues for ZP3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZP3 Gene



SOURCE GeneReport for Unigene cluster for ZP3 Gene Hs.656137

mRNA Expression by UniProt/SwissProt for ZP3 Gene

P21754-ZP3_HUMAN
Tissue specificity: Oocytes
genes like me logo Genes that share expression patterns with ZP3: view

Protein tissue co-expression partners for ZP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ZP3 Gene

Orthologs for ZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZP3 35
  • 79.63 (n)
  • 72.62 (a)
ZP3 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZP3 35
  • 79.17 (n)
  • 71.87 (a)
ZP3 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zp3 35
  • 74.54 (n)
  • 68.26 (a)
Zp3 16
Zp3 36
  • 67 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZP3 35
  • 99.46 (n)
  • 98.93 (a)
ZP3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zp3 35
  • 73.99 (n)
  • 67.06 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZP3 35
  • 61.78 (n)
  • 53.53 (a)
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394444 35
  • 55.95 (n)
  • 48.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3715 35
zebrafish
(Danio rerio)
Actinopterygii zp3a.2 35
  • 52.13 (n)
  • 41.49 (a)
zgc:171779 36
  • 27 (a)
ManyToMany
zgc:173556 36
  • 27 (a)
ManyToMany
zp3.2 36
  • 26 (a)
ManyToMany
zp3.2 36
  • 26 (a)
ManyToMany
zp3a.1 36
  • 27 (a)
ManyToMany
zp3a.2 36
  • 29 (a)
ManyToMany
zp3b 36
  • 22 (a)
ManyToMany
Species with no ortholog for ZP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP3 Gene

ENSEMBL:
Gene Tree for ZP3 (if available)
TreeFam:
Gene Tree for ZP3 (if available)

Paralogs for ZP3 Gene

Paralogs for ZP3 Gene

(2) SIMAP similar genes for ZP3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZP3 Gene

genes like me logo Genes that share paralogs with ZP3: view

Variants for ZP3 Gene

Sequence variations from dbSNP and Humsavar for ZP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs750103 -- 76,419,218(+) TGATT(G/T)GTGCA intron-variant
rs887048 -- 76,430,918(-) ACACT(A/G)CCCTC intron-variant
rs887049 -- 76,430,893(-) GCCAC(A/G)TGGCT intron-variant
rs916491 -- 76,437,883(-) AGCTT(C/T)TTCCT intron-variant
rs1019096 -- 76,417,007(-) GGGGA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZP3 Gene

Variant ID Type Subtype PubMed ID
nsv528969 CNV Gain 19592680
essv14753 CNV CNV 17122850
dgv120n16 CNV Deletion 17901297
dgv2104e1 CNV Complex 17122850
nsv888387 CNV Loss 21882294
esv2422494 CNV Duplication 17116639
nsv428174 CNV Gain 18775914
dgv232e55 CNV Gain 17911159
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
nsv7403 OTHER Inversion 18451855
dgv2107e1 CNV Complex 17122850
esv2669174 CNV Deletion 23128226
esv2584656 CNV Insertion 19546169
dgv234e55 CNV Gain 17911159
dgv235e55 CNV Loss 17911159
nsv517634 CNV Gain+Loss 19592680
esv23516 CNV Gain 19812545
esv33074 CNV Gain 17666407
dgv21n31 CNV Duplication 19718026

Variation tolerance for ZP3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZP3 Gene

HapMap Linkage Disequilibrium report
ZP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP3 Gene

Disorders for ZP3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZP3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ovarian disease
  • ovary disorder
infertility
reproductive system disease
  • non-neoplastic reproductive system disease
female reproductive system disease
  • female reproductive system disorder
- elite association
Search ZP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZP3

Human Genome Epidemiology (HuGE) Navigator
ZP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZP3
genes like me logo Genes that share disorders with ZP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZP3 Gene

Publications for ZP3 Gene

  1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PMID: 1478648) van Duin M. … Aitken R.J. (Genomics 1992) 2 23 67
  2. Human zona pellucida glycoproteins: functional relevance during fertilization. (PMID: 19850354) Gupta S.K. … Chakrabarti K. (J. Reprod. Immunol. 2009) 23 67
  3. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PMID: 19004505) Choudhury S. … Gupta S.K. (J. Reprod. Immunol. 2009) 23 67
  4. Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus. (PMID: 19246320) Bansal P. … Gupta S.K. (Biol. Reprod. 2009) 23 67
  5. Zona pellucida glycoprotein ZP3 and fertilization in mammals. (PMID: 19504560) Litscher E.S. … Wassarman P.M. (Mol. Reprod. Dev. 2009) 23 67

Products for ZP3 Gene

Sources for ZP3 Gene

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